inflammatory response

Reduce Inflammatory Processes with Mindfulness

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Reduce Inflammatory Processes with Mindfulness

 

By John M. de Castro, Ph.D.

 

“Millions of people around the world already enjoy the health benefits of mind-body interventions like yoga or meditation, but what they perhaps don’t realize is that these benefits begin at a molecular level and can change the way our genetic code goes about its business. These activities are leaving what we call a molecular signature in our cells, which reverses the effect that stress or anxiety would have on the body by changing how our genes are expressed. Put simply, MBIs cause the brain to steer our DNA processes along a path which improves our wellbeing.” – Ivana Buric

 

The immune system is designed to protect the body from threats like stress, infection, injury, and toxic chemicals. One of its tools is the Inflammatory response. This response works quite well for short-term infections and injuries. But when inflammation is protracted and becomes chronic, it can itself become a threat to health. It can produce autoimmune diseases such as colitis, Chron’s disease, arthritis, heart disease, increased cancer risk, lung disease, sleep disruption, gum disease, decreased bone health, psoriasis, and depression. Needless to say, chronic inflammation can create major health problems. Indeed, the presence of chronic inflammation is associated with reduced longevity. So, it is important for health to control the inflammatory response, allowing it to do its job in fighting off infection but reducing its activity when no external threat is apparent.

 

Of course, it is far better to prevent chronic inflammation in the first place than to treat it later. Mind-body techniques such as yoga, Tai Chi and meditation have been shown to adaptively reduce the inflammatory response. In today’s Research News article “Effects of Mind-Body Training on Cytokines and Their Interactions with Catecholamines.” (See summary below or view the full text of the study at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5561407/ ), Jang and colleagues recruited healthy adult Mind-Body Training (MBT) practitioners and a group of healthy adult non-practitioners. MBT consists of a combination of mindful movements, breathing exercises, and meditation. The recruited practitioners engaged in MBT on average for about an hour three or four times per week. Blood samples from all participants were drawn and assayed for cytokines, including TNF-Alpha, IL-6, IL-10, and IFN-Gamma, and the catecholamines, Norepinephrine, Epinephrine, and Dopamine.

 

They found that the Mind-Body Training (MBT) group had significantly higher levels of the anti-inflammatory cytokine, IL-10. Levels of the pro-inflammatory cytokines were lower in the MBT groups but the differences were not significant. In addition, they found that the higher the levels of IL-10, the higher the levels of the catecholamine ratios of Norepinephrine/Epinephrine and Dopamine/Epinephrine. Hence, MBT practice appears to be associated with decreases in inflammatory processes. In addition, high catecholamine ratios are associated with decreased stress levels, suggesting that the high IL-10 levels observed in the MBT group are associated with lower levels of stress.

 

The study did not actively manipulate MBT practice, so no conclusions about causation can be reached. The results, however, support the hypothesis that Mind-Body Training (MBT) is associated with decreased inflammatory responses and stress levels. Other research has shown that mindfulness practice can reduce inflammation and stress. So, it is reasonable to conclude that the present results were due to MBT practice. Since, chronic inflammation is detrimental to the health of the individual, the results suggest that MBT practice would help to improve or maintain the health and longevity of the individual.

 

So, reduce inflammatory processes with mindfulness.

 

“Chronic inflammation is associated with increased risk for psychiatric disorders, autoimmune conditions such as asthma and arthritis, cardiovascular disease, neurodegenerative disease and some types of cancer. But . . . mind-body interventions might help reduce the risk for inflammation-related disorders. And not just psychological ones, but even the physical ones like asthma or arthritis.” – Jo Marchant

 

CMCS – Center for Mindfulness and Contemplative Studies

 

This and other Contemplative Studies posts are also available on Google+ https://plus.google.com/106784388191201299496/posts and on Twitter @MindfulResearch

 

Study Summary

 

Jang, J. H., Park, H. Y., Lee, U. S., Lee, K.-J., & Kang, D.-H. (2017). Effects of Mind-Body Training on Cytokines and Their Interactions with Catecholamines. Psychiatry Investigation, 14(4), 483–490. http://doi.org/10.4306/pi.2017.14.4.483

 

Abstract

Objective

Mind-body training (MBT) may control reactions to stress and regulate the nervous and immune systems. The present study was designed to assess the effects of MBT on plasma cytokines and their interactions with catecholamines.

Methods

The study group consisted of 80 subjects who practice MBT and a control group of 62 healthy subjects. Plasma catecholamine (norepinephrine, NE; epinephrine, E; and dopamine, DA) and cytokine (TNF-alpha, IL-6, IFN-gamma, and IL-10) levels were measured, and the differences between the MBT and control groups and the interactions of cytokines with catecholamines were investigated.

Results

A significant increase in IL-10+IFN-gamma was found in females of the MBT group compared with controls. Also, a significant increase of IL-10 (anti-inflammatory cytokine) in the MBT group was shown in a specific condition in which TNF-alpha and IL-6 (pro-inflammatory cytokines) are almost absent (≤1 ng/L) compared with controls. In the MBT group, significant positive correlations were found between IL-10 and the NE/E ratio and between IL-10 and the DA/E ratio, whereas the control group did not show any such correlations.

Conclusion

MBT may increase IL-10, under specific conditions such as a decrease of pro-inflammatory cytokines or E, which may regulate the stress response and possibly contribute to effective and beneficial interactions between the nervous and immune systems.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5561407/

Reduce Genetic Markers of Inflammation with Yoga

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Reduce Genetic Markers of Inflammation with Yoga

 

By John M. de Castro, Ph.D.

 

“Yoga is fantastic for decreasing stress levels, and research has also shown that those who practice yoga regularly have higher levels of leptin and adiponectin in their bodies. Both of these natural chemicals work to alleviate inflammation in the body.” – Julie Montagu

 

The immune system is designed to protect the body from threats like stress, infection, injury, and toxic chemicals. One of its tools is the Inflammatory response. This response works quite well for short-term infections and injuries. But when inflammation is protracted and becomes chronic, it can itself become a threat to health. It can produce autoimmune diseases such as colitis, Chron’s disease, arthritis, heart disease, increased cancer risk, lung disease, sleep disruption, gum disease, decreased bone health, psoriasis, and depression. Needless to say, chronic inflammation can create major health problems. Indeed, the presence of chronic inflammation is associated with reduced longevity. So, it is important for health to control the inflammatory response, allowing it to do its job in fighting off infection but reducing its activity when no real external threat is apparent.

 

Of course, it is far better to prevent chronic inflammation in the first place than to treat it later. Mind-body techniques such as yoga, Tai Chi and meditation have been shown to adaptively reduce the inflammatory response. In today’s Research News article “Preliminary indications of the effect of a brief yoga intervention on markers of inflammation and DNA methylation in chronically stressed women.” (See summary below or view the full text of the study at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5290356/ ), Harkess and colleagues recruited women who were psychologically distressed and randomly assigned them to either a wait-list or to receive 8 weeks of twice a week for 1-hour yoga practice. Blood samples were obtained from the participants and measures of psychological distress, perceived stress, and positive and negative emotions, before and after the practice and 1 month later. Blood was assayed for concentrations of cytokines (IL-6, TNF), DNA methylation for immune candidates IL-6, CRP, and TNF.

