Mindfulness Changes Neural Activity and Improves Major Depressive Disorder

Mindfulness Changes Neural Activity and Improves Major Depressive Disorder

 

By John M. de Castro, Ph.D.

 

“People at risk for depression are dealing with a lot of negative thoughts, feelings and beliefs about themselves and this can easily slide into a depressive relapse. . . MBCT helps them to recognize that’s happening, engage with it in a different way and respond to it with equanimity and compassion.” – Willem Kuyken

 

Clinically diagnosed depression is the most common mental illness, affecting over 6% of the population. Major depression can be quite debilitating. Depression can be difficult to treat and is usually treated with anti-depressive medication. But, of patients treated initially with drugs only about a third attained remission of the depression. After repeated and varied treatments including drugs, therapy, exercise etc. only about two thirds of patients attained remission. But drugs often have troubling side effects and can lose effectiveness over time. In addition, many patients who achieve remission have relapses and recurrences of the depression. Even after remission some symptoms of depression may still be present (residual symptoms).

 

Being depressed and not responding to treatment or relapsing is a terribly difficult situation. The patients are suffering and nothing appears to work to relieve their intense depression. Suicide becomes a real possibility. So, it is imperative that other treatments be identified that can relieve the suffering. Mindfulness training has been shown to be an effective treatment for depression and its recurrence and even in the cases where drugs fail.

 

The most commonly used mindfulness technique for the treatment of depression is Mindfulness-Based Cognitive Therapy (MBCT).  MBCT involves mindfulness training, containing sitting and walking meditation and body scan, and cognitive therapy to alter how the patient relates to the thought processes that often underlie and exacerbate psychological symptoms. MBCT has been shown to be as effective as antidepressant drugs in relieving the symptoms of depression and preventing depression reoccurrence and relapse. In addition, it appears to be effective as either a supplement to or a replacement for these drugs. It is not known how MBCT produces its effects on major depression.

 

One way to observe the effects of MBCT on neural activity is to measure changes in the electroencephalogram (EEG), the rhythmic electrical activity that can be recorded from the scalp. The recorded activity can be separated into frequency bands. Delta activity consists of oscillations in the 0.5-3 cycles per second band. Theta activity in the EEG consists of oscillations in the 4-8 cycles per second band. Alpha activity consists of oscillations in the 8-12 cycles per second band. Beta activity consists of oscillations in the 15-25 cycles per second band while Gamma activity occurs in the 35-45 cycles per second band. Changes in these brain activities can be compared during different depths of meditation.

 

In today’s Research News article “Mindfulness-Based Cognitive Therapy in Recurrent MDD Patients With Residual Symptoms: Alterations in Resting-State Theta Oscillation Dynamics Associated With Changes in Depression and Rumination.” (See summary below or view the full text of the study at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8936084/ ) Wang and colleagues recruited patients with major depressive disorder being treated with drugs but with residual symptoms. They were provided with an 8-week program of Mindfulness-Based Cognitive Therapy (MBCT). Before and after training they were measured for mindfulness, depression, and rumination and had their resting state electroencephalogram (EEG) recorded.

 

After completing Mindfulness-Based Cognitive Therapy (MBCT) there were significant reductions in depression which produced an 88% remission rate. There were also significant increases in mindfulness and reductions in brooding rumination. In addition, there was a significant increase in the theta rhythm power in the electroencephalogram (EEG). Finally, the greater the increase in theta power the greater the reductions in depression and rumination.

 

Hence, they found that Mindfulness-Based Cognitive Therapy (MBCT) is effective in treating depression even in patients under treatment with drugs. They also found that these improvements were related to increased theta power in the electroencephalogram (EEG). So, MBCT appears to change brain activity along with depression. The changes in the neural activity may be a mechanism by which MBCT helps improve depression symptoms.

 

mindfulness is added to the standard depression treatment protocols, relapse rates decline.” – Sara Altshul

 

CMCS – Center for Mindfulness and Contemplative Studies

 

This and other Contemplative Studies posts are also available on Twitter @MindfulResearch

 

Study Summary

 

Wang, J., Ren, F., Gao, B., & Yu, X. (2022). Mindfulness-Based Cognitive Therapy in Recurrent MDD Patients With Residual Symptoms: Alterations in Resting-State Theta Oscillation Dynamics Associated With Changes in Depression and Rumination. Frontiers in psychiatry, 13, 818298. https://doi.org/10.3389/fpsyt.2022.818298

 

Abstract

Many patients with major depressive disorder (MDD) suffer from residual symptoms. Rumination is a specific known risk factor for the onset, severity, prolongation, and relapse of MDD. This study aimed to examine the efficacy and EEG substrates of mindfulness-based cognitive therapy (MBCT) in alleviating depression and rumination in an MDD population with residual symptoms. We recruited 26 recurrent MDD individuals who had residual symptoms with their current antidepressants to participate in the 8-week MBCT intervention. We evaluated the efficacy and changes in the dynamics of resting-state theta rhythm after the intervention, as well as the associations between theta alterations and improvements in depression and rumination. The participants showed reduced depression, enhanced adaptive reflective rumination, and increased theta power and phase synchronization after MBCT. The increased theta-band phase synchronizations between the right occipital regions and the right prefrontal, central, and parietal regions were associated with reduced depression, while the increase in theta power in the left parietal region was associated with improvements in reflective rumination. MBCT could alleviate depression and enhance adaptive, reflective rumination in recurrent MDD individuals with residual symptoms through the modulation of theta dynamics in specific brain regions.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8936084/

 

Improve Psychological Well-Being of Elementary School Children with Mindfulness

Improve Psychological Well-Being of Elementary School Children with Mindfulness

 

By John M. de Castro, Ph.D.

