contemplative practice

Mindfulness Improves Cognitive Function in Older Adults by Altering Brain Gene Expression

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Mindfulness Improves Cognitive Function in Older Adults by Altering Brain Gene Expression

 

By John M. de Castro, Ph.D.

 

“mindfulness may target inflammation, stress-related pathways, and neuroplasticity, thus reducing the risk of developing cerebrovascular disease and age-related neurodegeneration that could lead to the development of dementia.” – Ted Kheng Siang Ng

 

The aging process involves a systematic progressive decline in every system in the body, the brain included. The elderly frequently have problems with attention, thinking, and memory abilities, known as mild cognitive impairment. An encouraging new development is that mindfulness practices such as meditation training and mindful movement practices can significantly reduce these declines in cognitive ability. In addition, it has been found that

mindfulness practices reduce the deterioration of the brain that occurs with aging restraining the loss of neural tissue. Indeed, the brains of practitioners of meditation have been found to degenerate less with aging than non-practitioners. The mechanisms by which mindfulness affects the brain and reduces cognitive decline need to be investigated.

 

In today’s Research News article “Mindfulness intervention improves cognitive function in older adults by enhancing the level of miRNA-29c in neuron-derived extracellular vesicles.” (See summary below or view the full text of the study at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8575875/ ) Hashizume and colleagues recruited healthy elderly adults aged 65 and over and administered either 4 weeks , 3 times per week for 60 minutes of Mindfulness-Based Stress Reduction (MBSR) or a no-treatment wait-list condition. They were measured before and after treatment for cognitive function including delayed recall, visuospatial/executive function, attention, abstraction, language, naming, and orientation tasks. They also had blood drawn and assayed for extracellular vesicles and mRNA in the vesicles.

 

They found that in comparison to baseline and the wait list control, after Mindfulness-Based Stress Reduction (MBSR) there were significant improvement in cognitive function including delayed recall, visuospatial/executive function, attention, naming, and orientation tasks. The blood assays revealed that in comparison to baseline and the wait list control, after MBSR there were significant reductions in miR-29c in the extracellular vesicles and decreased expression of the genes DNMT3A, DNMT3B, and BACE1 in in the extracellular vesicles. In another study with mice they found that injection into the brain ventricles of miR-29c prevented cognitive decline in the animals.

 

The results suggest that mindfulness training improves cognitive function in the elderly. These improvements in cognition have been previously observed by other researchers. The new findings in the present research are the changes in the extracellular vesicles found in the plasma. The expression of the mRNA miR-29c controls the gene expressions of DNMT3A, DNMT3B, and BACE1. These genes are associated with the loss of neurons in the brain. With aging there is a degeneration of the brain including losses of neurons. Reductions in the expression of the genes that tend to produce neuronal loss after Mindfulness-Based Stress Reduction (MBSR) suggests that the training protects the brain from the loss of neurons. This may represent the mechanism by which mindfulness training protects the brain in aging individual which results in improved cognitive function. It may be how mindfulness training stops cognitive decline in the elderly.

 

So, mindfulness improves cognitive function in older adults by altering brain gene expression.

 

“an 8-week mindfulness-based training program improved cognition . . . in cognitively normal older adults, and that these improvements were associated with increased intrinsic connectivity within the default mode network.” – Gunes Sevinc

 

CMCS – Center for Mindfulness and Contemplative Studies

 

This and other Contemplative Studies posts are available on Twitter @MindfulResearch

 

Study Summary

 

Hashizume, S., Nakano, M., Kubota, K., Sato, S., Himuro, N., Kobayashi, E., Takaoka, A., & Fujimiya, M. (2021). Mindfulness intervention improves cognitive function in older adults by enhancing the level of miRNA-29c in neuron-derived extracellular vesicles. Scientific reports, 11(1), 21848. https://doi.org/10.1038/s41598-021-01318-y

 

Abstract

Although mindfulness-based stress reduction (MBSR) improves cognitive function, the mechanism is not clear. In this study, people aged 65 years and older were recruited from elderly communities in Chitose City, Japan, and assigned to a non-MBSR group or a MBSR group. Before and after the intervention, the Japanese version of the Montreal Cognitive Assessment (MoCA-J) was administered, and blood samples were collected. Then, neuron-derived extracellular vesicles (NDEVs) were isolated from blood samples, and microRNAs, as well as the target mRNAs, were evaluated in NDEVs. A linear mixed model analysis showed significant effects of the MBSR x time interaction on the MoCA-J scores, the expression of miRNA(miR)-29c, DNA methyltransferase 3 alpha (DNMT3A), and DNMT3B in NDEVs. These results indicate that MBSR can improve cognitive function by increasing the expression of miR-29c and decreasing the expression of DNMT3A, as well as DNMT3B, in neurons. It was also found that intracerebroventricular injection of miR-29c mimic into 5xFAD mice prevented cognitive decline, as well as neuronal loss in the subiculum area, by down-regulating Dnmt3a  and Dnmt3b  in the hippocampus. The present study suggests that MBSR can prevent neuronal loss and cognitive impairment by increasing the neuronal expression of miR-29c.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8575875/

 

Improve Anxiety Disorders with Mindfulness

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Improve Anxiety Disorders with Mindfulness

 

By John M. de Castro, Ph.D.

 

“[Anxiety Disorders] primarily involves unrelenting worry. With meditation, you can learn to accept those worries without letting them upset you, which is likely to diminish your stress.” – Arlin Cuncic

 

Anxiety disorders are the most common mental illness in the United States, affecting 40 million adults, or 18% of the population. A characterizing feature of anxiety disorders is that the sufferer overly identifies with and personalizes their thoughts. The sufferer has recurring thoughts, such as impending disaster, that they may realize are unreasonable, but are unable to shake. Anxiety disorders have generally been treated with drugs. But there are considerable side effects, and these drugs are often abused. There are several psychological therapies for anxiety. But, about 45% of the patients treated do not respond to the therapy. So, there is a need to develop alternative treatments. So, there is a need to develop alternative treatments. Recently, it has been found that mindfulness training can be effective for anxiety disorders. There has developed a considerable volume of research on the effectiveness of mindfulness-based therapies for anxiety disorders. So, it is reasonable to summarize what has been learned.

