Spirituality is Associated with the Long-Term Psychological Health of Cancer Survivors

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Spirituality is Associated with the Long-Term Psychological Health of Cancer Survivors

 

By John M. de Castro, Ph.D.

 

“spiritual or religious beliefs and practices create a positive mental attitude that may help a patient feel better and improve the well-being of family caregivers. Spiritual and religious well-being may help improve health and quality of life.” – National Cancer Institute

 

Surviving cancer has a huge impact on most people. Feelings of depression, anxiety, and fear are very common and are normal responses to this life-changing experience. These feeling can result from changes in body image, changes to family and work roles, feelings of grief at these losses, and physical symptoms such as pain, nausea, or fatigue. People might also fear death, suffering, pain, or all the unknown things that lie ahead. So, coping with the emotions and stress of a surviving cancer is a challenge and there are no simple treatments for these psychological sequelae of cancer.

 

Religion and spirituality become much more important to people when they survive cancer. It is thought that people take comfort in the spiritual when facing mortality. Hence, spirituality may be useful for the survivors of cancer to cope with their illness and the psychological difficulties resulting from the disease. Thus, there is a need to study the relationships of spirituality on the long-term psychological health of cancer survivors.

 

In today’s Research News article “The Influence of Daily Spiritual Experiences and Gender on Subjective Well-Being Over Time in Cancer Survivors.” (See summary below or view the full text of the study at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7500286/ ) Rudaz and colleagues garnered data from the longitudinal Midlife in the United States (MIDUS) study

of adults that was collected in 2005 and again in 2015. They selected participants who reported having survived cancer and extracted data on spiritual and religious coping, daily spiritual experiences, life satisfaction, positive emotions, and negative emotions.

 

They report that for both men and women the higher the levels of spiritual experiences at baseline the higher the levels of religious coping, life satisfaction, and positive emotions, and the lower the levels of negative emotions at baseline and 10 years later. In addition, they found that spiritual experiences at baseline moderated the association of life satisfaction at baseline with life satisfaction 10 years later such that participants with low life satisfaction at baseline had a greater increase in life satisfaction 10 years later when they were higher in spiritual experiences. Also, they found that for men but not women that spiritual experiences at baseline moderated the association of positive emotions at baseline with positive emotions 10 years later such that men with low positive emotions at baseline had a greater increase in positive emotions 10 years later when they were higher in spiritual experiences.

 

These results are correlational and as such causation cannot be determined. But they show that cancer survivors having high levels of spirituality is associated with better psychological health and this is maintained over time. They also show that spirituality is associated with better psychological health 10 years later in cancer survivors who were low in life satisfaction and positive emotions. Hence, spirituality is important for the psychological health of cancer survivors and this lasts over decades.

 

So, spirituality is associated with the long-term psychological health of cancer survivors.

 

“Patients reporting greater overall religiousness and spirituality also reported better physical health, greater ability to perform their usual daily tasks, and fewer physical symptoms of cancer and treatment.” – Science Daily

 

CMCS – Center for Mindfulness and Contemplative Studies

 

This and other Contemplative Studies posts are also available on Google+ https://plus.google.com/106784388191201299496/posts and on Twitter @MindfulResearch

 

Study Summary

 

Rudaz, M., Ledermann, T., & Grzywacz, J. G. (2019). The Influence of Daily Spiritual Experiences and Gender on Subjective Well-Being Over Time in Cancer Survivors. Archive for the psychology of religion = Archiv fur Religionspsychologie, 41(2), 159–171. https://doi.org/10.1177/0084672419839800

 

Abstract

Cancer survivors are at risk for poor subjective well-being, but the potential beneficial effect of daily spiritual experiences is unknown. Using data from the second and third wave of the Midlife in the United States (MIDUS) study, we examined the extent to which daily spiritual experiences at baseline moderate the association between subjective well-being at baseline and approximately 10 years later in cancer survivors (n = 288). Regression analyses, controlled for age, educational attainment, and religious/spiritual coping, showed that daily spiritual experiences moderated the association between life satisfaction at baseline and follow-up. Specifically, high spiritual experiences enhanced life satisfaction over time in cancer survivors with low life satisfaction at baseline. Also, daily spiritual experiences moderated the association between positive affect at baseline and follow-up, though this moderating effect was different for women and men. No moderating effect emerged for negative affect.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7500286/

 

Dyadic Mindfulness Training Improves the Mental Health of Metastatic Cancer Patients and their Spouses

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Dyadic Mindfulness Training Improves the Mental Health of Metastatic Cancer Patients and their Spouses

 

By John M. de Castro, Ph.D.

 

“Cancer is a traumatic event that changes a person’s life. Utilizing mindfulness tools can provide peace and hope. Practicing mindfulness on a daily basis can assist with long term effects of happiness and positivity. Even occasional mindfulness practice can help provide a break from the stress of cancer and fill patients with a sense of calm to confront the challenges they face.” – Erin Murphy-Wilczek

 

Receiving a diagnosis of cancer has a huge impact on most people. Feelings of depression, anxiety, and fear are very common and are normal responses to this life-changing and potentially life-ending experience. But cancer diagnosis is not necessarily a death sentence. Over half of the people diagnosed with cancer are still alive 10 years later and this number is rapidly increasing. But, surviving cancer carries with it a number of problems. Anxiety, depression, fatigue and insomnia are common symptoms in dealing with cancer. These issues extend not just to the patient but also to their partners in life. These symptoms markedly reduce the quality of life of both.

 

Mindfulness training has been shown to help with cancer recovery and help to relieve chronic pain. It can also help treat the residual physical and psychological symptoms, including stress,  sleep disturbance, fear, and anxiety and depression. But cancer does not occur in isolation. It effects both the patient but also their significant others. There has been considerable research conducted on the effectiveness of mindfulness practices in treating the psychological issues associated with cancer. But there is little research on treating the cancer patients and their spouses in mindfulness as dyads.

 

In today’s Research News article “A Mindfulness-Based Intervention as a Supportive Care Strategy for Patients with Metastatic Non-Small Cell Lung Cancer and Their Spouses: Results of a Three-Arm Pilot Randomized Controlled Trial.” (See summary below or view the full text of the study at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7648356/ ) Milbury and colleagues recruited adult patients undergoing treatment for metastatic non‐small cell lung cancer and their romantic partners. Couples were randomly assigned to usual care or to receive 4 one-hour sessions via videoconference of either couple-based meditation or supportive-expressive practice. Couple-based meditation incorporated meditation and couple’s emotion sharing exercises. Supportive-expressive practice involved discussion of cancer-related issues that couples share. They were measured before and after treatment and 3 months later for depression, cancer-related stress symptoms, and spiritual well-being.