 

“engaging in mindfulness meditation cultivates our ability to both focus and broaden our attention, which is a practical way to elicit psychological well-being.” – Jennifer Wolkin

 

Childhood is a miraculous period during which the child is dynamically absorbing information from every aspect of its environment. This is particularly evident during the elementary school years. Mindfulness training in school has been shown to have very positive effects. These include improvements in the cognitive, psychological, emotional and social domains. It is important to teach skills that improve well-being early in life. This can affect individuals throughout their lives. So, there is a need to further study the ability of mindfulness training to improve the well-being of elementary school students.

 

In today’s Research News article “Randomized Trial on the Effects of a Mindfulness Intervention on Temperament, Anxiety, and Depression: A Multi-Arm Psychometric Study.” (See summary below or view the full text of the study at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8945710/ ) Poli and colleagues recruited 5th grade students. They were measured before and after either 8 weeks of mindfulness training or no treatment for anxiety depression, and temperament.

 

They found that mindfulness training reduced anxiety levels and inhibition to novelty and increased attention, social orientation, positive emotionality. These results suggest that mindfulness training improves the psychological well-being of elementary school children.

 

Mindfulness improves the well-being of kids.

 

mental wellbeing does not mean being happy all the time and it does not mean you won’t experience negative or painful emotions, such as grief, loss, or failure, which are a part of normal life. However, whatever your age, mindfulness can help you lead a mentally healthier life and improve your wellbeing.” – Mental Health Foundation

 

CMCS – Center for Mindfulness and Contemplative Studies

 

This and other Contemplative Studies posts are also available on Twitter @MindfulResearch

 

Study Summary

 

Poli, A., Maremmani, A., Gemignani, A., & Miccoli, M. (2022). Randomized Trial on the Effects of a Mindfulness Intervention on Temperament, Anxiety, and Depression: A Multi-Arm Psychometric Study. Behavioral sciences (Basel, Switzerland), 12(3), 74. https://doi.org/10.3390/bs12030074

 

Abstract

Mindfulness is a mental state that can be achieved through meditation. So far, studies have shown that practicing mindfulness on a consistent and regular basis can improve attentional functions and emotional well-being. Mindfulness has recently begun to be used in the field of child development. The goal of this study is to assess if a mindfulness program may help primary school students in reducing anxiety and depression while also improving their temperamental characteristics. This multi-arm pre-post study included 41 subjects recruited in the fifth year of two primary school classes. Participants were randomly assigned to the experimental and control groups. The experimental group, but not the control group, underwent an eight-week mindfulness training. Every week, the program included 60-min group sessions. QUIT (Italian Questionnaires of Temperament) and TAD (Test for Anxiety and Depression in Childhood and Adolescence) were used to assess temperament, and anxiety and depression, respectively. Both groups were administered both instruments before and after mindfulness intervention. The mindfulness program lowered anxiety levels and was effective in changing temperament dimensions: there was an increase in social orientation (SO), positive emotionality (PE), and attention (AT), as well as a decrease in inhibition to novelty (IN) and negative emotionality. Path analysis revealed that AT may promote the improvement of both SO and IN. Similarly, PE may be promoted by the decrease of IN. Clinical implications are discussed.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8945710/

 

Mindful People are Resilient, Unstressed, Happy People

Mindful People are Resilient, Unstressed, Happy People

 

By John M. de Castro, Ph.D.

 

“practicing mindfulness may make us happier only if we learn to tolerate, make space for, and accept whatever experiences arise, rather than judging them, letting them define us, or running away from them.” – Melanie Greenberg

 

“Meditation leads to concentration, concentration leads to understanding, and understanding leads to happiness” – This wonderful quote from the modern day sage Thich Nhat Hahn is a beautiful pithy description of the benefits of mindfulness practice. Mindfulness allows us to view our experience and not judge it, not put labels on it, not make assumptions about it, not relate it to past experiences, and not project it into the future. Rather mindfulness lets us experience everything around and within us exactly as it is arising and falling away from moment to moment. There is a need to investigate the mechanisms by which mindfulness increases happiness.

 

In today’s Research News article “Resilience and Stress as Mediators in the Relationship of Mindfulness and Happiness.” (See summary below or view the full text of the study at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8850270/ ) Bajaj and colleagues had students from an Indian University complete measure of mindfulness, stress, resilience, and happiness.

 

They found that the higher the students levels of mindfulness, the greater their happiness and resilience and the lower their levels of stress. Mindfulness was associated with higher levels of happiness directly and also indirectly by being associated with higher levels of resilience which in turn were associated with higher happiness and also with lower levels of stress that were also in turn associated with greater happiness.

 

Hence, mindful students are happier, more resilient, and less stressed students all of which contribute to their happiness. Be mindful and be happy.

