Brain systems

Improve Mild Cognitive Impairment in the Elderly with Tai Chi

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By John M. de Castro, Ph.D.

 

“Tai Chi Chuan, the great ultimate, strengthens the weak, raises the sick, invigorates the debilitated, and encourages the timid.” –Cheng Man-ch’ing

The aging process involves a systematic progressive decline in every system in the body, the brain included. The elderly frequently have problems with attention, thinking, and memory abilities, known as mild cognitive impairment. This is often a prelude to more severe decline such a dementia. An encouraging new development is that mindfulness practices such as meditation training and mindful movement practices can significantly reduce these declines in cognitive ability.

 

Tai Chi is an ancient Chinese practice involving mindfulness and gentle movements. It is easy to learn, safe, and gentle. Tai Chi has been practiced for thousands of years with benefits for health and longevity. Tai Chi training is designed to enhance function and regulate the activities of the body through controlled breathing, mindful concentration, and gentle movements. Only recently though have the effects of this practice been scrutinized with empirical research. This research has found that it is effective for an array of physical and psychological issues. It appears to strengthen the immune system, reduce inflammation and increase the number of cancer killing cells in the bloodstream, improve cardiovascular health, reduce arthritis pain, improve balance and reduce falls. It also appears to improve attentional ability improve cognitive ability in the elderly, and relieve depression.

 

In today’s Research News article “Mitigating effects and mechanisms of Tai Chi on mild cognitive impairment in the elderly.” (See summary below or view the full text of the study at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9906996/  ) Wang and colleagues review and summarize the published randomized controlled studies of the effects of Tai Chi practice on patients diagnosed with mild cognitive decline.

 

They report that Tai Chi practice relieved the symptoms of mild cognitive decline and delayed the onset of more severe dementia. The benefits include improved memory, executive function, and sleep and reduced body pain. They also report that Tai Chi practice appears to produce these benefits by altering the brain including increased brain volume, connectivity, and white matter efficiency and reduce inflammation.

 

Hence, the published research suggests that Tai Chi practice is an effective treatment for patients with mild cognitive impairment.

 

“The moment we believe that success is determined by an ingrained level of ability as opposed to resilience and hard work, we will be brittle in the face of adversity.” – Joshua Waitzkin

 

CMCS – Center for Mindfulness and Contemplative Studies

 

This and other Contemplative Studies posts are also available on the Contemplative Studies Blog  http://contemplative-studies.org

 

Study Summary

 

Wang X, Si K, Gu W, Wang X. Mitigating effects and mechanisms of Tai Chi on mild cognitive impairment in the elderly. Front Aging Neurosci. 2023 Jan 6;14:1028822. doi: 10.3389/fnagi.2022.1028822. PMID: 36760710; PMCID: PMC9906996.

 

Abstract

Mild cognitive impairment (MCI) is a major public health concern that endangers health and decreases the quality of life of the elderly around the world. A recent clinical guideline has recommended regular exercise (twice per week) for patients with MCI as part of an overall approach to management. Tai Chi, a form of light-to-moderate-intensity mind-body exercise, is particularly suitable for seniors. This review aims to summarize epidemiological studies related to the effects of Tai Chi on symptom remission in older adults with MCI and reveal the potential mechanisms. Evidence suggested that Tai Chi can improve cognitive functions and alleviate the accompanying symptoms of MCI in the elderly potentially by activating the expression of signals in different brain regions, altering their connectivity, increasing the brain volume, and modulating brain-derived neurotropic and inflammation factors. Studies comparing various types of Tai Chi may contribute to the identification of paradigms that have appropriate intensities and difficulty and exert good effects on older people with MCI. In addition, studies are warranted to determine the frequency and duration of training that can optimize the beneficial effects of Tai Chi on MCI.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9906996/

Long-Term Meditation Changes Large-Scale Brain Connectivity

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Long-Term Meditation Changes Large-Scale Brain Connectivity

 

By John M. de Castro, Ph.D.

 

There has accumulated a large amount of research demonstrating that meditation practice has significant benefits for psychological, physical, and spiritual wellbeing. One way that meditation practices may produce these benefits is by altering the brain. The nervous system is a dynamic entity, constantly changing and adapting to the environment. It will change size, activity, and connectivity in response to experience. These changes in the brain are called neuroplasticity. Over the last decade neuroscience has been studying the effects of contemplative practices on the brain and has identified neuroplastic changes in widespread areas. In other words, meditation practice appears to mold and change the brain structures and connectivity, producing psychological, physical, and spiritual benefits, especially mindfulness.

 

Two in particular types of meditation can be characterized on a continuum with the degree and type of attentional focus. In focused attention meditation, the individual practices paying attention to a single meditation object, learns to filter out distracting stimuli, including thoughts, and learns to stay focused on the present moment, filtering out thoughts centered around the past or future. In open monitoring meditation, the individual opens up awareness to everything that’s being experienced regardless of its origin. These include bodily sensations, external stimuli, and even thoughts. The meditator just observes these thoughts and lets them arise and fall away without paying them any further attention. These differences are likely to produce different effects on the practitioners, their psychology and their brains.

 

In today’s Research News article “Long-Term and Meditation-Specific Modulations of Brain Connectivity Revealed Through Multivariate Pattern Analysis.” (See summary below or view the full text of the study at:  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10164028/ )  Guidotti  and colleagues recruited established long-term meditators (Buddhist Monks) and novice meditators. The novices practiced both focused and open monitoring meditation for 30 minutes per day for 10 days. Both groups then practiced both focused and open monitoring meditation while having their brains scanned with functional Magnetic Resonance Imaging (fMRI).

