Heart Rate Variability

Lower Opioid Cravings are Associated with Lower Depression, Higher Self-Regulation, and Higher Mindfulness

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Lower Opioid Cravings are Associated with Lower Depression, Higher Self-Regulation, and Higher Mindfulness

 

By John M. de Castro, Ph.D.

 

“mindfulness-based interventions could help people dependent on opioids increase their self-awareness and self-control over cravings and be less reactive to emotional and physical pain.” – Science Daily

 

Substance abuse and addiction is a terrible problem, especially opioid pain relievers. Opioid addiction has become epidemic and is rapidly increasing affecting more than 2 million Americans and an estimated 15 million people worldwide. In the U.S more than 20,000 deaths yearly were attributed to an overdose of prescription opioids, and another 13,000 deaths from heroin overdose. These statistics, although startling are only the tip of the iceberg. Drug use is associated with suicide, homicide, motor-vehicle injury, HIV infection, pneumonia, violence, mental illness, and hepatitis. It can render the individual ineffective at work, it tears apart families, it makes the individual dangerous both driving and not.

 

An effective treatment for addiction has been elusive. Most programs and therapies to treat addictions have poor success rates. Recent research is indicating that mindfulness has been found to be effective in treating addictions. One way that mindfulness may produce these benefits is by reducing cravings for opioids. It may also do so by affecting the ability of the addict to regulate their emotions. Indeed, mindfulness has been shown to improve emotional regulation.

 

In today’s Research News article “Autonomic and affective mediators of the relationship between mindfulness and opioid craving among chronic pain patients. Experimental and clinical psychopharmacology.” (See summary below or view the full text of the study at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355352/), Baker and Garland recruited non-cancer chronic pain patients who were taking opioid analgesics and had them complete self-report measures of mindfulness, opioid craving, and depression. They also measured their heart rates with an electrocardiogram (ECG) while looking at either neutral pictures or “opioid-related image (e.g., pills, pill bottles).” These data were analyzed to determine heart rate variability as a measure of the activity of the peripheral autonomic nervous system.

 

They found that the higher the levels of mindfulness the higher the levels of heart rate variability while looking at opioid-related pictures. And the lower the levels of depression and opioid cravings. Also, the higher the levels of depression, the higher the levels of opioid cravings. Employing a multivariate path analysis, they found that mindfulness was not associated with lower opioid cravings directly, but indirectly via mindfulness’ associations with heart rate variability and depression. That is, they found that mindfulness was associated with higher heart rate variability which was in turn associated with lower opioid cravings and also with lower depression which was in turn associated with lower opioid cravings.

 

Heart rate variability is thought to measure the nervous systems adjustments to the physiology involved in regulating its physical responses to stimuli. In other words, it’s a measure of self-regulation. The present results suggest that mindfulness is associated with greater self-regulation and this is associated with lower cravings for opioids. The results also suggest that depression is associated with higher cravings for opioids and that mindfulness interrupts this by being associated with lower depression.

 

These results are correlative and as such causation cannot be determined. Nevertheless, prior research has demonstrated causal links between mindfulness and lower cravings and depression. So, the present results likely result from causal connections. The findings also suggest the mechanism whereby mindfulness may lower cravings by contributing to the ability to regulate physical responses to opioid-related stimuli and by reducing depression. These results provide more support for the use of mindfulness training as a treatment for addictions.

 

So, lower opioid cravings are associated with lower depression, higher self-regulation, and higher mindfulness.

 

“people suffering from opioid addiction and chronic pain may have fewer cravings and less pain when adding mindfulness to the traditional methadone treatment.” – Grace Bullock

 

CMCS – Center for Mindfulness and Contemplative Studies

 

This and other Contemplative Studies posts are also available on Google+ https://plus.google.com/106784388191201299496/posts and on Twitter @MindfulResearch

 

Study Summary

 

Baker, A. K., & Garland, E. L. (2019). Autonomic and affective mediators of the relationship between mindfulness and opioid craving among chronic pain patients. Experimental and clinical psychopharmacology, 27(1), 55–63. https://doi.org/10.1037/pha0000225