 

we’re happiest when we are mindful of the moment, and we’re least happy when the mind is wandering.” – Melli O’Brian

 

CMCS – Center for Mindfulness and Contemplative Studies

 

This and other Contemplative Studies posts are also available on Twitter @MindfulResearch

 

Study Summary

 

Bajaj, B., Khoury, B., & Sengupta, S. (2022). Resilience and Stress as Mediators in the Relationship of Mindfulness and Happiness. Frontiers in psychology, 13, 771263. https://doi.org/10.3389/fpsyg.2022.771263

 

Abstract

The aim of the present study was to examine the mediation effects of resilience and stress, two perceived opposite constructs, in the relationship between mindfulness and happiness. Mindful Attention Awareness Scale, Connor–Davidson Resilience Scale, Subjective Happiness Scale, Depression Anxiety Stress Scales short version-21 were administered to 523 undergraduate university students in India. Structural Equation Modeling with bootstrapping was applied to test the mediating effects of resilience and stress. Results showed that resilience and stress partially mediated the mindfulness-happiness relationship. In addition, resilience partially mediated the relationship of mindfulness to stress. Findings suggest that mindfulness may play an influential role in enhancing happiness through the mediating effects of resilience and stress.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8850270/

 

Meditation is an Effective Treatment for a Variety of Medical Conditions

Meditation is an Effective Treatment for a Variety of Medical Conditions

 

By John M. de Castro, Ph.D.

 

“Mindfulness is not a cure-all. . . . There have been thousands of studies showing that there are psychological and physical benefits to mindfulness meditation, but the intention . . . is not to cure the disease or fully treat the symptoms, but to treat the whole person — and that includes their mental and emotional well-being — so they can live in greater health and joy.” – Men’s Health

 

Over the last several decades, research and anecdotal experiences have accumulated an impressive evidential case that meditation has positive benefits for the individual’s mental, physical, and spiritual life. Meditation appears to be beneficial both for healthy people and for people suffering from a myriad of mental and physical illnesses. It appears to be beneficial across ages, from children to the elderly. And it appears to be beneficial across genders, personalities, race, and ethnicity. The breadth and depth of benefits is unprecedented. There is no other treatment or practice that has been shown to come anyway near the range of mindfulness’ positive benefits.

 

Over the last few decades, a vast amount of research has been published on the benefits of meditation on the mental and physical health of the practitioners. So, it makes sense to step back and summarize what has been learned.

 

In today’s Research News article “Systematic Review for the Medical Applications of Meditation in Randomized Controlled Trials.” (See summary below or view the full text of the study at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8834867/ ) Kim and colleagues review and summarize the 104 published randomized controlled trials on the benefits of meditation practices on mental and physical well-being.

 

They report that the published research found that different studies report varying results but the most common significant benefits of meditation practice were improvements in fatigue, sleep quality, quality of life, stress, PTSD symptoms, blood pressure, intraocular pressure, and depression. In general yoga-based practices produced slightly better results than mindfulness based techniques,

 

Hence, meditation practices have been found to help improve mental and physical well-being.

 

meditation can improve mental health and reduce symptoms associated with chronic conditions.” – Ashley Welch

 

CMCS – Center for Mindfulness and Contemplative Studies

 

This and other Contemplative Studies posts are also available on Twitter @MindfulResearch

 

Study Summary

 

Kim, D. Y., Hong, S. H., Jang, S. H., Park, S. H., Noh, J. H., Seok, J. M., Jo, H. J., Son, C. G., & Lee, E. J. (2022). Systematic Review for the Medical Applications of Meditation in Randomized Controlled Trials. International journal of environmental research and public health, 19(3), 1244. https://doi.org/10.3390/ijerph19031244

 

Abstract

Background: Meditation has been increasingly adapted for healthy populations and participants with diseases. Its beneficial effects are still challenging to determine due to the heterogeneity and methodological obstacles regarding medical applications. This study aimed to integrate the features of therapeutic meditation in randomized controlled trials (RCTs). Methods: We conducted a systematic review of RCTs with meditation for populations with diseases using the PubMed database through June 2021. We analyzed the characteristics of the diseases/disorders, participants, measurements, and their overall benefits. Results: Among a total of 4855 references, 104 RCTs were determined and mainly applied mindfulness-based (51 RCTs), yoga-based (32 RCTs), and transcendental meditation (14 RCTs) to 10,139 patient-participants. These RCTs were conducted for participants with a total of 45 kinds of disorders; the most frequent being cancer, followed by musculoskeletal and connective tissue diseases and affective mood disorder. Seven symptoms or signs were frequently assessed: depressive mood, feeling anxious, quality of life, stress, sleep, pain, and fatigue. The RCTs showed a higher ratio of positive outcomes for sleep (73.9%) and fatigue (68.4%). Conclusions: This systematic review produced the comprehensive features of RCTs for therapeutic meditation. These results will help physicians and researchers further study clinical adaptations in the future as reference data.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8834867/

 

Improve Inflammatory and Stress Responses with Yoga

Improve Inflammatory and Stress Responses with Yoga

 

By John M. de Castro, Ph.D.

 

“yoga could slow the harmful physical effects of stress and inflammaging.” – Harvard Health

 

The immune system is designed to protect the body from threats like stress, infection, injury, and toxic chemicals. One of its tools is the Inflammatory response. This response works quite well for short-term infections and injuries. But when inflammation is protracted and becomes chronic, it can itself become a threat to health. It can produce autoimmune diseases such as colitis, Chron’s disease, arthritis, heart disease, increased cancer risk, lung disease, sleep disruption, gum disease, decreased bone health, psoriasis, and depression. Indeed, the presence of chronic inflammation is associated with reduced longevity.

