Brain Electrical Activity

Measure Mindfulness Better in Depressed Patients with Changes in the EEG

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Measure Mindfulness Better in Depressed Patients with Changes in the EEG

 

By John M. de Castro, Ph.D.

 

“as the popularity of mindfulness grows, brain imaging techniques are revealing that this ancient practice can profoundly change the way different regions of the brain communicate with each other – and therefore how we think – permanently.” – Tom Ireland

 

Mindfulness training has been shown to improve health and well-being. It has also been found to be effective for a large array of medical and psychiatric conditions, either stand-alone or in combination with more traditional therapies. As a result, mindfulness training has been called the third wave of therapies. One problem with understanding mindfulness effects is that there are, a wide variety of methods of measuring mindfulness. These methods primarily involve self-reports on paper and pencil scales. Unfortunately, these different measures differ conceptually and frequently produce divergent results.

 

Mindfulness training produces changes in the brain’s electrical activity. This can be measured by recording the electroencephalogram (EEG). The brain produces rhythmic electrical activity that can be recorded from the scalp. It is usually separated into frequency bands. One method to indirectly observe information processing in the brain is to measure the changes in the electrical activity that occur in response to specific stimuli. These are called event-related potentials or ERPs. The signal following a stimulus changes over time. The fluctuations of the signal after specific periods of time are thought to measure different aspects of the nervous system’s processing of the stimulus. Perhaps change in the ERPs resulting from mindfulness training may be a good measure of the increased mindfulness produced by the training and a strong predictor of symptom improvements.

 

In today’s Research News article “Measuring Mindfulness: A Psychophysiological Approach.” (See summary below or view the full text of the study at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6031749/ ), Bostanov and colleagues recruited adult patients with recurrent depression in remission and randomly assigned them to receive 8 weekly, 2 hour group sessions of either Mindfulness-Based Cognitive Therapy (MBCT) or group Cognitive Therapy (CT). They were also assigned 45 minutes of daily homework. MBCT begins with breath meditation and bodily sensation and progresses into learning to perceive thoughts and emotions as objects of mindful attention and as mental events and not as absolute truth, self or reality. CT contained all of the cognitive therapy components as MBCT but excluded mindfulness training.

 

The participants were measured before and after training for mindfulness, depression, positive and negative emotions, decentering, and curiosity. They also underwent recording from the scalp of electrical brain activity in response to a stimulus (event-related brain potentials, ERPs). With the participants instructed to perform breath meditation, they were periodically presented with a brief noise. The changes in the EEG in response to the noise were recorded and used to calculate the grand average event-related brain potentials.

 

They found that both the MBCT and CT groups had significant reductions in depression, rumination, and distraction and increases in mindfulness following the 8-week intervention period and one year later. Importantly, they found that the greater the change in the grand average event-related brain potentials resulting from treatment, the greater the reduction in depression symptoms and the greater the increase in mindfulness. These relationships were statistically strong. At the same time changes in the paper and pencil mindfulness measures were not significantly related to the improvements in depression.

 

These results suggest that changes in the brain are produced by mindfulness training and that these are reflected by changes in the electrical activity of the brain in response to sounds. The results further suggest that these brain activity changes are a better measure of the effectiveness of the mindfulness training than the traditional self-report measures. It was suggested that in the future these event related potential changes be used as the primary assessment instrument for mindfulness and the impact of mindfulness training on the individual.

 

So, measure mindfulness better in depressed patients with Changes in the EEG.

 

“Although meditation research is still in its infancy, a number of studies have investigated changes in brain activation at rest and during specific tasks that are associated with the practice of, or that follow, training in mindfulness meditation. There is emerging evidence that mindfulness meditation might cause neuroplastic changes in the structure and function of brain regions involved in regulation of attention, emotion and self-awareness.” – Sarah McKay

 

CMCS – Center for Mindfulness and Contemplative Studies

 

This and other Contemplative Studies posts are also available on Google+ https://plus.google.com/106784388191201299496/posts and on Twitter @MindfulResearch

 

Study Summary

 

Bostanov, V., Ohlrogge, L., Britz, R., Hautzinger, M., & Kotchoubey, B. (2018). Measuring Mindfulness: A Psychophysiological Approach. Frontiers in Human Neuroscience, 12, 249. http://doi.org/10.3389/fnhum.2018.00249

 

Abstract

Mindfulness-based interventions have proved effective in reducing various clinical symptoms and in improving general mental health and well-being. The investigation of the mechanisms of therapeutic change needs methods for assessment of mindfulness. Existing self-report measures have, however, been strongly criticized on various grounds, including distortion of the original concept, response bias, and other. We propose a psychophysiological method for the assessment of the mindfulness learned through time-limited mindfulness-based therapy by people who undergo meditation training for the first time. We use the individual pre-post-therapy changes (dERPi) in the event-related brain potentials (ERPs) recorded in a passive meditation task as a measure of increased mindfulness. dERPi is computed through multivariate assessment of individual participant’s ERPs. We tested the proposed method in a group of about 70 recurrently depressed participants, randomly assigned in 1.7:1 ratio to mindfulness-based cognitive therapy (MBCT) or cognitive therapy (CT). The therapy outcome was measured by the long-term change (dDS) relative to baseline in the depression symptoms (DS) assessed weekly, for 60 weeks, by an online self-report questionnaire. We found a strong, highly significant, negative correlation (r = −0.55) between dERPi (mean = 0.4) and dDS (mean = −0.7) in the MBCT group. Compared to this result, the relationship between dDS and the other (self-report) measures of mindfulness we used was substantially weaker and not significant. So was also the relationship between dERPi and dDS in the CT group. The interpretation of dERPi as a measure of increased mindfulness was further supported by positive correlations between dERPi and the other measures of mindfulness. In this study, we also replicated a previous result, namely, the increase (dLCNV) of the late contingent negative variation (LCNV) of the ERP in the MBCT group, but not in the control group (in this case, CT). We interpreted dLCNV as a measure of increased meditative concentration. The relationship between dLCNV and dDS was, however, very week, which suggests that concentration might be relatively unimportant for the therapeutic effect of mindfulness. The proposed psychophysiological method could become an important component of a “mindfulness test battery” together with self-report questionnaires and other newly developed instruments.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6031749/

 

Improve Attentional Focus with Meditation

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Improve Attentional Focus with Meditation

 

By John M. de Castro, Ph.D.

 

“realize that everything we think, feel, say, or do from one moment to the next all ultimately depend on the interactions between attention and awareness. Mindfulness is the optimum interaction between the two. Therefore, by skillfully working with attention and awareness to cultivate mindfulness, we can change everything we think, feel, say, and do for the better. In other words, we can completely transform who we are.” – Travis May

 

One of the primary effects of mindfulness training is an improvement in the ability to pay attention to the task at hand and ignore interfering stimuli. This is an important consequence of mindfulness training and produces improvements in thinking, reasoning, and creativity. The importance of heightened attentional ability to the individual’s ability to navigate the demands of complex modern life cannot be overstated. It helps at work, in relationships, or simply driving a car.

