Mindfulness Training Produces no Harm

May 26, 2022 psyjdc Leave a comment

By John M. de Castro, Ph.D.

“the occurrence of AEs during or after meditation practices is not uncommon, and may occur in individuals with no previous history of mental health problems.” – M. Farias

People begin meditation with the misconception that meditation will help them escape from their problems. Nothing could be further from the truth. In fact, meditation does the exact opposite, forcing the meditator to confront their issues. In meditation, the practitioner tries to quiet the mind. But, in that relaxed quiet state, powerful, highly emotionally charged thoughts and memories are likely to emerge. The strength here is that meditation is a wonderful occasion to begin to deal with these issues. But often the thoughts or memories are overwhelming. At times, professional therapeutic intervention may be needed.

Many practitioners never experience these negative experiences or only experience very mild states. There are, however, few systematic studies of the extent of negative experiences. In general, the research has reported that unwanted (negative) experiences are quite common with meditators, but for the most part, are short-lived and mild. There is, however, a great need for more research into the nature of the experiences that occur during meditation.

In today’s Research News article “). Prevalence of harm in mindfulness-based stress reduction.” (See summary below or view the full text of the study at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7889774/ ) Hirshberg and colleagues compared patients who had received treatment with Mindfulness-Based Stress Reduction (MBSR) program to those on a wait-list. MBSR was either delivered in community settings or was part of a formal randomized clinical trial and consisted of 8 weekly 2.5-hour sessions involving meditation, yoga, body scan, and group discussion with daily homework. They were measured before and after treatment for global psychological symptom severity and bothersome physical symptoms. They were also measured for anxiety, depression, interpersonal sensitivity, paranoid ideation, and psychoticism.

They found that Mindfulness-Based Stress Reduction (MBSR) significantly improved psychological and physical symptoms and only a small number of patients experienced increases in symptoms at a much lower proportion than control participants. There was not a single comparison in which MBSR led to greater harm than occurred in controls.

Hence, no evidence was found that mindfulness training led to harm greater than with no treatment while there was clear evidence for mindfulness training producing significantly lower levels of psychological and physical symptoms.

Mindfulness-Based Stress Reduction (MBSR) was clearly a safe and effective treatment to improve mental and physical well-being,

“Meditation isn’t magic. Like any other treatment for stress or mood disorders, it comes with side effects.” – Simon Spichak

CMCS – Center for Mindfulness and Contemplative Studies

This and other Contemplative Studies posts are also available on Twitter @MindfulResearch

Study Summary

Hirshberg, M. J., Goldberg, S. B., Rosenkranz, M., & Davidson, R. J. (2020). Prevalence of harm in mindfulness-based stress reduction. Psychological medicine, 1–9. Advance online publication. https://doi.org/10.1017/S0033291720002834

Abstract

Background

Mindfulness meditation has become a common method for reducing stress, stress-related psychopathology and some physical symptoms. As mindfulness programs become ubiquitous, concerns have been raised about their unknown potential for harm. We estimate multiple indices of harm following Mindfulness-based Stress Reduction (MBSR) on two primary outcomes: global psychological and physical symptoms. In secondary analyses we estimate multiple indices of harm on anxiety and depressive symptoms, discomfort in interpersonal relations, paranoid ideation and psychoticism.

Methods

Intent-to-treat analyses with multiple imputation for missing data were used on pre- and post-test data from a large, observational dataset (n = 2155) of community health clinic MBSR classes and from MBSR (n = 156) and waitlist control (n = 118) participants from three randomized controlled trials conducted contemporaneous to community classes in the same city by the same health clinic MBSR teachers. We estimate change in symptoms, proportion of participants with increased symptoms, proportion of participants reporting greater than a 35% increase in symptoms, and for global psychological symptoms, clinically significant harm.

Results

We find no evidence that MBSR leads to higher rates of harm relative to waitlist control on any primary or secondary outcome. On many indices of harm across multiple outcomes, community MBSR was significantly preventative of harm.