 

In today’s Research News article “A systematic review and meta-analysis of acceptance- and mindfulness-based interventions for DSM-5 anxiety disorders.” (See summary below or view the full text of the study at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8516851/ ) Haller and colleagues review, summarize, and perform a meta-analysis on the published research on the effectiveness of mindfulness-based therapies for anxiety disorders. They identified 23 randomized controlled trials including a total of 1815 patients with anxiety disorders; Generalized Anxiety Disorder, Social Anxiety Disorder, and mixed anxiety diagnoses. Twelve studies employed Acceptance and Commitment Therapy (ACT), 3 ones Mindfulness-Based Cognitive Therapy (MBCT), and 8 ones Mindfulness-Based Stress Reduction (MBSR).

 

They report that the published research studies found that Acceptance and Commitment Therapy (ACT), Mindfulness-Based Cognitive Therapy (MBCT), and Mindfulness-Based Stress Reduction (MBSR) in comparison to treatment as usual produced significant reduction in anxiety either based on clinician or patient reports and also depression in these patients. ACT appeared to have superior effects, followed by MBCT, and lastly MBSR. These effects, however, were no longer significant at follow up 6- and 12-months after the interventions.

 

This analysis of the published research suggests that mindfulness-based therapies are effective in relieving anxiety and depression in patients with anxiety disorders. But they appear to be only effective over the short term. More work needs to be done to optimize the effectiveness of these therapies and to identify how to make the effects longer lasting.

 

So, improve anxiety disorders with mindfulness.

 

“Mindfulness counters the overthinking and hypervigilance of anxiety. When we’re anxious, our minds are full of ruminations about the past and worries about the future, and the more anxiety pulls us away from the present moment, the more stressed and unhappy we are.  . . mindfulness offers a break from the worries and fears of anxiety.” – Tanya Peterson

 

CMCS – Center for Mindfulness and Contemplative Studies

 

This and other Contemplative Studies posts are available on Twitter @MindfulResearch

 

Study Summary

 

Haller, H., Breilmann, P., Schröter, M., Dobos, G., & Cramer, H. (2021). A systematic review and meta-analysis of acceptance- and mindfulness-based interventions for DSM-5 anxiety disorders. Scientific reports, 11(1), 20385. https://doi.org/10.1038/s41598-021-99882-w

 

Abstract

This meta-analysis systematically reviewed the evidence on standardized acceptance-/mindfulness-based interventions in DSM-5 anxiety disorders. Randomized controlled trials examining Acceptance and Commitment Therapy (ACT), Mindfulness-Based Cognitive Therapy (MBCT), and Mindfulness-Based Stress Reduction (MBSR) were searched via PubMed, Central, PsycInfo, and Scopus until June 2021. Standardized mean differences (SMD) and 95% confidence intervals (CI) were calculated for primary outcomes (anxiety) and secondary ones (depression and quality of life). Risk of bias was assessed using the Cochrane tool. We found 23 studies, mostly of unclear risk of bias, including 1815 adults with different DSM-5 anxiety disorders. ACT, MBCT and MBSR led to short-term effects on clinician- and patient-rated anxiety in addition to treatment as usual (TAU) versus TAU alone. In comparison to Cognitive Behavioral Therapy (CBT), ACT and MBCT showed comparable effects on both anxiety outcomes, while MBSR showed significantly lower effects. Analyses up to 6 and 12 months did not reveal significant differences compared to TAU or CBT. Effects on depression and quality of life showed similar trends. Statistical heterogeneity was moderate to considerable. Adverse events were reported insufficiently. The evidence suggests short-term anxiolytic effects of acceptance- and mindfulness-based interventions. Specific treatment effects exceeding those of placebo mechanisms remain unclear.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8516851/

Mindfulness is Associated with a Reduced Tendency to Ostracize

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Mindfulness is Associated with a Reduced Tendency to Ostracize

 

By John M. de Castro, Ph.D.

 

“adults scoring higher on trait mindfulness reported ostracizing coworkers less [and] demonstrated greater inclusion of a fellow group member being ostracized by others in the group.“ – Eric Jones

 

Humans are social animals. This is a great asset for the species as the effort of the individual is amplified by cooperation. In primitive times, this cooperation was essential for survival. But in modern times it is also essential, not for survival but rather for making a living and for the happiness of the individual. This deep need for positive social interactions heightens the pain of social rejection and ostracism. “Ostracism, or being excluded and ignored, is a detrimental experience for the target of ostracism because it harms the target’s relational needs of belonging, self-esteem, meaningful existence, and control, along with worsening the target’s mood.”

 

Mindfulness has been found to increase prosocial behaviors such as altruism, compassion and empathy and reduce antisocial behaviors such as violence and aggression. So, it is likely that mindfulness may affect the individual’s tendency to reject and ostracize others.

 

In today’s Research News article “Who Is Less Likely to Ostracize? Higher Trait Mindfulness Predicts More Inclusionary Behavior.” (See summary below or view the full text of the study at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8277536/ ) Jones and colleagues studied the relationship of mindfulness to ostracism in 3 studies. For all studies they recruited healthy adult workers online.

 

In the first study they had them complete measures of mindfulness, perceived ostracism, perceived stress, and instigation of ostracism. They found that the higher the levels of mindfulness the lower the levels of perceived ostracism, perceived stress, and instigation of ostracism. So, mindful workers are more sensitive to ostracism in the workplace and less likely to be involved in ostracism.

 

In the second study they had the participants play a simulated ball tossing game, Cyberball, where they tossed a ball to 3 other participants who were simulated did not exist other than in the program. In one condition the ball was tossed to all participants equally and in the ostracism condition one simulated participant had the ball tossed to them initially but then never again from anyone except the real participant who could toss the ball to the ostracized participant if they chose. They found that the higher the level of participant mindfulness the greater the proportion of simulated ball tosses were directed to the simulated “ostracized” participant. Neither empathy, personal distress, nor the other motives were found to mediate the effects of mindfulness.

 

In the third study they again had the participants play Cyberball with an ostracized simulated participant. There were 2 conditions in that the participants were either instructed at the beginning to pay attention to the other players or did not receive the attention instruction. They found that the attention instruction increased the percentage of tosses directed to the simulated “ostracized” participant. In the attention instruction condition the effects of mindfulness disappeared.