 

Attendance was high in both groups but the couple-based meditation reported that the sessions were more beneficial than the supportive-expressive practice group. They found that in comparison to baseline and the other groups at the 3-month follow-up the couple-based meditation patients and their significant others had significantly lower depression and cancer-related stress symptoms and higher spiritual well-being.

 

A strength of the study is that it had an active control condition, supportive-expressive practice, that contained therapeutic elements, expectancy effects and similar attention features to the couple-based meditation practice. This reduces the possibility of confounding variable being responsible for the results and suggests that the effects were due to the nature of the therapy. Another key aspect of this study is that the therapy was delivered via videoconference which may be responsible for the high attendance rates. This form of delivery is very convenient and flexible making it more likely to be effective.

 

There are great psychological and emotional problems co-occurring with cancer treatment for the patient and also for the patient’s romantic partner. So, these results are interesting and important suggesting that couple-based meditation practice can help relieve the suffering. The fact that the romantic partner was included was very important as the cancer effects both members of the dyad. Treating both prevents the suffering of one from interfering with the therapy for the other.

 

So, dyadic mindfulness training improves the mental health of metastatic cancer patients and their spouses.

 

“Being in this present moment, letting go, practicing non-attachment and acceptance are so helpful in dealing with uncertainty and fear. Mindfulness is something that they use for the rest of their lives for really great benefit.” – Linda Carlson

 

CMCS – Center for Mindfulness and Contemplative Studies

 

This and other Contemplative Studies posts are also available on Google+ https://plus.google.com/106784388191201299496/posts and on Twitter @MindfulResearch

 

Study Summary

 

Milbury, K., Li, Y., Durrani, S., Liao, Z., Tsao, A. S., Carmack, C., Cohen, L., & Bruera, E. (2020). A Mindfulness-Based Intervention as a Supportive Care Strategy for Patients with Metastatic Non-Small Cell Lung Cancer and Their Spouses: Results of a Three-Arm Pilot Randomized Controlled Trial. The oncologist, 25(11), e1794–e1802. Advance online publication. https://doi.org/10.1634/theoncologist.2020-0125

 

Abstract

Background

Although mindfulness‐based interventions have been widely examined in patients with nonmetastatic cancer, the feasibility and efficacy of these types of programs are largely unknown for those with advanced disease. We pilot‐tested a couple‐based meditation (CBM) relative to a supportive‐expressive (SE) and a usual care (UC) arm targeting psychospiritual distress in patients with metastatic lung cancer and their spousal caregivers.

Patients and Methods

Seventy‐five patient‐caregiver dyads completed baseline self‐report measures and were then randomized to one of the three arms. Couples in the CBM and SE groups attended four 60‐minute sessions that were delivered via videoconference. All dyads were reassessed 1 and 3 months later.

Results

A priori feasibility benchmarks were met. Although attendance was high in both groups, dyads in the CBM group indicated greater benefit of the sessions than those in the SE group (patients, CBM mean = 2.63, SE mean = 2.20, p = .003; spouses, CBM mean = 2.71, SE mean = 2.00, p = .005). Compared with the UC group, patients in the CBM group reported significantly lower depressive symptoms (p = .05; d = 0.53) and marginally reduced cancer‐related stress (p = .07; d = 0.68). Medium effect sizes in favor of the CBM compared with the SE group for depressive symptoms (d = 0.59) and cancer‐related stress (d = 0.54) were found. Spouses in the CBM group reported significantly lower depressive symptoms (p < .01; d = 0.74) compared with those in the UC group.

Conclusion

It seems feasible and possibly efficacious to deliver dyadic interventions via videoconference to couples coping with metastatic lung cancer. Mindfulness‐based interventions may be of value to managing psychological symptoms in the palliative care setting

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7648356/

 

Mindfulness is Related to Improved Psychological Health During the Covid-19 Pandemic.

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Mindfulness is Related to Improved Psychological Health During the Covid-19 Pandemic.

 

By John M. de Castro, Ph.D.

 

“During the current pandemic, there is so much uncertainty concerning the future, and many threats to our security (physical, social, emotional, and financial). It is totally natural and normal to feel anxious, fearful, and frustrated. . . Mindfulness can help us acknowledge this situation, without allowing us to be carried away with strong emotions; it can, in turn, help bring ourselves back to a centered calm. Only then can we see more clearly what it is we have control over and what it is that we do not.” – Michigan Medicine

 

Modern living is stressful under the best of conditions. But with the Covid-19 pandemic the levels of stress have been markedly increased. These conditions markedly increase anxiety. This is true for everyone but especially for healthcare workers and people caring for patients with COVID-19 and for people with pre-existing conditions that makes them particularly vulnerable. But it is also true for healthy individuals who worry about infection for themselves or loved ones.

 

The COVID-19 pandemic has also produced considerable economic stress, with loss of employment and steady income. For the poor this extends to high levels of food insecurity. This not only produces anxiety about the present but also for the future. It is important for people to engage in practices that can help them control their responses to the stress and their levels of anxiety. Mindfulness practices have been found routinely to reduce the psychological and physiological responses to stress, reduce anxiety levels, and improve mood. But there is a need to investigate the relationships of mindfulness to psychological health in relation to knowledge concerning Covid-19.

 

In today’s Research News article “Knowledge of COVID-19 and Its Influence on Mindfulness, Cognitive Emotion Regulation and Psychological Flexibility in the Indian Community.” (See summary below or view the full text of the study at: https://www.frontiersin.org/articles/10.3389/fpsyg.2020.589365/full?utm_source=F-AAE&utm_medium=EMLF&utm_campaign=MRK_1490157_69_Psycho_20201124_arts_A ) Dubey and colleagues recruited adults in India during the Covid-19 lockdown. They were measured online for their knowledge and awareness of Covid-19, depression, anxiety, perceived stress, mindfulness, emotion regulation, and acceptance of private experiences or experiential avoidance.

 

They found that the greater the amount of knowledge of Covid-19 the lower the levels of perceived stress, anxiety, catastrophizing, and depression and the higher the levels of mindfulness and psychological flexibility. In addition, they found that the higher the levels of mindfulness, the higher the levels of knowledge of Covid-19 and psychological flexibility and the lower the levels of perceived stress, anxiety, catastrophizing, and depression.

 

These findings are correlational and thus caution must be exercised in concluding causation. But in previous research it has been shown that mindfulness produces better emotion regulation by increasing psychological flexibility and by lowering the levels of psychological distress by lowering the levels of perceived stress, anxiety, catastrophizing, and depression. So, the relationships seen here are likely caused by mindfulness.

 

It is interesting that knowledge and awareness of Covid-19 appears to be crucial in dealing with its psychological impact on the individual. Higher levels of knowledge appear to mitigate the negative emotional effects of the pandemic, perhaps by improving the ability to be cognitively flexible in coping with it. When it comes to the pandemic ignorance is not bliss, rather it evokes grater psychological distress.