 

So, it is important for health to control the inflammatory response, allowing it to do its job in fighting off infection but reducing its activity when no external threat is apparent. Of course, it is far better to prevent chronic inflammation in the first place than to treat it later. Mind-body techniques such as yoga, Tai Chi and meditation have been shown to adaptively reduce the inflammatory response. The evidence is accumulating. So, it makes sense to step back and summarize what has been learned.

 

In today’s Research News article “The role of yoga in inflammatory markers. Brain, behavior, & immunity – health.” (See summary below or view the full text of the study at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8842003/ ) Estevan and colleagues review and summarize the published research studies of the effects of yoga practice on the inflammatory response.

 

They report that the published research found that yoga practice reduces the inflammatory response and stress hormones in a wide variety of conditions such a COPD, obesity cancer, and depression. So, the research suggests that yoga practice is an effective treatment to reduce the chronic inflammation.

 

Often, the precursor to illness is chronic inflammation. . . . Yoga — of various styles, intensities, and durations — reduced the biochemical markers of inflammation across several chronic conditions.” – Sarah Ezrin

 

 

CMCS – Center for Mindfulness and Contemplative Studies

 

This and other Contemplative Studies posts are also available on Twitter @MindfulResearch

 

Study Summary

 

Estevao C. (2022). The role of yoga in inflammatory markers. Brain, behavior, & immunity – health, 20, 100421. https://doi.org/10.1016/j.bbih.2022.100421

 

Abstract

Yoga is an ancient system for integrating the mind, body, and spirit. In the hatha yoga ashtanga tradition (the eight limb Patanjali Yoga), three of the limbs are meditation, breathwork (pranayama) and physical postures (asana), which are widely practised in yoga classes. The benefits of yoga for mental and physical health are rooted in the practice’s origins: in yoga, stress is said to be the root of all diseases.

The established fields of psychoneuroimmunology and immunopsychiatry study the interplay between the immune system and mood or mental states. This mini-review has shifted the emphasis from research that focuses on yoga’s benefits for stress, the most commonly studied outcome of yoga research, to a summary of the research on the effects of yoga practices on the immune system. The current literature bears strong evidence for the benefits of yoga on the levels of circulating cortisol and classical inflammatory markers, such as C-reactive protein (CRP) and cytokines such as interleukin-1 beta (IL-1β), interleukin 6 (IL-6), tumour necrosis factor-alpha (TNF-α) and interferon-gamma (INF-γ). The evidence for other less studied markers, telomerase activity, β-endorphins, Immunoglobulin A (IgA) and brain-derived neurotrophic factor (BDNF) is also growing. This mini-review centres around the interplay between yoga and these markers in stress management and depression, vascular and immune function in the older population, cardiovascular and metabolic diseases, auto-immune diseases, breast cancer and pregnancy.

Overall, the literature examined reveals the novelty of this field of research and sheds light on methodological challenges; however, it uncovers the potential for yoga to be used as adjuvant therapy in conditions with an inflammatory component.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8842003/

 

Improve Physical and Mental Health during Aging with Mindfulness

 

Improve Physical and Mental Health during Aging with Mindfulness

 

By John M. de Castro, Ph.D.

 

“The healthier and more active one’s lifestyle, the more likely he or she will maintain cognitive performance over time. And meditation may be a key ingredient for ensuring brain health and maintaining good mental performance.“ – Grace Bullock

 

The aging process involves a systematic progressive decline in every system in the body, the brain included. The elderly frequently have problems with attention, thinking, and memory abilities, known as mild cognitive impairment. An encouraging new development is that mindfulness practices such as meditation training and mindful movement practices can significantly reduce these declines in cognitive ability. In addition, it has been found that

mindfulness practices reduce the deterioration of the brain that occurs with aging restraining the loss of neural tissue. Indeed, the brains of practitioners of meditation have been found to degenerate less with aging than non-practitioners.

 

In today’s Research News article “Long-Term Physical Exercise and Mindfulness Practice in an Aging Population.” (See summary below or view the full text of the study at: https://www.frontiersin.org/articles/10.3389/fpsyg.2020.00358/full?utm_source=F-AAE&utm_medium=EMLF&utm_campaign=MRK_1832518_a0P58000000G0YfEAK_Psycho_20220317_arts_A&utm_source=sfmc&utm_medium=email&utm_campaign=Article+Alerts+V4.1-Frontiers&utm_term=%%%3d+++++++REDIRECTTO(+++++CONCAT(%27http%3a%2f%2fjournal.frontiersin.org%2farticle%2f%27%2c+TreatAsContent(field(%40article%2c+%27DOI__c%27))%2c+%27%2ffull%3futm_source%3dF-AAE%26utm_medium%3dEMLF%26utm_campaign%3dMRK_%27%2c+TreatAsContent(JobID)%2c+%27_%27%2c+TreatAsContent(%40FieldId)%2c+%27_%27%2c+TreatAsContent(Substring(Replace(Field(%40field%2c+%27Name%27)%2c+%27+%27%2c+%27%27)%2c+0%2c+6))% ) Tang and colleagues compared older adults (average age of 64 years) who were either experienced (> 10 years) meditators or exercisers on physical, mental, immune, stress, and brain plasticity measures.