 

There is evidence that mindfulness training improves attention by altering the brain. It appears That mindfulness training increases the size, connectivity, and activity of areas of the brain that are involved in paying attention. A common method to study the activity of the nervous system is to measure the electrical signal at the scalp above brain regions. Changes in this activity are measurable with mindfulness training. One method to observe attentional processing in the brain is to measure the changes in the electrical activity that occur in response to specific stimuli. These are called evoked potentials or ERPs. The signal following a stimulus changes over time. The fluctuations of the signal after specific periods of time are thought to measure different aspects of the nervous system’s processing of the stimulus.

 

The Pd response in the evoked potential (ERP) is a positive going electrical response occurring between a tenth to 3 tenths of a second following the target stimulus presentation. The Pd (distractor positivity) component is thought to reflect an attentional suppression process involved in preventing shifts in attention. The N2pc response is a negative electrical change that occurs around 2 tenths of a second following the target stimulus presentation. The N2pc response has been associated with the engagement of visual attention, deploying attentional processes when needed. These components of the evoked potential can be used to assess the nature of attentional processing before and after meditation, reflecting how meditation might improve attention.

 

In today’s Research News article “Meditation Effects on the Control of Involuntary Contingent Reorienting Revealed With Electroencephalographic and Behavioral Evidence.” (See summary below or view the full text of the study at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5962705/ ), Tsai and colleagues recruited a group of college students who were meditators and a group who were not. They were asked to perform a rapid serial visual presentation task before and after a 30-minute meditation or rest. Order was counterbalanced on two different days. During the task the Electroencephalogram (EEG) was recorded and event related potentials identified and recorded related to the onset of the target stimulus.

 

The rapid serial visual presentation task consisted of the rapid presentation on a computer screen of three letters on the left, center, and right of the middle of the screen. The subjects were asked to respond by pressing a key with the right hand when the central letter was red and between the letter A to J in the alphabet and with the left hand when the red letter was present and between letter Q to Z. A red letter in the center occurred only once in every 24 trials. New letters were presented very rapidly, every .067 seconds. On occasions a red letter was presented as a distractor in either the left or right position. The participants were instructed to only respond to the letter in the center.

 

They found that when the red distractor was present in the left or right positions performance was significantly less accurate than when it was absent. But, although performance significantly improved after both meditation and rest, it was significantly better after meditation than after rest. In addition, after meditation, the Pd (distractor positivity) component of the evoked potential in response to the presence of a distractor red letter was stronger than after rest.

 

These results are interesting and suggest that after meditation the individual is better able to ignore a distractor and respond more accurately to a target. The EEG results with the evoked potentials suggest that the nervous system, after meditation, becomes better able to suppress responding to distractors in the immediate environment. This suggests that meditation enhances attention by preventing a shift in attention to other stimuli in the environment and thereby maintaining attention on the intended focus. Hence, the results suggest that meditation may improve attention by altering the brain’s processing of the stimuli present making it better able to focus by preventing responding to other stimuli.

 

So, improve attentional focus with meditation.

 

“A long-term study finds that consistent and intensive meditation sessions can have a long-lasting effect on a person’s attention span and other cognitive abilities.” – Rick Nauert

 

CMCS – Center for Mindfulness and Contemplative Studies

 

This and other Contemplative Studies posts are also available on Google+ https://plus.google.com/106784388191201299496/posts and on Twitter @MindfulResearch

 

Study Summary

 

Tsai, S.-Y., Jaiswal, S., Chang, C.-F., Liang, W.-K., Muggleton, N. G., & Juan, C.-H. (2018). Meditation Effects on the Control of Involuntary Contingent Reorienting Revealed With Electroencephalographic and Behavioral Evidence. Frontiers in Integrative Neuroscience, 12, 17. http://doi.org/10.3389/fnint.2018.00017

 

Abstract

Prior studies have reported that meditation may improve cognitive functions and those related to attention in particular. Here, the dynamic process of attentional control, which allows subjects to focus attention on their current interests, was investigated. Concentrative meditation aims to cultivate the abilities of continuous focus and redirecting attention from distractions to the object of focus during meditation. However, it remains unclear how meditation may influence attentional reorientation, which involves interaction between both top-down and bottom-up processes. We aimed to investigate the modulating effect of meditation on the mechanisms of contingent reorienting by employing a rapid serial visual presentation (RSVP) task in conjunction with electrophysiological recording. We recruited 26 meditators who had an average of 2.9 years of meditation experience and a control group comprising 26 individuals without any prior experience of meditation. All subjects performed a 30-min meditation and a rest condition with data collected pre- and post-intervention, with each intervention given on different days. The state effect of meditation improved overall accuracy for all subjects irrespective of their group. A group difference was observed across interventions, showing that meditators were more accurate and more efficient at attentional suppression, represented by a larger Pd (distractor positive) amplitude of event related modes (ERMs), for target-like distractors than the control group. The findings suggested that better attentional control with respect to distractors might be facilitated by acquiring experience of and skills related to meditation training.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5962705/

 

Different Types of Meditation Techniques Affect Neural Activity Differently

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Different Types of Meditation Techniques Affect Neural Activity Differently

 

By John M. de Castro, Ph.D.

 

“The picture we have is that mindfulness practice increases one’s ability to recruit higher order, pre-frontal cortex regions in order to down-regulate lower-order brain activity.” – Adrienne Taren

 

Meditation training has been shown to improve health and well-being. It has also been found to be effective for a large array of medical and psychiatric conditions, either stand-alone or in combination with more traditional therapies. As a result, meditation training has been called the third wave of therapies. One problem with understanding meditation effects is that there are, a wide variety of meditation techniques and it is not known which work best for improving different conditions.

 

There are a number of different types of meditation. Many can be characterized on a continuum with the degree and type of attentional focus. In focused attention meditation, the individual practices paying attention to a single meditation object, learns to filter out distracting stimuli, including thoughts, and learns to stay focused on the present moment, filtering out thoughts centered around the past or future. Transcendental meditation is a silent mantra-based focused meditation in which a word or phrase is repeated over and over again with the meditator focusing attention on the mantra. This is designed to evoke the experience of pure awareness. In open monitoring meditation, the individual opens up awareness to everything that’s being experienced regardless of its origin. These include bodily sensations, external stimuli, and even thoughts. The meditator just observes these thoughts and lets them arise and fall away without paying them any further attention. Loving Kindness Meditation is designed to develop kindness and compassion to oneself and others. The individual systematically pictures different individuals from self, to close friends, to enemies and wishes them happiness, well-being, safety, peace, and ease of well-being.

 

These techniques have common properties of restful attention on the present moment, but there are large differences. These differences are likely to produce different effects on the practitioner. One way to distinguish between the effects of these different meditation techniques is to observe the effects of each technique on the brain’s activity. This can be measured by recording the electroencephalogram (EEG). The brain produces rhythmic electrical activity that can be recorded from the scalp. It is usually separated into frequency bands. Delta activity consists of oscillations in the 0.5-3 cycles per second band. Theta activity in the EEG consists of oscillations in the 4-7.5 cycles per second band. Alpha activity consists of oscillations in the 8-12 cycles per second band. Beta activity consists of oscillations in the 13-30 cycles per second band while Gamma activity occurs in the 30-100 cycles per second band.