 

The Covid-19 lockdown was obviously a time of great fear and anxiety, not only for the individual’s physical health but also for their economic stability. Being able to deal with the negative emotions produced is essential not only for the individual’ mental health but also for evoking constructive and adaptive responses. Mindfulness and knowledge of the pandemic appear to be important for doing just that.

 

So, mindfulness is related to improved psychological health during the Covid-19 Pandemic.

 

“These are trying times, but incorporating mindful practices into your daily routine can help calm anxiety and build healthy coping skills.” – Rae Jacobson

 

CMCS – Center for Mindfulness and Contemplative Studies

 

This and other Contemplative Studies posts are also available on Google+ https://plus.google.com/106784388191201299496/posts and on Twitter @MindfulResearch

 

Study Summary

 

Dubey N, Podder P and Pandey D (2020) Knowledge of COVID-19 and Its Influence on Mindfulness, Cognitive Emotion Regulation and Psychological Flexibility in the Indian Community. Front. Psychol. 11:589365. doi: 10.3389/fpsyg.2020.589365

 

ABSTRACT

The current global pandemic caused by COVID-19 has brought about an immense effect on the mental health of the general public. Considering the escalation in number of cases, mankind is facing a myriad of psychological problems, ranging from those related to taking precautions and maintaining safety to the ones caused by separation and bereavement. The current study aims to explore whether there is a significant difference between individuals with excellent, good, fair and vague knowledge of COVID-19 with respect to depression, anxiety, stress, level of mindfulness, specific cognitive emotion regulation strategies and psychological flexibility; to find out whether there is any significant relationship among these variables; and to determine whether knowledge of COVID-19, level of mindfulness, specific cognitive emotion regulation strategies and psychological flexibility are significant predictors of depression, anxiety and stress in the sample of the current study. The sample consisted of 402 individuals selected from the community following the research criteria. Data was collected using digital consent form, information schedule and questionnaires, from 3rd May to 13th May, 2020. The questionnaires consisted of a semi-structured interview schedule to assess knowledge of COVID-19, Depression, Anxiety and Stress Scale – 21, Five Facet Mindfulness Questionnaire-Short Form, Cognitive Emotion Regulation Questionnaire-Short version and Acceptance and Action Questionnaire-II. The data was statistically analyzed using analysis of variance test, correlational analysis and linear regression. The findings show that significant differences were present among individuals having varying degrees of knowledge of COVID-19 with respect to anxiety, level of mindfulness and psychological flexibility. Significant relationships were found to be present among the variables of the present study, having differing trends brought forward by the COVID-19 crisis. Certain socio-demographic characteristics and study variables were found to significantly predict the existing levels of depression, anxiety and stress in the current sample. The study suggests the necessity to formulate and implement appropriate mindfulness-based therapeutic interventions to address the mental health concerns arising as a result of the pandemic.

https://www.frontiersin.org/articles/10.3389/fpsyg.2020.589365/full?utm_source=F-AAE&utm_medium=EMLF&utm_campaign=MRK_1490157_69_Psycho_20201124_arts_A

 

Breathing-Focused Yoga Practices Produce Greater Benefits for College Students than Meditative-Focused Practices

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Breathing-Focused Yoga Practices Produce Greater Benefits for College Students than Meditative-Focused Practices

 

By John M. de Castro, Ph.D.

 

“Want to manage your anger so you don’t feel you’re always on the verge of blowing up? Want to feel less stressed and juggle all the things going on in your life? Need to focus better in class or while you do your homework? Yoga poses can help. But meditation and breathing really round out those benefits.” – Mary L. Gavin

 

Yoga training has been shown to improve health and well-being. It has also been found to be effective for a large array of medical and psychiatric conditions, either stand-alone or in combination with more traditional therapies. There are a wide variety of different yoga training techniques. Many varieties employ breath-focused practices while many others employ meditative-focused practices. Although the benefits of yoga practices in general are well studied there is little scientific research comparing breathing-focused versus meditative-focused yoga.

 

In today’s Research News article “Comparing the Psychological Effects of Meditation- and Breathing-Focused Yoga Practice in Undergraduate Students.” (See summary below or view the full text of the study at: https://www.frontiersin.org/articles/10.3389/fpsyg.2020.560152/full?utm_source=F-AAE&utm_medium=EMLF&utm_campaign=MRK_1490157_69_Psycho_20201124_arts_A ) Qi and colleagues recruited college students with no yoga experience and randomly assigned them to a once a week for 80 minutes 12-week program of either breath-focused yoga or meditation-focused yoga. During each Hatha yoga class the students received either 10 minutes of meditation practice or breathing practice. They were measured before and after the program for work intention, mindfulness, and perceived stress.

 

They found that both before and after yoga training the higher the participants’ levels of mindfulness the lower their levels of perceived stress. They further found that in comparison to baseline and the other yoga group, the breath-focused yoga group had significantly higher levels of perceived stress and mindfulness while the meditation-focused yoga group had significantly lower work intention.

 

These results are interesting and document the previously reported linkage between mindfulness and lower stress levels. But they go further in demonstrating that breath-focus is an important component of yoga practice for the improvement of mindfulness and the lowering of perceived stress. This suggests that breathing practice should be emphasized in yoga instruction. These results also suggest that yoga practice may be beneficial for college students who are routinely found to have high stress levels, reducing their stress and thereby allowing them to perform their best in their studies.

 

So, breathing-focused yoga practices produce greater benefits for college students than meditative-focused practices.

 

“Mindful yoga (or the integration of yoga and mindfulness meditation techniques) provides a healthy and safe environment for individuals to practice “being with” uncomfortable emotional and physical experiences, and to eventually reunite with and fully inhabit their bodies.” – Melissa Mercedes

 

CMCS – Center for Mindfulness and Contemplative Studies

 

This and other Contemplative Studies posts are also available on Google+ https://plus.google.com/106784388191201299496/posts and on Twitter @MindfulResearch

 

Study Summary

 

Qi X, Tong J, Chen S, He Z and Zhu X (2020) Comparing the Psychological Effects of Meditation- and Breathing-Focused Yoga Practice in Undergraduate Students. Front. Psychol. 11:560152. doi: 10.3389/fpsyg.2020.560152

 

ABSTRACT

Objectives: The present study aimed to compare the psychological effects of meditation- and breathing-focused yoga practice in undergraduate students.

Methods: A 12-weeks yoga intervention was conducted among a group of undergraduate students enrolled in four yoga classes at an academically prestigious university in Beijing, China. Four classes were randomized to meditation-focused yoga or breathing-focused yoga. A total of 86 participants finished surveys before and after the 12-weeks intervention, measuring work intention, mindfulness, and perceived stress. The repeated-measure multivariate analysis of covariance (MANCOVA) followed by univariate analyses were conducted to examine the differences in work intention, mindfulness, and stress between the two yoga intervention groups over the semester, after controlling for age and gender.

