Psychedelics

Psychedelic Drug Use and Meditation Practices are Positively Associated

psyjdc Leave a comment

New study links mindfulness meditation and psychedelic use to positive leadership outcomes at work

By John M. de Castro, Ph.D.

 

In today’s Research News article “Associations between psychedelic-related and meditation-related variables: A longitudinal study” (See summary below or view the full text of the study at: https://pmc.ncbi.nlm.nih.gov/articles/PMC11999004/ ) Simonsson and colleagues examined the relationships between the use of psychedelic drugs and mindfulness and meditation practices. They found that psychedelic use was associated with greater mindfulness and loving-kindness or compassion meditation practice and mindfulness was associated with less severe challenging psychedelic experiences.

 

Psychedelic drug use and meditation practices are positively associated.

 

CMCS – Center for Mindfulness and Contemplative Studies

 

This and other Contemplative Studies posts are also available on the Contemplative Studies Blog  http://contemplative-studies.org

 

Study Summary

 

Simonsson O, Chaturvedi S, Hendricks PS, Stenfors CUD, Osika W, Narayanan J, Palitsky R, Goldberg SB. Associations between psychedelic-related and meditation-related variables: A longitudinal study. J Psychiatr Res. 2025 Apr;184:457-463. doi: 10.1016/j.jpsychires.2025.03.025. Epub 2025 Mar 17. PMID: 40133019; PMCID: PMC11999004.

 

Abstract

Previous research has investigated associations between psychedelic experiences and meditation practice, but knowledge gaps remain. Using a longitudinal research design with a sample of US residents between 18 and 50 years old (N = 13,012), we investigated associations between psychedelic-related and meditation-related variables. The follow-up survey was completed by 7484 respondents, of whom 336 reported psychedelic use during the two-month study. In covariate-adjusted regression models, psychedelic use was associated with greater increases in the number of days of mindfulness and loving-kindness or compassion meditation practice in the past week, especially among those with no prior experience of psychedelics or meditation. Among those who reported psychedelic use, trait mindfulness and trait self-compassion at baseline were associated with less severe challenging psychedelic experiences, as well as lower odds of psychedelic-occasioned thoughts or attempts of self- or other-harm. However, among those who practiced meditation at baseline, psychedelic use was associated with greater increases in past-week frequency of loving-kindness or compassion meditation-related difficulties and impairments. Future research is warranted.

 

Psychedelic Use and Meditation Complement Each Other’s Impacts

psyjdc 1 Comment

Does the combination of psychedelics and meditation enhance mystical experiences?

By John M. de Castro, Ph.D.

 

In today’s Research News article “Associations between psychedelic-related and meditation-related variables: A longitudinal study” (See summary below or view the full text of the study at: https://pmc.ncbi.nlm.nih.gov/articles/PMC11999004/ )  Simonsson and colleagues examined the relationships between meditation and psychedelic use. They found that psychedelic use was associated with mindfulness and loving-kindness or compassion meditation practice while mindfulness was associated with less severe challenging psychedelic experiences, fewer psychedelic-occasioned thoughts or attempts of self- or other-harm.

 

Meditation and psychedelic use complement the impact of each.

 

CMCS – Center for Mindfulness and Contemplative Studies

 

This and other Contemplative Studies posts are also available on the Contemplative Studies Blog  http://contemplative-studies.org

 

Study Summary

 

Simonsson O, Chaturvedi S, Hendricks PS, et al. Associations between psychedelic-related and meditation-related variables: A longitudinal study. J Psychiatr Res. 2025;184:457-463. doi:10.1016/j.jpsychires.2025.03.025

 

Abstract

Previous research has investigated associations between psychedelic experiences and meditation practice, but knowledge gaps remain. Using a longitudinal research design with a sample of US residents between 18 and 50 years old (N = 13,012), we investigated associations between psychedelic-related and meditation-related variables. The follow-up survey was completed by 7484 respondents, of whom 336 reported psychedelic use during the two-month study. In covariate-adjusted regression models, psychedelic use was associated with greater increases in the number of days of mindfulness and loving-kindness or compassion meditation practice in the past week, especially among those with no prior experience of psychedelics or meditation. Among those who reported psychedelic use, trait mindfulness and trait self-compassion at baseline were associated with less severe challenging psychedelic experiences, as well as lower odds of psychedelic-occasioned thoughts or attempts of self- or other-harm. However, among those who practiced meditation at baseline, psychedelic use was associated with greater increases in past-week frequency of loving-kindness or compassion meditation-related difficulties and impairments. Future research is warranted.