Conclusions

Engagement in MBSR is not predictive of increased rates of harm relative to no treatment. Rather, MBSR may be protective against multiple indices of harm. Research characterizing the relatively small proportion of MBSR participants that experience harm remains important.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7889774/

Improve Sexual Function in Women with Breast Cancer with Mindfulness

May 18, 2022 psyjdc Leave a comment

Improve Sexual Function in Women with Breast Cancer with Mindfulness

By John M. de Castro, Ph.D.

“Mindfulness is extraordinary; it is as if they replace you with someone else. Positive thinking increased my willingness to return to life.” – International Society for Sexual Medicine

Because of great advances in treatment, many patients today are surviving cancer. But cancer survivors frequently suffer from anxiety, depression, mood disturbance, post-traumatic stress disorder (PTSD), sleep disturbance, fatigue, sexual dysfunction, loss of personal control, impaired quality of life, and psychiatric symptoms which have been found to persist even ten years after remission. Also, cancer survivors can have to deal with a heightened fear of reoccurrence. So, safe and effective treatments for the symptoms in cancer and the physical and psychological effects of the treatments are needed.

Mindfulness training has been shown to help with general cancer recovery. Mindfulness practices have been shown to improve the residual symptoms in cancer survivors. The Mindfulness-Based Stress Reduction (MBSR) program is a mindfulness training program that includes meditation practice, body scan, yoga, and discussion along with daily home practice. MBSR has been shown to be beneficial for cancer patients in general and also specifically for the symptoms of breast cancer survivors. So, it makes sense to further explore the effectiveness of MBSR training for the treatment of sexual function in breast cancer survivors.

In today’s Research News article “Impact of mindfulness-based stress reduction on female sexual function and mental health in patients with breast cancer.” (See summary below or view the full text of the study at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8799961/ ) Chang and colleagues recruited breast cancer survivors and provided them with either a 6-weeks of a Mindfulness-Based Stress Reduction (MBSR) program or treatment as usual. They were measured before and after for sexual function, anxiety, depression, perceived stress, and quality of life.

They found that Mindfulness-Based Stress Reduction (MBSR) produce significant increases in sexual arousal, lubrication, orgasm, and satisfaction and significant reductions in anxiety and perceived stress.

Because of the nature of the treatments for breast cancer, sexual confidence and performance may be challenged. It is very important to these women’s well-being that they return to normal engagement in sex. It is very encouraging that mindfulness training appears to improve sexual satisfaction in these women after treatment. This, in turn, markedly improves their mental health.

“Mindfulness-based stress reduction interventions are highly beneficial for reducing depression, fatigue, and stress in the short term. . . Breast cancer survivors are recommended to practice MBSR as part of their daily care routine.” – Yun-Chen Chang

CMCS – Center for Mindfulness and Contemplative Studies

This and other Contemplative Studies posts are also available on Twitter @MindfulResearch

Study Summary

Chang, Y. C., Lin, G. M., Yeh, T. L., Chang, Y. M., Yang, C. H., Lo, C., Yeh, C. Y., & Hu, W. Y. (2022). Impact of mindfulness-based stress reduction on female sexual function and mental health in patients with breast cancer. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 30(5), 4315–4325. https://doi.org/10.1007/s00520-021-06540-y

Abstract

Purpose

There have been few studies using mindfulness-based stress reduction (MBSR) to improve sexual function in Asian women with breast cancer. This study aimed to evaluate the impact of mindfulness intervention on female sexual function, mental health, and quality of life in patients with breast cancer.

Methods

Fifty-one women with breast cancer were allocated into 6-week MBSR (n=26) sessions or usual care (n=25), without differences in group characteristics. The research tools included the Female Sexual Function Index (FSFI), the Depression Anxiety Stress Scales-21 (DASS-21), and the EuroQol instrument (EQ-5D). The Greene Climacteric Scale (GCS) was used to verify the foregoing scale. The effects of MBSR were evaluated by the differences between the post- and pre-intervention scores in each scale. Statistical analyses consisted of the descriptive dataset and Mann-Whitney ranked-pairs test.