Results: The repeated-measure MANCOVA revealed significant group differences with a median effect size [Wilks’ lambda, Λ = 0.90, F(3, 80) = 3.10, p = 0.031, η2 = 0.104]. Subsequent univariate analyses showed that students in the breathing-focused yoga group had significant higher work intentions [F(1, 82) = 5.22; p = 0.025; η2p = 0.060] and mindfulness [F(1, 82) = 6.33; p = 0.014; η2p = 0.072] but marginally lower stress [F(1, 82) = 4.20; p = 0.044; η2p = 0.049] than students in the meditation-focused yoga group.

Conclusion: Yoga practice with a focus on breathing is more effective than that with a focus on meditation for undergraduates to retain energy for work, keep attention and awareness, and reduce stress.

https://www.frontiersin.org/articles/10.3389/fpsyg.2020.560152/full?utm_source=F-AAE&utm_medium=EMLF&utm_campaign=MRK_1490157_69_Psycho_20201124_arts_A

 

Improve Psychological Health and Quality of Life of Older Adults with Meditative Movement Practices.

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Improve Psychological Health and Quality of Life of Older Adults with Meditative Movement Practices.

 

By John M. de Castro, Ph.D.

 

“Mindful techniques can help older adults feel a sense of connection to their body. This can be critical for creating optimal health, even as they manage the ongoing changes in their body.” – Karen Fabian

 

The aging process involves a systematic progressive decline in every system in the body, the brain included. This includes our cognitive (mental) abilities which decline with age including impairments in memory, attention, and problem-solving ability. It is inevitable and cannot be avoided. Research has found that mindfulness practices reduce the deterioration of the brain that occurs with aging restraining the loss of neural tissue. Indeed, the brains of practitioners of meditation and yoga have been found to degenerate less with aging than non-practitioners. Tai Chi and Qigong have also been shown to be beneficial in slowing or delaying physical and mental decline with aging. The research findings are accumulating suggesting that a summarization of what has been learned is called for.

 

In today’s Research News article “Effects of Mind-Body Interventions Involving Meditative Movements on Quality of Life, Depressive Symptoms, Fear of Falling and Sleep Quality in Older Adults: A Systematic Review with Meta-Analysis.” (See summary below or view the full text of the study at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7559727/ ) Weber and colleagues  review, summarize, and perform a meta-analysis of the published randomized controlled studies (RCTs) of the effectiveness of the mind-body practices of Yoga, Tai Chi. Qigong, and Pilates to improve the psychological health and quality of life in the elderly (aged 60 and over). They identified 37 published RCTs, 21 of which employed Tai Chi. 5 Qigong, 10 Yoga, and 3 Pilates.

 

They separated studies employing Tai Chi and Qigong from those employing Yoga and Pilates. They report that the published studies found that all of the meditative movement practices significantly improved the quality of life, physical functioning, and sleep quality and reduced the fear of falling of older adults with small effect sizes. Only the Tai Chi and Qigong practices produced significant improvements in psychological functioning and social functioning while only the Yoga and Pilates produced significant improvements in depression. For Tai Chi and Qigong, they further report that practice occurring 3 or more times per week resulted in larger improvements in quality of life and depression than those with less than 3 practices per week.

 

These findings suggest that meditative movement practices have wide ranging benefits, albeit with relatively small effect sizes, on the physical, psychological, and social functioning of older adults and improve their overall quality of life. These are important benefits for the elderly helping to slow the progressive decline seen with aging. These practices when properly performed and supervised have very few adverse effects. Hence, they should be recommended for aging individuals as safe and effective practices to slow the progressive decline and improve their overall well-being.

 

So, improve psychological health and quality of life of older adults with meditative movement practices.

 

“When you age mindfully, you are fully aware and accepting of the challenges that come with the aging process, but you’re also aware of—and seizing—the opportunities that come with being blessed with what I call your ‘longevity bonus,’” – Andrea Brandt.

 

CMCS – Center for Mindfulness and Contemplative Studies

 

This and other Contemplative Studies posts are also available on Google+ https://plus.google.com/106784388191201299496/posts and on Twitter @MindfulResearch

 

Study Summary

 

Weber, M., Schnorr, T., Morat, M., Morat, T., & Donath, L. (2020). Effects of Mind-Body Interventions Involving Meditative Movements on Quality of Life, Depressive Symptoms, Fear of Falling and Sleep Quality in Older Adults: A Systematic Review with Meta-Analysis. International journal of environmental research and public health, 17(18), 6556. https://doi.org/10.3390/ijerph17186556

 

Abstract

Background: The aim of the present systematic meta-analytical review was to quantify the effects of different mind–body interventions (MBI) involving meditative movements on relevant psychological health outcomes (i.e., quality of life (QoL), depressive symptoms, fear of falling (FoF) and sleep quality) in older adults without mental disorders. Methods: A structured literature search was conducted in five databases (Ovid, PsycINFO, PubMed, SPORTDiscus, Web of Science). Inclusion criteria were: (i) the study was a (cluster) randomized controlled trial, (ii) the subjects were aged ≥59 years without mental illnesses, (iii) an intervention arm performing MBI compared to a non-exercise control group (e.g., wait-list or usual care), (iv) psychological health outcomes related to QoL, depressive symptoms, FoF or sleep quality were assessed and (v) a PEDro score of ≥5. The interventions of the included studies were sub-grouped into Tai Chi/Qigong (TCQ) and Yoga/Pilates (YP). Statistical analyses were conducted using a random-effects inverse-variance model. Results: Thirty-seven randomized controlled trials (RCTs) (comprising 3224 participants) were included. Small to moderate-but-significant overall effect sizes favoring experimental groups (Hedges’ g: 0.25 to 0.71) compared to non-exercise control groups were observed in all outcomes (all p values ≤ 0.007), apart from one subdomain of quality of life (i.e., social functioning, p = 0.15). Interestingly, a significant larger effect on QoL and depressive symptoms with increasing training frequency was found for TCQ (p = 0.03; p = 0.004). Conclusions: MBI involving meditative movements may serve as a promising opportunity to improve psychological health domains such as QoL, depressive symptoms, FoF and sleep quality in older adults. Hence, these forms of exercise may represent potential preventive measures regarding the increase of late-life mental disorders, which need to be further confirmed by future research.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7559727/

 

Improve Personality with Psychedelic Drugs

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Improve Personality with Psychedelic Drugs

 

By John M. de Castro, Ph.D.