 

The found that large-scale functional interactions in the brain could better predict both focused and open monitoring meditation styles in practiced meditators as opposed to novices. Open Monitoring meditation enhanced connectivity between regions that process somatosensory, auditory, and visual information. On the other hand, Focused Meditation enhanced connectivity between regions that are involved in attentional control and self-awareness.

 

These findings suggest that long-term meditation changes the brain to process different information in large-scale networks for focused versus open monitoring meditations, but not so much in novice meditators. Hence, long-term meditation practice changes the brain to facilitate brain processing of meditation type specific functions.

 

CMCS – Center for Mindfulness and Contemplative Studies

 

This and other Contemplative Studies posts are also available on Twitter @MindfulResearch

 

Study Summary

 

Guidotti R, D’Andrea A, Basti A, Raffone A, Pizzella V, Marzetti L. Long-Term and Meditation-Specific Modulations of Brain Connectivity Revealed Through Multivariate Pattern Analysis. Brain Topogr. 2023 May;36(3):409-418. doi: 10.1007/s10548-023-00950-3. Epub 2023 Mar 28. PMID: 36977909; PMCID: PMC10164028.

 

Abstract

Neuroimaging studies have provided evidence that extensive meditation practice modifies the functional and structural properties of the human brain, such as large-scale brain region interplay. However, it remains unclear how different meditation styles are involved in the modulation of these large-scale brain networks. Here, using machine learning and fMRI functional connectivity, we investigated how focused attention and open monitoring meditation styles impact large-scale brain networks. Specifically, we trained a classifier to predict the meditation style in two groups of subjects: expert Theravada Buddhist monks and novice meditators. We showed that the classifier was able to discriminate the meditation style only in the expert group. Additionally, by inspecting the trained classifier, we observed that the Anterior Salience and the Default Mode networks were relevant for the classification, in line with their theorized involvement in emotion and self-related regulation in meditation. Interestingly, results also highlighted the role of specific couplings between areas crucial for regulating attention and self-awareness as well as areas related to processing and integrating somatosensory information. Finally, we observed a larger involvement of left inter-hemispheric connections in the classification. In conclusion, our work supports the evidence that extensive meditation practice modulates large-scale brain networks, and that the different meditation styles differentially affect connections that subserve style-specific functions.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10164028/

 

Improve Brain Function in the Elderly with Mindfulness

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Improve Brain Function in the Elderly with Mindfulness

 

By John M. de Castro, Ph.D.

 

“Most people think that aging is irreversible and we know that there are mechanisms even in the human machinery that allow for the reversal of aging, through correction of diet, through anti-oxidants, through removal of toxins from the body, through exercise, through yoga and breathing techniques, and through meditation.” – Deepak Chopra

 

The aging process involves a systematic progressive decline in every system in the body, the brain included. This includes our cognitive (mental) abilities which decline with age including impairments in memory, attention, and problem-solving ability. It is inevitable and cannot be avoided. Research has found that mindfulness practices reduce the deterioration of the brain that occurs with aging restraining the loss of neural tissue. Indeed, the brains of practitioners of meditation and yoga have been found to degenerate less with aging than non-practitioners

 

In today’s Research News article “Cerebral Blood Flow and Brain Functional Connectivity Changes in Older Adults Participating in a Mindfulness-Based Stress Reduction Program.” (See summary below or view the full text of the study at:  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8869750/ ) Moss and colleagues recruited adults over the age of 65 years and provided them with an 8-week of once a week 2-hour programs of Mindfulness-Based Stress Reduction (MBSR) along with home practice. MBSR consists of meditation, yoga, and body scan practices along with group discussion. Before and after the program they were measured for anxiety and depression. In addition they underwent cerebral blood flow measurement and connectivity measurement with Magnetic Resonance Imaging (MRI).

 

They found that in comparison to baseline the elderly had significant decreases in depression and significant increases in cerebral blood flow in a variety of cortical areas after mindfulness training. They also found significantly increased connectivity between the anterior cingulate cortex and the left insular cortex, posterior cingulate cortex, putamen, and left orbitofrontal cortex.

 

These changes in the brains of the elderly are significant as they suggest that mindfulness training reverses, at least in part, the decline in the nervous system that occurs with aging. This is likely to also signal protection of cognitive capacity.

 

“There are great reasons to fear what happens if you don’t create a robust social schedule for the rest of your life or practice mindfulness meditation for the rest of your life.” ― John Medina

 

CMCS – Center for Mindfulness and Contemplative Studies

 

This and other Contemplative Studies posts are also available on Twitter @MindfulResearch

 

Study Summary

 

Moss AS, Reibel DK, Wintering N, Vedaei F, Porter H, Khosravi M, Heholt J, Alizadeh M, Mohamed FB, Newberg AB. Cerebral Blood Flow and Brain Functional Connectivity Changes in Older Adults Participating in a Mindfulness-Based Stress Reduction Program. Behav Sci (Basel). 2022 Feb 14;12(2):48. doi: 10.3390/bs12020048. PMID: 35200299; PMCID: PMC8869750.