 

They found that there were trends for improvements in all of the inflammation markers, but most were not significant. But, there was a significant improvement in the marker of DNA methylation in the region of Tumor Necrosis Factor, TNF. DNA methylation have been associated with poor physical health, and high levels of inflammation. So, the reduction in DNA methylation in the TNF region suggests a reduction in chronic inflammation. This may suggest that yoga practice might improve general health by reducing chronic inflammation.

 

It is reasonable to conclude that although there were many suggestive results, this pilot trial did not have sufficient statistical power to detect significant differences for most markers. Also, more extensive yoga practice beyond the 16 sessions in this trial, might produce more robust effects. In addition, the pilot trial lacked an active control condition. So, a number of sources of bias could be responsible for the results. The results, however, are sufficiently interesting and suggestive that they support conducting a larger randomized controlled clinical trial with an active control, perhaps aerobic exercise on the effectiveness of yoga practice on genetic markers of inflammation.

 

“There’s evidence that such “mind-body practices” dampen the activity of genes associated with inflammation – essentially reversing molecular damage caused by stress.” – Jo Marchant

 

CMCS – Center for Mindfulness and Contemplative Studies

 

This and other Contemplative Studies posts are also available on Google+ https://plus.google.com/106784388191201299496/posts and on Twitter @MindfulResearch

 

Study Summary

 

Harkess, K. N., Ryan, J., Delfabbro, P. H., & Cohen-Woods, S. (2016). Preliminary indications of the effect of a brief yoga intervention on markers of inflammation and DNA methylation in chronically stressed women. Translational Psychiatry, 6(11), e965–. http://doi.org/10.1038/tp.2016.234

 

Abstract

Yoga is associated with reduced stress and increased well-being, although the molecular basis for these benefits is not clear. Mounting evidence implicates the immune response, with current studies focused on protein immune markers (such as cytokines) in clinical populations. To explore the molecular impact, this pilot study uses a subsample (n=28) from a randomised waitlist control trial investigating the impact of an 8-week yoga intervention in a community population of women reporting psychological distress (N=116). We measured interleukin-6 (IL-6), tumour necrosis factor (TNF) and C-reactive protein (CRP) protein levels, and the DNA methylation of these genes and the global indicator, LINE-1. Correlations between these and psychological variables were explored, identifying moderate correlations with CRP protein levels, and methylation of IL-6, CRP and LINE-1. Many cytokine samples were below detection, however a Mann–Whitney U demonstrated a trend of moderate between-group effect for elevated IL-6 in the yoga group. Methylation analyses applied cross-sectional and non-controlled longitudinal analyses. Waist-to-height ratio and age were covaried. We demonstrated reduced methylation of the TNF region in the yoga group relative to the waitlist control group. No other genes demonstrated a significant difference. Longitudinal analysis further supported these results. This study is one of the first to explore yoga and immunological markers in a non-clinical population, and is the first study to explore DNA methylation. These findings indicate that further research into molecular impact of yoga on markers of immune function is warranted, with larger studies required.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5290356/

Reduce Inflammation in elderly Women with Yoga

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Reduce Inflammation in elderly Women with Yoga

 

By John M. de Castro, Ph.D.

 

“Inflammaging has been associated with conditions like diabetes, heart disease, stress, depression, and a weakened immune system. Several recent studies suggest that yoga could slow the harmful physical effects of stress and inflammaging.” – Marylynn Wei

 

The immune system is designed to protect the body from threats like stress, infection, injury, and toxic chemicals. One of its tools is the Inflammatory response. This response works quite well for short-term infections and injuries. But when inflammation is protracted and becomes chronic, it can itself become a threat to health. It can produce autoimmune diseases such as colitis, Chron’s disease, arthritis, heart disease, increased cancer risk, lung disease, sleep disruption, gum disease, decreased bone health, psoriasis, and depression. Needless to say, chronic inflammation can create major health problems. Indeed, the presence of chronic inflammation is associated with reduced longevity. So, it is important for health to control the inflammatory response, allowing it to do its job in fighting off infection but reducing its activity when no real external threat is apparent.

 

Of course, it is far better to prevent chronic inflammation in the first place than to treat it later. Mind-body techniques such as yoga, Tai Chi and meditation have been shown to adaptively reduce the inflammatory response. Aging is associated with a decline in immune system function and therefore an increase in chronic inflammation. As a result, the elderly are particularly vulnerable to chronic inflammation. So, it would make sense to test the effectiveness of mindfulness practices in the levels of inflammation in the elderly.

 

In today’s Research News article “Elderly-customized hatha yoga effects on the vascular inflammation factors of elderly women.” (See summary below or view the full text of the study at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5683994/ ), Kim and Ju Examined this issue by recruiting 14 healthy elderly women between the ages of 70 and 80 and randomly assigning 7 of the women to no treatment and 7 to receive a 10-week, 3 times per week for 60 minutes Hatha yoga program. The Hatha yoga poses were modified for the elderly performing many of the poses while sitting in a chair. Blood was drawn at the beginning and end of the program and assayed for inflammation markers of albumin, white blood cell count, fibrinogen, high sensitivity C-reactive protein, and erythrocyte sedimentation rate.

 

They found that there were no significant changes in the inflammation markers for the control group, but the Hatha yoga group showed significant changes signaling reduced inflammation. These changes included significantly increased albumin levels and decreased vascular inflammation markers of fibrinogen, high sensitivity C-reactive protein, and erythrocyte sedimentation rate. So, engaging in Hatha yoga practice appeared to reduce inflammation in these elderly women.

 

The results should be interpreted carefully as there was not an active control condition. So, it cannot be determined if the yoga practice per se was responsible for the improvements or simply any gentle exercise would produce comparable benefits. But, the fact that statistically significant findings were present with only 7 women in the yoga group is remarkable and suggests that the effects are robust. Future research should include men and have an active control condition, perhaps treadmill walking or similar gentle aerobic exercise.

 

So, reduce inflammation in elderly women with Yoga.