 

“the results of decreased neuroticism and increased openness and agreeableness were statistically significant when compared with the control groups, providing more specific support for ayahuasca’s therapeutic role.” – Alex Criddle

 

Psychedelic substances such as peyote, mescaline, LSD, Bufotoxin, ayahuasca and psilocybin have been used almost since the beginning of recorded history to alter consciousness and produce spiritually meaningful experiences. Psychedelics produce effects that are similar to those that are reported in spiritual awakenings. They report a loss of the personal self, a decentering. They experience what they used to refer to as the self as just a part of an integrated whole. They report feeling interconnected with everything else in a sense of oneness with all things. They experience a feeling of timelessness where time seems to stop and everything is taking place in a single present moment. They experience ineffability, being unable to express in words what they are experiencing and as a result sometimes producing paradoxical statements. And they experience a positive mood, with renewed energy and enthusiasm.

 

It is easy to see why people find these experiences so pleasant and eye opening. They often report that the experiences changed them forever. Even though the effects of psychedelic substances have been experienced and reported on for centuries, only very recently have these effects come under rigorous scientific scrutiny.

 

In today’s Research News article “Modulatory effects of ayahuasca on personality structure in a traditional framework.” (See summary below or view the full text of the study at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7524857/ ) Netzband and colleagues recruited adults seeking an experience with ayahuasca and a matched group of adults. The experimental group attended a 12-day retreat at the Ayahuasca Foundation where they received 6 standardized Ayahuasca sessions under close supervision. They were measured before and after the retreat and 6 months later for mystical experiences and the big five personality traits; openness to experience, conscientiousness, extraversion, agreeableness, and neuroticism.

 

They found that in comparison to the baseline and the matched control group that the group that received Ayahuasca had a significant decrease in neuroticism and an increase in agreeableness, and openness to experience after the retreat. These changes were stable as they were maintained at the 6-month follow-up. In addition, they found that the greater the mystical experiences occurring the greater the reduction in neuroticism.

 

It should be kept in mind that this is a non-equivalent control group design. It would have been a stronger design if the comparison group was a wait-list groups of Ayahuasca seekers. So, care must be taken in interpreting the results.

 

Neuroticism involves a tendency toward anxiety, depression, self-doubt, and other negative feelings. The results then suggest that Ayahuasca experience improves neuroticism thereby improving the mental health of the participants. This is also reflected in the increase in agreeableness, the positive traits of kindness, sympathy, cooperation, warmth, and consideration. These findings then suggest that psychedelic experiences improve the mental health of the participants. Since, the degree of improvement was related to the degree of mystical experience occurring, it is possible that having mystical experiences fundamentally changes the individual improving their psychological health. These findings are compatible with the use of psychedelics to treat mental illness.

 

So, improve personality with psychedelic drugs.

 

“After the ayahuasca use, more than 80% of those subjects showed clinical improvements that persisted at 6 months. The questionnaires showed significant reductions in depression and psychopathology. . . long-term users showed lower depression scores, and higher scores for self-transcendence and quality of life.” – Daniel F. Jiménez-Garrido

 

CMCS – Center for Mindfulness and Contemplative Studies

 

This and other Contemplative Studies posts are also available on Google+ https://plus.google.com/106784388191201299496/posts and on Twitter @MindfulResearch

 

Study Summary

 

Netzband, N., Ruffell, S., Linton, S., Tsang, W. F., & Wolff, T. (2020). Modulatory effects of ayahuasca on personality structure in a traditional framework. Psychopharmacology, 237(10), 3161–3171. https://doi.org/10.1007/s00213-020-05601-0

 

Abstract

Ayahuasca is a psychoactive plant brew containing dimethyltryptamine (DMT) and monoamine oxidase inhibitors (MAOIs). It originates from the Amazon basin, where it is used primarily for ceremonial purposes. Ayahuasca tourists are now entering certain communities seeking alternative physical or psychological healing, as well as spiritual growth.

Rationale

Recent evidence has shown that the similar acting psychedelic compound, psilocybin, facilitated long-term increases in trait openness following a single administration.

Objectives

This paper assesses the impact of ayahuasca on personality in a traditional framework catering for ayahuasca tourists.

Method

Within a mixed design, we examined the effect of ayahuasca on participants’ personality (measured by the NEO Personality Inventory 3 questionnaire) across time (pre- to post-ayahuasca administration, and 6-month follow-up), relative to a comparison group (who did not ingest ayahuasca).

Results

The results demonstrated significant increases in agreeableness pre- and post-ayahuasca administration and significant reductions in neuroticism in 24 participants, relative to the comparison group. Both of these changes were sustained at 6-month follow-up, and trait level increases were also observed in openness at this stage. Additionally, greater perceived mystical experience (measured using the Mystical Experience Questionnaire 30) was associated with increased reductions in neuroticism.

Conclusions

These findings, which indicate a positive mediating effect of ayahuasca on personality, support the growing literature suggesting potential therapeutic avenues for serotonergic psychedelics.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7524857/

 

Spirituality is Related to Healthy Behaviors and Psychological Well-Being

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Spirituality is Related to Healthy Behaviors and Psychological Well-Being

 

By John M. de Castro, Ph.D.

 

“Positive beliefs, comfort, and strength gained from religion, meditation, and prayer can contribute to well being. It may even promote healing. Improving your spiritual health may not cure an illness, but it may help you feel better. It also may prevent some health problems and help you cope better with illness, stress, or death.” – Robert Rich Jr.

 

Religion and spirituality have been promulgated as solutions to the challenges of life both in a transcendent sense and in a practical sense. What evidence is there that these claims are in fact true? The transcendent claims are untestable with the scientific method. But the practical claims are amenable to scientific analysis. There have been a number of studies of the influence of religiosity and spirituality on the physical and psychological well-being of practitioners mostly showing positive benefits, with spirituality encouraging personal growth and mental health. But there is still a need to investigate the relationships of spirituality with health-related behaviors and psychological well-being.

 

In today’s Research News article “The Relationship Between Spirituality, Health-Related Behavior, and Psychological Well-Being.” (See summary below or view the full text of the study at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7457021/ ) Bożek and colleagues recruited college students and had them complete measures of psychological well-being, spirituality, and health-related behaviors. The data were then subjected to a path analysis.

 

The analysis revealed that both spirituality and health-related behaviors were significantly positively directly related to psychological well-being, such that the higher the levels of each the higher the levels of well-being. But, in addition, spirituality indirectly affected psychological well-being by being positively related to health behaviors which, in turn, were positively related to well-being. They also found that these relationships were stronger in students who studied the psychosocial dimension of health and the human mind and spirit.

 

This study was correlational and as such causation cannot be determined. This is inevitable as it is nearly impossible to directly manipulate spirituality. But the results demonstrate that being high in spirituality is associated with psychological well-being in college students. In addition, spirituality is also clearly associated with engaging in behaviors that promote good health and these behaviors appear to also be associated with higher levels of psychological well-being. All of this suggests that spiritual students have better health and are happier.

 

So, spirituality is related to healthy behaviors and psychological well-being.