 

 

In today’s Research News article “.” (See summary below or view the full text of the study at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5890111/ ), and colleagues review and summarize the published research literature on the effects of various meditation techniques on neural activity as measured with the electroencephalogram (EEG). They report that meditation practice, in general, is associated with increased brain oscillations and the greater the amount of practice the greater the increase in oscillations. This suggests that meditation practice, regardless of type, effects neural activity.

 

Activity in the Theta band of the EEG (4-7.5 hz.) differs with the type of meditation practiced. Both, focused and open monitoring meditation increase Theta oscillations in the anterior portions of the cerebral cortex. But, focused meditation also increases Theta activity in the posterior cortex. Theta activity is associated with positive emotional states and memory.

 

Activity in the Alpha band of the EEG (6-12 hz.) differs with the type of meditation practiced. Both, focused and open monitoring meditation increase Alpha oscillations in the posterior portions of the cerebral cortex. But, focused meditation also increases Alpha activity in the anterior cortex while open monitoring meditation decreases Alpha on the left side of the frontal cortex. Alpha activity is associated with relaxation and drowsiness.

 

Activity in the Gamma band of the EEG (6-12 hz.) increases in the frontal regions with all forms of meditation. This is sometimes known as fast wave activity and is associated with sensory and cognitive processing. There is conflicting evidence regarding the effects of meditation practice on the other oscillatory bands.

 

This research makes it clear that meditation practice increases the brains electrical activity and there appears to be differences in the oscillatory patterns produced by different meditation techniques. This may help in identifying the underlying processes responsible for the differing effects of these practices. But, the research is at a very early stage of development and much more work will be required to come to any firm conclusions.

 

So, it is clear that different types of meditation techniques affect neural activity differently.

 

“It was already known that during meditation brain wave activity increases in areas like alpha waves. These MRIs showed something more permanent: denser gray matter in specific regions like the hippocampus, which is crucial for learning and memory, as well as in other areas associated with self-awareness, compassion, and reflection.” – Deepak Chopra

 

CMCS – Center for Mindfulness and Contemplative Studies

 

This and other Contemplative Studies posts are also available on Google+ https://plus.google.com/106784388191201299496/posts and on Twitter @MindfulResearch

 

Study Summary

 

Lee, D. J., Kulubya, E., Goldin, P., Goodarzi, A., & Girgis, F. (2018). Review of the Neural Oscillations Underlying Meditation. Frontiers in Neuroscience, 12, 178. http://doi.org/10.3389/fnins.2018.00178

 

Abstract

Objective: Meditation is one type of mental training that has been shown to produce many cognitive benefits. Meditation practice is associated with improvement in concentration and reduction of stress, depression, and anxiety symptoms. Furthermore, different forms of meditation training are now being used as interventions for a variety of psychological and somatic illnesses. These benefits are thought to occur as a result of neurophysiologic changes. The most commonly studied specific meditation practices are focused attention (FA), open-monitoring (OM), as well as transcendental meditation (TM), and loving-kindness (LK) meditation. In this review, we compare the neural oscillatory patterns during these forms of meditation.

Method: We performed a systematic review of neural oscillations during FA, OM, TM, and LK meditation practices, comparing meditators to meditation-naïve adults.

Results: FA, OM, TM, and LK meditation are associated with global increases in oscillatory activity in meditators compared to meditation-naïve adults, with larger changes occurring as the length of meditation training increases. While FA and OM are related to increases in anterior theta activity, only FA is associated with changes in posterior theta oscillations. Alpha activity increases in posterior brain regions during both FA and OM. In anterior regions, FA shows a bilateral increase in alpha power, while OM shows a decrease only in left-sided power. Gamma activity in these meditation practices is similar in frontal regions, but increases are variable in parietal and occipital regions.

Conclusions: The current literature suggests distinct differences in neural oscillatory activity among FA, OM, TM, and LK meditation practices. Further characterizing these oscillatory changes may better elucidate the cognitive and therapeutic effects of specific meditation practices, and potentially lead to the development of novel neuromodulation targets to take advantage of their benefits.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5890111/

 

Sustain Attention, Vigilance, and Energy in Nurses with Mindfulness

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Sustain Attention, Vigilance, and Energy in Nurses with Mindfulness

 

By John M. de Castro, Ph.D.

 

“As attention is rooted more firmly in the present and less on the past and/or future, depression, rumination, and anxiety decrease,” the article explains. “The resulting effect is energy that was once spent clinging to the past or worrying about the future can now be spent in the present.” Mindful nurse leaders are likewise aware of the employees and organizations behind their day-to-day work. They’re authentic. They connect with others. They stay in touch with their values.”

 

Medical professionals have to pay close and sustained attention to their jobs. The consequences of lapses and error can be catastrophic. Yet often their jobs are repetitive which can tax attention and reduce needed vigilance. Contemplative practices have been shown to improve attention and vigilance and to maintain high levels of performance on the job. In today’s Research News article “Positive Effects of Mindfulness-Based Training on Energy Maintenance and the EEG Correlates of Sustained Attention in a Cohort of Nurses.” (See summary below or view the full text of the study at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5838011/ ), Wong and colleagues investigate the effectiveness of mindfulness training to improve attention and vigilance in nurses tested in a laboratory environment.

 

They recruited nurses and trained them in mindfulness with an 8-week, once a week for 90 minutes, program based upon the Mindfulness-Based Stress Reduction (MBSR) program, containing meditation, body scan, and yoga practices. Training attendance was monitored and recorded. They were measured before and after training with a 20-minute psychomotor task requiring sustained attention and vigilance. In addition, the nurses were measured for sleep duration for two nights. They also completed scales of energy and mood and had their brain activity monitored during rest and during meditation, and with an electroencephalogram (EEG). They also recorded the event related potentials (ERP) in the EEG evoked by stimulus presentation during the attention and vigilance task.

 

They found that following mindfulness training the nurses had significantly smaller reduction in energy during performance of the attention and vigilance task and the greater the attendance at the mindfulness training sessions, the greater the energy sustainment. This was also true for their attention and vigilance, with nurses with high training attendance having significantly smaller reductions in response speed and significantly smaller increases in attentional lapses over the 20-minute task duration. Hence, those nurses with high mindfulness training attendance sustained their energy and attention better over the task period.

 

With the electroencephalogram (EEG), they found that after mindfulness training there were significantly smaller reductions in alpha rhythm power during meditation, suggesting improved attention. These improvements were higher in nurses who attended training more regularly. Similar findings were present with the EEG event related potentials (ERP), such that P3 amplitude reductions were lower over the attention and vigilance task, indicating greater sustainment of arousal and attention. Hence, brain electrical activity also suggested greater sustainment of attention following mindfulness training.