 

They report that the older adults who exercised had superior cardiovascular and respiratory fitness. But the older adults who meditated had superior physiological relaxation, quality of life, immune response, stress response, and brain plasticity. They conclude that the optimum results for older adults would be produced by combining meditation and exercise. Regardless, it is clear that meditation restrains the physical and mental deterioration with aging.

 

it’s heartening to know that age may not only bring wisdom or sore knees, but also more mindfulness.” – Jenn Director Knudsen 

 

CMCS – Center for Mindfulness and Contemplative Studies

 

This and other Contemplative Studies posts are also available on Twitter @MindfulResearch

 

Study Summary

 

Tang Y-Y, Fan Y, Lu Q, Tan L-H, Tang R, Kaplan RM, Pinho MC, Thomas BP, Chen K, Friston KJ and Reiman EM (2020) Long-Term Physical Exercise and Mindfulness Practice in an Aging Population. Front. Psychol. 11:358. doi: 10.3389/fpsyg.2020.00358

 

Previous studies have shown that physical exercise and mindfulness meditation can both lead to improvement in physical and mental health. However, it is unclear whether these two forms of training share the same underlying mechanisms. We compared two groups of older adults with 10 years of mindfulness meditation (integrative body-mind training, IBMT) or physical exercise (PE) experience to demonstrate their effects on brain, physiology and behavior. Healthy older adults were randomly selected from a large community health project and the groups were compared on measures of quality of life, autonomic activity (heart rate, heart rate variability, skin conductance response, respiratory amplitude/rate), immune function (secretory Immunoglobulin A, sIgA), stress hormone (cortisol) and brain imaging (resting state functional connectivity, structural differences). In comparison with PE, we found significantly higher ratings for the IBMT group on dimensions of life quality. Parasympathetic activity indexed by skin conductance response and high-frequency heart rate variability also showed more favorable outcomes in the IBMT group. However, the PE group showed lower basal heart rate and greater chest respiratory amplitude. Basal sIgA level was significantly higher and cortisol concentration was lower in the IBMT group. Lastly, the IBMT group had stronger brain connectivity between the dorsal anterior cingulate cortex (dACC) and the striatum at resting state, as well as greater volume of gray matter in the striatum. Our results indicate that mindfulness meditation and physical exercise function in part by different mechanisms, with PE increasing physical fitness and IBMT inducing plasticity in the central nervous systems. These findings suggest combining physical and mental training may achieve better health and quality of life results for an aging population.

https://www.frontiersin.org/articles/10.3389/fpsyg.2020.00358/full?utm_source=F-AAE&utm_medium=EMLF&utm_campaign=MRK_1832518_a0P58000000G0YfEAK_Psycho_20220317_arts_A&utm_source=sfmc&utm_medium=email&utm_campaign=Article+Alerts+V4.1-Frontiers&utm_term=%%%3d+++++++REDIRECTTO(+++++CONCAT(%27http%3a%2f%2fjournal.frontiersin.org%2farticle%2f%27%2c+TreatAsContent(field(%40article%2c+%27DOI__c%27))%2c+%27%2ffull%3futm_source%3dF-AAE%26utm_medium%3dEMLF%26utm_campaign%3dMRK_%27%2c+TreatAsContent(JobID)%2c+%27_%27%2c+TreatAsContent(%40FieldId)%2c+%27_%27%2c+TreatAsContent(Substring(Replace(Field(%40field%2c+%27Name%27)%2c+%27+%27%2c+%27%27)%2c+0%2c+6))%

 

Meditation Increases a Biological Marker that Protects Against Age-Related Decline

Meditation Increases a Biological Marker that Protects Against Age-Related Decline

 

By John M. de Castro, Ph.D.

 

meditation may have salutary effects on telomere length by reducing cognitive stress and stress arousal and increasing positive states of mind and hormonal factors that may promote telomere maintenance.” – Elissa Epel

 

One of the most exciting findings in molecular biology in recent years was the discovery of the telomere. This is a component of the DNA molecule that is attached to the ends of the strands. Recent genetic research has suggested that the telomere and its regulation is the biological mechanism that produces aging. As we age the tail of the DNA molecule called the telomere shortens. When it gets very short cells have a more and more difficult time reproducing and become more likely to produce defective cells. On a cellular basis, this is what produces aging. As we get older the new cells produced are more and more likely to be defective. The shortening of the telomere occurs each time the cell is replaced. So, slowly as we age it gets shorter and shorter.

 

Fortunately, there is a mechanism to protect the telomere. There is an enzyme in the body called telomerase that helps to prevent shortening of the telomere. It also promotes cell survival and enhances stress-resistance.  Research suggests that processes that increase telomerase activity tend to slow the aging process by protecting the telomere.  One activity that seems to increase telomerase activity and protect telomere length is mindfulness practice. Hence, engaging in mindfulness practices may protect the telomere and thereby slow the aging process.