 

“Many of the behaviors associated with wellness are key components of a healthy spiritual life. Examples include volunteerism, social responsibility, optimism, contributing to society, connectedness with others, feeling of belonging/being part of a group, and love of self/reason to care for self.” – Lauren Artess

 

CMCS – Center for Mindfulness and Contemplative Studies

 

This and other Contemplative Studies posts are also available on Google+ https://plus.google.com/106784388191201299496/posts and on Twitter @MindfulResearch

 

Study Summary

 

Bożek, A., Nowak, P. F., & Blukacz, M. (2020). The Relationship Between Spirituality, Health-Related Behavior, and Psychological Well-Being. Frontiers in psychology, 11, 1997. https://doi.org/10.3389/fpsyg.2020.01997

 

Abstract

Studies suggest a positive association of spirituality and health behaviors with well-being (especially subjective well-being), but still the precise character of such relationships between all these constructs remains unknown. The present study aims to explore the relations between spirituality, health-related behaviors, and psychological well-being in the context of acquired education. A questionnaire survey was conducted among 595 students from six different universities, whose study programs either focused on the human body or the human mind and spirit. Path analysis and linear regression were used to model the relationship between the examined constructs. The results show that both spirituality and health-related behaviors are positively related to psychological well-being, and that the relationship with spirituality is also mediated by health-related behaviors. Only spirituality is associated with the type of acquired education, especially in the group of students whose studies focus on the human mind and spirit. Moreover, spirituality in this group seems to display a stronger relationship with psychological well-being. These findings may contribute to the better understanding of some significant determinants of psychological well-being. They carry important implications for the faculty members responsible for curriculum preparation to account for teaching contents related to the conduct of a healthy lifestyle and to spiritual development.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7457021/

 

Increase Metabolism with Yogic Breathing Practices

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Increase Metabolism with Yogic Breathing Practices

 

By John M. de Castro, Ph.D.

 

“different yoga postures and breathing practices, which involve the control of respiratory rate and retention periods, may produce markedly different metabolic effects.” – Anupama Tyagi

 

Breathing is essential for life and generally occurs automatically. It’s easy to take for granted as it’s been there our entire lives. Nevertheless, we become more aware of it when it varies with circumstances, such as when we exercise and also in emotional states, especially fear and anxiety. But we rarely notice it during everyday ongoing life. Yet, its characteristics are associated with our state of well-being. Slow deep breathing is characteristic of a healthy relaxed state. Breathing exercises are common in yoga and meditation practices and have been found to have a number of beneficial effects. Classically, some yogic breathing techniques have been characterized as cooling. But this assertion has not been investigated with controlled scientific research.

 

In today’s Research News article “Body Temperature and Energy Expenditure During and After Yoga Breathing Practices Traditionally Described as Cooling.” (See summary below or view the full text of the study at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6977599/ ) Telles and colleagues recruited healthy participants, aged 19-25 years, who were experienced with yogic breathing. They had 4 28-minute sessions of 18 minutes of yogic breathing techniques that required mouth breathing with the protrusion of the tongue of sheetali pranayama or sitkari pranayama, or breath awareness, or quietly lying down. The sessions occurred on individual days in randomized orders. During each session they were measured for body temperature and oxygen consumption.

 

They found that during both of the yogic breathing sessions there were significant increases in body temperature, oxygen consumption, carbon dioxide eliminated, estimated energy expenditure, and non-protein respiratory quotient. On the other hand, during quiet lying down there were significant decreases in oxygen consumption, carbon dioxide eliminated, estimated energy expenditure.

 

Hence, the yogic breathing was not “cooling” but activating. Indeed, these results suggest that the yogic breathing techniques produce a mild hypermetabolic state that is similar to that found with mild exercise. It can be speculated that it is the activation produced by these techniques that is responsible for some of the benefits of yogic breathing techniques. Future research is needed to test this hypothesis.

 

So, increase metabolism with yogic breathing practices.

 

“We breathe constantly, it’s what we do. We cannot make ourselves stop breathing, except to only hold our breath for a few minutes, thankfully. However, what we can control is how we breathe. This control of how oxygen enters and exits the body has been linked to the improvement of bodily function and our nervous system, which includes stimulating our metabolism.” – Heather Lancaster

 

CMCS – Center for Mindfulness and Contemplative Studies

 

This and other Contemplative Studies posts are also available on Google+ https://plus.google.com/106784388191201299496/posts and on Twitter @MindfulResearch

 

Study Summary

 

Telles, S., Gandharva, K., Sharma, S. K., Gupta, R. K., & Balkrishna, A. (2020). Body Temperature and Energy Expenditure During and After Yoga Breathing Practices Traditionally Described as Cooling. Medical science monitor basic research, 26, e920107. https://doi.org/10.12659/MSMBR.920107

 

Abstract

Background

In traditional yoga texts, sheetali and sitkari pranayamas are described as cooling. The present study was aimed at recording the surface body temperature, oxygen consumed, and carbon dioxide eliminated before, during, and after performance of sheetali and sitkari pranayamas.

Material/Methods

Seventeen healthy male volunteers with ages between 19 to 25 years (average age 20.7±1.8 years) were assessed in 4 sessions, viz. sheetali pranayama, sitkari pranayama, breath awareness and quiet lying, on 4 separate days, in random sequence. The axillary surface body temperature (TRUSCOPE II, Schiller, China) and metabolic variables (Quark CPET, COSMED, Italy) were recorded in 3 periods: before (5 minutes), during (18 minutes), and after (5 minutes), in each of the 4 sessions. The heat index was calculated in the before and after periods, based on recordings of ambient temperature and humidity. Data were analyzed using SPSS (Version 24.0).

Results

Body temperature increased significantly during sheetali and sitkari (p<0.05, p<0.01; respectively) while it decreased after breath awareness and quiet lying down (p<0.01, p<0.001; respectively) when compared with respective post-exercise states. Oxygen consumption increased by 9.0% during sheetali (p<0.05) and by 7.6% during sitkari (p<0.01) while it decreased significantly during (p<0.05) and after (p<0.01) quiet lying down compared to respective pre-exercise states.

Conclusions

The results do not support the description of these yoga breathing practices as cooling. These yoga breathing practices may be used to induce a mild hypermetabolic state.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6977599/

 

Reduce Stress and Improve Mood in Healthcare Workers with Mindfulness

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Reduce Stress and Improve Mood in Healthcare Workers with Mindfulness

 

By John M. de Castro, Ph.D.

 

“mindfulness training among healthcare providers is advocated for the improvement of quality of care as well as a means to mitigate work-related stress and burnout. . . Given the potential for mindfulness to promote health and enrich the practice of medicine, its increased utilization among patients, physicians, and the population at large is encouraged.” – Matias P. Raski

 

Stress is epidemic in the western workplace with almost two thirds of workers reporting high levels of stress at work. In high stress occupations, like healthcare, burnout is all too prevalent. Burnout is the fatigue, cynicism, emotional exhaustion, sleep disruption, and professional inefficacy that comes with work-related stress. It is estimated that over 45% of healthcare workers experience burnout. It not only affects the healthcare providers personally, but also the patients, as it produces a loss of empathy and compassion. Burnout, in fact, it is a threat to the entire healthcare system. Currently, over a third of healthcare workers report that they are looking for a new job. Hence, burnout contributes to the shortage of doctors and nurses.

