Brain systems

Relaxation and Mindfulness Training Have Differing Psychological and Neural Effects

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Relaxation and Mindfulness Training Have Differing Psychological and Neural Effects

 

By John M. de Castro, Ph.D.

 

“this practice of nonjudgmental self-awareness is one of the most effective ways to improve mood and anxiety.” – Neda Gould

 

Mindfulness training has been shown to improve health and well-being. It has also been found to be effective for a large array of medical and psychiatric conditions, either stand-alone or in combination with more traditional therapies. As a result, mindfulness training has been called the third wave of therapies. One problem with understanding mindfulness training effects is that there are, a wide variety of mindfulness techniques and it is not known which work best for improving different conditions.

 

There are a number of different types of meditation. Many can be characterized on a continuum with the degree and type of attentional focus. In focused attention meditation, the individual practices paying attention to a single meditation object, learns to filter out distracting stimuli, including thoughts, and learns to stay focused on the present moment, filtering out thoughts centered around the past or future. In open monitoring meditation, the individual opens up awareness to everything that’s being experienced regardless of its origin. These include bodily sensations, external stimuli, and even thoughts.

 

These techniques have common properties of restful attention on the present moment, but there are large differences. These differences are likely to produce different effects on the practitioner. One way to distinguish between the effects of these different meditation techniques is to observe the effects of each technique on the brain.  In today’s Research News article “Common and Dissociable Neural Activity After Mindfulness-Based Stress Reduction and Relaxation Response Programs.” (See summary below or view the full text of the study at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5976535/ ), Sevinc and colleagues recruited adults and randomly assigned them to receive 8 weekly 2-hour group sessions with 20 minutes of daily home practice with guided recordings of either a Relaxation Response program or a Mindfulness-Based Stress Reduction (MBSR) program.

 

In the Relaxation Response program, the participants practiced a body scan with emphasis on relaxation and focused meditation on the breath in a 20-minute session. In the MBSR program the participants practiced body scan with focus on awareness of the sensations from the body for 2 weeks, yoga for 2 weeks, and open monitoring meditation for 2 weeks. The last 2 weeks the participants could chose whichever of the practices they wanted to perform. They were measured before and after training for perceived stress, mindfulness, self-compassion, rumination, and life stressors. They also underwent Magnetic Resonance Imaging (MRI) while they listened to a guided recording for the body scan from their home practices.

 

They found that both practices equivalently reduced perceived stress and increased mindfulness. But the Mindfulness-Based Stress Reduction (MBSR) program also significantly increased self-compassion and decreased rumination. Interestingly, although both practices produced increases functional connectivity between the prefrontal cortex and motor cortex, the two practices also produced different connectivities. When the body scan was practiced with emphasis on relaxation there was increased functional connectivity was with the right inferior frontal gyrus. This is an area that’s involved in behavioral inhibition. On the other hand, when the body scan was practiced with emphasis on awareness of sensations there was increased functional connectivity between the Insula and Cingulate Cortex, areas associated with sensory awareness.

 

Hence, although both practices were beneficial, the MBSR program appears to create better psychological well-being. In addition, the body scan technique used in the MBSR program, emphasizing sensory awareness, appears to increase the connectivity between brain areas that are involved in sensory awareness. On the other hand, a relaxation instruction with the body scan appears to produce increased brain systems devoted to restraining responses. Different mindfulness techniques produced different psychological and neural outcomes. Both appear to improve stress responding and mindfulness, but the MBSR program also produces better compassion for the self and less repetitive negative thinking, rumination.

 

So, there may be a place for the relaxation response program, but with these otherwise healthy adults, the Mindfulness-Based Stress Reduction (MBSR) program appears to produce superior results.

 

 “If you have unproductive worries,” you can train yourself to experience those thoughts completely differently. “You might think ‘I’m late, I might lose my job if I don’t get there on time, and it will be a disaster!’ Mindfulness teaches you to recognize, ‘Oh, there’s that thought again. I’ve been here before. But it’s just that—a thought, and not a part of my core self,’” – Elizabeth Hoge

 

CMCS – Center for Mindfulness and Contemplative Studies

 

This and other Contemplative Studies posts are also available on Google+ https://plus.google.com/106784388191201299496/posts and on Twitter @MindfulResearch

 

Study Summary

 

Sevinc, G., Hölzel, B. K., Hashmi, J., Greenberg, J., McCallister, A., Treadway, M., … Lazar, S. W. (2018). Common and Dissociable Neural Activity After Mindfulness-Based Stress Reduction and Relaxation Response Programs. Psychosomatic Medicine, 80(5), 439–451. http://doi.org/10.1097/PSY.0000000000000590

 

ABSTRACT

Objective

We investigated common and dissociable neural and psychological correlates of two widely used meditation-based stress reduction programs.

Methods

Participants were randomized to the Relaxation Response (RR; n = 18; 56% female) or the Mindfulness-Based Stress Reduction (MBSR; n = 16; 56% female) programs. Both programs use a “bodyscan” meditation; however, the RR program explicitly emphasizes physical relaxation during this practice, whereas the MBSR program emphasizes mindful awareness with no explicit relaxation instructions. After the programs, neural activity during the respective meditation was investigated using functional magnetic resonance imaging.

Results

Both programs were associated with reduced stress (for RR, from 14.1 ± 6.6 to 11.3 ± 5.5 [Cohen’s d = 0.50; for MBSR, from 17.7 ± 5.7 to 11.9 ± 5.0 [Cohen’s d = 1.02]). Conjunction analyses revealed functional coupling between ventromedial prefrontal regions and supplementary motor areas (p < .001). The disjunction analysis indicated that the RR bodyscan was associated with stronger functional connectivity of the right inferior frontal gyrus—an important hub of intentional inhibition and control—with supplementary motor areas (p < .001, family-wise error [FWE] rate corrected). The MBSR program was uniquely associated with improvements in self-compassion and rumination, and the within-group analysis of MBSR bodyscan revealed significant functional connectivity of the right anterior insula—an important hub of sensory awareness and salience—with pregenual anterior cingulate during bodyscan meditation compared with rest (p = .03, FWE corrected).

Conclusions

The bodyscan exercises in each program were associated with both overlapping and differential functional coupling patterns, which were consistent with each program’s theoretical foundation. These results may have implications for the differential effects of these programs for the treatment of diverse conditions.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5976535/

 

Improve Brain Size and Function in Healthy Elderly with Tai Chi

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Improve Brain Size and Function in Healthy Elderly with Tai Chi

 

By John M. de Castro, Ph.D.

 

“Epidemiologic studies have shown repeatedly that individuals who engage in more physical exercise or are more socially active have a lower risk of Alzheimer’s disease. The current findings suggest that this may be a result of growth and preservation of critical regions of the brain affected by this illness.” –  James Mortimer

 

The aging process involves a systematic progressive decline in every system in the body, the brain included. This includes our mental abilities which decline with age including impairments in memory, attention, and problem solving ability. It is inevitable and cannot be avoided. Using modern neuroimaging techniques, scientists have been able to view the changes that occur in the nervous system with aging. In addition, they have been able to investigate various techniques that might slow the process of neurodegeneration that accompanies normal aging. They’ve found that mindfulness practices reduce the deterioration of the brain that occurs with aging restraining the loss of neural tissue. Indeed, the brains of practitioners of meditation and yoga have been found to degenerate less with aging than non-practitioners.