 

The results are interesting and potentially important. They suggest that mindfulness training can improve nurses’ abilities to sustain attention and vigilance over a prolonged period. This was evidenced by both behavioral and EEG indicators of sustained attention and vigilance. This is potentially important as it may suggest that mindfulness training may improve performance on the job, reducing lapses and errors. Future research is needed to verify if, indeed, mindfulness training has similar effects on the job that it has in the laboratory.

 

So, sustain attention, vigilance, and energy in nurses with mindfulness.

 

“Burnout continues to be a significant occupational hazard in the nursing profession. Mindfulness may be the necessary approach to help combat nursing burnout, affording considerable promise for the future of the nursing profession.” – Pamela Heard

 

CMCS – Center for Mindfulness and Contemplative Studies

 

This and other Contemplative Studies posts are also available on Google+ https://plus.google.com/106784388191201299496/posts and on Twitter @MindfulResearch

 

Study Summary

 

Wong, K. F., Teng, J., Chee, M. W. L., Doshi, K., & Lim, J. (2018). Positive Effects of Mindfulness-Based Training on Energy Maintenance and the EEG Correlates of Sustained Attention in a Cohort of Nurses. Frontiers in Human Neuroscience, 12, 80. http://doi.org/10.3389/fnhum.2018.00080

 

Abstract

Mindfulness based training (MBT) is becoming increasingly popular as a means to improve general wellbeing through developing enhanced control over metacognitive processes. In this preliminary study, we tested a cohort of 36 nurses (mean age = 30.3, SD = 8.52; 2 male) who participated in an 8-week MBT intervention to examine the improvements in sustained attention and its energetic costs that may result from MBT. Changes in sustained attention were measured using the psychomotor vigilance task (PVT) and electroencephalography (EEG) was collected both during PVT performance, and during a brief period of meditation. As there was substantial variability in training attendance, this variable was used a covariate in all analyses. Following the MBT program, we observed changes in alpha power across all scalp regions during meditation that were correlated with attendance. Similarly, PVT performance worsened over the 8-week period, but that this decline was mitigated by good attendance on the MBT program. The subjective energy depletion due to PVT performance (measured using self-report on Likert-type scales) was also less in regular attendees. Finally, changes in known EEG markers of attention during PVT performance (P300 and alpha-band event-related desynchronization) paralleled these behavioral shifts. Taken together, our data suggest that sustained attention and its associated costs may be negatively affected over time in the nursing profession, but that regular attendance of MBT may help to attenuate these effects. However, as this study contained no control condition, we cannot rule out that other factors (e.g., motivation, placebo effects) may also account for our findings.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5838011/

 

Improve Brain Processing of Emotional Stimuli with Mindfulness

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Improve Brain Processing of Emotional Stimuli with Mindfulness

 

By John M. de Castro, Ph.D.

 

“If you’re a naturally mindful person, and you’re walking around very aware of things, you’re good to go. You shed your emotions quickly,” Moser said. “If you’re not naturally mindful, then meditating can make you look like a person who walks around with a lot of mindfulness.” – Jason Moser

 

The nervous system is a dynamic entity, constantly changing and adapting to the environment. It will change size, activity, and connectivity in response to experience. These changes in the brain are called neuroplasticity. Over the last decade neuroscience has been studying the effects of contemplative practices on the brain and has identified neuroplastic changes in widespread areas. In other words, mindfulness practices appears to mold and change the brain, producing psychological, physical, and spiritual benefits.

 

Mindfulness practice has been shown to improve emotion regulation. Practitioners demonstrate the ability to fully sense and experience emotions, but respond to them in more appropriate and adaptive ways. In other words, mindful people are better able to experience yet control their responses to emotions. This is a very important consequence of mindfulness. Humans are very emotional creatures and these emotions can be very pleasant, providing the spice of life. But, when they get extreme they can produce misery and even mental illness. The ability of mindfulness training to improve emotion regulation is thought to be the basis for a wide variety of benefits that mindfulness provides to mental health and the treatment of mental illness especially depression and anxiety disorders.

 

One way to measure emotional responses is to record brain activity with the electroencephalogram (EEG) that occurs in response to visual stimuli that reliably evoke emotional responses. In particular, the late positive potential (LPP) response in the EEG is a positive going electrical response to an emotion laden picture that occurs between 0.3 to 0.6 seconds following stimulus presentation. The LPP response has been associated with the presence of emotional information. As such, these electrical responses can be used to measure the brains response to emotional laden stimuli and can perhaps measure brain process of emotion regulation. It may be that simply being a mindful individual may be associated with different processing of emotional stimuli by the brain and this can be seen in the LPP response.

 

In today’s Research News article “Dispositional mindfulness and the attenuation of neural responses to emotional stimuli.” (See summary below or view the full text of the study at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3541486/ ), Brown and colleagues recruited college students and measured their enduring levels of mindfulness (trait mindfulness), attentional control, neuroticism, and levels of positive and negative emotions. They measured the electroencephalogram (EEG) changes in the students that occurred in response to pictures that evoked pleasant or unpleasant emotions at a high level (e.g. skydiving, erotica, vs. mutilations) or at a low level (e.g. flowers vs. pollution).

 

They found, confirming prior research, that the late positive potential (LPP) response in the EEG was larger after pictures that evoked strong emotions regardless of whether they were pleasant or unpleasant than after pictures that evoked weak emotions. Importantly, they found that the trait mindfulness of the participants modulated the response. Students high in mindfulness had smaller LPP responses to images that evoked strong emotions both pleasant and unpleasant than low mindfulness students. Hence, mindfulness was shown to lessen the brains response to emotion laden stimuli.

 

This is interesting research that suggests that mindfulness changes the brains processing of emotional stimuli, reducing the strength of the response. The LPP is indicative of the very early stage of brain processing of emotional material. So, the results suggest that the brains of mindful people improve their ability to regulate their emotions and that this occurs at a very early stage of neural processing. It reduces the magnitude of the initial response to emotions. This may make difficult or extreme emotion easier to handle.

 

So, improve brain processing of emotional stimuli with mindfulness.