 

The results suggest that high trait mindfulness is associated with less ostracizing of others in their work environments. The simulated ball tossing results suggested that mindfulness is also associated with lower ostracizing in artificial simulated conditions. But when an attention instruction is included the association with mindfulness goes away. This suggests that mindfulness results in a participant paying more attention to others around them and this produces a lowered tendency to ostracize others.

 

Ostracism is extremely harmful to individuals. So, methods to reduce ostracism are socially important. The results suggest that mindfulness may be an effective tool in countering ostracism by making individuals more attentive to others. It remains for future research to determine if training in mindfulness can reduce ostracism.

 

So, mindfulness is associated with a reduced tendency to ostracize.

 

“dispositional mindfulness predicted greater empathic concern for, and more helping behavior toward, an ostracized stranger [and] also promoted prosocial responsiveness to an ostracized stranger.“ – Daniel Berry

 

CMCS – Center for Mindfulness and Contemplative Studies

 

This and other Contemplative Studies posts are also available on Twitter @MindfulResearch

 

Study Summary

 

Jones, E. E., Wirth, J. H., Ramsey, A. T., & Wynsma, R. L. (2019). Who Is Less Likely to Ostracize? Higher Trait Mindfulness Predicts More Inclusionary Behavior. Personality & social psychology bulletin, 45(1), 105–119. https://doi.org/10.1177/0146167218780698

 

Abstract

Despite the pain ostracism (being excluded and ignored) causes, researchers have minimally investigated factors related to reducing its occurrence. We investigated the association between higher trait mindfulness (the tendency to be attentive to the present moment) and lower engagement in ostracism. In Study 1, employed adults scoring higher on trait mindfulness reported ostracizing coworkers less. In Study 2, participants possessing higher levels of trait mindfulness demonstrated greater inclusion of a fellow group member being ostracized by others in the group. Results suggested that attention, rather than empathy, was the psychological process responsible for greater inclusion of an ostracized group member by mindful individuals. Study 3 supported this conclusion, because participants responded similarly to those high in trait mindfulness when they were instructed to pay attention and ensure all players were included equally. Overall, we found that people with higher levels of trait mindfulness are more attentive to targets of ostracism.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8277536/

 

Improve Teachers’ Physiological and Psychological Well-Being with Mindfulness

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Improve Teachers’ Physiological and Psychological Well-Being with Mindfulness

 

By John M. de Castro, Ph.D.

 

“Mindfulness-based training can effectively reduce stress and burnout as well as symptoms of anxiety and depression at follow-up; it also shows promise in improving emotional regulation among teachers.” – Xiaolan Song

 

Stress is epidemic in the workplace with almost two thirds of workers reporting high levels of stress at work. This often produces burnout; fatigue, cynicism, emotional exhaustion, and professional inefficacy. In a school setting, this burnout and exhaustion not only affects teachers personally, but also the students and schools, as it produces a loss of enthusiasm, empathy, and compassion. Hence, there is a need to identify methods of reducing stress and improving teachers’ psychological health. Mindfulness has been demonstrated to be helpful in reducing the psychological and physiological responses to stress and for treating and preventing burnout. This suggests that mindfulness would improve the psychological and physiological well-being of teachers,

 

In today’s Research News article “Mindfulness meditation training effects on quality of life, immune function and glutathione metabolism in service healthy female teachers: A randomized pilot clinical trial.” (See summary below or view the full text of the study at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8566766/ ) Rodrigues de Oliveira and colleagues recruited healthy teachers and randomly assigned them to receive 8 weekly 2-hour sessions of either mindfulness training or lectures on applied neuroscience for educators. Mindfulness training included “mindful breathing, compassionate communication, loving-kindness, self-compassion, mindful listening, dealing with difficulties, the 3 step meditation, walking meditation, body scan with progressive relaxation, thoughts, emotions, gratitude, sounds and breathing” and home practice. The teachers were measured before and after training and 12 months later for quality of life, perceived stress, resilience, and positive and negative emotions. In addition, blood was drawn and assayed for cytokine levels, homocysteine, cysteine, and glutathione.

 

They found that in comparison to baseline and the lecture group, the group that received mindfulness training had significantly greater increases in physical, psychological, social, and environmental quality of life, resilience, positive emotions, cysteine, and glutathione and a significantly greater decrease in perceived stress, negative emotions, and the cytokines of IL-6 and IL-8.

 

These results suggest that mindfulness training improves teacher’s quality of life, and psychological well-being. Physically, it also reduced markers of inflammation and improved antioxidant systems. This suggests that mindfulness training makes teachers healthier and happier. Although not measures, this surely will help to reduce the likelihood of burnout and improve the quality of the teacher’s work in the classroom.

 

So, improve teachers’ physiological and psychological well-being with mindfulness.

 

“Teachers can use mindfulness as a resource to self-regulate emotions resulting from job stress, thereby increasing their ability to focus on the students and their performances in the classrooms.” – Kelsey Milne

 

CMCS – Center for Mindfulness and Contemplative Studies

 

This and other Contemplative Studies posts are available on Twitter @MindfulResearch

 

Study Summary

 

Rodrigues de Oliveira, D., Wilson, D., Palace-Berl, F., de Mello Ponteciano, B., Fungaro Rissatti, L., Sardela de Miranda, F., Piassa Pollizi, V., Fuscella, J. C., Mourão Terzi, A., Lepique, A. P., D’Almeida, V., & Demarzo, M. (2021). Mindfulness meditation training effects on quality of life, immune function and glutathione metabolism in service healthy female teachers: A randomized pilot clinical trial. Brain, behavior, & immunity – health, 18, 100372. https://doi.org/10.1016/j.bbih.2021.100372

 

Abstract

Background

Despite the crucial role of educators in encourage students’ academic learning, addressing educator stress inside the classroom remains a significant challenge in the educational context. Mindfulness Meditation training (MM) has been recommended as an environmental enrichment strategy in schools to help teachers cope with stress and cultivating a state of awareness in daily life. Although studies have shown that MM can improve immune system dynamics the biological mechanism underlying glutathione metabolism in a healthy human is unclear