 

Tai Chi and Qigong have also been shown to be beneficial in slowing or delaying physical and mental decline with aging and to increase brain matter in the elderly. In today’s Research News article “The Effects of Tai Chi Intervention on Healthy Elderly by Means of Neuroimaging and EEG: A Systematic Review.” (See summary below or view the full text of the study at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5915963/ ), Pan and colleagues review, summarize, and perform a meta-analysis of the 11 published research articles that examine the effects of Tai Chi practice on the brain of the elderly.

 

They find that there was 1 published study reporting that long-term Tai Chi practitioners have a thicker cortex in the brain. This is interesting but it cannot be determined if people who practice Tai Chi are simply people who have thicker cortexes. Other studies using functional Magnetic Imaging (fMRI) indicate that Tai Chi results in increased connectivity between brain structures and increased functional activity in the brain, so there is greater activity and signals are better sent from one area to another. Still other studies employing electroencephalographic (EEG) recordings indicate that Tai Chi produces greater electrical activity in the frontal areas of the cortex that are known to be involved in high level cognitive function (executive function)

 

One weakness in the studies is that the comparison groups are most often sedentary, not engaging in any exercise. As a result, it cannot be determined if the changes in the brain are due to Tai Chi per se or whether any form of exercise might have a similar effect. Future research should employ comparisons to groups performing other exercises.

 

Nevertheless, the results are encouraging; suggesting that Tai Chi can alter the brain in ways that may improve memory and cognitive performance. Significantly, Tai Chi practice is gentle and completely safe, can be used with the elderly and sickly, is inexpensive to administer, can be performed in groups or alone, at home or in a facility or even public park, and can be quickly learned. Also, it can be practiced in social groups without professional supervision. This can make it fun, improving the likelihood of long-term engagement in the practice. So, Tai Chi practice may be ideal for slowing or reversing age-related deterioration of the brain and the related cognitive decline.

 

So, improve brain size and function in healthy elderly with Tai Chi.

 

“The ability to reverse this trend with physical exercise and increased mental activity implies that it may be possible to delay the onset of dementia in older persons through interventions that have many physical and mental health benefits.” –  James Mortimer

 

CMCS – Center for Mindfulness and Contemplative Studies

 

This and other Contemplative Studies posts are also available on Google+ https://plus.google.com/106784388191201299496/posts and on Twitter @MindfulResearch

 

Study Summary

 

Pan, Z., Su, X., Fang, Q., Hou, L., Lee, Y., Chen, C. C., … Kim, M.-L. (2018). The Effects of Tai Chi Intervention on Healthy Elderly by Means of Neuroimaging and EEG: A Systematic Review. Frontiers in Aging Neuroscience, 10, 110. http://doi.org/10.3389/fnagi.2018.00110

 

Abstract

Aging is a process associated with a decline in cognitive and motor functions, which can be attributed to neurological changes in the brain. Tai Chi, a multimodal mind-body exercise, can be practiced by people across all ages. Previous research identified effects of Tai Chi practice on delaying cognitive and motor degeneration. Benefits in behavioral performance included improved fine and gross motor skills, postural control, muscle strength, and so forth. Neural plasticity remained in the aging brain implies that Tai Chi-associated benefits may not be limited to the behavioral level. Instead, neurological changes in the human brain play a significant role in corresponding to the behavioral improvement. However, previous studies mainly focused on the effects of behavioral performance, leaving neurological changes largely unknown. This systematic review summarized extant studies that used brain imaging techniques and EEG to examine the effects of Tai Chi on older adults. Eleven articles were eligible for the final review. Three neuroimaging techniques including fMRI (N = 6), EEG (N = 4), and MRI (N = 1), were employed for different study interests. Significant changes were reported on subjects’ cortical thickness, functional connectivity and homogeneity of the brain, and executive network neural function after Tai Chi intervention. The findings suggested that Tai Chi intervention give rise to beneficial neurological changes in the human brain. Future research should develop valid and convincing study design by applying neuroimaging techniques to detect effects of Tai Chi intervention on the central nervous system of older adults. By integrating neuroimaging techniques into randomized controlled trials involved with Tai Chi intervention, researchers can extend the current research focus from behavioral domain to neurological level.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5915963/

 

Strengthen the Brain’s Interoceptive Networks with Mindfulness

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Strengthen the Brain’s Interoceptive Networks with Mindfulness

 

By John M. de Castro, Ph.D.

 

“mindfulness strengthens interoception, operationalized here as the mean insula connection strength within the overall connectome.” – Strong et al.

 

Most of us spend the majority of our lives lost in thought. Even when we become aware of our surroundings it is principally of the sights and sounds surrounding us. It is usually only when something is very wrong that we become aware of our bodies, what is called interoceptive awareness. We are generally unaware of the signals from our bodies such as the breath, movements in the GI tract, heart beats accompanied with surges in blood pressure, the sensations from our muscles and joints, even the sensations from our skin. Adding to the lack of awareness of our bodies we are also unaware of our implicit beliefs and attitudes about our bodies and the emotions that accompany these attitudes.

 

To exemplify this, just for a moment start paying attention to the sensations coming from the contact of your clothing with your skin. You were in all probability totally unaware of these sensations until your attention was directed toward them. Now notice the feelings from your facial muscles. Are they tense, relaxed, or something in-between. You probably were not aware of their state yet they can be good indicators of stress and your emotional state. This can be a real problem as interoceptive awareness is extremely important for our awareness of our emotional state which is in turn needed to regulate and respond appropriately to the emotions. Being aware of the state of our bodies is also important for maintaining health, both for recognizing our physical state and also for making appropriate decisions about health-related behaviors. Interoceptive awareness is even fundamental to our sense of self and world view.

 

Most contemplative practices focus attention on our internal state and thus improve our body awareness. But, in fact there is little empirical evidence on how this is accomplished. The insula cortex is a large piece of cerebral cortex has been covered and is buried deep inside at the juncture of the parietal, temporal, and frontal lobes. The insula is highly interconnected with a wide variety of other cortical and subcortical areas of the brain and it has been implicated in interoceptive awareness. So, changes in the insula may well reflect changes in interoceptive awareness. This suggests that mindfulness training would produce changes in the insula cortex.

 

In today’s Research News article “Mindfulness training induces structural connectome changes in insula networks.” (See summary below or view the full text of the study at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5962606/ ), Sharp and colleagues examined the Magnetic Resonance Images (MRIs) from two groups of participants in a larger study. Both groups had received cognitive training plus physical fitness training, while one group received an additional mindfulness training. Training consisted of 3 70-minute training sessions per week for 16 weeks. Functional Magnetic Resonance Images (f-MRIs) were obtained before and after training as well as a subjective interoceptive awareness measure.