 

Preventing burnout has to be a priority. Unfortunately, it is beyond the ability of the individual to change the environment to reduce stress and prevent burnout. So, it is important that methods be found to reduce the individual’s responses to stress; to make the individual more resilient when high levels of stress occur. Contemplative practices have been shown to reduce the psychological and physiological responses to stress and improve well-being. Indeed, mindfulness has been shown to be helpful in treating and preventing burnout, increasing resilience, and improving sleep.

 

In today’s Research News article “Effect of a Brief Mindfulness-Based Program on Stress in Health Care Professionals at a US Biomedical Research Hospital: A Randomized Clinical Trial.” (See summary below or view the full text of the study at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7448827/ ) Ameli and colleagues recruited healthy adult health care professionals and randomly assigned them to a life as usual, no treatment, condition or to receive a brief course in mindfulness during work hours. The Mindfulness-Based Self-Care program met once a week for 1.5 hours for 5 weeks. The program provided training and discussion of mindful breathing, body scan, mindful walking, mindful movements, mindful eating, and loving-kindness meditation. In addition, participants practiced daily at home. They were measured before and after training and 8 weeks later for perceived stress, anxiety, burnout, positive and negative emotions, mindfulness, and mindful self-care.

 

They found that in comparison to baseline and the life as usual control group at the end of training the mindfulness group had significantly lower levels of perceived stress and anxiety and significantly higher levels of mindfulness, positive emotions, and mindful self-care. At the 8-week follow-up, the mindfulness groups had maintained their significant improvements in perceived stress, anxiety and mindfulness, but not positive emotions, and mindful self-care.

 

The study did not have an active control condition. So, the results must be interpreted with caution. But they are very similar to the results of a large number of prior studies that mindfulness training reduces perceived stress and anxiety, and increases positive emotions. The fading of the benefits in positive emotions and mindful self-care over the 8-week follow-up period suggests that periodic refresher mindfulness training may be needed to maintain benefits.

 

The present study demonstrated that these benefits can be achieved with a brief mindfulness training conducted in the workplace of health care professionals. Since, stress, time constraints, and burnout are commonplace in this group, being able to conveniently deliver effective mindfulness training briefly at work maximizes the utility of mindfulness training for healthcare professionals and increases the likelihood that they will participate and complete training.

 

So, reduce stress and improve mood in healthcare workers with mindfulness.

 

“Levels of stress and burnout in the healthcare profession have been exacerbated in recent decades . . . mindfulness training. . . can have significant positive impacts on participants’ job satisfaction, their relationships with patients, co-workers and administration, and their focus and creativity at work.” – Jason Green

 

CMCS – Center for Mindfulness and Contemplative Studies

 

This and other Contemplative Studies posts are also available on Google+ https://plus.google.com/106784388191201299496/posts and on Twitter @MindfulResearch

 

Study Summary

 

Ameli, R., Sinaii, N., West, C. P., Luna, M. J., Panahi, S., Zoosman, M., Rusch, H. L., & Berger, A. (2020). Effect of a Brief Mindfulness-Based Program on Stress in Health Care Professionals at a US Biomedical Research Hospital: A Randomized Clinical Trial. JAMA network open, 3(8), e2013424. https://doi.org/10.1001/jamanetworkopen.2020.13424

 

Key Points

Question

Is a brief mindfulness-based program effective and feasible in reducing stress among health care professionals during work hours?

Findings

In this randomized clinical trial including 78 participants randomized to a 5-session (7.5-hour total) mindfulness program or a life-as-usual control, participants in the mindfulness program reported reduced stress and anxiety compared with life-as-usual controls at the end of the intervention.

Meaning

This randomized clinical trial found that this brief mindfulness intervention was an effective way of reducing stress in a health care setting.

Question

Is a brief mindfulness-based program effective and feasible in reducing stress among health care professionals during work hours?

Findings

In this randomized clinical trial including 78 participants randomized to a 5-session (7.5-hour total) mindfulness program or a life-as-usual control, participants in the mindfulness program reported reduced stress and anxiety compared with life-as-usual controls at the end of the intervention.

Meaning

This randomized clinical trial found that this brief mindfulness intervention was an effective way of reducing stress in a health care setting.

Abstract

Importance

Stress among health care professionals is well documented. The use of mindfulness-based interventions to reduce stress has shown promising results; however, the time commitment of typical programs can be a barrier to successful implementation in health care settings.

Objective

To determine the efficacy and feasibility of a brief mindfulness-based program to reduce stress during work hours among health care professionals.

Design, Setting, and Participants

This intent-to-treat randomized clinical trial was conducted among full-time health care professionals at the Clinical Center at the National Institutes of Health in Bethesda, Maryland, between September 2017 and May 2018. Participants were randomized to receive mindfulness-based self-care (MBSC) training or life-as-usual control. Data were analyzed from June 2018 to January 2020.

Interventions

The MBSC intervention included 5 weekly, 1.5-hour in-class mindfulness practice sessions.

Main Outcomes and Measures

Stress level was the primary outcome, assessed with the Perceived Stress Scale 10-Item version. Secondary outcomes included anxiety, burnout, positive and negative affect, mindfulness (trait and state), and self-care. Assessments were taken at baseline and at the end of the intervention (week 5) in the intervention and control groups, and at follow-up (week 13) in the intervention group to test for a maintenance effect. A postprogram evaluation was also obtained.

Results

Of 82 randomized participants, 78 who completed the study at week 5 were included in the modified intent-to-treat analysis (median [interquartile range] age, 32 [23-48] years; 65 [83%] women), including 43 participants in the MBSC group and 35 participants in the control group. At the end of the intervention, compared with the control group, the MBSC group had reduced levels of stress (mean [SD] score, 17.29 [5.84] vs 18.54 [6.30]; P = .02) and anxiety (mean [SD] score, 2.58 [1.52] vs 4.23 [1.73]; P < .001), and improved positive affect (mean [SD] score, 35.69 [7.12] vs 31.42 [7.27]; P < .001), state mindfulness (mean [SD] score, 3.74 [1.18] vs 2.78 [1.16]; P < .001), and mindful self-care (mean [SD] score, 7.29 [2.44] vs 5.54 [2.77]; P < .001). Burnout, negative affect, and trait mindfulness levels did not differ between groups. Changes within the MBSC group through follow-up included sustained reductions in stress (change, –6.14; 95% CI, –7.84 to –4.44; P < .001), anxiety (change, –1.46; 95% CI, –1.97 to –0.94; P < .001), trait mindfulness (change, 0.63; 95% CI, 0.36 to 0.90; P < .001), and state mindfulness (change, 1.89; 95% CI, 1.39 to 2.39; P < .001).