 

Abstract

Prescription opioid misuse among chronic pain patients is associated with self-regulatory deficits, affective distress and opioid cue reactivity. Dispositional mindfulness has been associated with enhanced self-regulation, lower distress, and adaptive autonomic responses following drug cue exposure. We hypothesized that dispositional mindfulness might serve as a protective factor among opioid-treated chronic pain patients. We examined heart rate variability (HRV) during exposure to opioid cues and depressed mood as mediators of the association between dispositional mindfulness and opioid craving. Data were obtained from a sample of chronic pain patients (N=115) receiving long-term opioid pharmacotherapy. Participants self-reported opioid craving and depression, and HRV was measured during an opioid-cue dot probe task. Dispositional mindfulness was significantly positively correlated with HRV, and HRV was significantly inversely associated with opioid craving. Dispositional mindfulness was significantly negatively correlated with depression, and depression was significantly positively correlated with opioid craving. Path analysis revealed significant indirect effects of dispositional mindfulness on craving through both HRV and depression. Dispositional mindfulness may buffer against opioid craving among chronic pain patients prescribed opioids; this buffering effect may be a function of improved autonomic and affective responses.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355352/

 

Improve Autonomic Nervous System Function with Yogic Breathing

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Improve Autonomic Nervous System Function with Yogic Breathing

 

By John M. de Castro, Ph.D.

 

“The Bhramari pranayama breathing practice . . . .. is beneficial and instantly calming down the mind. It is one of the best breathing exercises to free the mind of distress, anxiety, or frustration and get rid of anger to a great level.” – Alpesh Jain

 

Breathing is essential for life and generally occurs automatically. It’s easy to take for granted as it’s been there our entire lives. Nevertheless, we become more aware of it when it varies with circumstances, such as when we exercise and also in emotional states, especially fear and anxiety. But we rarely notice it during everyday ongoing life. Yet, its characteristics are associated with our state of well-being. Slow deep breathing is characteristic of a healthy relaxed state. Breathing exercises are common in yoga practices and have been found to have a number of beneficial effects. Bhramari pranayama (Bee breathing) is a yogic breathing practice that adopts simple regulation of voluntary breathing involving an exhalation that simulates the typical humming sound of a bee.

 

Adolescence is a time of mental, physical, social, and emotional growth. It is during this time that higher levels of thinking, sometimes called executive function, develops. But adolescence can be a difficult time, fraught with challenges. During this time the child transitions to young adulthood; including the development of intellectual, psychological, physical, and social abilities and characteristics. There are so many changes occurring during this time that the child can feel overwhelmed and unable to cope with all that is required. It is not known whether training in Bhramari pranayama can be beneficial for adolescents.

 

In today’s Research News article “Effects of yoga breathing practice on heart rate variability in healthy adolescents: a randomized controlled trial.” (See summary below or view the full text of the study at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6997567/), Kuppusamy and colleagues recruited healthy adolescents, 13-18 years of age, and randomly assigned them to either Bhramari pranayama (Bee breathing) or no treatment. Yogic breathing was practiced in the morning for 30 minutes, 5 days per week for 6 months. The participants electrocardiogram (ECG) was measured at rest before and after training.

 

With the ECG they found that in comparison to baseline and the no-treatment control participants, the adolescents who practiced yogic breathing had significantly lower heart rates and significantly higher time and frequency domains of heart rate variability. Increased heart rate variability indicates greater activity of the parasympathetic division of the autonomic nervous system that is active during relaxation. Hence, the findings suggest that practicing yogic breathing improves autonomic function.

 

Increased heart rate variability is associated with lower stress and greater health and longevity and psychological well-being. Hence, increased heart rate variability in the adolescents who practiced Bhramari pranayama (Bee breathing) is an indicator of improved autonomic function that underlies greater health and well-being. This suggests that practicing yogic breathing would improve the youth’s ability to develop healthily during the turbulent times of the teen years.

 

So, improve autonomic nervous system function with yogic breathing.