Objective

The purpose of this study was to determine whether MM training benefits psychological and behavioral response, immunological functions and glutathione metabolism in service healthy female teachers from public schools

Methods

We randomly assigned 76 teachers to an 8-week Mindfulness-Based Health Program for Educators (MBHPEduca) or Neuroscience for Education program (Neuro-Educa; active control group). Using the quality of life as our primary outcome, perceived stress, negative affectivity, and resilience as our secondary outcome, and pro-inflammatory cytokines and glutathione levels as our third outcome at baseline and post-intervention that occurred in public schools. Blood samples were collected for the measurement of three proinflammatory markers, including interleukin-1β (IL-1β), interleukin-6 (IL-6), and interleukin-8 (IL-8) and three GSH metabolism, including Cysteine (Cys), Homocysteine (HCys) and GSH were conducted at pre-and post-intervention, with selfreported assessments over time. Treatment effects were analyzed using generalized estimating equations (GEE) with to intention to treat

Results

We observed statistically significant improvements to the MBHP-Educa group compared to active control in perceived stress, resilience, positive and negative affect, and quality of life after 8-weeks MM (p ​< ​0.0001). Further, the MBHP-Educa group exhibited lower circulating IL-6 production accompanied by high circulating GSH, and Cys (p ​< ​0.0001). Additional analyses indicated that enhancing quality of life through mindfulness meditation training was mediated by reducing perceived stress and serum levels of IL- 6 and increasing resilience and teachers ‘plasma GSH levels

Conclusions

The present study is a pilot trial with low-power and provides preliminary evidence that mindfulness meditation training help teachers to cope with stress in the school environment with an impact on the quality of life, immune function, and glutathione metabolism.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8566766/

 

Increase Physiological and Psychological Activation and Calmness with Qigong

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Increase Physiological and Psychological Activation and Calmness with Qigong

 

By John M. de Castro, Ph.D.

 

“regular [qigong] practice may help improve your balance, ease stress and anxiety, sharpen focus, and reduce your risk of chronic disease.” – Saundra Montijo

 

Qigong has been practiced for thousands of years with benefits for health and longevity. Qigong training is designed to enhance function and regulate the activities of the body through regulated breathing, mindful concentration, and gentle movements. Only recently though have the effects of these practices been scrutinized with empirical research. This research has found that they are effective for an array of physical and psychological issues.

 

In today’s Research News article “Relaxation or Regulation: The Acute Effect of Mind-Body Exercise on Heart Rate Variability and Subjective State in Experienced Qi Gong Practitioners.” (See summary below or view the full text of the study at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8208883/ ) Goldbeck and colleagues recruited experienced adult Qigong practitioners and measured their heat rate variability with the electrocardiogram (ECG) while at rest, during 2 10-minute sessions of qigong practice, and at rest again. Before and after the practices they completed measures of vitality, calmness, deep relaxation, meditative focus, and heightened body awareness.

 

They found that after the 10-minute qigong practices there were significant increases in vitality, calmness, pleasant body sensation, focused attention, body awareness, and perceived body activation. In addition, during the qigong sessions there was a significant decrease in heart rate variability. A decrease in heart rate variability is indicative of increased physiological activation (sympathetic nervous system activation).

 

The results are interesting and suggest that experienced qigong practitioners experience increases in both psychological and physiological activation in association with feelings of calmness during engagement in the practice. The physiological arousal is suggestive of the aerobic exercise component of qigong. It is interesting that calmness increased in synchrony with increased vitality and perceived body activation. This is suggestive of a state of “eutonic calmness” wherein activity is associated with pleasant calm feelings which has been postulated to be characteristic of mind-body exercises.

 

So, increase physiological and psychological activation and calmness with qigong.

 

“a little bit of regular practice, Qigong can have a powerful effect on mind, body and spirit. Reported benefits have included increased general health and well being, reduced levels of stress, and a brighter and more balanced outlook on life’s possibilities.” – Mei Quan

 

CMCS – Center for Mindfulness and Contemplative Studies

 

This and other Contemplative Studies posts are available on Twitter @MindfulResearch

 

Study Summary

 

Goldbeck, F., Xie, Y. L., Hautzinger, M., Fallgatter, A. J., Sudeck, G., & Ehlis, A. C. (2021). Relaxation or Regulation: The Acute Effect of Mind-Body Exercise on Heart Rate Variability and Subjective State in Experienced Qi Gong Practitioners. Evidence-based complementary and alternative medicine : eCAM, 2021, 6673190. https://doi.org/10.1155/2021/6673190

 

Abstract

Mind-body exercises such as Yoga or Qi Gong have demonstrated a wide range of health benefits and hold great promise for employment in clinical practice. However, the psychophysiological mechanism underlying these effects remains unclear. Theoretical frameworks highlight regulation as a characteristic and specific mechanism of mind-body exercise for which empirical evidence is scarce. To investigate the exact nature of this mechanism, we tracked acute changes in autonomic nervous system (ANS) activity and subjective state over a common form of mind-body exercise (Qi Gong). Heart rate variability (HRV) and subjective state were assessed in 42 Qi Gong practitioners from China and Germany during a standard moving Qi Gong exercise (Baduanjin). Relaxation in supine position prior and after the exercise served as a control condition to Qi Gong and to assess changes before and after the exercise. Following Qi Gong, all practitioners reported significantly increased subjective calmness and perceived body activation, attentional focus, and subjective vitality. On the physiological level, a significant decrease of parasympathetic modulation and increase in heart rate indicated a pattern of moderate general physiological activation during Qi Gong. A significant increase in overall RR-interval modulation and cardiac coherence during Qi Gong were indicative of a mechanism of active regulation. Examination of the RR-interval trajectories revealed a rhythmic pattern of ANS activation and deactivation in sync with activating and relaxing segments of the exercise. Significant changes in subjective state, not on the physiological level, before and after the exercise were observed. Significant associations between Qi-Gong-specific beliefs, age, cultural background, and experiential and physiological measures demonstrated the complexity of mind-body exercises as multicomponent interventions. Overall, this study highlights moderate general physiological activation, exercise-dependent rhythmic ANS modulation, and induction of a characteristic state of eutonic calmness as potential psychophysiological mechanisms underlying the health benefits of mind-body exercise.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8208883/

 

Improve the Psychological Well-Being of Parents of Children with Autism Spectrum Disorder with Mindfulness

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Improve the Psychological Well-Being of Parents of Children with Autism Spectrum Disorder with Mindfulness

 

By John M. de Castro, Ph.D.