 

They found that only after the training that included mindfulness training was there a significant increase in the strength of the connections between the insula cortex on the right side of the brain and the rest of the brain. These results suggest that mindfulness training alters the connectivity of the brain region that underlies interoceptive awareness. This may explain how mindfulness training improves body awareness and in turn the ability to sense and regulate emotions. Because emotion regulation is so fundamental to psychological health, these findings could explain how mindfulness training improves mental health and relieves mental illness.

 

So, strengthen the brain’s interoceptive networks with mindfulness.

 

“”Mindfulness” is a capacity for heightened present-moment awareness that we all possess to a greater or lesser extent. Training this capacity seems to have a quieting effect on brain areas associated with our subjective appraisal of our self. By considering thoughts and feelings as transitory mental events that occur, but are separate from the self, people are able to lessen their hold on their worries and positive mental health outcomes follow.” – Sian Bellock

 

CMCS – Center for Mindfulness and Contemplative Studies

 

This and other Contemplative Studies posts are also available on Google+ https://plus.google.com/106784388191201299496/posts and on Twitter @MindfulResearch

 

Study Summary

 

Paul B. Sharp, Bradley P. Sutton, Erick J. Paul, Nikolai Sherepa, Charles H. Hillman, Neal J. Cohen, Arthur F. Kramer, Ruchika Shaurya Prakash, Wendy Heller, Eva H. Telzer, Aron K. Barbey. Mindfulness training induces structural connectome changes in insula networks. Sci Rep. 2018; 8: 7929. Published online 2018 May 21. doi: 10.1038/s41598-018-26268-w

 

Abstract

Although mindfulness meditation is known to provide a wealth of psychological benefits, the neural mechanisms involved in these effects remain to be well characterized. A central question is whether the observed benefits of mindfulness training derive from specific changes in the structural brain connectome that do not result from alternative forms of experimental intervention. Measures of whole-brain and node-level structural connectome changes induced by mindfulness training were compared with those induced by cognitive and physical fitness training within a large, multi-group intervention protocol (n = 86). Whole-brain analyses examined global graph-theoretical changes in structural network topology. A hypothesis-driven approach was taken to investigate connectivity changes within the insula, which was predicted here to mediate interoceptive awareness skills that have been shown to improve through mindfulness training. No global changes were observed in whole-brain network topology. However, node-level results confirmed a priori hypotheses, demonstrating significant increases in mean connection strength in right insula across all of its connections. Present findings suggest that mindfulness strengthens interoception, operationalized here as the mean insula connection strength within the overall connectome. This finding further elucidates the neural mechanisms of mindfulness meditation and motivates new perspectives about the unique benefits of mindfulness training compared to contemporary cognitive and physical fitness interventions.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5962606/

 

Increase Brain Matter and Memory in Aging with Tai Chi

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Increase Brain Matter and Memory in Aging with Tai Chi

 

By John M. de Castro, Ph.D.

 

“Tai Chi can be used as exercise to improve the body, as well as reversing the natural tendency for the brain to shrink with age.” – Functional Aging Institute

 

The aging process involves a systematic progressive decline in every system in the body, the brain included. This includes our mental abilities which decline with age including impairments in memory, attention, and problem solving ability. It is inevitable and cannot be avoided. Using modern neuroimaging techniques, scientists have been able to view the changes that occur in the nervous system with aging. In addition, they have been able to investigate various techniques that might slow the process of neurodegeneration that accompanies normal aging. They’ve found that mindfulness practices reduce the deterioration of the brain that occurs with aging restraining the loss of neural tissue. Indeed, the brains of practitioners of meditation and yoga have been found to degenerate less with aging than non-practitioners.

 

Hence, there is some hope for age related cognitive decline, as there is evidence that it can be slowed. There are some indications that physical and mental exercise can reduce the rate of cognitive decline and lower the chances of dementia. For example, contemplative practices such as meditation, yoga, and Tai Chi and Qigong have all been shown to be beneficial in slowing or delaying physical and mental decline with aging. Mindfulness practices have been shown to improve cognitive processes while gentle mindful exercises such as Tai Chi and Qigong have been shown to slow age related cognitive decline. It would seem reasonable to hypothesize that Tai Chi and Baduanjin practices might decrease age related decreases in cognitive ability and degeneration of the nervous system.

 

In today’s Research News article “Tai Chi Chuan and Baduanjin increase grey matter volume in older adults: a brain imaging study.” (See summary below or view the full text of the study at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5659386/ ), Tao and colleagues recruited healthy sedentary older adults (50-70 years of age) and randomly assigned them to receive either Tai Chi practice, Baduanjin practice (a very similar practice to Tai Chi), or no-treatment. Practice occurred for 12 weeks, 5 days per week, for 1 hour. Before and after training the participants underwent Magnetic Resonance Imaging (MRI) scans of their brains. They were also measured for memory ability.

 

They found that in comparison to baseline and control participants, the Tai Chi or Baduanjin practice participants had significant increases in the amount of grey matter in the left insula, left putamen, left parahippocampus/hippocampus, left amygdala, and left inferior temporal lobe. Hence, Tai Chi or Baduanjin practice appeared to produce increases in neural tissue. In addition, the Tai Chi or Baduanjin practice participants had significant increases in overall memory ability and visual reproduction memory. These improvements in memory were related to the increases in grey matter, with large increases in neural tissue associated with large improvements in memory. Hence, Tai Chi or Baduanjin practice not only increased neural tissue and memory, but the increases in both changed together in the same direction.

 

Caution must be taken in interpreting these results as the control condition was inactive. As a result, it cannot be determined if Tai Chi or Baduanjin practice per se or any form of exercise could produce comparable benefits. Further research is needed employing other forms of exercise to compare to the effects of Tai Chi or Baduanjin practice.

 

Nonetheless, these results are interesting and exciting. They suggest that Tai Chi or Baduanjin practice can reduce or possibly reverse brain degeneration and cognitive decline associated with aging. By engaging in these mindful movement practices aging individuals appear to preserve their brains and their mental ability. In addition, the fact that these practices are safe, convenient, low cost, and social suggests that they can be widely applied to the aging population.

 

So, increase brain matter and memory in aging with Tai Chi.

 

“Keep your brain younger longer by adding tai chi to your workout routine.” – Linda Melone

 

CMCS – Center for Mindfulness and Contemplative Studies

 

This and other Contemplative Studies posts are also available on Google+ https://plus.google.com/106784388191201299496/posts and on Twitter @MindfulResearch

 

Study Summary

 

Tao, J., Liu, J., Liu, W., Huang, J., Xue, X., Chen, X., … Kong, J. (2017). Tai Chi Chuan and Baduanjin increase grey matter volume in older adults: a brain imaging study. Journal of Alzheimer’s Disease : JAD, 60(2), 389–400. http://doi.org/10.3233/JAD-170477

 

Abstract

The aim of this study is to investigate and compare how 12-weeks of Tai Chi Chuan and Baduanjin exercise can modulate brain structure and memory function in older adults. Magnetic Resonance Imaging(MRI) and memory function measurements (Wechsler Memory Scale-Chinese revised, WMS-CR)were applied at both the beginning and end of the study. Results showed that both Tai Chi Chuan and Baduanjin could significantly increase grey matter volume (GMV) in the insula, medial temporal lobe (MTL), and putamen after 12-weeks of exercise. No significant differences were observed in grey matter volume (GMV) between the Tai Chi Chuan and Baduanjin groups. We also found that compared to healthy controls, Tai Chi Chuan and Baduanjin significantly improved visual reproduction subscores on the WMS-CR. Baduanjin also improved mental control, recognition, touch and comprehension memory subscores of the WMS-CR compared to the control group. Memory quotient (MQ)and visual reproduction subscores were both associated with GMV increases in the putamen and hippocampus. Our results demonstrate the potential of Tai Chi Chuan and Baduanjin exercise for the prevention of memory deficits in older adults.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5659386/

Improve Post-Traumatic Stress Disorder (PTSD) with Mindfulness

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Improve Post-Traumatic Stress Disorder (PTSD) with Mindfulness

 

By John M. de Castro, Ph.D.