 

“The impact that mindfulness exerts on our brain is borne from routine: a slow, steady, and consistent reckoning of our realities, and the ability to take a step back, become more aware, more accepting, less judgmental, and less reactive. Just as playing the piano over and over again over time strengthens and supports brain networks involved with playing music, mindfulness over time can make the brain, and thus, us, more efficient regulators, with a penchant for pausing to respond to our worlds instead of mindlessly reacting.” – Jennifer Wolkin

 

CMCS – Center for Mindfulness and Contemplative Studies

 

This and other Contemplative Studies posts are also available on Google+ https://plus.google.com/106784388191201299496/posts and on Twitter @MindfulResearch

 

Study Summary

 

Brown, K. W., Goodman, R. J., & Inzlicht, M. (2013). Dispositional mindfulness and the attenuation of neural responses to emotional stimuli. Social Cognitive and Affective Neuroscience, 8(1), 93–99. http://doi.org/10.1093/scan/nss004

 

Abstract

Considerable research has disclosed how cognitive reappraisals and the modulation of emotional responses promote successful emotion regulation. Less research has examined how the early processing of emotion-relevant stimuli may create divergent emotional response consequences. Mindfulness—a receptive, non-evaluative form of attention—is theorized to foster emotion regulation, and the present study examined whether individual differences in mindfulness would modulate neural responses associated with the early processing of affective stimuli. Focus was on the late positive potential (LPP) of the event-related brain potential to visual stimuli varying in emotional valence and arousal. This study first found, replicating past research, that high arousal images, particularly of an unpleasant type, elicited larger LPP responses. Second, the study found that more mindful individuals showed lower LPP responses to high arousal unpleasant images, even after controlling for trait attentional control. Conversely, two traits contrasting with mindfulness—neuroticism and negative affectivity—were associated with higher LPP responses to high arousal unpleasant images. Finally, mindfulness was also associated with lower LPP responses to motivationally salient pleasant images (erotica). These findings suggest that mindfulness modulates neural responses in an early phase of affective processing, and contribute to understanding how this quality of attention may promote healthy emotional functioning.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3541486/

Improve the Ability to Control the Brain’s Activity with Prayer and Meditation

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Improve the Ability to Control the Brain’s Activity with Prayer and Meditation

 

By John M. de Castro, Ph.D.

 

“You can sculpt your brain just as you’d sculpt your muscles if you went to the gym. Our brains are continuously being sculpted, whether you like it or not, wittingly or unwittingly.” – Ritchie Davidson

 

The nervous system is a dynamic entity, constantly changing and adapting to the environment. It will change size, activity, and connectivity in response to experience. For example, the brain area that controls the right index finger has been found to be larger in blind subjects who use braille than in sighted individuals.  Similarly, cab drivers in London who navigate the twisting streets of the city, have a larger hippocampus, which is involved in spatial navigation, than predefined route bus drivers. These changes in the brain are called neuroplasticity. Over the last decade neuroscience has been studying the effects of contemplative practices on the brain and has identified neuroplastic changes in widespread areas. In other words, meditation practice appears to mold and change the brain, producing psychological, physical, and spiritual benefits.

 

Prayer and meditation can be quite similar. It is possible that they can both produce changes to the brain. Since, both involve a degree of self-control, it is possible that they both change the brain to enhance self-control mechanisms. In today’s Research News article “Ability to Gain Control Over One’s Own Brain Activity and its Relation to Spiritual Practice: A Multimodal Imaging Study.” (See summary below or view the full text of the study at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5442174/ ), Kober and colleagues studied the ability of meditation and prayer to alter the nervous system and improve self-control. They recruited healthy adults who reported either a low or a high frequency of prayer or meditation. They were measured for spirituality and religiousness, mindfulness and locus of control. In addition, the participants had their brains scanned with Magnetic Resonance Imaging (MRI).

 

The participants had their brain activity measured with an electroencephalogram (EEG). They were shown a display with three bars the height of which was determined by brain activity in the 4-7 hertz (Theta), 12-25 hertz (SMR- Sensory-motor rhythm), and 21-35 hertz (Beta) range respectively. They received rewards (points) whenever their SMR was above a prescribed threshold and both their Theta and Beta were below a certain threshold. In other words, whenever their EEG reflected a specific prescribed pattern. If the participant was able to increase their SMR and decrease their Theta and Beta rhythms over training, it indicated and ability to control their brain activity.

 

They found, not surprisingly, that the high frequency group had higher levels of religiosity and mindfulness than the low frequency group. Importantly, they found a significant difference in the groups in their ability to control their brains. In particular, they found that the high frequency of meditation or prayer group was able to significantly increase their SMR while decreasing their Theta and Beta rhythms over training, while the low frequency group was not. When asked about their mental strategies to control their brain waves, the high frequency group reported significantly more “doing nothing”, similar to meditating or praying, than the low frequency group. Hence, the group who meditated and prayed often showed an ability to control their brains activity by employing a meditative strategy.

 

These are striking results. It has been known that with reward (biofeedback) people could learn to change their brain activity. But, it has never been shown before that people who prayed or meditated often would be significantly better at it than those who didn’t. The high frequency group is “assumed to be experts in focusing attention on inner states and self-referential processes.” This suggests that focused meditative practice improves the individual’s ability to control their brain activity. In other words, spiritual practice made them better at “doing nothing” and preventing thoughts from disrupting control of brain activity.

 

So, improve the ability to control the brain’s activity with prayer and meditation.

 

“The idea that there’s something specific about religious practices that changes your brain is just ridiculous. Everything changes your brain. Your brain is changing now, as is mine, as we’re having this conversation. There’s nothing special or magical about engaging in religious practices and showing certain changes in brain structure or function.” – Richard Sloan

 

CMCS – Center for Mindfulness and Contemplative Studies

 

This and other Contemplative Studies posts are also available on Google+ https://plus.google.com/106784388191201299496/posts and on Twitter @MindfulResearch

 

Study Summary

 

Kober, S. E., Witte, M., Ninaus, M., Koschutnig, K., Wiesen, D., Zaiser, G., … Wood, G. (2017). Ability to Gain Control Over One’s Own Brain Activity and its Relation to Spiritual Practice: A Multimodal Imaging Study. Frontiers in Human Neuroscience, 11, 271. http://doi.org/10.3389/fnhum.2017.00271

 

Abstract

Spiritual practice, such as prayer or meditation, is associated with focusing attention on internal states and self-awareness processes. As these cognitive control mechanisms presumably are also important for neurofeedback (NF), we investigated whether people who pray frequently (N = 20) show a higher ability of self-control over their own brain activity compared to a control group of individuals who rarely pray (N = 20). All participants underwent structural magnetic resonance imaging (MRI) and one session of sensorimotor rhythm (SMR, 12–15 Hz) based NF training. Individuals who reported a high frequency of prayer showed improved NF performance compared to individuals who reported a low frequency of prayer. The individual ability to control one’s own brain activity was related to volumetric aspects of the brain. In the low frequency of prayer group, gray matter volumes in the right insula and inferior frontal gyrus were positively associated with NF performance, supporting prior findings that more general self-control networks are involved in successful NF learning. In contrast, participants who prayed regularly showed a negative association between gray matter volume in the left medial orbitofrontal cortex (Brodmann’s area (BA) 10) and NF performance. Due to their regular spiritual practice, they might have been more skillful in gating incoming information provided by the NF system and avoiding task-irrelevant thoughts.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5442174/

Improve Calmness with Alternate Nostril Yoga Breathing

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Improve Calmness with Alternate Nostril Yoga Breathing

 

By John M. de Castro, Ph.D.