 

In today’s Research News article “Impact of Meditation-Based Lifestyle Practices on Mindfulness, Wellbeing, and Plasma Telomerase Levels: A Case-Control Study.” (See summary below or view the full text of the study at: https://www.frontiersin.org/articles/10.3389/fpsyg.2022.846085/full?utm_source=F-AAE&utm_medium=EMLF&utm_campaign=MRK_1827462_a0P58000000G0YfEAK_Psycho_20220308_arts_A&utm_source=sfmc&utm_medium=email&utm_campaign=Article+Alerts+V4.1-Frontiers&utm_term=%%%3d++++++REDIRECTTO(+++++CONCAT(%27http%3a%2f%2fjournal.frontiersin.org%2farticle%2f%27%2c+TreatAsContent(field(%40article%2c+%27DOI__c%27))%2c+%27%2ffull%3futm_source%3dF-AAE%26utm_medium%3dEMLF%26utm_campaign%3dMRK_%27%2c+TreatAsContent(JobID)%2c+%27_%27%2c+TreatAsContent(%40FieldId)%2c+%27_%27%2c+TreatAsContent(Substring(Replace(Field(%40field%2c+%27Name%27)%2c+%27+%27%2c+%27%27)%2c+0%2c+6))%2c ) Dasanayaka  and colleagues examine the telomerase activity in long-term meditators in comparison to matched control participants.

 

They report that the long-term meditators have significantly higher levels of telomerase in their bloodstream, mindfulness, and quality of life. They also found that the higher the levels of mindfulness the higher the levels of telomerase.

 

These findings support the contention that meditation can help protect against the physical and mental deterioration that occurs with aging by increasing the levels of telomerase thereby protecting the telomere.

 

Meditation also helps to protect our telomeres, the protective caps at the end of our chromosomes. Telomeres are longest when we’re young and naturally shorten as we age. Shorter telomeres are associated with stress and higher risk for many diseases including cancer, and depend on the telomerase enzyme to enable them to rebuild and repair.” – Paula Watkins

 

CMCS – Center for Mindfulness and Contemplative Studies

 

This and other Contemplative Studies posts are also available on Twitter @MindfulResearch

 

Study Summary

 

Dasanayaka NN, Sirisena ND and Samaranayake N (2022) Impact of Meditation-Based Lifestyle Practices on Mindfulness, Wellbeing, and Plasma Telomerase Levels: A Case-Control Study. Front. Psychol. 13:846085. doi: 10.3389/fpsyg.2022.846085

 

Meditation involves psychophysical training which can result in a range of benefits including creating a calm mind and increasing self-awareness, relaxation, and tranquility. Increasing evidence, mostly based on short-term focused interventions, suggests that meditation-based activities may also have favorable effects on physical wellbeing including cellular aging. Hence, the aim of this study was to investigate if continued practice of meditation benefited quality of life, state of mindfulness, and plasma telomerase level in healthy adults. 30 long-term and skilled meditators were recruited from meditation centers in different parts of the island following a two-tier screening process of 70 eligible participants and 30 age- and gender-matched healthy non-meditators were recruited from the community. Mindfulness level and the quality of life were measured using the Five Facet Mindfulness Questionnaire (FFMQ) and Quality of Life Questionnaire, respectively, while the levels of plasma telomerase enzyme were measured using Enzyme-Linked Immunosorbent Assay. Skilled meditators had a better mindfulness level (p < 0.001) and quality of life (QOL; p < 0.001) than those in the comparison group. Similarly, higher plasma telomerase levels were observed in skilled meditators compared to non-meditators (p = 0.002). Trait mindfulness level and plasma telomerase level showed a significant relationship with the duration of meditation practice (p = 0.046 and p = 0.011, respectively). Regression analysis indicated that trait mindfulness level (p < 0.001) significantly predicts the plasma telomerase level. The findings of this comparative study add to the evidence on sustained benefits of meditation on wellbeing and healthy aging and supports incorporating meditation-based activities into lifestyle practices.

https://www.frontiersin.org/articles/10.3389/fpsyg.2022.846085/full?utm_source=F-AAE&utm_medium=EMLF&utm_campaign=MRK_1827462_a0P58000000G0YfEAK_Psycho_20220308_arts_A&utm_source=sfmc&utm_medium=email&utm_campaign=Article+Alerts+V4.1-Frontiers&utm_term=%%%3d++++++REDIRECTTO(+++++CONCAT(%27http%3a%2f%2fjournal.frontiersin.org%2farticle%2f%27%2c+TreatAsContent(field(%40article%2c+%27DOI__c%27))%2c+%27%2ffull%3futm_source%3dF-AAE%26utm_medium%3dEMLF%26utm_campaign%3dMRK_%27%2c+TreatAsContent(JobID)%2c+%27_%27%2c+TreatAsContent(%40FieldId)%2c+%27_%27%2c+TreatAsContent(Substring(Replace(Field(%40field%2c+%27Name%27)%2c+%27+%27%2c+%27%27)%2c+0%2c+6))%2c

 

Improve the Regulation of Emotions with Yoga

Improve the Regulation of Emotions with Yoga

 

By John M. de Castro, Ph.D.

 

“yoga has an important role in regulating the feelings of the adolescents and the students who practice yoga are more happy, energetic, focused, and healthy.” – Yasmin Janjhua

 

Emotions are important to our well-being. They provide the spice of life, the joy, the love, the happiness. But they can be troubling producing sadness, hurt and fear. They can also be harmful such as the consequences of out-of-control anger or suicidal depression. We need emotions, but we must find ways to keep them under control. Emotion regulation is the term used to describe the ability to control emotions. It is not eliminating or suppressing them. Far from it, emotion regulation allows for the emotion to be fully felt and experienced. But it maintains the intensity of the emotion at a manageable level and also produces the ability to respond to the emotion appropriately and constructively. Clearly, emotion regulation is a key to a happier life.