Results

Although MBSR did not significantly improve sexual desire and depression in patients with breast cancer, MBSR could improve parts of female sexual function [i.e., Δarousal: 5.73 vs. -5.96, Δlubrication: 3.35 vs. -3.48, and Δsatisfaction: 8.48 vs. 1.76; all p <.005], with a range from small to medium effect sizes. A significantly benefits were found on mental health [Δanxiety: -10.92 vs.11.36 and Δstress: -10.96 vs.11.40; both p <.001], with large effect sizes, ranging from 0.75 to 0.87.

Conclusion

Our study revealed that MBSR can improve female sexual function and mental health except for sexual desire and depression in women with breast cancer. Medical staff can incorporate MBSR into clinical health education for patients with breast cancer to promote their overall quality of life.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8799961/

Effectiveness of Mindfulness Training on Stress Depends Upon Baseline Levels of Anxiety and Sleep Disruption

April 19, 2022 psyjdc Leave a comment

Effectiveness of Mindfulness Training on Stress Depends Upon Baseline Levels of Anxiety and Sleep Disruption

By John M. de Castro, Ph.D.

“Chronic stress can impair the body’s immune system and make many other health problems worse. By lowering the stress response, mindfulness may have downstream effects throughout the body.” – American Psychological Association

Mindfulness training has been shown to improve health and well-being in healthy individuals. It has also been found to be effective for a large array of medical and psychiatric conditions, either stand-alone or in combination with more traditional therapies. One of the primary effects of mindfulness that may be responsible for many of its benefits is that it improves the physiological and psychological responses to stress. But there are large individual differences in the effectiveness of mindfulness training for reduction in stress and its effects. Hence, there is a need to investigate what individual characteristics may predict the positive benefits of mindfulness training.

In today’s Research News article “Do gender, anxiety, or sleep quality predict mindfulness-based stress reduction outcomes?.” (See summary below or view the full text of the study at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7814316/ ) Brown and colleagues recruited adult participants in an 8-week Mindfulness-Based Stress Reduction (MBSR) program. the program consists of weekly training meetings that include meditation, yoga, and body scan along with group discussion and daily home practice. The participants were measured before and after the program for anxiety. depression, sleep quality, stress-related symptoms, and emotion regulation.

They found that in comparison to baseline after the Mindfulness-Based Stress Reduction (MBSR) program there was a significant decrease in stress-related symptoms and emotion suppression and a significant increase in cognitive reappraisal. Participants who were high in anxiety and sleep disruptions at baseline had significantly greater reductions in stress-related symptoms and greater increases in cognitive reappraisal after MBSR. In addition, men had significantly greater decreases in emotion suppression after MBSR than women.

This study lacked a control (comparison condition). So, caution must be exercised in reaching definitive conclusions. But previous controlled studies have demonstrated that mindfulness training results in significant decreases in the physiological and psychological responses to stress and improvements in emotion regulation. So, the present findings are likely due to the impact of the Mindfulness-Based Stress Reduction (MBSR) program.

The study demonstrates that the characteristics of the participants at the beginning of the Mindfulness-Based Stress Reduction (MBSR) program predict it’s impact. Participants who are highly anxious and have troubled sleep at the start tend to benefit the most. Since anxiety and sleep disruption tend to contribute to stress and mindfulness training has been shown to decrease anxiety and improve sleep, it is not surprising that they would be predictive of greater reduction in stress-related symptoms. Nevertheless, the results suggest that MBSR should be employed particularly for anxious individuals and those with troubled sleep.

So, effectiveness of mindfulness training on stress depends upon baseline levels of anxiety and sleep disruption.