 

“mindfulness instruction may help to ease the stress of parenting young children with autism.” – B. Grace Bullock

 

Providing care for children with autism spectrum disorder (ASD) can be particularly challenging. These children’s behavior is characterized, in varying degrees, by difficulties in social interaction, verbal and nonverbal communication and repetitive behaviors. These make it difficult to relate to the child and receive the kind of positive feelings that often help to support caregiving. The challenges of caring for a child with ASD require that the parent be able to deal with stress, to regulate their own emotions, and to be sensitive and attentive to their child. These skills are exactly those that are developed in mindfulness training. It improves the psychological and physiological responses to stress. It improves emotion regulation. And it improves the ability to maintain attention and focus in the face of high levels of distraction.

 

A therapeutic technique that contains mindfulness training and Cognitive Behavioral Therapy (CBT) is Acceptance and Commitment Therapy (ACT). It focuses on the individual’s thoughts, feelings, and behavior and how they interact to impact their psychological and physical well-being. It then works to change thinking to alter the interaction and produce greater life satisfaction. ACT employs mindfulness practices to increase awareness and develop an attitude of acceptance and compassion in the presence of painful thoughts and feelings. ACT teaches individuals to “just notice”, accept and embrace private experiences and focus on behavioral responses that produce more desirable outcomes. It is not known whether ACT can improve the psychological well-being of parents of children with autism spectrum disorder. 

 

In today’s Research News article “The Effect of Acceptance and Commitment Therapy for Improving Psychological Well-Being in Parents of Individuals with Autism Spectrum Disorders: A Randomized Controlled Trial.” (See summary below or view the full text of the study at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7892587/ ) Marino and colleagues recruited families with children between the ages of 4-10 and diagnosed with autism spectrum disorder and randomly assigned them to receive 24 weekly 90-minute sessions of either Acceptance and Commitment Therapy (ACT) or positive parent training to teach behavioral management skills to the children. The parents were measured before and after training for psychological flexibility, their emotions, the severity of disruptive and non-compliant behaviors in the children, behavior congruent with values, mindfulness, parental distress, parent-child dysfunction, and difficult child measures.

 

They found that in comparison to baseline and the positive parent training group, the group that received either Acceptance and Commitment Therapy (ACT) had significantly greater improvements in psychological flexibility, their emotions, the severity of disruptive and non-compliant behaviors in the children, behavior congruent with values, mindfulness, and parental distress.

 

The results are exciting particularly because of the strength of the research design. The control condition was an alternative therapy that met similarly over a similar period of time. This controls for most sources of research confounding which greatly improves the strength of the conclusions. These results suggest that Acceptance and Commitment Therapy (ACT) is a safe and effective treatment for parents of children with autism spectrum disorder improving the parent’s psychological well-being and also the children’s’ behavior.. One of the key differences between ACT and positive parent training is the training in mindfulness. This suggests that mindfulness may be the key training for the benefits to the parents.

 

So, improve the psychological well-being of parents of children with autism spectrum disorder with mindfulness.

 

“mindfulness means that parents are developing more compassion for themselves instead of feeling like it’s the end of the world when they do yell. Instead, they can mindfully reflect, repair if needed, and try again.” Katy Oberle

 

CMCS – Center for Mindfulness and Contemplative Studies

 

This and other Contemplative Studies posts are also available on Twitter @MindfulResearch

 

Study Summary

 

Marino, F., Failla, C., Chilà, P., Minutoli, R., Puglisi, A., Arnao, A. A., Pignolo, L., Presti, G., Pergolizzi, F., Moderato, P., Tartarisco, G., Ruta, L., Vagni, D., Cerasa, A., & Pioggia, G. (2021). The Effect of Acceptance and Commitment Therapy for Improving Psychological Well-Being in Parents of Individuals with Autism Spectrum Disorders: A Randomized Controlled Trial. Brain sciences, 11(7), 880. https://doi.org/10.3390/brainsci11070880

 

Abstract

Background: Acceptance and Commitment Therapy (ACT) has been demonstrated as effective in improving psychological well-being in several clinical domains, but there is no evidence regarding the parents of children with Autism Spectrum Disorder (ASD). Methods: In this randomized controlled trial, we evaluated the efficacy of the ACT matrix behavioral protocol in comparison to the Parent Training (PT) program, measuring several primary and secondary outcomes prior to and following treatments. Twelve parents were randomly and equally assigned to two demographically matched groups wherein individuals underwent 24 weekly meetings of ACT protocol (experimental group) or conventional PT (control group). Results: Parents enrolled in the ACT protocol demonstrated significant improvement in psychological flexibility, awareness states, personal values in everyday life, and parental stress, whereas reduced scores were elicited in parents’ perceptions of their child’s disruptive behaviors. Conclusions: The results of this randomized controlled trial, if repeated with a large number of subjects, could open the way to include ACT protocols in daily practice to support the development of new parenting skills.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8301771/

 

Improve Neuropsychological Disorders with Yoga

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Improve Neuropsychological Disorders with Yoga

 

By John M. de Castro, Ph.D.

 

“yoga might be considered as an effective adjuvant for the patients with various neurological disorders including stroke, Parkinson’s disease, multiple sclerosis, epilepsy, Alzheimer’s disease, dementia, headache, myelopathy, neuropathies.” – A.Mooventhan

 

Mindfulness training and yoga practices have been shown to improve health and well-being in healthy individuals. They have also been found to be effective for a large array of medical and psychiatric conditions, either stand-alone or in combination with more traditional therapies. There has accumulated a large amount of research on the effectiveness of yoga practice for the treatment of a variety of physical and mental issues. Hence, it would be useful to summarize what has been learned.

 

In today’s Research News article “Therapeutic role of yoga in neuropsychological disorders.” (See summary below or view the full text of the study at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8546763/ ) Nourollahimoghadam and colleagues review and summarize the published research regarding the effectiveness of yoga practice for the treatment of a variety of neuropsychological disorders.