 

“There’s also good news for those of us who have a regular yoga practice. Several studies now report that a regular yoga practice brings down the levels of stress hormones that promote inflammation, lowers the levels of a number of pro-inflammatory molecules in the body and brings down inflammation that is beneficial in conditions like arthritis, reduces a subset of pro-inflammatory molecules called cytokines thereby relieving severe pain seen in diseases like fibromyalgia, and Inhibits inflammation that in turn weakens and even kills cancerous cells in people with cancer.” -Ram Rao

 

CMCS – Center for Mindfulness and Contemplative Studies

 

This and other Contemplative Studies posts are also available on Google+ https://plus.google.com/106784388191201299496/posts and on Twitter @MindfulResearch

 

Study Summary

 

Kim, S., & Ju, S. (2017). Elderly-customized hatha yoga effects on the vascular inflammation factors of elderly women. Journal of Physical Therapy Science, 29(10), 1708–1711. http://doi.org/10.1589/jpts.29.1708

 

Abstract

[Purpose] The aim of this study was to examine the effects of the application of elderly-customized hatha yoga on the vascular inflammation factors of elderly women. [Subjects and Methods] This research was conducted with 14 elderly women, between 70 and 80 years old, divided into an elderly-customized hatha yoga group (n=7) and a control group (n=7). The application group participated in a hatha yoga program designed to be elderly-friendly for 10 weeks. At the end of the program, the vascular inflammation factors were measured, including the albumin, white blood cell count, fibrinogen, high sensitivity C-reactive protein (hs-CRP), and erythrocyte sedimentation rate (ESR). [Results] In the hatha yoga group, the albumin increased significantly after the application, when compared to the level before the application, while the fibrinogen, hs-CRP, and ESR decreased significantly. In the control group, the vascular inflammation factor levels before and after the application period were not significantly different. [Conclusion] Based on the results of this study, the application of elderly-customized hatha yoga created positive changes in the vascular inflammation factors of elderly women.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5683994/

Reduce Inflammatory Markers and Blood Fat Levels with Yoga

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Reduce Inflammatory Markers and Blood Fat Levels with Yoga

 

By John M. de Castro, Ph.D.

 

“So far, the results suggest that different mind-body interventions may well all be working in a similar way. If your main purpose is to reduce inflammation to improve health. “it seems it really doesn’t matter which one you choose”. – Ivana Buric

 

The immune system is designed to protect the body from threats like stress, infection, injury, and toxic chemicals. One of its tools is the Inflammatory response. This response works quite well for short-term infections and injuries. But when inflammation is protracted and becomes chronic, it can itself become a threat to health. It can produce autoimmune diseases such as colitis, Chron’s disease, arthritis, heart disease, increased cancer risk, lung disease, sleep disruption, gum disease, decreased bone health, psoriasis, and depression.

 

Cardiovascular disease is the number one killer, claiming more lives than all forms of cancer combined. High blood fat levels are an important risk factor for cardiovascular disease. They increase the risk of a heart attack or stroke three-fold. The good news is that in general, diet, exercise, and weight loss can reduce the levels of fat circulating in the blood.

 

Of course, it is far better to prevent chronic inflammation and cardiovascular disease in the first place than to treat it later. Mind-body techniques such as yoga, Tai Chi and meditation have been shown to adaptively reduce the inflammatory response. Similarly, contemplative practices have also been shown to be helpful for heart health particularly those that are also exercises such as tai chi and yoga. Most of these results were obtained from treating diseased individuals. It is important to establish if yoga practice can be effective in preventing chronic inflammation and cardiovascular disease also in healthy individuals who are in potentially toxic environments.

 

In today’s Research News article “Effect of yoga training on inflammatory cytokines and C-reactive protein in employees of small-scale industries.” (See summary below or view the full text of the study at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5561768/ ), Shete and colleagues recruited healthy adults who worked in manufacturing chemicals, paints, and steel; environments that are prone to producing inflammation. They were randomly assigned to either a wait-list control or to receive 3-minths of yoga practice, 6 days per week for 1 hour per day. The yoga practice consisted of stretching, postures, and breathing exercises. The participants were measured before and after training for blood levels of lipids including cholesterol, triglyceride, and HDL, LDL and VLDL, and blood levels of inflammatory markers, IL-6, TNF-α, and hs-CRP.

 

They found that in comparison to baseline and the wait-list control group, the group that practiced yoga had significantly improved levels of blood fats, including lower levels of cholesterol and Low Density Lipoprotein (LDL), and lower levels of the inflammatory markers Interleukin-6 (IL-6), and tumor necrosis factor (TNF-α). Hence, the results suggest that yoga practice produces significant reductions in inflammation and blood fat levels.

 

Conclusions from these results must be tempered as the control group did not have an active comparison such as aerobic exercise. So, it cannot be determined if exercise of yoga in particular was responsible for the improvements. But, the results clearly show that engaging in yoga practice can lower the levels of risk factors for chronic inflammation and cardiovascular disease even in workers who are employed in high risk occupations. This could improve health and well-being, and increase longevity.

 

So, reduce inflammatory markers and blood fat levels with yoga.

 

“new research . . . has demonstrated that individuals who are naturally mindful tend to have healthier hearts and a reduced risk of obesity. In the face of temptations to eat junk food and sit in front of the TV all day, they seem to have chosen a healthier path that we all could emulate.” – Adam Hoffman

 

CMCS – Center for Mindfulness and Contemplative Studies

 

This and other Contemplative Studies posts are also available on Google+ https://plus.google.com/106784388191201299496/posts and on Twitter @MindfulResearch

 

Study Summary

 

Shete, S. U., Verma, A., Kulkarni, D. D., & Bhogal, R. S. (2017). Effect of yoga training on inflammatory cytokines and C-reactive protein in employees of small-scale industries. Journal of Education and Health Promotion, 6, 76. http://doi.org/10.4103/jehp.jehp_65_17

 

Abstract

OBJECTIVE:

The present study intends to see the effect of yoga practices on lipid profile, interleukin (IL)-6, tumor necrosis factor (TNF)-α, and high-sensitivity-C-reactive protein (hs-CRP) among apparently healthy adults exposed to occupational hazards.

MATERIALS AND METHODS:

In the present study, 48 participants aged 30–58 years (41.5 ± 5.2) who were exposed to occupational hazards were randomized into two groups, that is, experimental and wait-list control. All the participants were assessed for lipid profile, IL-6, TNF-α, and hs-CRP at the baseline and after completion of 3 months of yoga training intervention. The experimental group underwent yoga training intervention for 1 h for 6 days a week for 3 months, whereas control group continued with their daily activities except yoga training. Data analysis was done using statistical software SPSS Version 20.0. Data were analyzed using paired t-tests and independent t-test.

RESULTS:

The results of within group comparison revealed highly significant changes in cholesterol (P < 0.001), high-density lipoprotein (P < 0.001), low-density lipoprotein (LDL)(P < 0.01), hs-CRP (P < 0.01), IL-6 (P < 0.001), and TNF-α (P < 0.001) in experimental group. Comparison between experimental and control group revealed significant changes in cholesterol (P < 0.01), LDL (P < 0.05), IL-6 (P < 0.01), TNF-α (P < 0.01), and hs-CRP (P < 0.01).

CONCLUSION:

A yoga-based lifestyle intervention seems to be a highly promising alternative therapy which favorably alters inflammatory markers and metabolic risk factors.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5561768/

Protect the Aging Brain with Meditation

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Protect the Aging Brain with Meditation

 

By John M. de Castro, Ph.D.