 

“Overall, there is a lot of evidence supporting mindfulness as a treatment approach for adults with PTSD, and a recent burgeoning literature corroborating positive neurological changes is following suit.” – Jennifer Wolkin

 

Experiencing trauma is quite common. It has been estimated that 60% of men and 50% of women will experience a significant traumatic event during their lifetime. But, only a fraction will develop Post-Traumatic Stress Disorder (PTSD). But this still results in a frightening number of people with 7%-8% of the population developing PTSD at some point in their life. For military personnel, it’s much more likely for PTSD to develop with about 11% – 20% of those who have served in a war zone developing PTSD.

 

PTSD involves a number of troubling symptoms including reliving the event with the same fear and horror in nightmares or with a flashback. PTSD sufferers avoid situations that remind them of the event this may include crowds, driving, movies, etc. and may avoid seeking help because it keeps them from having to think or talk about the event. They often experience negative changes in beliefs and feelings including difficulty experiencing positive or loving feelings toward other people, avoiding relationships, memory difficulties, or see the world as dangerous and no one can be trusted. Sufferers may feel hyperarousal, feeling keyed up and jittery, or always alert and on the lookout for danger. They may experience sudden anger or irritability, may have a hard time sleeping or concentrating, may be startled by a loud noise or surprise.

 

Obviously, these are troubling symptoms that need to be addressed. There are a number of therapies that have been developed to treat PTSD. One of which, mindfulness training has been found to be particularly effective. Mindfulness Based Stress Reduction (MBSR) has been found to improve PTSD symptoms. It has been shown that mindfulness practices can alter the brain structures and connectivity and this may underlie the beneficial effects of mindfulness on PTSD.

 

In today’s Research News article “Mindfulness-based treatments for posttraumatic stress disorder: a review of the treatment literature and neurobiological evidence.” (See summary below or view the full text of the study at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5747539/ ), Boyd and colleagues review and summarize the published research literature on the effects of mindfulness training on the brain and its relationship to improvements in PTSD symptoms. They report that there is substantial evidence that a variety of mindfulness-based treatments including Mindfulness-Based Stress Reduction (MBSR), Mindfulness-Based Cognitive Therapy (MBCT), and Loving Kindness Meditation are effective for relieving the symptoms of PTSD.

 

In regards to brain function, they report that mindfulness practices result in greater activity in the prefrontal cortex, structures that are involved in higher level thought processes and attention and lower activity in the amygdala region that is associated with emotional arousal. In addition, there is increased connectivity between these two regions. This could explain the ability of mindfulness practices to reduce hyperarousal and emotionality with more rational thought and improvement in emotional regulation. In addition, they report that a series of midline cortical structures labelled the default mode network (DMN) have increased connectivity, suggesting an improvement in self-referential thinking.

 

There is increased activity in a series of cortical structures that connect to lower centers in the brain labelled the salience network (SN) that appears to be involved in detecting particularly important stimuli and regulating emotional responses to them. This may result in the PTSD sufferer having a greater ability to respond appropriately to things in the environment that may have previously produced flashbacks and hyperarousal. Finally, mindfulness training appears to improve the activity and connectivity of the brain’s Central Executive Network (CEN), including dorsolateral prefrontal cortex and the posterior parietal cortex, that is associated with high level thinking.

 

These findings suggest that mindfulness training alters brain function to increase thinking and reasoning in contrast to emotional arousal. This is exactly what the PTSD patient needs as PTSD tends to produce the opposite pattern with decreased reasoning and increased emotional responding. Hence these findings suggest that mindfulness training acts on the nervous system to counter the abnormal brain responses that occur with PTSD and thereby relieve the symptoms of PTSD. Obviously much more research is needed. But a coherent picture is emerging of the alterations in the nervous system produced by mindfulness training that are responsible for its beneficial effects on the symptoms of PTSD.

 

So, improve post-traumatic stress disorder (PTSD) with mindfulness.

 

“This type of attention training may help patients notice when they are stuck in a negative pattern of thought or rumination and make it a little easier to shift their attention to other things. And if you think about what mindfulness meditation is, that makes perfect sense. The ‘muscle’ that you are training is the ability to catch yourself when you are not thinking about your breath and move it to something else.” – Tony King

 

CMCS – Center for Mindfulness and Contemplative Studies

 

This and other Contemplative Studies posts are also available on Google+ https://plus.google.com/106784388191201299496/posts and on Twitter @MindfulResearch

 

Study Summary

 

Jenna E. Boyd, Ruth A. Lanius, Margaret C. McKinnon. Mindfulness-based treatments for posttraumatic stress disorder: a review of the treatment literature and neurobiological evidence. J Psychiatry Neurosci. 2018 Jan; 43(1): 7–25. Published online 2017 Oct 3. doi: 10.1503/jpn.170021

 

Abstract

Mindfulness-based treatments for posttraumatic stress disorder (PTSD) have emerged as promising adjunctive or alternative intervention approaches. A scoping review of the literature on PTSD treatment studies, including approaches such as mindfulness-based stress reduction, mindfulness-based cognitive therapy and metta mindfulness, reveals low attrition with medium to large effect sizes. We review the convergence between neurobiological models of PTSD and neuroimaging findings in the mindfulness literature, where mindfulness interventions may target emotional under- and overmodulation, both of which are critical features of PTSD symptomatology. Recent emerging work indicates that mindfulness-based treatments may also be effective in restoring connectivity between large-scale brain networks among individuals with PTSD, including connectivity between the default mode network and the central executive and salience networks. Future directions, including further identification of the neurobiological mechanisms of mindfulness interventions in patients with PTSD and direct comparison of these interventions to first-line treatments for PTSD are discussed.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5747539/

Improve Memory and Frontal Lobe Function in Older Adults with Mind-Body Practices

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Improve Memory and Frontal Lobe Function in Older Adults with Mind-Body Practices

 

By John M. de Castro, Ph.D.

 

“Scientists . . . found increases in brain volume and improvements on tests of memory and thinking in Chinese seniors who practiced Tai Chi three times a week.” – Science Daily

 

The nervous system is a dynamic entity, constantly changing and adapting to the environment. It will change size, activity, and connectivity in response to experience. These changes in the brain are called neuroplasticity.  Over the last decade neuroscience has been studying the effects of contemplative practices on the brain and has identified neuroplastic changes in widespread area. and have found that meditation practice appears to mold and change the brain, producing psychological, physical, and spiritual benefits.