 

They report that the published research found that yoga practice produced significant improvements in physical illnesses including migraine headaches, Alzheimer’s Disease, epilepsy, multiple sclerosis, Parkinson’s Disease, and neuropathy. Yoga practice also produced significant improvements in psychological well-being including anxiety, stress, depression, bipolar disorder, schizophrenia, somatoform disorders, obsessive-compulsive disorder, and burnout. They further report that yoga may produce its beneficial effects by altering the chemistry, electrical activity, structures, and connectivity within the brain.

 

Hence Yoga practice appears to have a myriad of positive physical and psychological benefits. The authors, however, point to weaknesses in the research including small sample sizes, short-term follow-up, confounding variables, and lack of appropriate controls. So, more and better controlled studies are needed to verify the benefits of yoga practice. Hence, the present state of knowledge supports the engagement in yoga practice to advance the physical and mental well-being of both ill and healthy individuals.

 

So, improve neuropsychological disorders with yoga.

 

“Yoga can be a helpful practice of self-care for people with multiple sclerosis (MS) and other neurological conditions (such as stroke, traumatic brain injury, Parkinson’s disease, Lyme’s disease, Lou Gehrig’s disease).” – Mary Hilliker

 

CMCS – Center for Mindfulness and Contemplative Studies

 

This and other Contemplative Studies posts are also available on on Twitter @MindfulResearch

 

Study Summary

 

Nourollahimoghadam, E., Gorji, S., Gorji, A., & Khaleghi Ghadiri, M. (2021). Therapeutic role of yoga in neuropsychological disorders. World journal of psychiatry, 11(10), 754–773. https://doi.org/10.5498/wjp.v11.i10.754

 

Abstract

Yoga is considered a widely-used approach for health conservation and can be adopted as a treatment modality for a plethora of medical conditions, including neurological and psychological disorders. Hence, we reviewed relevant articles entailing various neurological and psychological disorders and gathered data on how yoga exerts positive impacts on patients with a diverse range of disorders, including its modulatory effects on brain bioelectrical activities, neurotransmitters, and synaptic plasticity. The role of yoga practice as an element of the treatment of several neuropsychological diseases was evaluated based on these findings.

Core Tip: A multitude of beneficial effects of yoga practice and the underlying mechanisms of action have been reported and point out its role as an influential element in the integrative therapy of various neuropsychological disorders. In the planning of further investigations, studies should be designed to achieve more accuracy and precision in the heterogeneous field of yoga practices and potential fields of application.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8546763/

 

Improve Worker Well-Being in Spite of Work-Life Conflicts with Mindfulness

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Improve Worker Well-Being in Spite of Work-Life Conflicts with Mindfulness

 

By John M. de Castro, Ph.D.

 

“For many busy professionals, the phrase “work-life balance” can seem like an oxymoron. In today’s world of multi-tasking and 24/7 connectivity, work can seem omnipresent and overwhelming. How can you possibly maintain your competitive edge at work while also nurturing a healthy personal life? . . . Mindfulness can bring us back into balance by acting as a bridge between work and life.” – Dorsey Standish

 

Work is very important for our health and well-being. We spend approximately 25% of our adult lives at work. Indeed, the work environment has even become an important part of our social lives, with friendships and leisure time activities often attached to the people we work with. But work-related stress is epidemic in the western workplace. Almost two thirds of workers reporting high levels of stress at work. This stress can result in impaired health and can result in burnout; producing fatigue, cynicism, and professional inefficacy. To help overcome unhappiness, stress, and burnout, mindfulness practices have been implemented in the workplace. These mindfulness practices have been shown to markedly reduce the physiological and psychological responses to stress.

 

One of the stresses produced by the modern work environments results from work conflicting with the rest of the workers’ lives harming their well-being and mental health. But there is little understanding regarding how these conflicts affect the worker and what practices might help to mitigate the effects of work-life conflicts. Mindfulness helps to prevent the harmful effects of conflicts. So, it may help to blunt the effects of work-life conflict on the individual’s well-being.

 

In today’s Research News article “When Work Conflicts With Personal Projects: The Association of Work-Life Conflict With Worker Wellbeing and the Mediating Role of Mindfulness.” (See summary below or view the full text of the study at: https://www.frontiersin.org/articles/10.3389/fpsyg.2021.539582/full?utm_source=F-AAE&utm_medium=EMLF&utm_campaign=MRK_1771688_a0P58000000G0YfEAK_Psycho_20211111_arts_A ) Pacheco and colleagues recruited adult workers and had them complete a questionnaire measuring mindfulness, positive mental health, well-being in the workplace, personality, and work-life conflict, including time-based conflict and strain-based conflict..

 

They report that the higher the levels of mindfulness the higher the levels of positive mental health and well-being in the workplace and the lower the levels of time-based conflict and strain-based conflict. They also found that the higher the levels of both time-based conflict and strain-based conflict the lower the levels of positive mental health and well-being in the workplace.

 

Using linear structural modelling to assess the interrelationships between the variables they found that both time-based conflict and strain-based conflict were associated with lower well-being in the workplace directly and also indirectly by being associated with lower mindfulness which was associated with lower well-being in the workplace. They also found that both time-based conflict and strain-based conflict were associated with lower positive mental health only indirectly by being associated with lower mindfulness which was associated with lower positive mental health.

 

These findings are correlational. So, no conclusions regarding causation can be reached. But in previous controlled research mindfulness training has been shown to improve mental health and well-being. So, the relationships with mindfulness observed here are likely due to causal connections. The findings, then, suggest that the conflicts between work and life in general are factors in lowering workers’ mental health and well-being at work. The findings further suggest that mindfulness is an important intermediary where mindfulness is a promoter of positive mental health and well-being at work, but work-life conflicts reduce mindfulness. Future research should attempt to train mindfulness to observe whether it can mitigate the negative effects of work-life conflicts.

 

So, improve worker well-being in spite of work-life conflicts with mindfulness.