“The benefits of mindfulness training may persist for years, because learning to be mindful is something that can be applied to your daily routine.” – Arielle Silverman

CMCS – Center for Mindfulness and Contemplative Studies

This and other Contemplative Studies posts are available on Twitter @MindfulResearch

Study Summary

Brown, M. M., Arigo, D., Wolever, R. Q., Smoski, M. J., Hall, M. H., Brantley, J. G., & Greeson, J. M. (2021). Do gender, anxiety, or sleep quality predict mindfulness-based stress reduction outcomes?. Journal of health psychology, 26(13), 2656–2662. https://doi.org/10.1177/1359105320931186

Abstract

Although mindfulness-based stress reduction (MBSR) can improve health and well-being, less is known about factors that predict outcomes. This prospective observational study examined gender and baseline anxiety and sleep quality as predictors of change in emotion regulation and stress symptoms following an 8-week MBSR program. Women and men reported similar improvement in stress symptoms and cognitive reappraisal, whereas men improved more in emotion suppression. Individuals with higher anxiety and worse sleep pre-treatment benefited most in terms of decreased stress. Evaluating pre-treatment characteristics could help determine optimal candidates for MBSR training and could optimize outcomes for both women and men.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7814316/

Increase the Levels of the Anti-Stress Hormone Dehydroepiandrosterone with Mindfulness

April 18, 2022 psyjdc Leave a comment

Increase the Levels of the Anti-Stress Hormone Dehydroepiandrosterone with Mindfulness

By John M. de Castro, Ph.D.

“Best known by researchers as the “longevity molecule” and stress counter-puncher, DHEA is one of the most important hormones in the body. As we get older our DHEA levels decrease year after year, opening us up to disease and accelerated aging. . . Luckily, meditation provides a dramatic boost in DHEA hormone levels.” – EOC Institute

Mindfulness training has been shown to improve health and well-being in healthy individuals. It has also been found to be effective for a large array of medical and psychiatric conditions, either stand-alone or in combination with more traditional therapies. One of the primary effects of mindfulness that may be responsible for many of its benefits is that it improves the physiological and psychological responses to stress. Stress is accompanied by release of stress-related hormones such as cortisol. But it is also associated with release of the steroid hormone dehydroepiandrosterone (DHEA) which tends to counteract the negative effects of cortisol. This would predict that, mindfulness training would result in an increase in DHEA in stressed individuals. But this prediction has not been assessed.

In today’s Research News article “Effect of Mindfulness-Based Stress Reduction on dehydroepiandrosterone-sulfate in adults with self-reported stress. A randomized trial.” (See summary below or view the full text of the study at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8604255/ ) Jørgensen and colleagues recruited adults with self-reported high levels of stress and randomly assigned them to a wait-list control condition, or to receive either weekly 90-minute sessions for 8 weeks of either Local Stress Reduction (LSR) or Mindfulness-Based Stress reduction (MBSR). LSR was based upon Acceptance and Commitment Therapy (ACT) and differed from MBSR in a number of ways but primarily on an emphasis on cognitive behavioral changes. The participants had blood drawn before and after the programs and assayed for dehydroepiandrosterone‐sulfate (DHEAS). They were also measured for resilience, and well-being.

They found that in comparison to baseline, the wait-list control group, and the group that received Local Stress Reduction (LSR), the group that received Mindfulness-Based Stress reduction (MBSR) had significantly higher levels of dehydroepiandrosterone‐sulfate (DHEAS), resilience and well-being. A strength of this study was then inclusion of an active control condition, LSR. This eliminates a large number of alternative confounding interpretations of the results and makes the conclusions much stronger of MBSR causing the effects.

DHEAS is a hormone that tends to counteract the deleterious effects of stress hormones. Hence, MBSR improved both the psychological and physiological well-being of the high stress participants. High levels of stress are a major source of ill health. So, counteracting the effects of stress may be an important contributor to the health and well-being of the individual. This is particularly important for individual experiencing high levels of perceived stress as in the present study..

So, increase the levels of the anti-stress hormone dehydroepiandrosterone with mindfulness.