 

The aging process involves a systematic progressive decline in every system in the body, the brain included. Starting in the 20s there is a progressive decrease in the volume and activity of the brain as the years go by. Researchers have been able to investigate various techniques that might slow the process of neurodegeneration that accompanies normal aging. They’ve found that mindfulness practices reduce the deterioration of the brain that occurs with aging restraining the loss of neural tissue. Indeed, the brains of practitioners of meditation, yoga and Tai Chi have all been found to degenerate less with aging than non-practitioners. A practice, similar to Tai Chi, Baduanjin is a mind-body training consisted of 8 movements for limbs, body-trunk, and eye movements. But it has not been evaluated for application to aging individuals.

Because Tai Chi and Baduanjin are not strenuous, involving slow gentle movements, and are safe, having no appreciable side effects, they are appropriate for all ages including the elderly and for individuals with illnesses that limit their activities or range of motion.

 

In today’s Research News article “Tai Chi Chuan and Baduanjin Mind-Body Training Changes Resting-State Low-Frequency Fluctuations in the Frontal Lobe of Older Adults: A Resting-State fMRI Study.” (See summary below or view the full text of the study at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5670503/ ), Tao and colleagues recruited older sedentary adults (50 to 70 years of age) and randomly assigned them to either a no-treatment control who were provided health information or to practice either Tai Chi or Baduanjin mind-body training for 12 weeks, one hour per day, five days per week. Participants were measured before and after training for memory and cognitive functions. They also underwent functional-Magnetic Resonance Imaging (f-MRI).

 

They found that the Tai Chi and Baduanjin groups did not differ, but, in comparison to baseline and the education control group they had significant (18%-24%) increases in memory performance after training. The brain scans demonstrated that, in comparison to the education control group the Baduanjin group had significant increases in activity in the low frequency range in the Medial Prefrontal Cortex while the Tai Chi group had significant increases in activity in the low frequency range in the Dorsal Lateral Prefrontal Cortex. Importantly, they found that the greater the increase in activity in the Prefrontal Areas the greater the improvement in memory.

 

Hence, the results showed that both mind-body practices of Tai Chi and Baduanjin improved memory in older adults in association with increases in Prefrontal Lobe activity. The Prefrontal cortex has been associated previously with memory, attention, and high-level thinking (executive function). The present results suggest that the mind-body practices of Tai Chi and Baduanjin act to improve memory in older adults by producing neuroplastic changes that increase activity in the brain’s Prefrontal Areas. Interestingly, the results also show that the two mind-body practices may act on different mechanisms in the brain; with Tai Chi acting on the medial areas of the Prefrontal Cortex while Baduanjin acting on the Dorsal Lateral areas.

 

Memory deteriorates with aging and this can progress to severe memory impairments and dementia. The results of this study suggest that engagement in the mind-body practices of Tai Chi and Baduanjin may be able to slow or prevent that decline by strengthening brain processing in the Prefrontal Cortex. Since both Tai Chi and Baduanjin are simple and safe exercises that can be easily learned and practiced at home alone or in groups, they are economical and scalable practices to improve memory during aging. As such, they should be recommended for older adults.

 

So, improve memory and frontal lobe function in older adults with mind-body practices.

 

“Because Tai Chi can be done indoors or out, and as a group activity or by yourself, it suits both people who like to work out alone at home and those who prefer to get their exercise in a social setting.” – Mark Huntsman

 

CMCS – Center for Mindfulness and Contemplative Studies

 

This and other Contemplative Studies posts are also available on Google+ https://plus.google.com/106784388191201299496/posts and on Twitter @MindfulResearch

 

Study Summary

 

Tao, J., Chen, X., Liu, J., Egorova, N., Xue, X., Liu, W., … Kong, J. (2017). Tai Chi Chuan and Baduanjin Mind-Body Training Changes Resting-State Low-Frequency Fluctuations in the Frontal Lobe of Older Adults: A Resting-State fMRI Study. Frontiers in Human Neuroscience, 11, 514. http://doi.org/10.3389/fnhum.2017.00514

 

Abstract

Age-related cognitive decline is a significant public health concern. Recently, non-pharmacological methods, such as physical activity and mental training practices, have emerged as promising low-cost methods to slow the progression of age-related memory decline. In this study, we investigated if Tai Chi Chuan (TCC) and Baduanjin modulated the fractional amplitude of low-frequency fluctuations (fALFF) in different frequency bands (low-frequency: 0.01–0.08 Hz; slow-5: 0.01–0.027 Hz; slow-4: 0.027–0.073 Hz) and improved memory function. Older adults were recruited for the randomized study. Participants in the TCC and Baduanjin groups received 12 weeks of training (1 h/day for 5 days/week). Participants in the control group received basic health education. Each subject participated in memory tests and fMRI scans at the beginning and end of the experiment. We found that compared to the control group: (1) TCC and Baduanjin groups demonstrated significant improvements in memory function; (2) TCC increased fALFF in the dorsolateral prefrontal cortex (DLPFC) in the slow-5 and low-frequency bands; and (3) Baduanjin increased fALFF in the medial PFC in the slow-5 and low-frequency bands. This increase was positively associated with memory function improvement in the slow-5 and low-frequency bands across the TCC and Baduanjin groups. Our results suggest that TCC and Baduanjin may work through different brain mechanisms to prevent memory decline due to aging.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5670503/

Protect the Aging Brain with Yoga

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Protect the Aging Brain with Yoga

 

By John M. de Castro, Ph.D.

 

“We’ve all known yogis who seemed to defy the hands of time. The current study is just one of a long list of studies indicating that yoga may promote healthy aging. Whether it be more growth hormone or less stress, a well-balanced yoga practice is good for you.” – Grace Bullock

 

Human life is one of constant change. We revel in our increases in physical and mental capacities during development, but regret their decreases during aging. The aging process involves a systematic progressive decline in every system in the body, the brain included. Starting in the 20s there is a progressive decrease in the volume of the brain as we age. But, the nervous system is a dynamic entity, constantly changing and adapting to the environment. It will change size, activity, and connectivity in response to experience. These changes in the brain are called neuroplasticity.

 

Over the last decade neuroscience has been studying the effects of contemplative practices on the brain and has identified neuroplastic changes in widespread area. and have found that meditation practice appears to mold and change the brain, producing psychological, physical, and spiritual benefits. In addition, they have been able to investigate various techniques that might slow the process of neurodegeneration that accompanies normal aging. They’ve found that mindfulness practices reduce the deterioration of the brain that occurs with aging restraining the loss of neural tissue. Indeed, the brains of practitioners of meditation and yoga have been found to degenerate less with aging than non-practitioners.

 

In today’s Research News article “Greater Cortical Thickness in Elderly Female Yoga Practitioners—A Cross-Sectional Study.” See summary below or view the full text of the study at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5476728/, Afonso and colleagues recruited women over 60 years of age with at least 8 years of Hatha yoga practice and a group of women, matched for age, education and physical activity, who had never practiced yoga, meditation, or other mind-body practices. They were measured for their ability to perform daily tasks of living, depression, and cognitive function. All participants underwent brain scanning with Magnetic Resonance Imaging (MRI).