 

“[mindfulness] is effective for encouraging work–life balance and improve well-being.” – Sarah Elena Althammer

 

CMCS – Center for Mindfulness and Contemplative Studies

 

This and other Contemplative Studies posts are also available on Twitter @MindfulResearch

 

Study Summary

 

Pacheco T, Coulombe S and Meunier S (2021) When Work Conflicts With Personal Projects: The Association of Work-Life Conflict With Worker Wellbeing and the Mediating Role of Mindfulness. Front. Psychol. 12:539582. doi: 10.3389/fpsyg.2021.539582

 

The negative emotional and health effects of work-life conflict (WLC) have been demonstrated in numerous studies regarding organizational psychology and occupational health. However, little is known about WLC’s relationship with positive wellbeing outcomes, including emotional, psychological, and social aspects of workers’ thriving. Furthermore, the mediating processes underlying the effects of WLC remain mostly unknown. The current study investigated the associations of perceived time- and strain-based WLC with positive mental health and thriving at work, as well as the mediating role of mindfulness in these associations. It is argued that WLC causes reduced mindfulness capacities among workers, which is in turn associated with lower positive wellbeing given the importance of mindfulness in emotion regulation. A sample of 330 workers based in Québec, Canada, completed an online survey including a measure of strain- and time-based interference with personal projects (i.e., the goals and activities that define the daily life of an individual) and validated scales of wellbeing outcomes and mindfulness. Results of structural equation modeling revealed negative associations between time- and strain-based WLC with positive mental health and thriving at work. Work-life conflict was related to lower mindfulness, which played a mediating role in the associations between time-based WLC with positive mental health and thriving at work, as well as strain-based WLC with positive mental health. The mediation was complete for the time-based WLC and positive mental health association, but partial for the other mediated pathways, highlighting the need for more research to identify additional mediators. These results highlight that beyond resulting in negative emotional/health outcomes often studied in previous research, WLC may be associated with workers’ reduced potential to live a fulfilling life, in general and in the workplace. Recommendations (e.g., mindfulness intervention to promote emotional regulation, personal project intervention) for workplace policymakers and practitioners are identified.

https://www.frontiersin.org/articles/10.3389/fpsyg.2021.539582/full?utm_source=F-AAE&utm_medium=EMLF&utm_campaign=MRK_1771688_a0P58000000G0YfEAK_Psycho_20211111_arts_A

 

Psychedelic Drug Experiences Produce Long-Term Improvements in Psychological Well-Being

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Psychedelic Drug Experiences Produce Long-Term Improvements in Psychological Well-Being

 

By John M. de Castro, Ph.D.

 

“Awe may be a critically important emotional experience during psychedelic treatment in generating compassion, empathy, and overall well-being” – Eve Ekman

 

Psychedelic substances such as peyote, mescaline, LSD, Bufotoxin, ayahuasca and psilocybin have been used almost since the beginning of recorded history to alter consciousness and produce spiritually meaningful experiences. People find these experiences extremely pleasant. eye opening, and even transformative. They often report that the experiences changed them forever. Psychedelics have also been found to be clinically useful as they markedly improve mood, increase energy and enthusiasm and greatly improve clinical depression. Even though the effects of psychedelic substances have been experienced and reported on for centuries, only very recently have these effects come under rigorous scientific scrutiny.

 

In today’s Research News article “Sustained, Multifaceted Improvements in Mental Well-Being Following Psychedelic Experiences in a Prospective Opportunity Sample.” (See summary below or view the full text of the study at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8277190/ ) Mans and colleagues recruited adults who were planning on having a psychedelic experience and had them complete a questionnaire before and after the experience and 2 weeks, 4 weeks, and 2 years after measuring well-being, depression, self-esteem, life orientation, emotional stability, meaning in life, acceptance, resilience, mindfulness, social connectedness, gratitude, spiritual transcendence, Spiritual and Religious Attitudes in Dealing with Illness, trust, and compassion and after the experience only Challenging Experience Questionnaire (CEQ), the Mystical Experience Questionnaire (MEQ), and the Emotional Breakthrough.

 

They found that in comparison to baseline after the psychedelic experiences there were significant improvements in all measures except spirituality that were maintained over follow-up. Factor analysis revealed three clusters of measures labelled as being well, staying well, and spirituality. They found that after the psychedelic experiences there were large significant improvements in being and staying well that were still present 2 years later.

 

It should be noted that there wasn’t a comparison, control, condition present and that the participants self-selected to engage in psychedelic experiences. Hence, a myriad of confounding alternative explanations for the findings abound, particularly participant expectancy effects (placebo effects). So, great caution must be exercised in drawing conclusions regarding the effects of psychedelic drugs. But placebo effects are generally transitory and don’t last over substantial periods of time and the present improvements lasted for at least 2 years, making it unlikely that confounding variable explanations are viable.

 

It is interesting that spirituality was not affected as psychedelic drugs have been employed throughout history as a part of spiritual development. It is possible that the context of spiritual ceremony is essential for the effects of psychedelic drugs being interpreted as spiritual effects.

 

The results of the present study suggest that people who engage in psychedelic experiences have profound improvements in their well-being that are sustained for at least 2 years. The magnitude and duration of the effects may explain why psychedelics have such profound effects on people with mental illnesses producing relief of symptoms and appear to be safe and effective treatments for mental illnesses.

 

So, psychedelic drug experiences produce long-term improvements in psychological well-being.

 

“use of psychedelic substances in a naturalistic setting is associated with experiences of personal transformation, a sense of altered moral values, increased feelings of social connectedness, and a more positive mood.” – Matthias Forstmann

CMCS – Center for Mindfulness and Contemplative Studies

 

This and other Contemplative Studies posts are also available on Google+ https://plus.google.com/106784388191201299496/posts and on Twitter @MindfulResearch

 

Study Summary

 

Mans, K., Kettner, H., Erritzoe, D., Haijen, E., Kaelen, M., & Carhart-Harris, R. L. (2021). Sustained, Multifaceted Improvements in Mental Well-Being Following Psychedelic Experiences in a Prospective Opportunity Sample. Frontiers in psychiatry, 12, 647909. https://doi.org/10.3389/fpsyt.2021.647909

 