 

Abstract

There is a growing interest in the potential beneficial effects of mindfulness meditation training in protecting against age-related physical, emotional, and cognitive decline. The current prospective, single-center, single-arm study investigated if functional magnetic resonance imaging-based changes in cerebral blood flow and brain functional connectivity could be observed in 11 elderly adults (mean age 79) after participation in a Mindfulness-Based Stress Reduction (MBSR) program. The results showed significantly (p < 0.05) altered cerebral blood flow and functional connectivity in the cingulate gyrus, limbic structures, and subregions of the temporal and frontal lobes, similar to findings of other meditation-related studies in younger populations. Furthermore, these changes were also associated with significant improvements in depression symptoms. This study suggests that the MBSR program can potentially modify cerebral blood flow and connectivity in this population.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8869750/

 

Mindfulness Training Alters the Brain to Improve Internally Oriented Attention

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Mindfulness Training Alters the Brain to Improve Internally Oriented Attention

 

By John M. de Castro, Ph.D.

 

“Regular practice of mindfulness can help you grow a wiser, more connected, and stress-proof brain.” – Melanie Greenberg

 

There has accumulated a large amount of research demonstrating that meditation practice has significant benefits for psychological, physical, and spiritual wellbeing. One way that meditation practices may produce these benefits is by altering the brain. Meditation practice appears to mold and change the brain structures and connectivity, producing psychological, physical, and spiritual benefits, especially mindfulness.

 

Meditation practice results in a shift in mental processing. It produces a reduction of mind wandering and self-referential thinking and an increase in attention and higher-level thinking. The neural system that underlie mind wandering is termed the Default Mode Network (DMN) and consists in a set of brain structures including medial prefrontal cortex, posterior cingulate, lateral temporal cortex and the hippocampus. The neural system that underlies executive functions such as attention and higher-level thinking is termed the Central Executive Network (CEN) and includes the dorsolateral prefrontal cortex, posterior parietal cortex, and cingulate cortex. The salience network has been shown to direct attention to significant aspects of the environment. Hence the shift in thought process may well be associated with changes in the relationship of these systems.

 

The evidence of the effects of mindfulness practices on the Default Mode Network (DMN) and the Salience Network has been accumulating. So, it makes sense to summarize what has been learned. In today’s Research News article “Meta-analytic evidence that mindfulness training alters resting state default mode network connectivity.” (See summary below or view the full text of the study at:  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9293892/ ) Rahrig and colleagues review, summarize, and perform a meta-analysis of the published research on the effects of mindfulness training on brain systems.

 

They identified 12 published research studies. They report that the research studies found that mindfulness training produced increased functional connectivity between the dorsal anterior cingulate cortex a component of the salience network and the posterior cingulate cortex a component of the default mode network. This suggests that mindfulness training increases the attention to significant aspects of internal processes. It can be hypothesized that this results in an internal attention to the internal mental processes of the mind.

 

“How we pay attention to the present moment largely determines the character of our experience, and therefore, the quality of our lives.” – Sam Harris

 

 

CMCS – Center for Mindfulness and Contemplative Studies

 

This and other Contemplative Studies posts are also available on Twitter @MindfulResearch

 

Study Summary

Rahrig H, Vago DR, Passarelli MA, Auten A, Lynn NA, Brown KW. Meta-analytic evidence that mindfulness training alters resting state default mode network connectivity. Sci Rep. 2022 Jul 18;12(1):12260. doi: 10.1038/s41598-022-15195-6. PMID: 35851275; PMCID: PMC9293892.

 

Abstract

This meta-analysis sought to expand upon neurobiological models of mindfulness through investigation of inherent brain network connectivity outcomes, indexed via resting state functional connectivity (rsFC). We conducted a systematic review and meta-analysis of rsFC as an outcome of mindfulness training (MT) relative to control, with the hypothesis that MT would increase cross-network connectivity between nodes of the Default Mode Network (DMN), Salience Network (SN), and Frontoparietal Control Network (FPCN) as a mechanism of internally-oriented attentional control. Texts were identified from the databases: MEDLINE/PubMed, ERIC, PSYCINFO, ProQuest, Scopus, and Web of Sciences; and were screened for inclusion based on experimental/quasi-experimental trial design and use of mindfulness-based training interventions. RsFC effects were extracted from twelve studies (mindfulness n = 226; control n = 204). Voxel-based meta-analysis revealed significantly greater rsFC (MT > control) between the left middle cingulate (Hedge’s g = .234, p = 0.0288, I2 = 15.87), located within the SN, and the posterior cingulate cortex, a focal hub of the DMN. Egger’s test for publication bias was nonsignificant, bias = 2.17, p = 0.162. In support of our hypothesis, results suggest that MT targets internetwork (SN-DMN) connectivity implicated in the flexible control of internally-oriented attention.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9293892/

 

Improve Chronic Fatigue Syndrome with Tai Chi

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Improve Chronic Fatigue Syndrome with Tai Chi

 

By John M. de Castro, Ph.D.

 

“Tai chi does not mean oriental wisdom or something exotic. It is the wisdom of your own senses, your own mind and body together as one process.” – Chungliang Al Huang

 

Myalgic encephalomyelitis/Chronic Fatigue Syndrome (CFS) occurs in about 0.2% of the population. It produces a profound, prolonged, and debilitating tiredness that is not corrected by rest. When severe, it can produce a chronic and extreme tiredness, so severe that sufferers can become bed-bound or need to use a wheel-chair. It produces muscle pain, brain fog and dizziness, poor memory, disturbed sleep and trouble with digestion.