“DHEA is one of the most important hormones in the body. It helps counteract the effects of cortisol as well as provide the raw materials for making other necessary hormones. Low DHEA is linked to increased risk of mortality. Individuals who practice meditation have 43 percent more DHEA than their peers.” – Renew Youth

CMCS – Center for Mindfulness and Contemplative Studies

This and other Contemplative Studies posts are available on Twitter @MindfulResearch

Study Summary

Jørgensen, M. A., Pallesen, K. J., Fjorback, L. O., & Juul, L. (2021). Effect of Mindfulness-Based Stress Reduction on dehydroepiandrosterone-sulfate in adults with self-reported stress. A randomized trial. Clinical and translational science, 14(6), 2360–2369. https://doi.org/10.1111/cts.13100

Abstract

Long‐term stress can lead to long‐term increased cortisol plasma levels, which increases the risk of numerous diseases. Dehydroepiandrosterone (DHEA) and its sulfated form dehydroepiandrosterone‐sulfate (DHEAS), together DHEA(S), have shown to counteract some of the effects of cortisol and may be protective during stress. The program “Mindfulness‐Based Stress Reduction” (MBSR) has shown to have positive effects on stress. The present study examined a possible effect of MBSR on DHEAS in plasma compared to a waiting list and a locally developed stress reduction program (LSR) in people with self‐reported stress. The study was a three‐armed randomized controlled trial conducted in a municipal health care center in Denmark. It included 71 participants with self‐reported stress randomized to either MBSR (n = 24) or LSR (n = 23), or a waiting list (n = 24). Blood samples were collected at baseline and at 12 weeks follow‐up to estimate effects of MBSR on DHEAS. The effect of MBSR on DHEAS was statistically significant compared to both the waiting list and LSR. We found a mean effect of 0.70 µmol/L (95% confidence interval [CI] = 0.18–1.22) higher DHEAS in the MBSR group compared with the waiting list group and a mean effect of 0.54 µmol/L (95% CI = 0.04–1.05) higher DHEAS in the MBSR group compared with the LSR group. Findings indicate an effect on DHEAS of the MBSR program compared to a waiting list and LSR program in people with self‐reported stress. However, we consider our findings hypothesis‐generating and validation by future studies is essential.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8604255/

Improve Education Students Psychological Well-Being with Mindfulness

March 31, 2022 psyjdc Leave a comment

Improve Education Students Psychological Well-Being with Mindfulness

By John M. de Castro, Ph.D.

“Mindfulness practices help anchor the mind, creating space to become aware of our thoughts and feelings, and keeps us in the present moment, all of which helps reduce stress and anxiety and boosts levels of attention and concentration.” – Rebecca Enderby

In the modern world education is a key for success. There is a lot of pressure on university students to excel so that they can get the best jobs after graduation. The pressure can lead to stress, anxiety, and depression which can impede the student’s mental health, well-being, and school performance. But it is, for the most part, beyond the ability of the individual to change the environment to reduce stress, so it is important that methods be found to reduce the college students’ responses to stress; to make them more resilient when high levels of stress occur. Contemplative practices including meditation, mindfulness training, exercise, Tai Chi and Qigong, and yoga practice have been shown to reduce the psychological and physiological responses to stress, relieve anxiety, and reduce depression

In today’s Research News article “The Effects of a Mindfulness Program on Mental Health in Students at an Undergraduate Program for Teacher Education: A Randomized Controlled Trial in Real-Life.” (See summary below or view the full text of the study at: https://www.frontiersin.org/articles/10.3389/fpsyg.2021.722771/full?utm_source=F-AAE&utm_medium=EMLF&utm_campaign=MRK_1790561_a0P58000000G0YfEAK_Psycho_20211214_arts_A ) Juul and colleagues recruited teacher education college students and randomly assigned them to a wait-list control condition or to receive 8 weekly 2.5 hour sessions of the Mindfulness-Based Stress Reduction (MBSR) program. The program consists of training in meditation, body scan, and yoga, group discussion, and daily home practice. They were measured before and after training and 3 months later for perceived stress, anxiety, depression, well-being, resilience, mindfulness, and resting state cognitive activity.

They found that in comparison to baseline and the wait-list control group, the group that received Mindfulness-Based Stress Reduction (MBSR) had significantly higher well-being and significantly lower levels of perceived stress, anxiety, depression, and resting state cognitive activity of distracting thoughts, thoughts of self and comfort. In addition, they found that the effect of MBSR on perceived stress was in part mediated by resting state cognitive activity of distracting thoughts and comfort and by thoughts of self on anxiety and depression. These effects were still present at the 3-month follow-up measurement.