 

“The noise of bhramari’s buzzing can drown out the endless mental tape loops that can fuel emotional suffering, making it a useful starting point for those whose minds are too “busy” to meditate.” – Timothy McCall

 

CMCS – Center for Mindfulness and Contemplative Studies

 

This and other Contemplative Studies posts are also available on Google+ https://plus.google.com/106784388191201299496/posts and on Twitter @MindfulResearch

 

Study Summary

 

Kuppusamy, M., Kamaldeen, D., Pitani, R., Amaldas, J., Ramasamy, P., Shanmugam, P., & Vijayakumar, V. (2020). Effects of yoga breathing practice on heart rate variability in healthy adolescents: a randomized controlled trial. Integrative medicine research, 9(1), 28–32. https://doi.org/10.1016/j.imr.2020.01.006

 

Abstract

Background

This study was conducted among healthy adolescents to assess the effects of a yoga breathing practice (Bhramari pranayama, Bhr.P) towards cardiac autonomic function using heart rate variability (HRV) parameters.

Methods

Of the 730 eligible subjects screened, 520 healthy adolescents who met the inclusion and exclusion criteria were randomly assigned to either yoga breathing group (n = 260) or control group (n = 260). The yoga breathing group practiced Bhr.P. five days a week for a duration of six months while the control group continued with their daily routine without any intervention. Outcome measures were time and frequency domain of HRV in both groups which were assessed before and after the intervention using Lead II ECG. Linear models were used in the analysis of short term HRV.

Results

After 6 months of yoga breathing, the time domain parameters of short term HRV showed significant (P < 0.05) improvement towards the parasympathetic domain. Frequency domain parameters also showed the same direction of changes. In contrast, control group subjects showed a trend towards a sympathetic domain.

Conclusion

The present study showed a positive shift in cardiac autonomic modulation towards parasympathetic predominance after 6 months of yoga breathing practice among apparently healthy adolescents.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6997567/

 

Content Free Awareness is Associated with Increased Brain Attentional Activity and Decreased Self-Awareness Activity

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Content Free Awareness is Associated with Increased Brain Attentional Activity and Decreased Self-Awareness Activity

 

By John M. de Castro, Ph.D.

 

“While scientists do not yet fully understand the true origin of consciousness, many agree that it can be measured within the brainwave patterns of the individual.” – EOC Institute

 

In meditation there occurs a number of different states of consciousness. One of the highest levels achieved is content free awareness. In this state there is nothing that the meditator is aware of other than awareness. The meditator is aware and aware of being aware, but nothing else. Changes in awareness are associated with changes in the activity of the brain which can be seen in the Electroencephalogram (EEG) and also in functional Magnetic Resonance Imaging (fMRI). But content free awareness is elusive and what activity in the brain accompanies it is unknown.

 

In today’s Research News article “Content-Free Awareness: EEG-fcMRI Correlates of Consciousness as Such in an Expert Meditator.” (See summary below or view the full text of the study at: https://www.frontiersin.org/articles/10.3389/fpsyg.2019.03064/full?utm_source=F-AAE&utm_medium=EMLF&utm_campaign=MRK_1254058_69_Psycho_20200225_arts_A), Winter and colleagues recruited an meditator with 40 years of experience and over 50,000 hours of formal meditation practice. They simultaneously recorded heart rate, respiration, and brain activity with an electroencephalogram (EEG) and functional Magnetic Resonance Imaging (fMRI) during rest, attention to external stimuli, attention to internal stimuli including memories, and during meditation in a state of content-minimized awareness. After the content free awareness “he reported that he had no awareness of any mental content or any sensory event, including the noise of the MRI scanner. Similarly, he reported having had no experience of self, time, or space of any kind whatsoever at this stage.”

 

They found that heart rate and respiration decreased over the various states reaching its lowest levels during content free awareness. They found that there was a sharp decrease in EEG alpha rhythm power and increase in theta rhythm power during content free awareness. Finally, they found a decrease in functional connectivity in the posterior default mode network and increase in the dorsal attention network during content free awareness.