 

Unfortunately, there are no known cures for CFS. The usual treatments for fatigue are targeted at symptom relief and include exercise and drugs. As an alternative to these traditional treatments, mindfulness training has been shown to reduce fatigue. Tai Chi is a mindfulness practice that includes movement and balance training. The ability of Tai Chi to improve Chronic Fatigue Syndrome (CFS) needs investigation.

 

In today’s Research News article “Altered Effective Connectivity of Resting-State Networks by Tai Chi Chuan in Chronic Fatigue Syndrome Patients: A Multivariate Granger Causality Study.” (See summary below or view the full text of the study at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9203735/  ) Li and colleagues recruited adult patients with Chronic Fatigue Syndrome (CFS) and a group of healthy adults who had never practiced Tai Chi and provided them with 2 weekly 1 hour sessions of Tai Chi for 4 weeks. They were measured before and after training for health-related quality of life and had their brains scanned with Magnetic Resonance Imaging (MRI).

 

They found that in comparison to the healthy adults before Tai Chi the patients with Chronic Fatigue Syndrome (CFS) had significantly lower health-related quality of life and lower connectivity between the Sensorimotor Network (SMN) and the Default Mode Network (DMN). After Tai Chi training the patients with CFS had significant increases in health-related quality of life and improved connectivity between the SMN and DMN.

 

These findings demonstrate that Tai Chi practice can improve the symptoms of Chronic Fatigue Syndrome (CFS) potentially by strengthening connectivity in the brain. This is important as CFS is a mysterious disorder and these findings suggest that a lower level of brain connectivity may underlie the disorder. In addition, they show that Tai Chi practice may at least partially reverse these symptoms.

 

“Tai Chi Chuan, the great ultimate, strengthens the weak, raises the sick, invigorates the debilitated, and encourages the timid.” – Cheng Man-ch’ing

 

CMCS – Center for Mindfulness and Contemplative Studies

 

This and other Contemplative Studies posts are also available on Twitter @MindfulResearch

 

Study Summary

 

Li Y, Wu K, Hu X, Xu T, Li Z, Zhang Y, Li K. Altered Effective Connectivity of Resting-State Networks by Tai Chi Chuan in Chronic Fatigue Syndrome Patients: A Multivariate Granger Causality Study. Front Neurol. 2022 Jun 3;13:858833. doi: 10.3389/fneur.2022.858833. PMID: 35720086; PMCID: PMC9203735.

 

Abstract

Numerous evidence has shown that patients with chronic fatigue syndrome (CFS) have changes in resting brain functional connectivity, but there is no study on the brain network effect of Tai Chi Chuan intervention in CFS. To explore the influence of Tai Chi Chuan exercise on the causal relationship between brain functional networks in patients with CFS, 21 patients with CFS and 19 healthy controls were recruited for resting-state functional magnetic resonance imaging (rs-fMRI) scanning and 36-item Short-Form Health Survey (SF-36) scale assessment before and after 1month-long training in Tai Chi Chuan. We extracted the resting brain networks using the independent component analysis (ICA) method, analyzed the changes of FC in these networks, conducted Granger causality analysis (GCA) on it, and analyzed the correlation between the difference causality value and the SF-36 scale. Compared to the healthy control group, the SF-36 scale scores of patients with CFS were lower at baseline. Meanwhile, the causal relationship between sensorimotor network (SMN) and default mode network (DMN) was weakened. The above abnormalities could be improved by Tai Chi Chuan training for 1 month. In addition, the correlation analyses showed that the causal relationship between SMN and DMN was positively correlated with the scores of Role Physical (RP) and Bodily Pain (BP) in CFS patients, and the change of causal relationship between SMN and DMN before and after training was positively correlated with the change of BP score. The findings suggest that Tai Chi Chuan is helpful to improve the quality of life for patients with CFS. The change of Granger causality between SMN and DMN may be a readout parameter of CFS. Tai Chi Chuan may promote the functional plasticity of brain networks in patients with CFS by regulating the information transmission between them.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9203735/

 

Meditation Changes the Structures and Connectivity in the Brain

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Meditation Changes the Structures and Connectivity in the Brain

 

By John M. de Castro, Ph.D.

 

“[Meditation] practice appears to have an amazing variety of neurological benefits – from changes in grey matter volume to reduced activity in the “me” centers of the brain to enhanced connectivity between brain regions.” – Alice G. Walton

 

There has accumulated a large amount of research demonstrating that meditation practice has significant benefits for psychological, physical, and spiritual wellbeing. One way that meditation practices may produce these benefits is by altering the brain. The nervous system is a dynamic entity, constantly changing and adapting to the environment. It will change size, activity, and connectivity in response to experience. These changes in the brain are called neuroplasticity. Over the last decade neuroscience has been studying the effects of contemplative practices on the brain and has identified neuroplastic changes in widespread areas. In other words, meditation practice appears to mold and change the brain structures and connectivity, producing psychological, physical, and spiritual benefits, especially mindfulness.

 

In today’s Research News article “Meditation-induced effects on whole-brain structural and effective connectivity.” (See summary below or view the full text of the study at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9232427/ ) De Filippi and colleagues recruited experienced meditators (> 1000 hours of experience) and control non-meditators and scanned their brains with functional Magnetic Resonance Imaging (fMRI) while at rest and while meditating.

 

They found that there were significant differences in whole brain activity between meditation and at rest and that these differences differed between experienced meditators and controls. They also found that experienced meditators had increased connectivity between the left hemisphere sub networks including the somatomotor, dorsal attention, subcortical, and visual networks. Hence, they found neuroplastic changes in the brain produced by meditation practice.