 

They found that the yoga practitioners had significantly greater cortical thickness in the frontal lobes than the control group while there were no areas where the yoga practitioners had significantly less cortical thickness. Hence, the practice of yoga appears to protect the prefrontal cortical areas from age related degeneration. This replicates previous findings that mindfulness practices, in general, increase the size of the prefrontal cortex. The prefrontal areas are important for high level thinking, including attention, behavioral inhibition, and executive functions. Hence, their preservation is important for the maintenance of cognitive ability with aging. So, the practice of yoga should be viewed as an important means to preserve the brain and mental ability and thereby age successfully.

 

So, protect the aging brain with yoga.

 

“scientifically and medically, most of the claims made for yoga practice stand up. The benefits on both body and mind are legion. The anti-ageing impact is profound. Doing yoga reduces back pain, improves balance and muscle strength and reverses muscle loss. It improves symptoms of rheumatoid arthritis, menopausal symptoms, even the control of type 2 diabetes. It decreases anxiety and depression. It hugely enhances flexibility. There are endless sound academic sources to back up these statements as well as the testimony of countless practitioners.” – Carla McKay

CMCS – Center for Mindfulness and Contemplative Studies

 

This and other Contemplative Studies posts are also available on Google+ https://plus.google.com/106784388191201299496/posts and on Twitter @MindfulResearch

 

Study Summary

 

Afonso, R. F., Balardin, J. B., Lazar, S., Sato, J. R., Igarashi, N., Santaella, D. F., … Kozasa, E. H. (2017). Greater Cortical Thickness in Elderly Female Yoga Practitioners—A Cross-Sectional Study. Frontiers in Aging Neuroscience, 9, 201. http://doi.org/10.3389/fnagi.2017.00201

 

Abstract

Yoga, a mind-body activity that requires attentional engagement, has been associated with positive changes in brain structure and function, especially in areas related to awareness, attention, executive functions and memory. Normal aging, on the other hand, has also been associated with structural and functional brain changes, but these generally involve decreased cognitive functions. The aim of this cross-sectional study was to compare brain cortical thickness (CT) in elderly yoga practitioners and a group of age-matched healthy non-practitioners. We tested 21 older women who had practiced hatha yoga for at least 8 years and 21 women naive to yoga, meditation or any mind-body interventions who were matched to the first group in age, years of formal education and physical activity level. A T1-weighted MPRAGE sequence was acquired for each participant. Yoga practitioners showed significantly greater CT in a left prefrontal lobe cluster, which included portions of the lateral middle frontal gyrus, anterior superior frontal gyrus and dorsal superior frontal gyrus. We found greater CT in the left prefrontal cortex of healthy elderly women who trained yoga for a minimum of 8 years compared with women in the control group.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5476728/

Improve Brain Systems Underlying Mental Well-Being with Gratitude Meditation

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Improve Brain Systems Underlying Mental Well-Being with Gratitude Meditation

By John M. de Castro, Ph.D.

“benefit of meditation. Or, rather, some ancient benefit that is just now being confirmed with fMRI or EEG. The practice appears to have an amazing variety of neurological benefits – from changes in grey matter volume to reduced activity in the “me” centers of the brain to enhanced connectivity between brain regions.” – Alice Walton

There has accumulated a large amount of research demonstrating that meditation has significant benefits for psychological, physical, and spiritual wellbeing. Its positive effects are so widespread that it is difficult to find any other treatment of any kind with such broad beneficial effects on everything from mood and happiness to severe mental and physical illnesses. This raises the question of how meditation could do this. One possibility is that mindfulness practice results in beneficial changes in the nervous system.

The nervous system is a dynamic entity, constantly changing and adapting to the environment. It will change size, activity, and connectivity in response to experience. These changes in the brain are called neuroplasticity. Over the last decade neuroscience has been studying the effects of contemplative practices on the brain and has identified neuroplastic changes in widespread areas. In other words, mindfulness practice appears to mold and change the brain, producing psychological, physical, and spiritual benefits.

These neuroplastic changes, however, result from the summation of individual changes occurring to the nervous system in real time produced by the immediate behavior. In order to better understand the process by which behavior affects the nervous system, it is important to look initially at the short-term changes produced by behavior. Loving-kindness meditation has been shown to produce improvement in the regulation of emotions and also changes the areas of the nervous system involved in emotion regulation. To better understand the processes involved it is important to look at the short-term effects of focusing on gratitude on the nervous system.

In today’s Research News article “Effects of gratitude meditation on neural network functional connectivity and brain-heart coupling.” See summary below or view the full text of the study at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5506019/, Kyeong and colleagues recruited meditation-naïve adults. They were measured before testing for depression, competence, relatedness, and autonomy. The participants laid in a brain scanner and were instructed to think deeply in a gratitude condition and a resentment condition while their heart rate was recorded and functional Magnetic Resonance Imaging (f-MRI) was performed. In the gratitude condition the participants were instructed to think about and visualize their mother for 4 minutes and tell her in their mind how much they love and appreciate her. In the resentment condition the participants were instructed to think about and visualize a person who made them angry. The two conditions were presented in counterbalanced order to two randomly assigned groups.

They found that the heart rate was significantly lower during the gratefulness condition indicating the positive emotional effects of gratitude. In addition, they found that the functional connectivity of brain areas was significantly related to heart rate in the gratefulness condition but not the resentment condition. Hence, experiencing gratefulness connects central and peripheral mechanisms of emotion. They found that the functional connectivity of neural systems were altered during and after the two conditions. But, the gratitude condition altered the functional connectivity of brain areas associated with emotions and motivation.

These results suggest that the immediate focusing on gratitude produces momentary alterations of brain systems associated with the regulation of emotions and self-motivation. When carried out over a period of time this could sum to produce relatively permanent changes in these neural systems. This may be the mechanism by which loving-kindness meditation improves emotional well-being. These results are a useful start at unravelling the processes by which mental contents can produce relatively permanent alterations of the nervous system and thereby produce relatively permanent changes in the individual’s mood and regulation of that mood.

So, improve brain systems underlying mental well-being with gratitude meditation.