 

These are interesting results but it must be kept in mind that this was from a single adept expert meditator. Nevertheless, they provide a glimpse at the state of the nervous system during the deepest mental state occurring during meditation. The default mode network is involved in mind wandering, daydreaming, and self-referential thought. The fact that the connectivity within this system was markedly reduced during content free awareness suggests that non-specific mental activity and the idea of self are greatly reduced if not eliminated. The fact that connectivity within the dorsal attentional network increased while there was no increase in the sensory areas of the brain suggests that during content free awareness there was a focused attention that was decoupled from sensory experience. Hence, the brain activity observed in this meditator markedly corresponds to the mental state achieved.

 

So, content free awareness is associated with increased brain attentional activity and decreased self-awareness activity.

 

“The higher state of consciousness is somewhere in between the waking, sleeping and dreaming states. Here, we know we “are” but we don’t know “where” we are. This knowledge that I “am,” but I don’t know “where” I am or “what” I am, is called Shiva.” – Ravi Shankar

 

CMCS – Center for Mindfulness and Contemplative Studies

 

This and other Contemplative Studies posts are also available on Google+ https://plus.google.com/106784388191201299496/posts and on Twitter @MindfulResearch

 

Study Summary

 

Winter U, LeVan P, Borghardt TL, Akin B, Wittmann M, Leyens Y and Schmidt S (2020) Content-Free Awareness: EEG-fcMRI Correlates of Consciousness as Such in an Expert Meditator. Front. Psychol. 10:3064. doi: 10.3389/fpsyg.2019.03064

 

The minimal neural correlate of the conscious state, regardless of the neural activity correlated with the ever-changing contents of experience, has still not been identified. Different attempts have been made, mainly by comparing the normal waking state to seemingly unconscious states, such as deep sleep or general anesthesia. A more direct approach would be the neuroscientific investigation of conscious states that are experienced as free of any specific phenomenal content. Here we present serendipitous data on content-free awareness (CFA) during an EEG-fMRI assessment reported by an extraordinarily qualified meditator with over 50,000 h of practice. We focused on two specific cortical networks related to external and internal awareness, i.e., the dorsal attention network (DAN) and the default mode network (DMN), to explore the neural correlates of this experience. The combination of high-resolution EEG and ultrafast fMRI enabled us to analyze the dynamic aspects of fMRI connectivity informed by EEG power analysis. The neural correlates of CFA were characterized by a sharp decrease in alpha power and an increase in theta power as well as increases in functional connectivity in the DAN and decreases in the posterior DMN. We interpret these findings as correlates of a top-down-initiated attentional state excluding external sensory stimuli and internal mentation from conscious experience. We conclude that the investigation of states of CFA could provide valuable input for new methodological and conceptual approaches in the search for the minimal neural correlate of consciousness.

https://www.frontiersin.org/articles/10.3389/fpsyg.2019.03064/full?utm_source=F-AAE&utm_medium=EMLF&utm_campaign=MRK_1254058_69_Psycho_20200225_arts_A

 

Have Consistent Physiological Responses to Differing Circumstances with Mindfulness

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Have Consistent Physiological Responses to Differing Circumstances with Mindfulness

 

By John M. de Castro, Ph.D.

 

“Heart rate variability differs from basic heart rate tracking that measures beats per minute in that it actually measures the time variance between heartbeats. With this heart rate variability, you can actually get a good picture of the resilience of the heart organ, which is a good predictor of both well-being and longevity.” – Kyle Pearce

 

In our lives we are confronted with a variety of situations and environments. In order to successfully navigate these differing situations, we must be able to adapt and self-regulate. The Autonomic Nervous System (ANS) is designed to adapt physiologically to the varying demands on us. It is composed of 2 divisions; the sympathetic division underlies activation, including increases in heart rate and blood pressure, while the parasympathetic division underlies relaxation, including decreases in heart rate and blood pressure. A measure of the balance between these systems is provided by the variability of the heart rate.

 

Heart Rate Variability (HRV) refers to the change in the time intervals between consecutive heart beats. Higher levels of HRV are indicative of flexibility in the Autonomic Nervous System and are associated with adaptability to varying environments. Mindfulness has been associated with a psychological flexibility and a greater ability to adapt appropriately to differing situations. It makes sense then to investigate the relationship of mindfulness to and Heart Rate Variability (HRV).