 

“long-term engagement in mindfulness meditation may enhance cognitive performance in older adults, and that with persistent practice, these benefits may be sustained. That’s great news for the millions of aging adults working to combat the negative effects of aging on the brain.” B. Grace Bullock

 

Human life is one of constant change. We revel in our increases in physical and mental capacities during development, but regret their decreases during aging. The aging process involves a systematic progressive decline in every system in the body, the brain included. Starting in the 20s there is a progressive decrease in the volume of the brain as we age.

 

The nervous system is a dynamic entity, constantly changing and adapting to the environment. It will change size, activity, and connectivity in response to experience. These changes in the brain are called neuroplasticity.  Over the last decade neuroscience has been studying the effects of contemplative practices on the brain and has identified neuroplastic changes in widespread area. and have found that meditation practice appears to mold and change the brain, producing psychological, physical, and spiritual benefits. In addition, they have been able to investigate various techniques that might slow the process of neurodegeneration that accompanies normal aging. They’ve found that mindfulness practices reduce the deterioration of the brain that occurs with aging restraining the loss of neural tissue. Indeed, the brains of practitioners of meditation and yoga have been found to degenerate less with aging than non-practitioners.

 

In today’s Research News article “Promising Links between Meditation and Reduced (Brain) Aging: An Attempt to Bridge Some Gaps between the Alleged Fountain of Youth and the Youth of the Field.” See summary below or view the full text of the study at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5447722/, Kurth and colleagues review and summarize the published research literature on the neuroprotective effects of meditation in the elderly. They discuss the ideas that the aging based deterioration of the brain is due to a number of processes, including changes in the DNA telomeres, inflammation, stress, and neuroplasticity and that meditation appears to effect all of these processes.

 

There has accumulated evidence that meditation protects against age related decline at the molecular genetic level. As we age the length of a DNA structures called the telomeres progressively shorten. It is thought that the shorter the telomeres get the more difficult it becomes for cells to replicate properly and thus leads to decline. Mindfulness training in general and meditation specifically, has been shown to reduce the shortening of the telomeres with aging. Kurth and colleagues speculate that this is one mechanism by which meditation protects the brain from age related decline.

 

As we age the natural inflammatory response that normally occurs to protect against infection begins to increase in general and lose its specificity to fighting particular diseases, pathogens, and injuries. It becomes more widespread damaging normal tissues. Mindfulness training in general and meditation specifically has been shown to reduce inflammatory responses. It seems reasonable that this is another mechanism by which meditation protects the body from age related decline.

 

Stress is present throughout life. But if it is too intense or prolonged the biological responses to stress begin to damage the body. These stress induced changes are similar to age related deterioration. Stress effects may accumulate over time. Hence, the older we get the greater the total stress induced damage. Mindfulness training in general and meditation specifically has been shown to improve emotion regulation and to reduce the physiological and psychological responses to stress. This is hypothesized to be another mechanism by which meditation protects the brain from deterioration with aging.

 

Neuroplasticity is a change in the size and connectivity of brain structures as they are exercised over a prolonged period of time. Mindfulness training in general and meditation specifically has been shown to produce neuroplastic changes in the brain, increasing the size and connectivity of brain structures. This process would tend to counteract brain degeneration with aging and may be another mechanism by which meditation protects the brain during aging.

 

Hence there has accumulated evidence that meditation reduces the deterioration of the brain with aging. It appears to do so by altering a number of different mechanisms including changes in the DNA telomeres, inflammation, stress, and neuroplasticity. This protection of the brain may be responsible to the ability of meditation to reduce the decline in mental abilities that occur with aging. This would tend to make aging a more benign process.

 

So, protect the aging brain with meditation.

 

We expected rather small and distinct effects located in some of the regions that had previously been associated with meditating. Instead, what we actually observed was a widespread effect of meditation that encompassed regions throughout the entire brain.” – Florian Kurth

 

CMCS – Center for Mindfulness and Contemplative Studies

 

This and other Contemplative Studies posts are also available on Google+ https://plus.google.com/106784388191201299496/posts and on Twitter @MindfulResearch

 

Study Summary

 

Kurth, F., Cherbuin, N., & Luders, E. (2017). Promising Links between Meditation and Reduced (Brain) Aging: An Attempt to Bridge Some Gaps between the Alleged Fountain of Youth and the Youth of the Field. Frontiers in Psychology, 8, 860. http://doi.org/10.3389/fpsyg.2017.00860

 

Abstract

Over the last decade, an increasing number of studies has reported a positive impact of meditation on cerebral aging. However, the underlying mechanisms for these seemingly brain-protecting effects are not well-understood. This may be due to the fact, at least partly, that systematic empirical meditation research has emerged only recently as a field of scientific scrutiny. Thus, on the one hand, critical questions remain largely unanswered; and on the other hand, outcomes of existing research require better integration to build a more comprehensive and holistic picture. In this article, we first review theories and mechanisms pertaining to normal (brain) aging, specifically focusing on telomeres, inflammation, stress regulation, and macroscopic brain anatomy. Then, we summarize existing research integrating the developing evidence suggesting that meditation exerts positive effects on (brain) aging, while carefully discussing possible mechanisms through which these effects may be mediated.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5447722/

Improve Psychology and Physiology with a Meditation and Yoga Retreat

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Improve Psychology and Physiology with a Meditation and Yoga Retreat

 

By John M. de Castro, Ph.D.

 

“Yoga is fantastic for decreasing stress levels, and research has also shown that those who practice yoga regularly have higher levels of leptin and adiponectin in their bodies. Both of these natural chemicals work to alleviate inflammation in the body.” –  Julie Montagu

 

The immune system is designed to protect the body from threats like stress, infection, injury, and toxic chemicals. One of its tools is the Inflammatory response. This response works quite well for short-term infections and injuries. But when inflammation is protracted and becomes chronic, it can itself become a threat to health. It can produce autoimmune diseases such as colitis, Chron’s disease, arthritis, heart disease, increased cancer risk, lung disease, sleep disruption, gum disease, decreased bone health, psoriasis, and depression. Needless to say, chronic inflammation can create major health problems. Indeed, the presence of chronic inflammation is associated with reduced longevity. So, it is important for health to control the inflammatory response, allowing it to do its job in fighting off infection but reducing its activity when no external threat is apparent.

 

Of course, it is far better to prevent chronic inflammation in the first place than to treat it later. Mind-body techniques such as yoga, Tai Chi and meditation have been shown to adaptively reduce the inflammatory response. Most of these results were obtained from treating diseased individuals. It is important to establish if Mind-body techniques can be effective in preventing chronic inflammation also in healthy individuals. In today’s Research News article “Yoga, Meditation and Mind-Body Health: Increased BDNF, Cortisol Awakening Response, and Altered Inflammatory Marker Expression after a 3-Month Yoga and Meditation Retreat.” See summary below or view the full text of the study at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5483482/, Cahn and colleagues investigate the effects of a 3-month yoga and meditation retreat on the functioning of the immune and activation systems.

 

They recruited male and female experienced yoga and meditation practitioners (average of 2 hours practice per day for 4.5 years) who were participating in a 3-month yoga and meditation retreat. The retreat involved daily yoga (about 1.5 hours per day), meditation (about 2 hours), and chanting (about 1 hour) practices and a vegetarian diet. They were measured before and during the last week of the retreat for mindfulness, psychological symptoms, and absorption. They also provided a saliva sample for cortisol assay and a blood sample for markers of the inflammatory processes.