“Being distracted exacts a cost on our well-being, If we become more mindful of our everyday activities, we can learn well-being and become happier.” – Ritchie Davidson

CMCS – Center for Mindfulness and Contemplative Studies

This and other Contemplative Studies posts are available at the Contemplative Studies Blog http://contemplative-studies.org/wp/
They are also available on Google+ https://plus.google.com/106784388191201299496/posts and on Twitter @MindfulResearch

Study Summary

Kyeong, S., Kim, J., Kim, D. J., Kim, H. E., & Kim, J.-J. (2017). Effects of gratitude meditation on neural network functional connectivity and brain-heart coupling. Scientific Reports, 7, 5058. http://doi.org/10.1038/s41598-017-05520-9

Abstract
A sense of gratitude is a powerful and positive experience that can promote a happier life, whereas resentment is associated with life dissatisfaction. To explore the effects of gratitude and resentment on mental well-being, we acquired functional magnetic resonance imaging and heart rate (HR) data before, during, and after the gratitude and resentment interventions. Functional connectivity (FC) analysis was conducted to identify the modulatory effects of gratitude on the default mode, emotion, and reward-motivation networks. The average HR was significantly lower during the gratitude intervention than during the resentment intervention. Temporostriatal FC showed a positive correlation with HR during the gratitude intervention, but not during the resentment intervention. Temporostriatal resting-state FC was significantly decreased after the gratitude intervention compared to the resentment intervention. After the gratitude intervention, resting-state FC of the amygdala with the right dorsomedial prefrontal cortex and left dorsal anterior cingulate cortex were positively correlated with anxiety scale and depression scale, respectively. Taken together, our findings shed light on the effect of gratitude meditation on an individual’s mental well-being, and indicate that it may be a means of improving both emotion regulation and self-motivation by modulating resting-state FC in emotion and motivation-related brain regions.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5506019/

Improve Alzheimer’s Disease Risk Factors with Mindfulness

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Improve Alzheimer’s Disease Risk Factors with Mindfulness

 

By John M. de Castro, Ph.D.

 

“MBSR may reduce hippocampal atrophy and improve functional connectivity in the same areas of the brain most affected by Alzheimer’s disease. MBSR is a relatively simple intervention, with very little downside that may provide real promise for these individuals who have very few treatment options.” – Rebecca Wells

 

In the course of normal aging, there is a slow decline in cognitive ability. But, for some the decline can be excessive producing dementia. Alzheimer’s disease is the most common form of dementia. It involves an irreversible progressive loss of mental function associated with brain degeneration. The early stages are typified by memory loss but as the disease progresses patients can lose the ability to carry on a conversation or carry on normal life functions, and eventually leads to death. In fact, Alzheimer’s disease is the sixth leading cause of death in the U.S. On average, this progression lasts about 8 years but can last as long as 20 years. Alzheimer’s typically first emerges after age 65, but can occur at younger ages.

 

It is estimated that 5 million Americans have Alzheimer’s disease. Unfortunately, there are no known cures for Alzheimer’s disease. But, there are treatments that can help relieve the symptoms. These include drug treatments. Recently, mindfulness practices have been shown to improve the symptoms of age related dementia. It has been shown that chronic stress is a risk factor for the development of Alzheimer’s disease. Mindfulness-Based Stress Reduction (MBSR) is a mindfulness technique that was designed to reduce stress and its effects. So, it would seem reasonable to study the ability of MBSR to relieve the symptoms of Alzheimer’s disease.

 

In today’s Research News article “Plasma REST: a novel candidate biomarker of Alzheimer’s disease is modified by psychological intervention in an at-risk population.” See summary below or view the full text of the study at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5537638/, Ashton and colleagues examined the association of a biomarker, repressor element 1-silencing transcription (REST), with Alzheimer’s disease and the ability of Mindfulness-Based Stress Reduction (MBSR) to alter REST and the early symptoms of Alzheimer’s disease. They recruited patients over 65 years of age with diagnosed Alzheimer’s disease and healthy elderly control participants. They scanned their brains with Magnetic Resonance Imaging (MRI) and collected blood samples to measure the plasma levels of REST. They also recruited individuals over 65 years of age with anxiety, depression, and mild cognitive impairment. They were randomly assigned to receive an 8-week program of either MBSR or health education. They measured memory, verbal fluency, executive function, anxiety, depression, worry, and collected blood samples to measure the plasma levels of REST.

 

They found that REST levels were significantly lower in Alzheimer’s disease patients than healthy control participants. Also, the lower the levels of REST the lower the brain volumes in these patients. In addition, the REST levels in participants with mild cognitive impairment who later expressed full blown Alzheimer’s disease were significantly lower than those participants who did not. MBSR produced a significant increase in REST and the greater the level of REST increase the greater the improvement in anxiety and depression.

 

These are very interesting and potentially important findings that suggest that levels of repressor element 1-silencing transcription (REST) in the blood may be a marker for Alzheimer’s disease. It is lower in patients with active Alzheimer’s disease and in people with mild cognitive impairment who would eventually develop Alzheimer’s disease and is associated with reduced brain volume. MBSR participation increases REST and the increase is associated with improved symptoms. This suggests that low REST levels identify Alzheimer’s disease patients and that mindfulness practice can increase REST levels.

 

Repressor element 1-silencing transcription (REST) promotes the development of neurons. So, low levels of REST may be a sign that neural development has slowed or stopped and this may be an important mechanism for the development of Alzheimer’s disease. Interestingly, mindfulness training may be able to reverse the decline in REST and could potentially restrain the development of the disease. It is not known how MBSR could affect REST, but it can be speculated that the ability of MBSR to reduce the physiological and psychological responses to stress may be involved.

 

So, improve Alzheimer’s disease risk factors with mindfulness.

 

“Perceived stress can be altered by mindfulness-based stress reduction, cognitive-behavioural therapies and stress-reducing drugs. These interventions may postpone or even prevent an individual’s cognitive decline.” – Mindy Katz

 

CMCS – Center for Mindfulness and Contemplative Studies

 

This and other Contemplative Studies posts are also available on Google+ https://plus.google.com/106784388191201299496/posts and on Twitter @MindfulResearch

 

Study Summary

 

Ashton, N. J., Hye, A., Leckey, C. A., Jones, A. R., Gardner, A., Elliott, C., … Marchant, N. L. (2017). Plasma REST: a novel candidate biomarker of Alzheimer’s disease is modified by psychological intervention in an at-risk population. Translational Psychiatry, 7(6), e1148–. http://doi.org/10.1038/tp.2017.113

 

Abstract

The repressor element 1-silencing transcription (REST) factor is a key regulator of the aging brain’s stress response. It is reduced in conditions of stress and Alzheimer’s disease (AD), which suggests that increasing REST may be neuroprotective. REST can be measured peripherally in blood plasma. Our study aimed to (1) examine plasma REST levels in relation to clinical and biological markers of neurodegeneration and (2) alter plasma REST levels through a stress-reduction intervention—mindfulness training. In study 1, REST levels were compared across the following four well-characterized groups: healthy elderly (n=65), mild cognitive impairment who remained stable (stable MCI, n=36), MCI who later converted to dementia (converter MCI, n=29) and AD (n=65) from the AddNeuroMed cohort. REST levels declined with increasing severity of risk and impairment (healthy elderly>stable MCI>converter MCI>AD, F=6.35, P<0.001). REST levels were also positively associated with magnetic resonance imaging-based hippocampal and entorhinal atrophy and other putative blood-based biomarkers of AD (Ps<0.05). In study 2, REST was measured in 81 older adults with psychiatric risk factors for AD before and after a mindfulness-based stress reduction intervention or an education-based placebo intervention. Mindfulness-based training caused an increase in REST compared with the placebo intervention (F=8.57, P=0.006), and increased REST was associated with a reduction in psychiatric symptoms associated with stress and AD risk (Ps<0.02). Our data confirm plasma REST associations with clinical severity and neurodegeneration, and originally, that REST is modifiable by a psychological intervention with clinical benefit.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5537638/

Improve Post-Traumatic Stress Disorder in Combat Veterans with Mindfulness

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Improve Post-Traumatic Stress Disorder in Combat Veterans with Mindfulness

 

By John M. de Castro, Ph.D.