The study demonstrates that mindfulness training improves the mental health of stresses teacher education college students. It has been routinely shown in previous research with a variety of groups that mindfulness training produces reduced levels of perceived stress, anxiety, and depression and increased levels of well-being. The new finding is that these improvements in mental health produced by the mindfulness training appear to be in part mediated by changes in the students’ resting state cognitive activity. In other words, the training appears to alter the mental contents of the students which in turn improves their mental health. The mindfulness trained students appear to have fewer distracting thoughts, thoughts of self and comfort and these reductions appear to improve their psychological well-being.

So, improve education students psychological well-being with mindfulness.

“It’s no secret that college can quickly become a major stressor for many students. Balancing multiple classes on top of work, a social life, and a million other things is a lot to take on at once. Don’t let yourself become too overwhelmed with everything. Instead, try . . . mindfulness.” – Savannah Byers

CMCS – Center for Mindfulness and Contemplative Studies

This and other Contemplative Studies posts are available on Twitter @MindfulResearch

Study Summary

Juul L, Brorsen E, Gøtzsche K, Nielsen BL and Fjorback LO (2021) The Effects of a Mindfulness Program on Mental Health in Students at an Undergraduate Program for Teacher Education: A Randomized Controlled Trial in Real-Life. Front. Psychol. 12:722771. doi: 10.3389/fpsyg.2021.722771

Background: In this study, we aimed to investigate the effects of a mindfulness program including Mindfulness-Based Stress Reduction (MBSR) on the mental health of student teachers when offered at their educational institution in a real-life context.

Methods: A parallel randomized controlled trial (RCT) was conducted among self-selected student teachers at a Danish undergraduate program for teacher education in the autumns of 2019 and 2020. Participation was not recommended in case of (1) clinical depression or a diagnosis of psychosis or schizophrenia, (2) abuse of alcohol, drugs, and/or medicine. Randomization was performed by a Statistician who was blinded to the identity of the students. Data was collected using self-reported questionnaires. The primary outcome was a change in perceived stress 3 months from baseline. Secondary outcome measures were symptoms of anxiety and depression, well-being, resilience, mindfulness, and thoughts and feelings during rest. The effects were analyzed according to the intention-to-treat principle using mixed-effect linear regression models. Mediating effects of mindfulness skills on the mental health outcomes were explored using structural equation modeling.

Results: The study group included 67 student teachers with 34 allocated to the intervention group (median age: 25 years; women: n = 24, 71%); and 33 students (median age: 25 years; women: n = 25, 76%) allocated to a waiting list control group. At baseline, mean Perceived Stress Scale (PSS) scores were 18.88 (SD: 5.75) in the intervention group and 17.91 (SD: 6.36) in the waiting list control group. A total of 56 students completed the questionnaire at a 3-month follow-up (28 in both the intervention- and the control group). Statistically significant effects of the intervention were found on perceived stress, symptoms of anxiety and depression, well-being, and on three of seven resting-state dimensions. No effects were found on resilience or mindfulness. Statistically significant mediated effects via resting-state dimensions were found.

Conclusion The findings suggested that offering a mindfulness program at an undergraduate program for teacher education could significantly improve the mental health among self-selected students within 3 months. Results of mediation analysis supported the hypothesis that some of the effects might be explained by reduced distracting thoughts.

https://www.frontiersin.org/articles/10.3389/fpsyg.2021.722771/full?utm_source=F-AAE&utm_medium=EMLF&utm_campaign=MRK_1790561_a0P58000000G0YfEAK_Psycho_20211214_arts_A

Reduce Stress and Increase Well-Being in People with Schizophrenia with Mindfulness

March 29, 2022 psyjdc Leave a comment

Reduce Stress and Increase Well-Being in People with Schizophrenia with Mindfulness

By John M. de Castro, Ph.D.