 

They found that although the participants had high psychological health before the retreat that following the retreat there were significant reductions in psychological symptoms including depression, anxiety, and bodily symptoms and an increase in mindfulness. There were also significant increases in the neurotrophic factor, BDNF, pro-inflammatory factors, and cortisol levels immediately after waking up in the morning. Hence participation in the retreat produced improved psychological health, brain protection and development factor, and increased inflammatory system activity, and morning activation. The study did not have a control condition. So, the results could be due simply to the passage of time or expectancy or attentional effects. Future studies should include a control condition.

 

The improved mental health is similar to prior research findings that mindfulness practices improve anxiety, depression, and somatic symptoms. They are, however, a bit surprising as the participants were very psychologically healthy at the beginning of the retreat. This underscores the power of mindfulness practices in improving mental health. The increase in BDNF levels also underscores the ability of mindfulness practices to improve brain processing as BDNF is a neurotrophic factor that promotes neuroplasticity and brain health. The biological results are quite surprising. They conflict with previous research that has shown that mindfulness practices decrease inflammatory factors and cortisol levels. It is possible that because the participants were experienced practitioners that the beneficial effects of mindfulness practices were already high and further improvements would be difficult to detect. In addition, the retreat was physically demanding. As such, increased inflammation would be adaptive.

 

So, improve the physiology to control inflammation and stress with a meditation and yoga retreat.

 

“The more we learn about yoga, the more we realize the benefits aren’t all in the mind. . . Yoga helps people to relax, making the heart rate go down, which is great for those with high blood pressure. The poses help increase flexibility and strength, bringing relief to back pain sufferers. Now, . . . it seems that those meditative sun salutations and downward dog poses can reduce inflammation, the body’s way of reacting to injury or irritation.” – Susan Brink

 

CMCS – Center for Mindfulness and Contemplative Studies

 

This and other Contemplative Studies posts are also available on Google+ https://plus.google.com/106784388191201299496/posts and on Twitter @MindfulResearch

 

Study Summary

 

Cahn, B. R., Goodman, M. S., Peterson, C. T., Maturi, R., & Mills, P. J. (2017). Yoga, Meditation and Mind-Body Health: Increased BDNF, Cortisol Awakening Response, and Altered Inflammatory Marker Expression after a 3-Month Yoga and Meditation Retreat. Frontiers in Human Neuroscience, 11, 315. http://doi.org/10.3389/fnhum.2017.00315

 

Abstract

Thirty-eight individuals (mean age: 34.8 years old) participating in a 3-month yoga and meditation retreat were assessed before and after the intervention for psychometric measures, brain derived neurotrophic factor (BDNF), circadian salivary cortisol levels, and pro- and anti-inflammatory cytokines. Participation in the retreat was found to be associated with decreases in self-reported anxiety and depression as well as increases in mindfulness. As hypothesized, increases in the plasma levels of BDNF and increases in the magnitude of the cortisol awakening response (CAR) were also observed. The normalized change in BDNF levels was inversely correlated with BSI-18 anxiety scores at both the pre-retreat (r = 0.40, p < 0.05) and post-retreat (r = 0.52, p < 0.005) such that those with greater anxiety scores tended to exhibit smaller pre- to post-retreat increases in plasma BDNF levels. In line with a hypothesized decrease in inflammatory processes resulting from the yoga and meditation practices, we found that the plasma level of the anti-inflammatory cytokine Interleukin-10 was increased and the pro-inflammatory cytokine Interleukin-12 was reduced after the retreat. Contrary to our initial hypotheses, plasma levels of other pro-inflammatory cytokines, including Interferon Gamma (IFN-γ), Tumor Necrosis Factor (TNF-α), Interleukin-1β (IL-1β), Interleukin-6 (IL-6), and Interleukin-8 (IL-8) were increased after the retreat. Given evidence from previous studies of the positive effects of meditative practices on mental fitness, autonomic homeostasis and inflammatory status, we hypothesize that these findings are related to the meditative practices throughout the retreat; however, some of the observed changes may also be related to other aspects of the retreat such as physical exercise-related components of the yoga practice and diet. We hypothesize that the patterns of change observed here reflect mind-body integration and well-being. The increased BDNF levels observed is a potential mediator between meditative practices and brain health, the increased CAR is likely a reflection of increased dynamic physiological arousal, and the relationship of the dual enhancement of pro- and anti-inflammatory cytokine changes to healthy immunologic functioning is discussed.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5483482/

Change Gene Expression to Lessen the Effects of Chronic Stress with Mind-Body Practices

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Change Gene Expression to Lessen the Effects of Chronic Stress with Mind-Body Practices

 

By John M. de Castro, Ph.D.

 

“Millions of people around the world already enjoy the health benefits of mind-body interventions like yoga or meditation, but what they perhaps don’t realise is that these benefits begin at a molecular level and can change the way our genetic code goes about its business. These activities are leaving what we call a molecular signature in our cells, which reverses the effect that stress or anxiety would have on the body by changing how our genes are expressed. Put simply, MBIs cause the brain to steer our DNA processes along a path which improves our wellbeing.” – Ivana Buric

 

There is an accumulating volume of research findings to demonstrate that Mind-body practices have highly beneficial effects on the health and well-being of humans. These include meditation, yoga, tai chi, qigong, biofeedback, progressive muscle relaxation, guided imagery, hypnosis, and deep breathing exercises. Because of their proven benefits the application of these practices to relieving human suffering has skyrocketed.

 

It is clear that Mind-body practices affect the physiology. In other words, the mind can alter the body. In turn, the genes can affect our minds. In fact, the genes have been shown to affect an individual’s inherent level of mindfulness. These interactions are well documented. The mechanisms by which they occur, however, are not well understood. It has been shown that contemplative practices help create balance in the inflammatory response which is very beneficial for health. But, the mechanism through which contemplative practices affect the immune system is not known. The genes dictate all of the chemical processes in our bodies including immune and inflammatory responses. So, it would seem reasonable to investigate whether alterations in gene expressions might be the intermediary between mind-body therapies and health.

 

The immune system is designed to protect the body from threats like stress, infection, injury, and toxic chemicals. One of its tools is the Inflammatory response. Its primary effect is to increase blood circulation around the infected area, dilating the blood vessels around the site of inflammation. It also produces gaps in the cell walls surrounding the infected area, allowing the larger immune cells, to pass. It also tends to increase body temperature to further fight infection. This response works quite well for short-term infections and injuries and as such is an important defense mechanism for the body. But when inflammation is protracted and becomes chronic, it can itself become a threat to health, producing autoimmune diseases such as colitis, Chron’s disease, arthritis, heart disease, increased cancer risk, lung disease, sleep disruption, gum disease, decreased bone health, psoriasis, and depression.