 

Mindfulness practices have been shown to improve emption regulation. Exercise has also been shown to improve mental health. Yoga is both a mindfulness practice and an exercise. It has been shown to have a myriad of benefits for psychological and physical health, social, and spiritual well-being. So, there is reason to believe that yoga practice may improve emotion regulation. How this might work in young adults has not been well explored.

 

In today’s Research News article “”I Just Find It Easier to Let Go of Anger”: Reflections on the Ways in Which Yoga Influences How Young People Manage Their Emotions.” (See summary below or view the full text of the study at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8645589/ ) Hagen and colleagues examine the changes in emotions that occur in teenagers during participation in an 8-week yoga class. The teens received semi-structured interviews and filled out logs of their experiences.

 

The youths reported that yoga reduced negative emotions and improved their ability to regulate these emotions. This is very important for everyone but especially during the highly volatile teenage years. By making the teens more aware of their emotions and improving their ability to understand their origins, they become better at working with them as opposed to suppressing or ignoring them. Hence, yoga practice may be an important means to help teens navigate this difficult period.

 

Yoga is beneficial for everyone, from 3 years to 103! It might be said though, that the 13-18 year old age group needs it the most.” – Lyn Russell

 

 

CMCS – Center for Mindfulness and Contemplative Studies

 

This and other Contemplative Studies posts are available on Twitter @MindfulResearch

 

Study Summary

 

Hagen, I., Skjelstad, S., & Nayar, U. S. (2021). “I Just Find It Easier to Let Go of Anger”: Reflections on the Ways in Which Yoga Influences How Young People Manage Their Emotions. Frontiers in psychology, 12, 729588. https://doi.org/10.3389/fpsyg.2021.729588

 

Abstract

In this article we discuss how young people experienced a school-based yoga intervention. We pay particular attention to how yoga provides a space for young people to deal with their emotions. We base our discussion on qualitative data from young people in Norway who participated in the European research project “Hippocampus: Promoting Mental Health and Wellbeing among Young People through Yoga.” The qualitative results are based on experiences described by these young people in individual semi-structured interviews and in diaries or logs. Our data include nine interviews performed in the spring of 2019 with young people of Norwegian and refugee background in their late teens and early twenties. There were also 133 logs noted by the students exposed to the yoga intervention. In the qualitative interviews, young people talk about yoga and emotional management, improved sleep habits, and regulation. They also report improved ability to regulate and cope with stress. Yoga seemed especially beneficial for refugee trauma. In this article, we have chosen to focus on the utterances of young people about emotions, as those were quite dominant in our data, especially in the interview material. We have identified instances of emotional regulation, but also of emotional processes and changes of emotions, all of which were related to these young students practicing yoga. The impact of yoga on emotions illustrates the potential of yoga to improve the well-being and mental health of young people.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8645589/

Be Happier, More Resilient, and Less Stressed with Mindfulness

Be Happier, More Resilient, and Less Stressed with Mindfulness

 

By John M. de Castro, Ph.D.

 

There is no way to happiness — happiness is the way.” – Thich Nhat Hanh

 

Being mindful increases happiness, improves the ability to bounce back from difficulties, resilience, and reduces physiological and psychological responses to stress. These effects are well established. But it is not known how mindfulness, resilience, and stress interact.

 

In today’s Research News article “Resilience and Stress as Mediators in the Relationship of Mindfulness and Happiness.” (See summary below or view the full text of the study at: https://www.frontiersin.org/articles/10.3389/fpsyg.2022.771263/full?utm_source=F-AAE&utm_medium=EMLF&utm_campaign=MRK_1816931_a0P58000000G0YfEAK_Psycho_20220215_arts_A ) Bajaj and colleagues measure mindfulness, resilience and stress in college students and find that mindfulness is associated with greater happiness not only by directly promoting happiness but also indirectly. First it is associated with increased resilience, and this is associated with higher happiness and second, mindfulness is associated with less stress and being less stressed, not surprisingly, improves happiness.

 

This suggests that be happier mindfulness should be practiced, to be more resilient and thereby happier mindfulness should be practiced, and to be better at dealing with stress and thereby happier mindfulness should be practiced.

 

Happiness, not in another place but this place… not for another hour, but this hour.” – Walt Whitman

 

CMCS – Center for Mindfulness and Contemplative Studies

 

This and other Contemplative Studies posts are also on Twitter @MindfulResearch

 

Study Summary

 

Bajaj B, Khoury B and Sengupta S (2022) Resilience and Stress as Mediators in the Relationship of Mindfulness and Happiness. Front. Psychol. 13:771263. doi: 10.3389/fpsyg.2022.771263

 

The aim of the present study was to examine the mediation effects of resilience and stress, two perceived opposite constructs, in the relationship between mindfulness and happiness. Mindful Attention Awareness Scale, Connor–Davidson Resilience Scale, Subjective Happiness Scale, Depression Anxiety Stress Scales short version-21 were administered to 523 undergraduate university students in India. Structural Equation Modeling with bootstrapping was applied to test the mediating effects of resilience and stress. Results showed that resilience and stress partially mediated the mindfulness-happiness relationship. In addition, resilience partially mediated the relationship of mindfulness to stress. Findings suggest that mindfulness may play an influential role in enhancing happiness through the mediating effects of resilience and stress.

https://www.frontiersin.org/articles/10.3389/fpsyg.2022.771263/full?utm_source=F-AAE&utm_medium=EMLF&utm_campaign=MRK_1816931_a0P58000000G0YfEAK_Psycho_20220215_arts_A

 

Spirituality May Alter the Brain to Protect Against Major Depression

Spirituality May Alter the Brain to Protect Against Major Depression

 

By John M. de Castro, Ph.D.