 

“alternate nostril breathing . . . it’s thought to harmonize the two hemispheres of the brain, resulting in a balanced in physical, mental and emotional well-being. While science has yet to really explore what might be going on in terms of hemispheric functioning during this practice, recent studies have confirmed some pretty powerful effects of this practice.” – Paula Watkins

 

Yoga practice is becoming increasingly popular in the west, for good reason. It has documented benefits for the individual’s psychological and physical health and well-being. It has also been shown to have cognitive benefits, improving memory. Yoga, however, consists of a number of components including, poses, breathing exercises, meditation, concentration, and philosophy/ethics.  So, it is difficult to determine which facet or combination of facets of yoga are responsible for which benefit. Hence, it is important to begin to test each component in isolation to determine its effects.

 

Alternate nostril yoga breathing is a regulated breathing alternating between the left and right nostril. Breathing through each nostril is thought to affect its respective hemisphere in the brain producing differential effects. In today’s Research News article “Hemisphere specific EEG related to alternate nostril yoga breathing.” (See summary below or view the full text of the study at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5525313/ ), Telles and colleagues examine the effects of alternate nostril yoga breathing on brain activity and the emotional state of the practitioner. They recruited healthy adult practitioners of alternate nostril yoga breathing. They were randomly assigned on different days to either practice alternate nostril yoga breathing, breath awareness, or quiet sitting for 18 minutes. Before, during, and after each practice the electroencephalogram (EEG) was recorded from the scalp of the practitioners.

 

They found that during alternate nostril yoga breathing there was significantly decreased activity in the frontal lobes of the brain in both the Beta frequency band (13-30 cycles per second) of the EEG and the Theta frequency band (4-7.5 cycles per second). On the other hand, during quiet sitting there was increased Beta activity and decreased Alpha band (8-12 cycles per second) activity.

 

Theta activity in the EEG of the frontal lobe is associated with positive emotional states and memory activity. Beta activity is associated with increased alertness, excitement, and arousal. Alpha activity is associated with complex cognitive (thought) processes. Hence, during alternate nostril yoga breathing the EEG activity suggests that the practitioner goes into a state of relaxation (reduced arousal) while during quiet sitting the practitioner goes into a state of arousal with decreased thinking.

 

This study demonstrates that the different components of yoga practice may have strikingly different effects on the nervous system and the state of the practitioner. The results are interesting and verify that alternate nostril yoga breathing produces different changes in brain activity than breath awareness or quiet sitting. The results suggest that alternate nostril yoga breathing produces a relaxed, calm state. This further suggests that this technique might be useful for treating anxiety disorders. Indeed, there is evidence that alternate nostril yoga breathing calms the anxious individual.

 

So, improve calmness with alternate nostril yoga breathing.

 

““alternate nostril breathing,” is a simple yet powerful technique that settles the mind, body, and emotions. You can use it to quiet your mind before beginning a meditation practice, and it is particularly helpful to ease racing thoughts if you are experiencing anxiety, stress, or having trouble falling asleep.” – Melissa Eisler

 

CMCS – Center for Mindfulness and Contemplative Studies

 

This and other Contemplative Studies posts are also available on Google+ https://plus.google.com/106784388191201299496/posts and on Twitter @MindfulResearch

 

Study Summary

 

Telles, S., Gupta, R. K., Yadav, A., Pathak, S., & Balkrishna, A. (2017). Hemisphere specific EEG related to alternate nostril yoga breathing. BMC Research Notes, 10, 306. http://doi.org/10.1186/s13104-017-2625-6

 

Abstract

Background

Previously, forced unilateral nostril breathing was associated with ipsilateral, or contralateral cerebral hemisphere changes, or no change. Hence it was inconclusive. The present study was conducted on 13 normal healthy participants to determine the effects of alternate nostril yoga breathing on (a) cerebral hemisphere asymmetry, and (b) changes in the standard EEG bands.

Methods

Participants were randomly allocated to three sessions (a) alternate nostril yoga breathing (ANYB), (b) breath awareness and (c) quiet sitting, on separate days. EEG was recorded from bilaterally symmetrical sites (FP1, FP2, C3, C4, O1 and O2). All sites were referenced to the ipsilateral ear lobe.

Results

There was no change in cerebral hemisphere symmetry. The relative power in the theta band was decreased during alternate nostril yoga breathing (ANYB) and the beta amplitude was lower after ANYB. During quiet sitting the relative power in the beta band increased, while the amplitude of the alpha band reduced.

Conclusion

The results suggest that ANYB was associated with greater calmness, whereas quiet sitting without specific directions was associated with arousal. The results imply a possible use of ANYB for stress and anxiety reduction.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5525313/

Reduce Depression by Improving Brain Responses with Mindfulness

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Reduce Depression by Improving Brain Responses with Mindfulness

 

By John M. de Castro, Ph.D.

 

“If we accept that you can’t control your thoughts or feelings, but rather focus on cultivating your awareness of them, and regulate their impact, without getting caught up with them, then life can be far less stressful. The important thing is to realize that the content of our thoughts and emotions is less important than how we let them affect us.” – Ray Williams

 

Clinically diagnosed depression is the most common mental illness, affecting over 6% of the population. Depression can be difficult to treat. It is usually treated with anti-depressive medication. But, of patients treated initially with drugs only about a third attained remission of the depression. After repeated and varied treatments including drugs, therapy, exercise etc. only about two thirds of patients attained remission. But, drugs often have troubling side effects and can lose effectiveness over time. In addition, many patients who achieve remission have relapses and recurrences of the depression.

 

One of the characterizing features of depression is flat affect. Depressed individuals do not appear to react emotionally to either positive or negative events in their lives. Good things do not improve their mood and bad things don’t worsen it. This lack of reactivity tends to interfere with recovery from depression. Mindfulness training is an alternative treatment for depression. It has been shown to be an effective treatment for depression and is also effective for the prevention of its recurrence. This suggests that mindfulness training may help to reverse the flat affect, the lack of emotional reactivity.

 

In today’s Research News article “Brief training in mindfulness may normalize a blunted error-related negativity in chronically depressed patients.” (See summary below or view the full text of the study at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5709439/ ), Fissler and colleagues employed an electrical response of the brain to the commission of an error, error related negativity, to measure non-reactivity in depressed patients and the effects of mindfulness training on this response.

 

They recruited adult depressed patients and healthy individuals as control participants. They were measured for depression both by clinical interview and self-report. Participants were asked to perform a sustained attention to response task in which single digits were presented and the participants were asked to press a space bar for all digits except the number 3. During the task, the Electroencephalogram (EEG) was recorded from the scalp to measure brain responses. The brain frontal lobe electrical response on correct trials was compared to that when errors were committed to measure error related negativity. After baseline measurement, the depressed patients were randomly assigned to either receive 2 weeks of mindfulness training or rest. The mindfulness training consisted of 25 minutes of meditation twice a day for 6 days per week. Resting depressed patients were asked to schedule rest periods on a similar schedule.