Abstract

In the last 15 years, psychedelic substances, such as LSD and psilocybin, have regained legitimacy in clinical research. In the general population as well as across various psychiatric populations, mental well-being has been found to significantly improve after a psychedelic experience. Mental well-being has large socioeconomic relevance, but it is a complex, multifaceted construct. In this naturalistic observational study, a comprehensive approach was taken to assessing well-being before and after a taking a psychedelic compound to induce a “psychedelic experience.” Fourteen measures of well-being related constructs were included in order to examine the breadth and specificity of change in well-being. This change was then analysed to examine clusters of measures changing together. Survey data was collected from volunteers that intended to take a psychedelic. Four key time points were analysed: 1 week before and 2 weeks, 4 weeks, and 2 years after the experience (N = 654, N = 315, N = 212, and N = 64, respectively). Change on the included measures was found to cluster into three factors which we labelled: 1) “Being well”, 2) “Staying well,” and 3) “Spirituality.” Repeated Measures Multivariate Analysis of Variance revealed all but the spirituality factor to be improved in the weeks following the psychedelic experience. Additional Mixed model analyses revealed selective increases in Being Well and Staying Well (but not Spirituality) that remained statistically significant up to 2 years post-experience, albeit with high attrition rates. Post-hoc examination suggested that attrition was not due to differential acute experiences or mental-health changes in those who dropped out vs. those who did not. These findings suggest that psychedelics can have a broad, robust and sustained positive impact on mental well-being in those that have a prior intention to use a psychedelic compound. Public policy implications are discussed.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8277190/

 

Focused Meditation Changes Brain Activity Differently Then Open Monitoring Meditation

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Focused Meditation Changes Brain Activity Differently Then Open Monitoring Meditation

 

By John M. de Castro, Ph.D.

 

“It’s like asking a sport expert ‘what does sport do to your body’. The expert would say, do you mean swimming or horse-riding? You can imagine mental training being as complex.” – Tanya

Meditation training has been shown to improve health and well-being. It has also been found to be effective for a large array of medical and psychiatric conditions. One problem with understanding meditation effects is that there are a number of different types of meditation. Classically they’ve been characterized on a continuum with the degree and type of attentional focus. In focused attention meditation, the individual practices paying attention to a single meditation object, often the breath. In open monitoring meditation, the individual opens up awareness to everything that’s being experienced including thoughts regardless of their origin.

 

One way to observe the effects of meditation techniques is to measure the effects of each technique on the brain’s activity. This can be done by recording the Magnetoencephalography (MEG). It measures the magnetic fields associate with the brain’s electrical activity. This produces a mapping of structures that are active moment to moment. Whether these different meditation types produce different patterns of activity in the brain has not been extensively studied.

 

In today’s Research News article “Mining the Mind: Linear Discriminant Analysis of MEG Source Reconstruction Time Series Supports Dynamic Changes in Deep Brain Regions During Meditation Sessions.” (See summary below or view the full text of the study at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8556220/ ) Calvetti and colleagues recruited 2 Buddhist monks who were highly experienced meditators and recorded their brain activity with Magnetoencephalography (MEG) over 6-minute periods while at rest, during focused attention meditation, and during open monitoring meditation.

 

They found that different brain area activities occurred during the two types of meditation particularly in the anterior and posterior cingulate cortex and insular cortex. They also found differences in the activities of core structures in the limbic system including the amygdala, accumbens, putamen, thalamus, and caudate.

 

That the two meditation styles produce different brain activity patterns is not surprising as they differ considerably in cognitive contents, particularly the involvement in attentional processes. The structures involved, however, are interesting as they are in general associated with emotional processing (limbic system and cortical areas) and motor movements (Caudate and Putamen). During neither meditation style are there either high emotions or motor movements. So, there is no clear reason why these structures should differ between focused attention meditation and open monitoring meditation. It should be kept in mind that the participants are unusual in the amount of practice and the number of years of practice and do not represent the general meditation population.

 

It is clear, however, that focused meditation changes brain activity differently than open monitoring meditation in highly experienced meditators.

 

“Many meditation techniques are available today. Contrary to common belief there are distinct differences between techniques, such as the effort involved, their impact on the brain, and whether or not they result in verifiable benefits.” – Transcendental Meditation

 

CMCS – Center for Mindfulness and Contemplative Studies

 

This and other Contemplative Studies posts are also available on Google+ https://plus.google.com/106784388191201299496/posts and on Twitter @MindfulResearch

 

Study Summary

 

Calvetti, D., Johnson, B., Pascarella, A., Pitolli, F., Somersalo, E., & Vantaggi, B. (2021). Mining the Mind: Linear Discriminant Analysis of MEG Source Reconstruction Time Series Supports Dynamic Changes in Deep Brain Regions During Meditation Sessions. Brain topography, 34(6), 840–862. https://doi.org/10.1007/s10548-021-00874-w

 

Abstract

Meditation practices have been claimed to have a positive effect on the regulation of mood and emotions for quite some time by practitioners, and in recent times there has been a sustained effort to provide a more precise description of the influence of meditation on the human brain. Longitudinal studies have reported morphological changes in cortical thickness and volume in selected brain regions due to meditation practice, which is interpreted as an evidence its effectiveness beyond the subjective self reporting. Using magnetoencephalography (MEG) or electroencephalography to quantify the changes in brain activity during meditation practice represents a challenge, as no clear hypothesis about the spatial or temporal pattern of such changes is available to date. In this article we consider MEG data collected during meditation sessions of experienced Buddhist monks practicing focused attention (Samatha) and open monitoring (Vipassana) meditation, contrasted by resting state with eyes closed. The MEG data are first mapped to time series of brain activity averaged over brain regions corresponding to a standard Destrieux brain atlas. Next, by bootstrapping and spectral analysis, the data are mapped to matrices representing random samples of power spectral densities in α, β, γ, and θ frequency bands. We use linear discriminant analysis to demonstrate that the samples corresponding to different meditative or resting states contain enough fingerprints of the brain state to allow a separation between different states, and we identify the brain regions that appear to contribute to the separation. Our findings suggest that the cingulate cortex, insular cortex and some of the internal structures, most notably the accumbens, the caudate and the putamen nuclei, the thalamus and the amygdalae stand out as separating regions, which seems to correlate well with earlier findings based on longitudinal studies.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8556220/