 

Adding a Psychedelic Drug to Mindfulness Training Enhances Relief of Burnout and Depression

psyjdc Leave a comment

Combining psychedelics with meditation increases mindfulness and mystical-type transcendence

By John M. de Castro, Ph.D.

 

In today’s Research News article “Psilocybin-Assisted Group Psychotherapy + Mindfulness Based Stress Reduction (MBSR) for Frontline Healthcare Provider COVID-19 Related Depression and Burnout: A Randomized Clinical Trial” (See summary below or view the full text of the study at: https://pmc.ncbi.nlm.nih.gov/articles/PMC11722457/pdf/nihpp-2024.12.31.24319806v1.pdf )  Lewis and colleagues performed a randomized clinical trial of the effectiveness of Mindfulness training (8-wks of Mindfulness Based Stress Reduction – MBSR) with or without an additional Psychedelic drug (psilocybin) on the mental health of healthcare workers suffering from burnout and depression.

 

They found that the addition of the psychedelic drug significantly increased the relief of depression, burnout, and demoralization and the improvement of connectedness produced by the mindfulness training.

 

Hence, psychedelic drugs enhance the effectiveness of mindfulness training on burnout.

 

CMCS – Center for Mindfulness and Contemplative Studies

 

This and other Contemplative Studies posts are also available on the Contemplative Studies Blog  http://contemplative-studies.org

 

Study Summary

 

Lewis BR, Hendrick J, Byrne K, Odette M, Wu C, Garland EL. Psilocybin-Assisted Group Psychotherapy + Mindfulness Based Stress Reduction (MBSR) for Frontline Healthcare Provider COVID-19 Related Depression and Burnout: A Randomized Clinical Trial. medRxiv [Preprint]. 2025 Jan 1:2024.12.31.24319806. doi: 10.1101/2024.12.31.24319806. PMID: 39802794; PMCID: PMC11722457.

 

Abstract

Objective

This clinical trial sought to evaluate the safety and preliminary efficacy of psilocybin and MBSR for frontline healthcare providers with symptoms of depression and burnout related to the COVID-19 pandemic.

Methods

This was a randomized controlled trial that enrolled physicians and nurses with frontline clinical work during the COVID-19 pandemic and symptoms of depression and burnout. Participants were randomized in a 1:1 ratio to either an 8-week MBSR curriculum alone or an 8-week MBSR curriculum plus group psilocybin-assisted psychotherapy (PAP) with 25mg psilocybin. Symptoms of depression and burnout were assessed at baseline, and 2-weeks and 6-months post intervention utilizing the Quick Inventory of Depressive Symptoms (QIDS-SR-16) and Maslach Burnout Inventory Human Services Survey for Medical Professionals (MBI-HSS-MP), respectively. Secondary outcome measures included the Demoralization Scale (DS-II) and the Watt’s Connectedness Scale (WCS). Adverse events and suicidality were assessed through 6-month follow-up.

Results

25 participants were enrolled and randomized. There were 12 study-related AEs recorded that were Grade 1-2 and no serious AEs. There was larger decrease in QIDS score for the MBSR+PAP arm compared to MBSR-only from baseline to 2-weeks post-intervention and significant between-group differences favoring MBSR+PAP on subscales of the MBI-HSS-MP as well as the DS-II and WCS.

Conclusions

Group psilocybin-assisted therapy plus MBSR was associated with clinically significant improvement in depressive symptoms without serious adverse events and with greater reduction in symptoms than MBSR alone. Study findings suggest that integrating psilocybin with mindfulness training may represent a promising treatment for depression and burnout among physicians and nurses.