 

They found that the depressed patients were slower and made more errors on the sustained attention to response task than the health controls. In addition, the depressed patients had a significantly lower error related negativity in the EEG from the frontal lobe than controls, signifying less reactivity in these patients. They further compared the depressed patients who meditated to those who rested and found that both groups had decreased depression levels, but the meditators had significantly greater reductions in depression. Importantly, the depressed patients who meditated had an increased error related negativity response while the depressed patients who rested did not. This indicates that meditation improved depression and the brains electrical responses to events.

 

These are interesting and important results. It is well established that mindfulness training (meditation) significantly improves depression and this effect was repeated in this study. But, the results also suggest that meditation changes the brain of depressed patients, making it more responsive to environmental events. This suggests that meditation training may, to some extent, reverse the flat affect of depressed patients and that this occurs in combination with decreased depression. It cannot be established from this study if there is a causal connection between the flat affect and depression improvements. But, it is clear that mindfulness training (meditation) improves both.

 

So, reduce depression by improving brain responses with mindfulness.

 

“When unhappy or stressful thoughts occur, rather than taking them personally and merely reacting, mindfulness teaches you to observe such thoughts with friendly curiosity. You learn to catch negative patterns of thinking before they put you into a downward spiral. Over time, mindfulness can bring about long-term changes in mood and increased levels of happiness.” Sylvia Brafman

 

CMCS – Center for Mindfulness and Contemplative Studies

 

This and other Contemplative Studies posts are also available on Google+ https://plus.google.com/106784388191201299496/posts and on Twitter @MindfulResearch

 

Study Summary

 

Fissler, M., Winnebeck, E., Schroeter, T. A., Gummbersbach, M., Huntenburg, J. M., Gärtner, M., & Barnhofer, T. (2017). Brief training in mindfulness may normalize a blunted error-related negativity in chronically depressed patients. Cognitive, Affective & Behavioral Neuroscience, 17(6), 1164–1175. http://doi.org/10.3758/s13415-017-0540-x

 

Abstract

The error-related negativity (ERN), an evoked-potential that arises in response to the commission of errors, is an important early indicator of self-regulatory capacities. In this study we investigated whether brief mindfulness training can reverse ERN deficits in chronically depressed patients. The ERN was assessed in a sustained attention task. Chronically depressed patients (n = 59) showed significantly blunted expression of the ERN in frontocentral and frontal regions, relative to healthy controls (n = 18). Following two weeks of training, the patients (n = 24) in the mindfulness condition showed a significantly increased ERN magnitude in the frontal region, but there were no significant changes in patients who had received a resting control (n = 22). The findings suggest that brief training in mindfulness may help normalize aberrations in the ERN in chronically depressed patients, providing preliminary evidence for the responsiveness of this parameter to mental training.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5709439/

Change Your Brain’s Activity with Mindfulness

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Change Your Brain’s Activity with Mindfulness

 

By John M. de Castro, Ph.D.

 

“The impact that mindfulness exerts on our brain is borne from routine: a slow, steady, and consistent reckoning of our realities, and the ability to take a step back, become more aware, more accepting, less judgmental, and less reactive. Just as playing the piano over and over again over time strengthens and supports brain networks involved with playing music, mindfulness over time can make the brain, and thus, us, more efficient regulators, with a penchant for pausing to respond to our worlds instead of mindlessly reacting.” – Jennifer Wolkin

 

There has accumulated a large amount of research demonstrating that mindfulness practices have significant benefits for psychological, physical, and spiritual wellbeing. Its positive effects are so widespread that it is difficult to find any other treatment of any kind with such broad beneficial effects on everything from mood and happiness to severe mental and physical illnesses. This raises the question of how meditation could do this. The nervous system is a dynamic entity, constantly changing and adapting to the environment. It will change size, activity, and connectivity in response to experience. These changes in the brain are called neuroplasticity. Over the last decade neuroscience has been studying the effects of contemplative practices on the brain and has identified neuroplastic changes in widespread areas. In other words, mindfulness practices appears to mold and change the brain, producing psychological, physical, and spiritual benefits.

 

If mindfulness training can alter the nervous system then perhaps simply being a mindful individual will be associated with differences in the same brain regions. This idea was examined in today’s Research News article “Resting Brain Activity Related to Dispositional Mindfulness: a PET Study.” See summary below or view the full text of the study at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5506209/, Gartenschläger and colleagues recruited normal and psychologically disturbed individuals and measured their levels of mindfulness, depression, and anxiety. The participants then underwent a brain scan for neural activity (Positron Emission Tomography, PET Scan).

 

They found that the higher the participant’s level of mindfulness, the lower the levels of both depression and anxiety. This is not surprising as mindfulness training has been shown repeatedly to produce lower levels of anxiety and depression. They also found that the higher the levels of mindfulness the higher the resting brain activity in the superior parietal lobule and in precuneus and superior parietal lobule and the lower the activity in the inferior frontal orbital gyrus and anterior thalamus.

 

These results are complex but the lower activity in the Thalamus may represent lower levels of general activation of the brain in mindful individuals. Also, the lower activity in the inferior frontal orbital gyrus may represent lower levels of language processing in mindful individuals, possibly indicating less internal language, thinking, with individuals high in mindfulness. In addition, the higher activity in the parietal lobe and precuneus may represent greater activity in the Default Mode Network (DMN) of which these structures are a part. The DMN is associated with a sense of self, self-referential thinking, and mind wandering. This suggests that mindful individuals while at rest, with their eyes closed, may be less activated (more at rest), have less internal language (thought), and have their minds wandering.

 

It may seem counterintuitive that mindful individuals’ minds may be wandering more as mindfulness has been shown to be associated with less mind wandering. But, the situation of lying in a scanner with eyes closed may be one in which discursive thought is perfectly appropriate. In any case, these are interesting results that add to our understanding of the brain systems involved in mindfulness. It will require considerable future research to paint a complete picture of the neural systems underlying mindfulness and being altered by mindfulness training.

 

So, change your brain’s activity with mindfulness.

 

“The practice of mindfulness can train our brains to have a new default. Instead of automatically falling into the stream of past or future rumination that ignites the depression loop, mindfulness draws our attention to the present moment. As we practice mindfulness, we actually start wiring neurons that balance the brain in a way that is naturally an antidepressant.” – Alex Korb

 

CMCS – Center for Mindfulness and Contemplative Studies

 

This and other Contemplative Studies posts are also available on Google+ https://plus.google.com/106784388191201299496/posts and on Twitter @MindfulResearch

 

Study Summary

 

Gartenschläger, M., Schreckenberger, M., Buchholz, H.-G., Reiner, I., Beutel, M. E., Adler, J., & Michal, M. (2017). Resting Brain Activity Related to Dispositional Mindfulness: a PET Study. Mindfulness, 8(4), 1009–1017. http://doi.org/10.1007/s12671-017-0677-2

 