“In schizophrenic patients, mindfulness intervention leads to better psychosocial functioning, improved positive emotions, and reduced negative symptoms.” – Jia‐Ling Sheng

Schizophrenia is the most common form of psychosis. Its effects about 1% of the population worldwide. It appears to be highly heritable and involves changes in the brain. It is characterized by both positive and negative symptoms. Positive symptoms include hallucinations; seeing and, in some cases, feeling, smelling or tasting things that aren’t there, or delusions; unshakable beliefs that, when examined rationally, are obviously untrue. Negative symptoms include a reduced ability to function normally, neglect of personal hygiene, lack of emotion, blank facial expressions, speaking in a monotone, loss of interest in everyday activities, social withdrawal, an inability to experience pleasure, and a lack of insight into their symptoms. The symptoms of schizophrenia usually do not appear until late adolescence or early adulthood.

Schizophrenia is very difficult to treat with psychotherapy and is usually treated with antipsychotic drugs. These drugs, however, are not always effective, sometimes lose effectiveness, and can have some difficult side effects. Mindfulness training has been shown to be beneficial for a variety of mental health problems, including psychosis. Mindfulness has also been shown to associated with lower symptom severity of schizophrenia.

In today’s Research News article “Effects of Mindfulness-Based Stress Reduction (MBSR) on Stress, Heart Rate Variability, Affect, and Wellbeing among People with Schizophrenia.” (See summary below or view the full text of the study at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8617870/ ) Kim and colleagues recruited patients who had been diagnosed with schizophrenia at two centers. The participants from one center constituted the no-treatment control condition while those from the other received 8-weekly 60 minute sessions of the Mindfulness-Based Stress Reduction (MBSR) program. The participants were measured before and after the treatment and 6 weeks later for perceived stress, positive and negative emotions, well-being, and heart rate variability.

They found that in comparison to baseline and the control group, the group that received Mindfulness-Based Stress Reduction (MBSR) had significantly lower perceived stress and negative emotions and significantly higher heart rate variability. Increases in heart rate variability indicates a reduction in physiological activation, an increase in parasympathetic relaxation, providing a physiological indicator of reduced stress. These changes remained significant at the 6 week follow up.

These findings demonstrate that mindfulness training with Mindfulness-Based Stress Reduction (MBSR) is effective in reducing stress and negative emotions in patients diagnosed with schizophrenia. Mindfulness training has been shown, in the past with a variety of groups to reduce stress, negative emotions, and heart rate variability. The present findings demonstrate that mindfulness training also improves the psychological well-being in patients with a major mental illness. This suggests that MBSR should be incorporated into the treatment program for patients who had been diagnosed with schizophrenia.

So, reduce stress and increase well-being in people with schizophrenia with mindfulness.

“meditation is the best and successful treatment for Schizophrenia without any side-effects, caused by the very strong medications.” – Ruchi Singhal

CMCS – Center for Mindfulness and Contemplative Studies

This and other Contemplative Studies posts are available on Twitter @MindfulResearch

Study Summary

Kim, A. S., Jang, M. H., & Sun, M. J. (2021). Effects of Mindfulness-Based Stress Reduction (MBSR) on Stress, Heart Rate Variability, Affect, and Wellbeing among People with Schizophrenia. International journal of environmental research and public health, 18(22), 11871. https://doi.org/10.3390/ijerph182211871

Abstract

Mindfulness-based stress reduction programs have been found to be effective in reducing the stress response and improving the psychological wellbeing of various populations. We aimed to confirm the effects of a mindfulness-based stress reduction program on perceived stress, heart rate variability, positive and negative affect, and subjective wellbeing of community-dwelling people with schizophrenia. The participants in this study were 26 people with schizophrenia (experimental group: 14, control group: 12) enrolled in two community mental health centers located in Gyeonggi Province in South Korea. In the experimental group, the mindfulness-based stress reduction program was applied once a week for 60 min over 8 weeks. The experimental group showed a significantly greater decrease in perceived stress and negative affect, as well as significantly greater improvement in heart rate variability than the control group. The mindfulness-based stress reduction program was an effective nursing intervention to reduce stress and negative affect in people with schizophrenia.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8617870/

Improve Well-Being in Adults who Experienced Childhood Maltreatment with Mindfulness

March 10, 2022 psyjdc Leave a comment

Improve Well-Being in Adults who Experienced Childhood Maltreatment with Mindfulness

By John M. de Castro, Ph.D.