 

“Now, as the popularity of mindfulness grows, brain imaging techniques are revealing that this ancient practice can profoundly change the way different regions of the brain communicate with each other – and therefore how we think – permanently.” – Tom Ireland

 

CMCS – Center for Mindfulness and Contemplative Studies

 

This and other Contemplative Studies posts are also available on Twitter @MindfulResearch

 

Study Summary

 

De Filippi, E., Escrichs, A., Càmara, E., Garrido, C., Marins, T., Sánchez-Fibla, M., Gilson, M., & Deco, G. (2022). Meditation-induced effects on whole-brain structural and effective connectivity. Brain structure & function, 227(6), 2087–2102. https://doi.org/10.1007/s00429-022-02496-9

 

Abstract

In the past decades, there has been a growing scientific interest in characterizing neural correlates of meditation training. Nonetheless, the mechanisms underlying meditation remain elusive. In the present work, we investigated meditation-related changes in functional dynamics and structural connectivity (SC). For this purpose, we scanned experienced meditators and control (naive) subjects using magnetic resonance imaging (MRI) to acquire structural and functional data during two conditions, resting-state and meditation (focused attention on breathing). In this way, we aimed to characterize and distinguish both short-term and long-term modifications in the brain’s structure and function. First, to analyze the fMRI data, we calculated whole-brain effective connectivity (EC) estimates, relying on a dynamical network model to replicate BOLD signals’ spatio-temporal structure, akin to functional connectivity (FC) with lagged correlations. We compared the estimated EC, FC, and SC links as features to train classifiers to predict behavioral conditions and group identity. Then, we performed a network-based analysis of anatomical connectivity. We demonstrated through a machine-learning approach that EC features were more informative than FC and SC solely. We showed that the most informative EC links that discriminated between meditators and controls involved several large-scale networks mainly within the left hemisphere. Moreover, we found that differences in the functional domain were reflected to a smaller extent in changes at the anatomical level as well. The network-based analysis of anatomical pathways revealed strengthened connectivity for meditators compared to controls between four areas in the left hemisphere belonging to the somatomotor, dorsal attention, subcortical and visual networks. Overall, the results of our whole-brain model-based approach revealed a mechanism underlying meditation by providing causal relationships at the structure-function level.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9232427/

 

Different Meditation Techniques Improve Well-Being Through Different Brain Systems

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Different Meditation Techniques Improve Well-Being Through Different Brain Systems

 

By John M. de Castro, Ph.D.

 

‘Meditation can alter the mechanism of your brain after some time.” – Perpetua Neo

 

There has accumulated a large amount of research demonstrating that meditation practice has significant benefits for psychological, physical, and spiritual wellbeing. One way that meditation practices may produce these benefits is by altering the brain. The nervous system is a dynamic entity, constantly changing and adapting to the environment. It will change size, activity, and connectivity in response to experience. These changes in the brain are called neuroplasticity. Over the last decade neuroscience has been studying the effects of contemplative practices on the brain and has identified neuroplastic changes in widespread areas. In other words, meditation practice appears to mold and change the brain structures and connectivity, producing psychological, physical, and spiritual benefits, especially mindfulness.

 

There are, however, a wide variety of meditation practices and there has been extensive research into the impact of these different practices on the brain psychological well-being. The different practices can be classified as to whether they focus on present centered awareness (attention to present moment sensation and perception), meta-awareness (attention to consciousness), or non-reactive self-related processing (nonjudgmental attention to and acceptance of self-related perceptions). There is a need to summarize what has been learned about the psychological effects and brain activities related to these different meditation classifications.

 

In today’s Research News article “Classification of Mindfulness Meditation and Its Impact on Neural Measures in the Clinical Population.” (See summary below or view the full text of the study at: https://www.frontiersin.org/articles/10.3389/fpsyg.2022.891004/full?utm_source=F-AAE&utm_medium=EMLF&utm_campaign=MRK_1885330_a0P58000000G0YfEAK_Psycho_20220614_arts_A ) Ngan and colleagues reviewed and summarized the published research literature on the effects of meditation techniques focusing on present moment attention, meta-awareness, or non-reactive self-related processing on brain systems and psychological well-being. They found 12 published research studies.

 

They report that the published research studies found that meditation focusing on present centered awareness was associated with neural activity in the brain’s salience network that is associated with identifying important aspects of the environment to pay attention to. They also found that meditation focusing on meta-awareness was associated with neural activity in the brain’s default mode network that is associated with self-related processing and mind wandering. Finally, they found that meditation focusing on meta-awareness was associated with neural activity in the brain’s default mode network interconnections with the executive network that is associated with high level thinking.

 

So, although all meditation focuses produce beneficial psychological effects, they may do so through different neural mechanisms.