Abstract

Mindfulness denotes a state of consciousness characterized by receptive attention to and awareness of present events and experiences. As a personality trait, it constitutes the ability to become aware of mental activities such as sensations, images, feelings, and thoughts, and to disengage from judgment, conditioned emotions, and their cognitive processing or automatic inhibition. Default brain activity reflects the stream of consciousness and sense of self at rest. Analysis of brain activity at rest in persons with mindfulness propensity may help to elucidate the neurophysiological basis of this important mental trait. The sample consisted of 32 persons—23 with mental disorders and 9 healthy controls. Dispositional mindfulness (DM) was operationalized by Mindful Attention Awareness Scale (MAAS). Brain activity at rest with eyes closed was assessed by fluorodeoxyglucose positron emission tomography (F-18-FDG PET). After adjustment for depression, anxiety, age and years of education, resting glucose metabolism in superior parietal lobule and left precuneus/Brodmann area (BA) 7 was positively associated with DM. Activity of the left inferior frontal orbital gyrus (BA 47) and bilateral anterior thalamus were inversely associated with DM. DM appears to be associated with increased metabolic activity in some core area of the default mode network (DMN) and areas connected to the DMN, such as BA 7, hosting sense of self functions. Hypometabolism on the other hand was found in some nodes connected to the DMN, such as left inferior frontal orbital gyrus and bilateral thalamus, commonly related to functions of memory retrieval, decision making, or outward attention.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5506209/

Correct Brain Rhythms and Reduce Depression with Mindfulness

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Correct Brain Rhythms and Reduce Depression with Mindfulness

 

By John M. de Castro, Ph.D.

 

“Mindfulness, or paying full attention to the present moment, can be very helpful in improving the cognitive symptoms of depression.  . . Through mindfulness, individuals start to see their thoughts as less powerful. These distorted thoughts – such as “I always make mistakes” or “I’m a horrible person” – start to hold less weight. . . We ‘experience’ thoughts and other sensations, but we aren’t carried away by them. We just watch them come and go.” –  Margarita Tartakovsky

 

Clinically diagnosed depression is the most common mental illness, affecting over 6% of the population. Major depression can be quite debilitating. It is also generally episodic, coming and going. Some people only have a single episode but most have multiple reoccurrences of depression.  Depression can be difficult to treat and usually treated with anti-depressive medication. But, of patients treated initially with drugs only about a third attained remission of the depression. After repeated and varied treatments including drugs, therapy, exercise etc. only about two thirds of patients attained remission. But, drugs often have troubling side effects and can lose effectiveness over time. In addition, many patients who achieve remission have relapses and recurrences of the depression. Even after remission some symptoms of depression may still be present (residual symptoms).

 

Being depressed and not responding to treatment or relapsing is a terribly difficult situation. The patients are suffering and nothing appears to work to relieve their intense depression. Suicide becomes a real possibility. So, it is imperative that other treatments be identified that can be applied when the typical treatments fail. Mindfulness training is another alternative treatment for depression. It has been shown to be an effective treatment for depression and is also effective for the prevention of its recurrence. Mindfulness training is also known to change the nervous system.

 

The brain shows synchronous activity where large numbers of neural cells are active together in burst. This activity can be recorded in the electroencephalogram (EEG). They appear as oscillations (waves) in the electrical signals that occur at certain frequencies. Over time these frequencies are fairly stable which is reflected in a correlation over time of the waves. This is called Long-Range Temporal Correlations (LRTC). This signal changes with mental illness and brain disease. So, it is reasonable to study the LRTC in depressed patients and the effect of mindfulness training on it.

 

In today’s Research News article “Aberrant Long-Range Temporal Correlations in Depression Are Attenuated after Psychological Treatment.” See summary below or view the full text of the study at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5488389/, Gärtner and colleagues recruited depressed and healthy control patients and randomly assigned them to receive either 2 weeks of mindfulness training or education on stress reduction. Mindfulness training consisted of two 25-minute guided meditation per day for 6 days per week. The stress reduction education group was asked to rest on the same schedule. Before and after training they were measured for mental illness, depression, and rumination, and the EEG recorded at rest with eyes closed.

 

They found that the there was a significant elevation of the Long-Range Temporal Correlations (LRTC) in the depressed patients in the frontal and temporal cortices. In addition, mindfulness training, but not stress reduction education, produced a significant reduction in both depression and rumination. Further, after mindfulness training there was a significant reduction in the LRTC signal and the larger the reduction in the LRTC the greater the reduction in depression. Hence, they found that depression was associated with heightened neural synchrony and that mindfulness training reduced that synchrony to normal levels while relieving depression. These appeared to be related, as the larger the reduction, normalizing, in the synchrony the greater the reduction in depression.

 

These are interesting results that suggest that mindfulness training changes the brain in beneficial ways for depressed patients, normalizing the brain activity and the depressive symptoms. Mindfulness training has been previously demonstrated to reduce depression. The present results suggest how the training may be altering the brain to relieve depression by correcting aberrant brain activity in the frontal and parietal lobes of the brain. These results, however, only demonstrate that both brain activity and depression change after mindfulness training and does not demonstrate a causal connection between the brain activity and depression. It will remain for future research to investigate whether they are causally connected.

 

So, correct brain rhythms and reduce depression with mindfulness.

 

“Mindfulness practices of MBCT allowed people to be more intentionally aware of the present moment, which gave them space to pause before reacting automatically to others. Instead of becoming distressed about rejection or criticism, they stepped back to understand their own automatic reactions—and to become more attuned to others’ needs and emotions. Awareness gave them more choice in how to respond, instead of becoming swept up in escalating negative emotion.” – Emily Nauman

 

CMCS – Center for Mindfulness and Contemplative Studies

 

This and other Contemplative Studies posts are also available on Google+ https://plus.google.com/106784388191201299496/posts and on Twitter @MindfulResearch

 

Study Summary

 

Gärtner, M., Irrmischer, M., Winnebeck, E., Fissler, M., Huntenburg, J. M., Schroeter, T. A., … Barnhofer, T. (2017). Aberrant Long-Range Temporal Correlations in Depression Are Attenuated after Psychological Treatment. Frontiers in Human Neuroscience, 11, 340. http://doi.org/10.3389/fnhum.2017.00340

 

Abstract

The spontaneous oscillatory activity in the human brain shows long-range temporal correlations (LRTC) that extend over time scales of seconds to minutes. Previous research has demonstrated aberrant LRTC in depressed patients; however, it is unknown whether the neuronal dynamics normalize after psychological treatment. In this study, we recorded EEG during eyes-closed rest in depressed patients (N = 71) and healthy controls (N = 25), and investigated the temporal dynamics in depressed patients at baseline, and after attending either a brief mindfulness training or a stress reduction training. Compared to the healthy controls, depressed patients showed stronger LRTC in theta oscillations (4–7 Hz) at baseline. Following the psychological interventions both groups of patients demonstrated reduced LRTC in the theta band. The reduction of theta LRTC differed marginally between the groups, and explorative analyses of separate groups revealed noteworthy topographic differences. A positive relationship between the changes in LRTC, and changes in depressive symptoms was observed in the mindfulness group. In summary, our data show that aberrant temporal dynamics of ongoing oscillations in depressive patients are attenuated after treatment, and thus may help uncover the mechanisms with which psychotherapeutic interventions affect the brain.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5488389/