 

“Mindfulness-based approaches have been shown to be useful for problems commonly seen in trauma survivors such as anxiety and hyperarousal. Mindfulness practice has potential to be of benefit to individuals with PTSD, either as a tertiary or a stand-alone treatment.” – National Center for PTSD

 

Experiencing trauma is quite common. It has been estimated that 60% of men and 50% of women will experience a significant traumatic event during their lifetime. But, only a fraction will develop Post-Traumatic Stress Disorder (PTSD). But this still results in a frightening number of people with 7%-8% of the population developing PTSD at some point in their life. For military personnel, it’s much more likely for PTSD to develop with about 11% – 20% of those who have served in a war zone developing PTSD.

 

PTSD involves a number of troubling symptoms including reliving the event with the same fear and horror in nightmares or with a flashback. PTSD sufferers avoid situations that remind them of the event this may include crowds, driving, movies, etc. and may avoid seeking help because it keeps them from having to think or talk about the event. They often experience negative changes in beliefs and feelings including difficulty experiencing positive or loving feelings toward other people, avoiding relationships, memory difficulties, or see the world as dangerous and no one can be trusted. Sufferers may feel hyperarousal, feeling keyed up and jittery, or always alert and on the lookout for danger. They may experience sudden anger or irritability, may have a hard time sleeping or concentrating, may be startled by a loud noise or surprise.

 

Obviously, these are troubling symptoms that need to be addressed. There are a number of therapies that have been developed to treat PTSD. One of which, mindfulness training has been found to be particularly effective. Mindfulness Based Stress Reduction (MBSR) has been found to improve PTSD symptoms. MBSR involves a combination of mindfulness practices including, meditation, body scan, and yoga. In today’s Research News article “A Pilot Study of the Effects of Mindfulness-Based Stress Reduction on Post-traumatic Stress Disorder Symptoms and Brain Response to Traumatic Reminders of Combat in Operation Enduring Freedom/Operation Iraqi Freedom Combat Veterans with Post-traumatic Stress Disorder.” See summary below or view the full text of the study at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5574875/, Bremner and colleagues examine the effectiveness of Mindfulness Based Stress Reduction (MBSR) for the treatment of PTSD in combat veterans.

 

They recruited combat veterans from the wars in Iraq and randomly assigned them to receive either an 8-week program of Mindfulness Based Stress Reduction (MBSR) or Present-Centered Group Therapy (PCGT). PCGT involved 8-weeks of psycho-education and group discussion of present day problems. They were measured before and after treatment and 6 months later for PTSD symptoms, psychiatric issues, mindfulness, and spiritual well-being. The veterans also underwent a Positron Emission Tomography (PET) brain scan while viewing pictures of the Iraq war or neutral pictures.

 

They found that MBSR, but not the control PCGT condition, produced significant reductions in PTSD symptoms, particularly avoidance and hyperarousal, and increases in mindfulness that were maintained even 6-months after the end of treatment. All of the veterans showed increased activation in frontal and temporal cortical regions and decreased activation in subcortical areas when viewing combat related pictures. After MBSR, in comparison to baseline and the control group, the veterans had significantly increased activation of the anterior cingulate and inferior parietal cortex, and decreased activation in the insula and precuneus. Activation of the anterior cingulate cortex is associated with improved emotion regulation and has been previously associated with relief of trauma symptoms while decreased activity in the insula has been associated with decreases in hyperarousal.

 

The results of this pilot study are interesting and potentially important. The study is unusual in that it had an active control condition that improves the strength of the conclusions. The results demonstrate that Mindfulness Based Stress Reduction (MBSR) produces lasting improvements in PTSD symptoms in combat veterans. They also show that MBSR produces changes in the nervous system areas that may underlie the symptoms. Hence, MBSR appears to be a safe and effective treatment of Post-Traumatic Stress Disorder (PTSD) that can relieve the suffering resulting from trauma.

 

So, improve post-traumatic stress disorder in combat veterans with mindfulness.

 

“Mindfulness-based stress reduction approaches are likely to work just as well for non-veterans who have been exposed to civilian traumas such as physical or sexual assaults.” Alan Peterson

 

CMCS – Center for Mindfulness and Contemplative Studies

 

This and other Contemplative Studies posts are also available on Google+ https://plus.google.com/106784388191201299496/posts and on Twitter @MindfulResearch

 

Study Summary

 

Bremner, J. D., Mishra, S., Campanella, C., Shah, M., Kasher, N., Evans, S., … Carmody, J. (2017). A Pilot Study of the Effects of Mindfulness-Based Stress Reduction on Post-traumatic Stress Disorder Symptoms and Brain Response to Traumatic Reminders of Combat in Operation Enduring Freedom/Operation Iraqi Freedom Combat Veterans with Post-traumatic Stress Disorder. Frontiers in Psychiatry, 8, 157. http://doi.org/10.3389/fpsyt.2017.00157

 

Abstract

Objective

Brain imaging studies in patients with post-traumatic stress disorder (PTSD) have implicated a circuitry of brain regions including the medial prefrontal cortex, amygdala, hippocampus, parietal cortex, and insula. Pharmacological treatment studies have shown a reversal of medial prefrontal deficits in response to traumatic reminders. Mindfulness-based stress reduction (MBSR) is a promising non-pharmacologic approach to the treatment of anxiety and pain disorders. The purpose of this study was to assess the effects of MBSR on PTSD symptoms and brain response to traumatic reminders measured with positron-emission tomography (PET) in Operation Enduring Freedom/Operation Iraqi Freedom (OEF/OIF) combat veterans with PTSD. We hypothesized that MBSR would show increased prefrontal response to stress and improved PTSD symptoms in veterans with PTSD.

Method

Twenty-six OEF/OIF combat veterans with PTSD who had recently returned from a combat zone were block randomized to receive eight sessions of MBSR or present-centered group therapy (PCGT). PTSD patients underwent assessment of PTSD symptoms with the Clinician-Administered PTSD Scale (CAPS), mindfulness with the Five Factor Mindfulness Questionnaire (FFMQ) and brain imaging using PET in conjunction with exposure to neutral and Iraq combat-related slides and sound before and after treatment. Nine patients in the MBSR group and 8 in the PCGT group completed all study procedures.

Results

Post-traumatic stress disorder patients treated with MBSR (but not PCGT) had an improvement in PTSD symptoms measured with the CAPS that persisted for 6 months after treatment. MBSR also resulted in an increase in mindfulness measured with the FFMQ. MBSR-treated patients had increased anterior cingulate and inferior parietal lobule and decreased insula and precuneus function in response to traumatic reminders compared to the PCGT group.

Conclusion

This study shows that MBSR is a safe and effective treatment for PTSD. Furthermore, MBSR treatment is associated with changes in brain regions that have been implicated in PTSD and are involved in extinction of fear responses to traumatic memories as well as regulation of the stress response.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5574875/