 

“it really matters what you practice—the observed brain changes were specific to different types of training and coincided with improvements in emotional and cognitive skills.” – Tania Singer

 

CMCS – Center for Mindfulness and Contemplative Studies

 

This and other Contemplative Studies posts are also available on Twitter @MindfulResearch

 

Study Summary

 

Ngan STJ and Cheng PWC (2022) Classification of Mindfulness Meditation and Its Impact on Neural Measures in the Clinical Population. Front. Psychol. 13:891004. doi: 10.3389/fpsyg.2022.891004

 

Different forms of mindfulness meditation are increasingly integrated in the clinical practice in the last three decades. Previous studies have identified changes in the neurophysiology and neurochemistry of the brain resulting from different mindfulness meditation practices in the general population. However, research on neural correlates of different types of meditation, particularly on the clinical outcomes, is still very sparse. Therefore, the aim of this article is to review the neural impact of mindfulness meditation interventions on different mental disorders via the classification of main components of mindfulness meditation. The clearer classification of mindfulness meditation may inform future clinical practice and research directions.

https://www.frontiersin.org/articles/10.3389/fpsyg.2022.891004/full?utm_source=F-AAE&utm_medium=EMLF&utm_campaign=MRK_1885330_a0P58000000G0YfEAK_Psycho_20220614_arts_A

 

Meditation and Mind Wandering Alter Brain Network Activity Differently

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Meditation and Mind Wandering Alter Brain Network Activity Differently

 

By John M. de Castro, Ph.D.

 

“in addition to altering specific functional connectivity, meditation leads to reconfiguration of whole-brain network architecture.” – Shogo Kajimura

 

There has accumulated a large amount of research demonstrating that meditation practice has significant benefits for psychological, physical, and spiritual wellbeing. One way that meditation practices may produce these benefits is by altering the brain. The nervous system is a dynamic entity, constantly changing and adapting to the environment. It will change size, activity, and connectivity in response to experience. These changes in the brain are called neuroplasticity. Over the last decade neuroscience has been studying the effects of contemplative practices on the brain and has identified neuroplastic changes in widespread areas. In other words, meditation practice appears to mold and change the brain structures and connectivity, producing psychological, physical, and spiritual benefits, especially mindfulness.

 

Meditation practice results in a shift in mental processing. It produces a reduction of mind wandering and self-referential thinking and an increase in attention and higher-level thinking. The neural system that underlie mind wandering is termed the Default Mode Network (DMN) and consists in a set of brain structures including medial prefrontal cortex, posterior cingulate, lateral temporal cortex and the hippocampus. The neural system that underlies executive functions such as attention and higher-level thinking is termed the Central Executive Network (CEN) and includes the dorsolateral prefrontal cortex, posterior parietal cortex, and cingulate cortex. The salience network has been shown to direct attention to significant aspects of the environment. Hence the shift in thought process may well be associated with changes in the relationship of these systems.

 

In today’s Research News article “Spectral dynamic causal modeling of mindfulness, mind-wandering, and resting-state in the triple network using fMRI.” (See summary below or view the full text of the study at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8893127/ ) Kim and colleagues recruited healthy adult males and had them pay attention mindfully or allow their minds to wander while having their brains scanned with functional Magnetic Resonance Imaging (fMRI).

 

They found that during mindfulness the central executive network had enhanced connectivity with the salience network through the default mode network. On the other hand, during mind wandering the default mode network had greater connectivity to the central executive network. This suggests that during mindfulness the neural systems enhanced attention to significant stimuli while during mind wandering the neural systems enhanced attention to internally generated thinking.

 

Hence, the brain’s network activity is different during different mind states.

 

“meditation states in long-term practitioners induced highly specific connectivity patterns of fronto-parietal and medial frontal networks relative to rest. This observation generally indicates that the executive processes of attentional control and cognitive monitoring have a specific role in supporting brain states of meditation.” – Juliana Yordanova

 

CMCS – Center for Mindfulness and Contemplative Studies

 

This and other Contemplative Studies posts are also available on Twitter @MindfulResearch

 

Study Summary

 

Kim, H. C., & Lee, J. H. (2022). Spectral dynamic causal modeling of mindfulness, mind-wandering, and resting-state in the triple network using fMRI. Neuroreport, 33(5), 221–226. https://doi.org/10.1097/WNR.0000000000001772

 

Objective

Functional connectivity in intrinsic brain networks, namely, the triple network, which includes the salience network, default mode network (DMN) and central executive network (CEN), has been suggested as prominent, major networks involved in human cognition and mental state–mindfulness, mind-wandering and resting-state. Despite the established roles of functional connections within and between intrinsic networks, there has been limited research on the effective connectivity of mindfulness, mind-wandering and resting-state using the triple network, as well as on their direct comparisons.

Methods

We employed spectral dynamic causal modeling to compare effective connectivity patterns across mindfulness (i.e. attention focused on physical sensations of breathing), mind-wandering (i.e. connecting thoughts) and resting-state (i.e. relaxing while remaining calm and awake) conditions using functional MRI data of healthy subjects who underwent ambulatory training by practicing mindfulness and mind-wandering (N = 59).

Results

When comparing mindfulness and mindwandering conditions, our analysis results revealed that salience network and CEN interacted depending on mindfulness or mind-wandering. When mindfulness or mind-wandering was compared to resting-state, mindfulness increased the effective connectivity from the left CEN to salience network through DMN, whereas mindwandering increased the effective connectivity from the DMN to right CEN.

Conclusion

To the best of our knowledge, this is the first study to examine possible differences in effective connectivity patterns among mindfulness, mind-wandering and resting-state using the triple network. We believe that our findings will provide deeper insights into the neural substrates of mindfulness compared to mind-wandering and resting-state.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8893127/

 

Improve the Symptoms of Parkinson’s Disease with Long-Term Tai Chi Practice

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Improve the Symptoms of Parkinson’s Disease with Long-Term Tai Chi Practice

 

By John M. de Castro, Ph.D.