Mind-body practices appear to relax the physical systems of the body including the immune system, reducing inflammation. Mind-body techniques such as yoga, Tai Chi and meditation have been shown to adaptively reduce the inflammatory response. Hence, it makes sense to investigate the effects of mind-body practices on gene expressions that underlie the immune and inflammatory responses. In today’s Research News article “What Is the Molecular Signature of Mind–Body Interventions? A Systematic Review of Gene Expression Changes Induced by Meditation and Related Practices.” See summary below or view the full text of the study at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5472657/, Buric and colleagues review and summarize the published research literature on the effects of mind-body practices on gene expressions.

 

They found 18 published research articles. These articles, in general, report that following engaging in mind-body practices there is a reduction in the expression of genes that are involved in the inflammatory response resultant from chronic stress, particularly downregulation of NF-κB-targeted genes. It has been well established that mind-body practices reduce the psychological and physiological responses to stress. The published research on the effects of mind-body practices on gene expressions provide a mechanism by which these practices affect the stress response. They do so by affecting the physiology on the molecular level altering the genes that underlie the chemical processes involved in the inflammatory responses to stress.

 

These findings suggest that Mind-body practices can improve the health and well-being of the practitioner. One of the premiere mechanisms by which this is accomplished is by reducing the individual’s responses to the debilitating effects of chronic stress. Many of the difficulties produced by chronic stress are caused by producing a chronic inflammatory response damaging tissues. It appears that mind-body practices improve health by altering the genes that underlie these processes.

 

So, change gene expression to lessen the effects of chronic stress with mind-body practices.

 

“doing yoga or meditating may lead to a decrease in cyctokine production, and a reversal of the inflammatory gene, which ultimately lowers the risk of inflammation-related diseases and conditions.” – Brianna Steinhilber

 

CMCS – Center for Mindfulness and Contemplative Studies

 

This and other Contemplative Studies posts are also available on Google+ https://plus.google.com/106784388191201299496/posts and on Twitter @MindfulResearch

 

Study Summary

 

Buric, I., Farias, M., Jong, J., Mee, C., & Brazil, I. A. (2017). What Is the Molecular Signature of Mind–Body Interventions? A Systematic Review of Gene Expression Changes Induced by Meditation and Related Practices. Frontiers in Immunology, 8, 670. http://doi.org/10.3389/fimmu.2017.00670

 

Abstract

There is considerable evidence for the effectiveness of mind–body interventions (MBIs) in improving mental and physical health, but the molecular mechanisms of these benefits remain poorly understood. One hypothesis is that MBIs reverse expression of genes involved in inflammatory reactions that are induced by stress. This systematic review was conducted to examine changes in gene expression that occur after MBIs and to explore how these molecular changes are related to health. We searched PubMed throughout September 2016 to look for studies that have used gene expression analysis in MBIs (i.e., mindfulness, yoga, Tai Chi, Qigong, relaxation response, and breath regulation). Due to the limited quantity of studies, we included both clinical and non-clinical samples with any type of research design. Eighteen relevant studies were retrieved and analyzed. Overall, the studies indicate that these practices are associated with a downregulation of nuclear factor kappa B pathway; this is the opposite of the effects of chronic stress on gene expression and suggests that MBI practices may lead to a reduced risk of inflammation-related diseases. However, it is unclear how the effects of MBIs compare to other healthy interventions such as exercise or nutrition due to the small number of available studies. More research is required to be able to understand the effects of MBIs at the molecular level.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5472657/

Improve Inflammatory Biomarkers in Healthy and Cancer Patients with Mindfulness

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Improve Inflammatory Biomarkers in Healthy and Cancer Patients with Mindfulness

 

By John M. de Castro, Ph.D.

 

“stressed-out adults who practised mindfulness meditation not only had their brain connectivity altered, they also had reduced levels of a key inflammation biomarker, known as Interleukin-6, four months later. That’s important because, in high doses, Interleukin-6 has been linked to inflammation-related diseases such as cancer, Alzheimer’s, and autoimmune conditions.” – Fiona McDonald

 

The immune system is designed to protect the body from threats like stress, infection, injury, and toxic chemicals. One of its tools is the Inflammatory response. This response works quite well for short-term infections and injuries. But when inflammation is protracted and becomes chronic, it can itself become a threat to health. It can produce autoimmune diseases such as colitis, Chron’s disease, arthritis, heart disease, increased cancer risk, lung disease, sleep disruption, gum disease, decreased bone health, psoriasis, and depression. Needless to say, chronic inflammation can create major health problems. Indeed, the presence of chronic inflammation is associated with reduced longevity. So, it is important for health to control the inflammatory response, allowing it to do its job in fighting off infection but reducing its activity when no external threat is apparent.

 

Of course it is far better to prevent chronic inflammation in the first place than to treat it later. Mind-body techniques such as yoga, Tai Chi and meditation have been shown to adaptively reduce the inflammatory response. Most of these results were obtained from treating diseased individuals. It is important to establish if Mind-body techniques can be effective in preventing chronic inflammation also in healthy individuals. In today’s Research News article “Effects of mindfulness-based interventions on biomarkers in healthy and cancer populations: a systematic review.” See summary below or view the full text of the study at:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5324275/

Sanada and colleagues review the published research literature on the effects of Mind-body practices on biomarkers of the inflammatory response and compare the effects in healthy individuals to that of cancer patients.

 

They examined randomized controlled trials that trained participants in Mind-body practices for at least 6 weeks and measured biomarkers of the inflammatory response including  cytokines, neuropeptides and C-reactive protein (CRP). They found 7 studies on healthy individuals and 6 on cancer patients. They found that the literature, in general, indicated that Mind-body techniques had significant effects on these inflammatory biomarkers, but different studies using different techniques found that different biomarkers were affected. In regard to healthy individuals the studies reported no effects of Mind-body practices on cytokines, but significant increases in neuropeptides, particularly insulin-like growth factor 1 (IGF-1). In cancer patients the literature reports that Mind-body practices result in reduction of cytokines that promote inflammation, particularly IL-6 and TNF. In general the results for Mind-body practices effects on inflammatory biomarkers were mixed and at times contradictory.

 

These results are interesting and suggest that Mind-body practices affect inflammatory biomarkers in both healthy individuals and cancer patients. But, it is clear that the effects are not simple and straightforward. This could well be due to the mixture of different Mind-body practices. Even individual techniques such as Mindfulness-Based Stress Reduction (MBSR) contain complex mixtures of Mind-body practices. As such, it is difficult to separate out their varying effects. But, nevertheless the literature suggests that Mind-body practices affect the inflammatory response, which may, to some extent, explain these practices’ beneficial effects on health.

 

So, improve inflammatory biomarkers in healthy and cancer patients with mindfulness.