 

“spirituality or religion may protect against major depression by thickening the brain cortex and counteracting the cortical thinning that would normally occur with major depression.” – Lisa Miller

 

Spirituality is defined as “one’s personal affirmation of and relationship to a higher power or to the sacred. Spirituality has been promulgated as a solution to the challenges of life both in a transcendent sense and in a practical sense. There have been a number of studies of the influence of spirituality on the physical and psychological well-being of practitioners mostly showing positive benefits, with spirituality encouraging personal growth and mental health.

 

One way that spirituality can have its effects on the individual is by altering the brain. The nervous system is a dynamic entity, constantly changing and adapting to the environment. It will change size, activity, and connectivity in response to experience. These changes in the brain are called neuroplasticity.  Over the last decade neuroscience has been studying the effects of contemplative practices on the brain and has identified neuroplastic changes in widespread area. and have found that meditation practice appears to mold and change the brain, producing psychological, physical, and spiritual benefits. So, religion and spirituality may be associated with changes in the nervous system associated with better mental health.

 

In today’s Research News article “Altruism and “love of neighbor” offer neuroanatomical protection against depression. Psychiatry research.” (See summary below or view the full text of the study at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8672211/ ) Miller and colleagues reanalyzed longitudinal data obtained from individuals at risk for major depression and matched normal participants. At 30 and 35 years of age the participants brains were scanned with Magnetic Resonance Imaging (MRI) and the participants completed measures of major depressive disorder, level of depression and spirituality including measures of altruism, love thy neighbor as self, interconnectedness, contemplative practice, and commitment to religion/spirituality.

 

They found that the low risk of depression group had significantly greater cortical thickness in the Ventral Frontotemporal Network (VFTN), in comparison to the high-risk group. The VFTN had been previously shown to be associated with spiritual experience. They also found that in the at-risk for major depression group the greater the cortical thickness in the VFTN the lower levels of depression and the lower the risk of developing major depressive disorder. Across all participants, the higher the spirituality measures of altruism and love thy neighbor as self the greater the cortical thickness in the VFTN. In addition, in the high-risk group, the higher the levels of the spirituality measure of love thy neighbor as self the lower the levels of depression and the lower the risk of developing major depressive disorder.

 

The results demonstrate that the thickness of the Ventral Frontotemporal Network (VFTN) is associated with lower levels of depression and risk of major depressive disorder. In addition, thee results suggest that for people with a high risk of developing major depressive disorder spirituality particularly in the of altruism and love thy neighbor as self categories is associated with protection of the cortical areas from deterioration and this in turn is associated with lower depression and risk of major depressive disorder.

 

These results suggest that spirituality is associated protection from depression by protecting the brain particularly in people at high risk of developing major depressive disorder. These are correlative results, so it is not possible to determine causation. Future research needs to determine if promotion of spirituality, perhaps by training in contemplative practices, might produce neuroplastic changes in the brain and protect against the development of major depressive disorder.

 

So, spirituality may alter the brain to protect against major depression.

 

there is neurobiological basis of spirituality and depression risk. It is unlikely to be harmful, and may very well help to steer the religious depressed patient to more spiritual contemplation, and the non-religious one to more meditation and reflection.” – Emily Deans

 

CMCS – Center for Mindfulness and Contemplative Studies

 

This and other Contemplative Studies posts are available on Twitter @MindfulResearch

 

Study Summary

 

Miller, L., Wickramaratne, P., Hao, X., McClintock, C. H., Pan, L., Svob, C., & Weissman, M. M. (2021). Altruism and “love of neighbor” offer neuroanatomical protection against depression. Psychiatry research. Neuroimaging, 315, 111326. https://doi.org/10.1016/j.pscychresns.2021.111326

 

Abstract

We prospectively investigate protective benefits against depression of cortical thickness across nine regions of a Ventral Frontotemporal Network (VFTN), previously associated with spiritual experience. Seventy-two participants at high and low risk for depression (Mean age 41 years; 22–63 years; 40 high risk, 32 low risk) were drawn from a three-generation, thirty-eight year study. FreeSurfer estimated cortical thickness over anatomical MRIs of the brain (Year 30) for each of the nine ROIs. Depression (MDD with SAD-L; symptoms with PHQ; Years 30 and 38) and spirituality (self-report on five phenotypes; Year 35), respectively, were associated with the weighted average of nine regions of interest. VFTN thickness was: 1) positively associated (p<0.01) with two of five spiritual phenotypes, altruism and love of neighbor, interconnectedness at a trend level, but neither commitment nor practice, 2) inversely associated with a diagnosis of MDD (SADS-L Year 30, for any MDD in the past ten years), and 3) prospectively neuroanatomically protective against depressive symptoms (PHQ-9 Year 38) for those at high familial risk.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8672211/