 

“Tai chi training appears to reduce balance impairments in patients with mild-to-moderate Parkinson’s disease, with additional benefits of improved functional capacity and reduced falls.” – Fuzhong Li

 

Parkinson’s Disease (PD) is an incurable progressive degenerative disease of the central nervous system. The condition is caused by the death of nerve cells in the brain that produce the neurotransmitter dopamine. There are around seven million people worldwide living with PD. Its physical symptoms include resting tremor, slow movements, muscle rigidity, problems with posture and balance, loss of automatic movements, and slurring of speech. Balance is a particular problem as it effects mobility and increases the likelihood of falls, restricting activity and reducing quality of life.

 

There are no cures for Parkinson’s Disease (PD) or even treatments to slow its progression. There are only treatments that can produce symptomatic relief. So, there is a need to discover new and different treatments. Mindfulness training has been found to improve the psychological symptoms and the quality of life with PD patients.  In addition, combinations of mindfulness and exercise such as Tai Chi and yoga practices have been shown to improve the symptoms of Parkinson’s Disease. The mechanisms of  how Tai Chi practice improves the symptoms of Parkinson’s disease are not known.

 

In today’s Research News article “Mechanisms of motor symptom improvement by long-term Tai Chi training in Parkinson’s disease patients.” (See summary below or view the full text of the study at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8819852/ ) Li and colleagues recruited early-stage Parkinson’s Disease patients and randomly assigned them to 1 year of no treatment, brisk walking, or Tai Chi practice. They were measured at baseline, 6 months, and 1 year for Parkinson’s Disease symptoms, balance, timed up and go, and gait analysis. They also had blood drawn and analyzed for inflammatory cytokines and protein metabolites. In addition, they had their brains scanned with functional Magnetic Resonance Imaging (fMRI).

 

They found that in comparison with baseline, no treatment, and brisk walking, Tai Chi practice produced significant increases in balance and significant decreases in step width at both 6 and 12 months. In comparison to no treatment Tai Chi practice produced significant decreases in Parkinson’s Disease symptoms, timed up and go, and blood cytokine levels and a significant increase in amino acid metabolism. In addition, improvements in Parkinson’s Disease symptoms were associated with increased connectivity in the brain Default Mode Network, increased amino acid metabolism, and decreased blood cytokine levels.

 

The results suggest that Tai Chi practice over a prolonged period improves the symptoms of Parkinson’s Disease and is superior to brisk walking in doing so. The results also suggest that Tai Chi practice may produce these improvements by altering physiological processes including the brain, inflammatory system, and protein metabolism.

 

So, improve the symptoms of Parkinson’s Disease with long-term Tai Chi practice.

 

“The incorporation of Tai Chi in the daily life of Parkinson’s disease patients allowed them to stay functionally and physically active. Improvement of physical parameters indicated that Tai Chi had the potential to slow down the progression of Parkinson’s disease.” – Allison Rodriquez

 

CMCS – Center for Mindfulness and Contemplative Studies

 

This and other Contemplative Studies posts are also available on Twitter @MindfulResearch

 

Study Summary

 

Li, G., Huang, P., Cui, S. S., Tan, Y. Y., He, Y. C., Shen, X., Jiang, Q. Y., Huang, P., He, G. Y., Li, B. Y., Li, Y. X., Xu, J., Wang, Z., & Chen, S. D. (2022). Mechanisms of motor symptom improvement by long-term Tai Chi training in Parkinson’s disease patients. Translational neurodegeneration, 11(1), 6. https://doi.org/10.1186/s40035-022-00280-7

 

Abstract

Background

Tai Chi has been shown to improve motor symptoms in Parkinson’s disease (PD), but its long-term effects and the related mechanisms remain to be elucidated. In this study, we investigated the effects of long-term Tai Chi training on motor symptoms in PD and the underlying mechanisms.

Methods

Ninety-five early-stage PD patients were enrolled and randomly divided into Tai Chi (n = 32), brisk walking (n = 31) and no-exercise (n = 32) groups. At baseline, 6 months and 12 months during one-year intervention, all participants underwent motor symptom evaluation by Berg balance scale (BBS), Unified PD rating-scale (UPDRS), Timed Up and Go test (TUG) and 3D gait analysis, functional magnetic resonance imaging (fMRI), plasma cytokine and metabolomics analysis, and blood Huntingtin interaction protein 2 (HIP2) mRNA level analysis. Longitudinal self-changes were calculated using repeated measures ANOVA. GEE (generalized estimating equations) was used to assess factors associated with the longitudinal data of rating scales. Switch rates were used for fMRI analysis. False discovery rate correction was used for multiple correction.

Results

Participants in the Tai Chi group had better performance in BBS, UPDRS, TUG and step width. Besides, Tai Chi was advantageous over brisk walking in improving BBS and step width. The improved BBS was correlated with enhanced visual network function and downregulation of interleukin-1β. The improvements in UPDRS were associated with enhanced default mode network function, decreased L-malic acid and 3-phosphoglyceric acid, and increased adenosine and HIP2 mRNA levels. In addition, arginine biosynthesis, urea cycle, tricarboxylic acid cycle and beta oxidation of very-long-chain fatty acids were also improved by Tai Chi training.

Conclusions

Long-term Tai Chi training improves motor function, especially gait and balance, in PD. The underlying mechanisms may include enhanced brain network function, reduced inflammation, improved amino acid metabolism, energy metabolism and neurotransmitter metabolism, and decreased vulnerability to dopaminergic degeneration.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8819852/

 

Improve Depression by Changing the Brain with Mindfulness

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Improve Depression by Changing the Brain with Mindfulness

 

By John M. de Castro, Ph.D.