 

In today’s Research News article “Trait Mindfulness Is Associated With the Self-Similarity of Heart Rate Variability.” (See summary below or view the full text of the study at: https://www.frontiersin.org/articles/10.3389/fpsyg.2019.00314/full?utm_source=F-AAE&utm_medium=EMLF&utm_campaign=MRK_925884_69_Psycho_20190305_arts_A ), Sun and colleagues recruited college students and had them complete a measures of mindfulness. The students were also measured for heart rate variability (HRV) under 4 3-minute conditions, “a calming phase, a mental arithmetic task, a recovery phase, and mindfulness practice.”

 

They found that the participants level of mindfulness was not significantly associated with any direct measures of heart rate variability. Rather, mindfulness was associated with the consistency of heart rate variability between the response on different tasks. Hence, students high in mindfulness tended to have heart rate variability responses in the different phases that were very similar. In other words, heart rate variability during calming, mental arithmetic, and mindfulness practice were very consistent.

 

These results are correlational and as such conclusions about causation cannot be reached. But it can be speculated that mindfulness keeps the responses of the autonomic nervous system consistent making it easier to cope with varying circumstances. This level consistent responding may promote health and well-being. This suggests that greater focus on what is happening in the moment (mindfulness) may promote the ability to regulate one’s physiological responses and thereby to adapt to differing circumstances.

 

So, have consistent physiological responses to differing circumstances with mindfulness.

 

“Meditation is one technique that may help improve Heart Rate Variability (HRV) in both the short term and long-term. The end goal is not just to increase HRV, but it is to help the body better recover from stress related damages.” – Sam Sly

 

CMCS – Center for Mindfulness and Contemplative Studies

 

This and other Contemplative Studies posts are also available on Google+ https://plus.google.com/106784388191201299496/posts and on Twitter @MindfulResearch

 

Study Summary

 

Sun S, Hu C, Pan J, Liu C and Huang M (2019) Trait Mindfulness Is Associated With the Self-Similarity of Heart Rate Variability. Front. Psychol. 10:314. doi: 10.3389/fpsyg.2019.00314

 

Previous studies have linked trait mindfulness with better self-regulation and adaptation. Heart rate variability (HRV) is a good physiological indicator of the capacity for self-regulation and adaptation. The present study explored the relationship between trait mindfulness and HRV from the viewpoint of crosstalking between different HRV parameter pairs, which would reflect the dynamic interactions between each pair of HRV parameters in different processes. We measured the trait mindfulness of seventy-four undergraduate students and recorded nine HRV parameters during the following four consecutive experimental phases: (1) calming phase, (2) mental arithmetic task phase, (3) recovery phase, and (4) mindfulness practice phase. The relationship between trait mindfulness and HRV was explored at the following three levels: (1) the absolute level, i.e., HRV parameters in four different states, (2) the difference-change level, i.e., differences in HRV parameters between different states, and (3) the crosstalking level, i.e., self-similarity of crosstalking HRV parameter pairs. The results supported the following hypothesis: trait mindfulness, as measured by the Mindful Attention Awareness Scale (MAAS), was significantly and positively correlated with the self-similarity of crosstalking HRV parameter pairs but was not significantly correlated with the HRV parameters at the difference-change and absolute levels. These findings indicate that as trait mindfulness increases, the ability to maintain ANS function homeostasis improves.

HIGHLIGHTS

– Trait mindfulness is associated with better self-regulation and adaptation.

– Heart rate variability (HRV) is a good physiological indicator of the capacity for self-regulation and adaptation.

– Trait mindfulness is significantly correlated with self-similarity of crosstalking HRV parameter pairs but not with the HRV parameters at the difference-change or absolute levels.

https://www.frontiersin.org/articles/10.3389/fpsyg.2019.00314/full?utm_source=F-AAE&utm_medium=EMLF&utm_campaign=MRK_925884_69_Psycho_20190305_arts_A