 

“It turns out that some of the most difficult elements of the cancer experience are very well-suited to a mindfulness practice.” – Linda Carlson

 

CMCS – Center for Mindfulness and Contemplative Studies

 

This and other Contemplative Studies posts are also available on Google+ https://plus.google.com/106784388191201299496/posts and on Twitter @MindfulResearch

 

Study Summary

Sanada, K., Alda Díez, M., Salas Valero, M., Pérez-Yus, M. C., Demarzo, M. M. P., Montero-Marín, J., … García-Campayo, J. (2017). Effects of mindfulness-based interventions on biomarkers in healthy and cancer populations: a systematic review. BMC Complementary and Alternative Medicine, 17, 125. http://doi.org/10.1186/s12906-017-1638-y

 

Abstract

Background

Only a small number of articles have investigated the relationship between mindfulness-based interventions (MBIs) and biomarkers. The aim of this systematic review was to study the effect of MBIs on specific biomarkers (cytokines, neuropeptides and C-reactive protein (CRP)) in both healthy subjects and cancer patients.

Methods

A search was conducted using PubMed, EMBASE, PsycINFO and the Cochrane library between 1980 and September 2016.

Results

A total of 13 studies with 1110 participants were included. In the healthy population, MBIs had no effect on cytokines, but were found to increase the levels of the neuropeptide insulin-like growth factor 1 (IGF-1). With respect to neuropeptide Y, despite the absence of post-intervention differences, MBIs may enhance recovery from stress. With regard to CRP, MBIs could be effective in lower Body Mass Index (BMI) individuals. In cancer patients, MBIs seem to have some effect on cytokine levels, although it was not possible to determine which specific cytokines were affected. One possibility is that MBIs might aid recovery of the immune system, increasing the production of interleukin (IL)-4 and decreasing interferon gamma (IFN-γ).

Conclusions

MBIs may be involved in changes from a depressive/carcinogenic profile to a more normalized one. However, given the complexity and different contexts of the immune system, and the fact that this investigation is still in its preliminary stage, additional randomized controlled trials are needed to further establish the impact of MBI programmes on biomarkers in both clinical and non-clinical populations.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5324275/

Live Longer with Yoga and Meditation

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Live Longer with Yoga and Meditation

 

By John M. de Castro, Ph.D.

 

“A growing body of research supports the immediate benefits of meditation, such as reduced stress and anxiety levels, lower blood pressure, and enhanced happiness. While these initial perks may be reason enough for us to practice, meditation’s positive impact appears to be even more far-reaching, potentially adding years to our lives and improving cognitive function well into old age.” – Rina Deshpande

 

One of the most exciting findings in molecular biology in recent years was the discovery of the telomere. This is a component of the DNA molecule that is attached to the ends of the strands. Recent genetic research has suggested that the telomere and its regulation is the biological mechanism that produces aging. It has been found that the genes, coded on the DNA molecule, govern cellular processes in our bodies. One of the most fundamental of these processes is cell replication. Cells are constantly turning over. Dying cells or damaged are replaced by new cells. The cells turn over at different rates but most cells in the body are lost and replaced between every few days to every few months. Needless to say, we’re constantly renewing ourselves.

 

As we age the tail of the DNA molecule called the telomere shortens. When it gets very short cells have a more and more difficult time reproducing and become more likely to produce defective cells. On a cellular basis, this is what produces aging. As we get older the new cells produced are more and more likely to be defective. The shortening of the telomere occurs each time the cell is replaced. So, slowly as we age it gets shorter and shorter. This has been called a “mitotic clock.” This is normal. But, telomere shortening can also be produced by oxidative stress, which can be produced by psychological and physiological stress. This is mediated by stress hormones and the inflammatory response. So, chronic stress can accelerate the aging process. In other words, when we’re chronically stressed we get older faster.

 

Fortunately, there is a mechanism to protect the telomere. There is an enzyme in the body called telomerase that helps to prevent shortening of the telomere. It also promotes cell survival and enhances stress-resistance.  Research suggests that processes that increase telomerase activity tend to slow the aging process by protecting the telomere.  One activity that seems to increase telomerase activity and protect telomere length is mindfulness practice. Hence, engaging in mindfulness practices may protect the telomere and thereby slow the aging process.

 

In today’s Research News article “Impact of Yoga and Meditation on Cellular Aging in Apparently Healthy Individuals: A Prospective, Open-Label Single-Arm Exploratory Study.” See summary below or view the full text of the study at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5278216/

Tolahunase and colleagues examined the effects of a program of yoga and meditation on biomarkers of cellular aging in a healthy population. They recruited healthy adults, aged 35-65 years who led modern sedentary lifestyles and provided them with a 12-week program of Hatha and Raja yogic meditation, breathing exercises, and postures. Sessions were held five days per week for 90 minutes. Participants were measured before and after treatment for a variety of biomarkers of cellular aging.

 

They found that at the end of the 12-week program there were significant reductions in the levels of the oxidative stress and inflammatory response related biomarkers 8-OH2dG, ROS, cortisol, and IL-6suggesting a reduction in chemical activity that tends to increase cellular aging. They also found that there were significant increases in TAC a marker of antioxidant activity, and markers of cellular aging of telomerase activity, an enzyme that protects the telomeres, β-endorphin, BDNF, and sirtuin-1. Hence, they found clear evidence that the meditation and yoga program greatly reduced the underlying biochemical processes of cellular aging in an otherwise healthy group of adults.

 

It should be mentioned that there wasn’t a control condition, particularly one that included light exercise. So, it cannot be determined if the results were due to participant expectancies, experimenter bias, attentional effects, the effects of exercise in a sedentary population, or many other potential confounding factors. A randomized controlled clinical trial including a group engaging in light exercise is needed to clarify the causal factors involved. Regardless of the explanation, this study demonstrated that the yoga and meditation program resulted in improvements in biomarkers that suggest that there was a slowing of the processes of cellular aging that underlie the aging of the body. This suggests that engaging in this or similar programs may lead to a longer, healthier life.

 

So, Live Longer with Yoga and Meditation.

 

“Yoga and meditation are well-documented to have psychological, emotional and physical benefits for people at all stages of health, including cancer patients. Now breakthrough research reveals yoga and meditation can positively affect DNA.” – Elaine Gavalas

 

CMCS – Center for Mindfulness and Contemplative Studies

 

This and other Contemplative Studies posts are also available on Google+ https://plus.google.com/106784388191201299496/posts and on Twitter @MindfulResearch

 

Study Summary

 

Tolahunase, M., Sagar, R., & Dada, R. (2017). Impact of Yoga and Meditation on Cellular Aging in Apparently Healthy Individuals: A Prospective, Open-Label Single-Arm Exploratory Study. Oxidative Medicine and Cellular Longevity, 2017, 7928981. http://doi.org/10.1155/2017/7928981

 

Abstract

This study was designed to explore the impact of Yoga and Meditation based lifestyle intervention (YMLI) on cellular aging in apparently healthy individuals. During this 12-week prospective, open-label, single arm exploratory study, 96 apparently healthy individuals were enrolled to receive YMLI. The primary endpoints were assessment of the change in levels of cardinal biomarkers of cellular aging in blood from baseline to week 12, which included DNA damage marker 8-hydroxy-2′-deoxyguanosine (8-OH2dG), oxidative stress markers reactive oxygen species (ROS), and total antioxidant capacity (TAC), and telomere attrition markers telomere length and telomerase activity. The secondary endpoints were assessment of metabotrophic blood biomarkers associated with cellular aging, which included cortisol, β-endorphin, IL-6, BDNF, and sirtuin-1. After 12 weeks of YMLI, there were significant improvements in both the cardinal biomarkers of cellular aging and the metabotrophic biomarkers influencing cellular aging compared to baseline values. The mean levels of 8-OH2dG, ROS, cortisol, and IL-6 were significantly lower and mean levels of TAC, telomerase activity, β-endorphin, BDNF, and sirtuin-1 were significantly increased (all values p < 0.05) post-YMLI. The mean level of telomere length was increased but the finding was not significant (p = 0.069). YMLI significantly reduced the rate of cellular aging in apparently healthy population.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5278216/

 

Change the Genes and the Brain for the Better with Mindfulness

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Change the Genes and the Brain for the Better with Mindfulness

 

By John M. de Castro, Ph.D.