 

“mindfulness-based cognitive therapy is just as effective as medication in preventing depression relapse among adults with a history of recurrent depression, and in reducing depressive symptoms among those with active depression.” – Deborah Yip

 

Clinically diagnosed depression is the most common mental illness, affecting over 6% of the population. Major depression can be quite debilitating. Depression can be difficult to treat and is usually treated with anti-depressive medication. But, of patients treated initially with drugs only about a third attained remission of the depression. After repeated and varied treatments including drugs, therapy, exercise etc. only about two thirds of patients attained remission. But drugs often have troubling side effects and can lose effectiveness over time. In addition, many patients who achieve remission have relapses and recurrences of the depression. Even after remission some symptoms of depression may still be present (residual symptoms).

 

Being depressed and not responding to treatment or relapsing is a terribly difficult situation. The patients are suffering, and nothing appears to work to relieve their intense depression. Suicide becomes a real possibility. So, it is imperative that other treatments be identified that can relieve the suffering. Mindfulness training has been shown to be an effective treatment for depression and its recurrence and even in the cases where drugs fail.

 

The most used mindfulness technique for the treatment of depression is Mindfulness-Based Cognitive Therapy (MBCT).  MBCT involves mindfulness training, containing sitting and walking meditation and body scan, and cognitive therapy to alter how the patient relates to the thought processes that often underlie and exacerbate psychological symptoms. MBCT has been shown to be as effective as antidepressant drugs in relieving the symptoms of depression and preventing depression reoccurrence and relapse. In addition, it appears to be effective as either a supplement to or a replacement for these drugs. It is unclear, however if MBCT is also effective in treating late life depression in the elderly.

 

In today’s Research News article “Mindfulness-Based Cognitive Therapy Regulates Brain Connectivity in Patients With Late-Life Depression.” (See summary below or view the full text of the study at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8882841/ ) Li and colleagues recruited older adults (over 60 years of age) with late life depression and randomly assigned them to receive 8 weekly sessions of Mindfulness-Based Cognitive Therapy (MBCT) with daily home practice or treatment as usual. They were measured before and after training and 3 months later for depression, anxiety, and cognitive function, they also underwent functional magnetic resonance imaging (fMRI).

 

They found that in comparison to baseline and the treatment as usual group, those that received Mindfulness-Based Cognitive Therapy (MBCT) had significantly lower depression after training and at the 3 month follow-up. In addition, the greater the amount of home meditation practice the greater the reductions in depression. They also found that after treatment there was a significant increase in functional connectivity between the amygdala and cerebral cortex. In addition, the greater the increase in functional connectivity, the greater the reductions in depression.

 

These findings suggest that Mindfulness-Based Cognitive Therapy (MBCT) is a safe and effective treatment for late life depression. But they also suggest that changes in the connectivity between brain areas may underlie the improvements in depression.

 

So, change the brain to improve late life depression with mindfulness.

 

“MBCT (combined with antidepressants or delivered alongside antidepressant tapering/discontinuation) is comparable to maintenance antidepressants alone in preventing subsequent relapse.” – Oxford Mindfulness Centre

 

CMCS – Center for Mindfulness and Contemplative Studies

 

This and other Contemplative Studies posts are also available on Twitter @MindfulResearch

 

Study Summary

 

Li, H., Yan, W., Wang, Q., Liu, L., Lin, X., Zhu, X., Su, S., Sun, W., Sui, M., Bao, Y., Lu, L., Deng, J., & Sun, X. (2022). Mindfulness-Based Cognitive Therapy Regulates Brain Connectivity in Patients With Late-Life Depression. Frontiers in psychiatry, 13, 841461. https://doi.org/10.3389/fpsyt.2022.841461

 

Abstract

Late-life depression (LLD) is an important public health problem among the aging population. Recent studies found that mindfulness-based cognitive therapy (MBCT) can effectively alleviate depressive symptoms in major depressive disorder. The present study explored the clinical effect and potential neuroimaging mechanism of MBCT in the treatment of LLD. We enrolled 60 participants with LLD in an 8-week, randomized, controlled trial (ChiCTR1800017725). Patients were randomized to the treatment-as-usual (TAU) group or a MBCT+TAU group. The Hamilton Depression Scale (HAMD) and Hamilton Anxiety Scale (HAMA) were used to evaluate symptoms. Magnetic resonance imaging (MRI) was used to measure changes in resting-state functional connectivity and structural connectivity. We also measured the relationship between changes in brain connectivity and improvements in clinical symptoms. HAMD total scores in the MBCT+TAU group were significantly lower than in the TAU group after 8 weeks of treatment (p < 0.001) and at the end of the 3-month follow-up (p < 0.001). The increase in functional connections between the amygdala and middle frontal gyrus (MFG) correlated with decreases in HAMA and HAMD scores in the MBCT+TAU group. Diffusion tensor imaging analyses showed that fractional anisotropy of the MFG-amygdala significantly increased in the MBCT+TAU group after 8-week treatment compared with the TAU group. Our study suggested that MBCT improves depression and anxiety symptoms that are associated with LLD. MBCT strengthened functional and structural connections between the amygdala and MFG, and this increase in communication correlated with improvements in clinical symptoms.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8882841/