Conclusions and Relevance

This randomized clinical trial found that this brief mindfulness-based intervention was an effective and feasible means to reduce stress in health care professionals. Larger studies are needed to assess the effects on clinical care and patient outcomes.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7448827/Importance

 

Improve Mood in Patients with HIV with Mindfulness

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Improve Mood in Patients with HIV with Mindfulness

 

By John M. de Castro, Ph.D.

 

“Given the stress-reduction benefits of mindfulness meditation training. . . there can be health protective effects not just in people with HIV but in folks who suffer from daily stress,” – David Creswell

 

More than 35 million people worldwide and 1.2 million people in the United States are living with HIV infection. These include a significant number of children and adolescents. In 1996, the advent of the protease inhibitor and the so-called cocktail changed the prognosis for HIV. Since this development a 20-year-old infected with HIV can now expect to live on average to age 69. Hence, living with HIV is a long-term reality for a very large group of people.

 

People living with HIV infection experience a wide array of physical and psychological symptoms which decrease their perceived quality of life. The symptoms include chronic pain, muscle aches, anxiety, depression, weakness, fear/worries, difficulty with concentration, concerns regarding the need to interact with a complex healthcare system, stigma, and the challenge to come to terms with a new identity as someone living with HIV. Mindfulness training has been shown to improve psychological well-being, lower depression and strengthen the immune system of patients with HIV infection.

 

In today’s Research News article “). A randomized, controlled trial of mindfulness-based stress reduction in HIV infection.” (See summary below or view the full text of the study at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7656978/ ) Hecht and colleagues recruited adult patients with HIV who were not on antiretroviral therapy and randomly assigned to receive 8 weeks of either Mindfulness-Based Stress Reduction (MBSR) or education on managing HIV. The MBSR program met once a week for 2.5 hours and included meditation, body scan, and yoga practice, daily home practice, and discussion. HIV management education met once a week for 1,5 hours. The participants were measured before and after training and 3 and 9 months later for depression, positive and negative emotions, perceived stress, and mindfulness. In addition, blood was drawn and assayed for CD-4+ T cell counts, viral load, and the inflammatory markers of C-reactive protein, D-dimer, and Interleukin 6.

 

They found that both groups decreased in CD-4+ T cell counts over the 12 months of the study with no change in viral load or the inflammatory markers. The group that received Mindfulness-Based Stress Reduction (MBSR) had significant reductions in depression and perceived stress and increases in positive emotions 3 months but not 12 months after training. There were no significant improvements in the HIV education group. Mindfulness increased significantly in the MBSR group and was sustained at the 9 month follow-up.

 

The lack of effectiveness of Mindfulness-Based Stress Reduction (MBSR) on CD4+ T-cell counts and viral load in comparison to HIV education were disappointing. Previous studies had found that mindfulness training improved these measures. The authors attributed this to their having a more active control condition than previous studies. As a result, they cautioned against making inferences about mindfulness training effectiveness without an equivalent active control condition.

 

On the other hand, the study found that Mindfulness-Based Stress Reduction (MBSR) produced improvements in the psychological state of the patients which lasted for 3 months after the conclusion of training but tended to wane thereafter. These results are not surprising as improvements in depression, positive emotions, and perceived stress as a result of mindfulness training have been routinely reported in prior research. Hence, mindfulness training appears to improve the mood but not the HIV infection or inflammatory responses of HIV patients.

 

So, improve mood in patients with HIV with mindfulness.

 

“The results also support a role for MBSR in enhancing problem solving, life-satisfaction, and emotional regulation in youth with HIV-infection.” – AMRA

 

CMCS – Center for Mindfulness and Contemplative Studies

 

This and other Contemplative Studies posts are also available on Google+ https://plus.google.com/106784388191201299496/posts and on Twitter @MindfulResearch

 

Study Summary

 

Hecht, F. M., Moskowitz, J. T., Moran, P., Epel, E. S., Bacchetti, P., Acree, M., Kemeny, M. E., Mendes, W. B., Duncan, L. G., Weng, H., Levy, J. A., Deeks, S. G., & Folkman, S. (2018). A randomized, controlled trial of mindfulness-based stress reduction in HIV infection. Brain, behavior, and immunity, 73, 331–339. https://doi.org/10.1016/j.bbi.2018.05.017

 

Abstract

Objective:

Evidence links depression and stress to more rapid progression of HIV-1 disease. We conducted a randomized controlled trial to test whether an intervention aimed at improving stress management and emotion regulation, mindfulness-based stress reduction (MBSR), would improve immunological (i.e. CD4+ t-cell counts) and psychological outcomes in persons with HIV-1 infection.

Methods:

We randomly assigned participants with HIV-1 infection and CD4 T-cell counts > 350 cells/μl who were not on antiretroviral therapy in a 1:1 ratio to either an MBSR group (n=89) or an HIV disease self-management skills group (n=88). The study was conducted at the University of California at San Francisco. We assessed immunologic (CD4, c-reactive protein, IL-6, and d-dimer) and psychological measures (Beck Depression Inventory for depression, modified Differential Emotions Scale for positive and negative affect, Perceived stress-scale, and mindfulness) at 3, 6 and 12 months after initiation of the intervention; we used multiple imputation to address missing values.

Results:

We observed statistically significant improvements from baseline to 3-months within the MBSR group in depression, positive and negative affect, perceived stress, and mindfulness; between group differences in change were significantly greater in the MBSR group only for positive affect (per item difference on DES-positive 0.25, 95% CI 0.049, 0.44, p = .015). By 12 months the between group difference in positive affect was not statistically significant, although both groups had trends toward improvements compared to baseline in several psychological outcomes that were maintained at 12-months; these improvements were only statistically significant for depression and negative affect in the MBSR group and perceived stress for the control group. The groups did not differ significantly on rates of antiretroviral therapy initiation (MBSR = 39%, control = 29%, p = .22). After 12 months, the mean decrease in CD4+ T-cell count was 49.6 cells/μl in participants in the MBSR arm, compared to 54.2 cells/μl in the control group, a difference of 4.6 cells favoring the MBSR group (95% CI, −44.6, 53.7, p=.85). The between group differences in other immunologic-related outcomes (c-reactive protein, IL-6, HIV-1 viral load, and d-dimer) were not statistically significant at any time point.

Conclusions:

MBSR improved positive affect more than an active control arm in the 3 months following the start of the intervention. However, this difference was not maintained over the 12-month follow-up and there were no significant differences in immunologic outcomes between intervention groups. These results emphasize the need for further carefully designed research if we are to translate evidence linking psychological states to immunological outcomes into evidence-based clinical practices.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7656978/