 

“Scientists looked at how mindfulness practice affected genetic differences between one group of expert meditators compared with a control group of untrained meditators. “most interestingly, the changes were observed in genes that are the current targets of anti-inflammatory and analgesic drugs.” – Perla Kaliman

 

There is an accumulating volume of research findings to demonstrate that mind-body therapies have highly beneficial effects on the health and well-being of humans. These include meditation, yoga, tai chi, qigong, biofeedback, progressive muscle relaxation, guided imagery, hypnosis, and deep breathing exercises. Because of their proven benefits the application of these practices to relieving human suffering has skyrocketed.

 

It is clear that Mind-body therapies affect the physiology. In other words, the mind can alter the body. One way it can do that is by altering the nervous system. Meditation training has been shown to alter the nervous system, increasing the size and connectivity of structures associated with present moment awareness, higher level thinking, and regulation of emotions, while decreasing the size and connectivity of structures associated with mind wandering and self-referential thinking, known as the Default Mode Network (DMN). The brain is capable of changing and adapting in a process called neuroplasticity. As a result, the neural changes produced by meditation training become relatively permanent.

 

The mind can also affect the physiology through altering genetic processes. The genes dictate all of the chemical processes in our bodies including the immune system and the inflammatory response. In turn, the genes can affect our minds. In fact, the genes have been shown to affect an individual’s inherent emotions and level of mindfulness.

 

There has been a considerable amount of research over the last decade on the effects of mind-body therapies on the nervous system and gene expression. In today’s Research News article “The Embodied Mind: A Review on Functional Genomic and Neurological Correlates of Mind-Body Therapies.” See summary below. Muehsam and colleagues review and summarize these studies. They categorized the studies as either top-down, where mind-body therapies alter the physiology by altering attention, intention, and cognitive processes, or bottom-up, where the physical processes involved in mind-body therapies affect the nervous system. Hence, mind-body therapies act by altering the immune systems and the nervous system.

 

One of the primary actions of mind-body therapies is to reduce the psychological and physiological responses to stress which, in turn, affects wellness and well-being.  Studies indicate that these therapies alter the response of the brain-hormone axis that results in the production of glucocorticoids and alters the balance of sympathetic and parasympathetic nervous systems. Both of these effects alter gene expression, cellular aging, immune function, and healthy brain function. In addition, mind-body therapies can alter the immune systems inflammatory processes via action on the vagus nerve. This reduces the damage that can occur due to chronic stress producing chronic inflammation. Thus mind-body therapies act by eliminating or lessening the harmful effects of chronic stressors, thus allowing the body’s innate healing responses to be fully expressed.

 

The second major way mind-body practices impact the individual’s health and well-being is through neuromodulation. Mind-body practices alter the individual’s cognitive/affective state which have been shown to influence activity in brain regions including orbitofrontal cortex, anterior cingulate cortex, amygdala, hippocampus, and somatosensory cortex. These practices alter the volume of brain tissue, its activity, and its connectivity with other brain regions and appear to produce relatively permanent changes in the brain via neuroplasticity. In addition, they decrease the size and connectivity of structures associated with mind wandering and self-referential thinking, known as the Default Mode Network (DMN). These changes, in turn, affect attention, learning, and emotion regulation, all of which are important for psychological health.

 

So, the published research literature reflects an increasing understanding of not only the beneficial effects of mind-body practices, but also the physiological processes and mechanisms though which these benefits occur. This produces a clear picture that mind-body practices act through the nervous and immune systems to improve the health and well-being of the practitioners.

 

“Mindfulness:  a way to keep our brains healthy, to support self-regulation and effective decision-making capabilities, and to protect ourselves from toxic stress. It can be integrated into one’s religious or spiritual life, or practiced as a form of secular mental training.  When we take a seat, take a breath, and commit to being mindful, particularly when we gather with others who are doing the same, we have the potential to be changed.” – Christina Congleton

 

CMCS – Center for Mindfulness and Contemplative Studies

 

This and other Contemplative Studies posts are also available on Google+ https://plus.google.com/106784388191201299496/posts

 

Study Summary

Muehsam D, Lutgendorf S, Mills PJ, Rickhi B, Chevalier G, Bat N, Chopra D, Gurfein B. The Embodied Mind: A Review on Functional Genomic and Neurological Correlates of Mind-Body Therapies. Neurosci Biobehav Rev. 2016 Dec 22. pii: S0149-7634(16)30325-6. doi: 10.1016/j.neubiorev.2016.12.027. [Epub ahead of print] Review.

 

Highlights

  • Functional genomic and neurological correlates of mind-body practices are reviewed.
  • EEG and Neuroimaging correlates of mind-body therapies and meditation are reviewed.
  • Mechanisms of action by which mind-body practices influence health outcomes are discussed

Abstract

A broad range of mind-body therapies (MBTs) are used by the public today, and a growing body of clinical and basic sciences research has resulted in evidence-based integration of many MBTs into clinical practice. Basic sciences research has identified some of the physiological correlates of MBT practices, leading to a better understanding of the processes by which emotional, cognitive and psychosocial factors can influence health outcomes and well-being. In particular, results from functional genomics and neuroimaging describe some of the processes involved in the mind-body connection and how these can influence health outcomes. Functional genomic and neurophysiological correlates of MBTs are reviewed, detailing studies showing changes in sympathetic nervous system activation of gene transcription factors involved in immune function and inflammation, electroencephalographic and neuroimaging studies on MBT practices, and persistent changes in neural function and morphology associated with these practices. While the broad diversity of study designs and MBTs studied presents a patchwork of results requiring further validation through replication and longitudinal studies, clear themes emerge for MBTs as immunomodulatory, with effects on leukocyte transcription and function related to inflammatory and innate immune responses, and neuromodulatory, with effects on brain function and morphology relevant for attention, learning, and emotion regulation. By detailing the potential mechanisms of action by which MBTs may influence health outcomes, the data generated by these studies have contributed significantly towards a better understanding of the biological mechanisms underlying MBTs.