“mindfulness-based interventions can be beneficial for childhood maltreatment survivors to alleviate psychological symptoms including stress, anxiety, recurrent depression, substance use, and post-traumatic stress.” – Diane Joss

Childhood trauma can leave in its wake symptoms which can haunt the victims for the rest of their lives. These include persistent recurrent re-experiencing of the traumatic event, including flashbacks and nightmares, loss of interest in life, detachment from other people, increased depression, anxiety and emotional arousal, including outbursts of anger, difficulty concentration, and jumpiness, startling easily. Unfortunately, childhood maltreatment can continue to affect mental and physical health throughout the individual’s life. How individuals cope with childhood maltreatment helps determine the effects of the maltreatment on their mental health.

It has been found that experiencing the feelings and thoughts produced by trauma completely, allows for better coping. This can be provided by mindfulness. Indeed, mindfulness has been found to be effective for relieving trauma symptoms. But it is not known how mindfulness works to impact the psychological well-being of adults who experienced childhood maltreatment.

In today’s Research News article “Nonattachment Predicts Empathy, Rejection Sensitivity, and Symptom Reduction After a Mindfulness-Based Intervention Among Young Adults with a History of Childhood Maltreatment.” (See summary below or view the full text of the study at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7205188/ ) Joss and colleagues recruited patience with a history of childhood maltreatment including physical and emotional abuse or neglect, and sexual abuse, verbal abuse, witnessing violence between parents or physical abuse of siblings.

They were assigned to either a wait-list control condition or to receive mindfulness training. The training was modelled after the Mindfulness-Based Stress Reduction (MBSR) program and met once a week for eight weeks along with daily home practice and contained “breath awareness meditation, body scan meditation, mindful yoga, open awareness meditation, loving-kindness meditation, walking meditation, mountain meditation, mindful eating as well as noticing mindful moments in daily lives”. They were measured before and after training for mindfulness, childhood trauma, adverse childhood experiences, anxiety sensitivity, PTSD symptoms, rejection sensitivity, nonattachment, and interpersonal reactivity.

They found that in comparison to baseline and the wait-list control group, the group that received mindfulness training had significantly higher levels of mindfulness and nonattachment and significantly lower levels of PTSD symptoms, rejection sensitivity, and interpersonal reactivity. In addition, the greater the attendance at the mindfulness training sessions the greater the increases in mindfulness and nonattachment and decreases in personal distress and anxiety sensitivity. Further they found that mindfulness was associated with reduced rejection sensitivity indirectly by being associated with higher levels of nonattachment and empathy which were in turn associated with lower levels of rejection sensitivity.

The results suggest that mindfulness training improves the psychological well-being of young adults who had experienced childhood maltreatment in a dose dependent way. Nonattachment is a “flexible way of relating to one’s experiences without clinging to or suppressing them” and is increased by mindfulness training. In addition, empathy is “the capacity to understand others’ perspectives and to feel and share others’ feelings” and is increased by mindfulness training. These factors in turn appear to be important for the improvement in psychological well-being. In other words, mindfulness increases the ability to let go of experiences and not ruminate or worry about them and improves empathy and these factors improve the well-being of young adults who had experienced childhood maltreatment. All this suggests that mindfulness training should be recommended for people who experienced childhood maltreatment to reduce the impact of the trauma and improve psychological well-being.

So, improve well-being in adults who experienced childhood maltreatment with mindfulness.

“Mindfulness skills tend to be lower among adolescents and adults exposed to various forms of childhood maltreatment.” – Alan R. King

CMCS – Center for Mindfulness and Contemplative Studies

This and other Contemplative Studies posts are available on Twitter @MindfulResearch

Study Summary

Joss, D., Lazar, S. W., & Teicher, M. H. (2020). Nonattachment Predicts Empathy, Rejection Sensitivity, and Symptom Reduction After a Mindfulness-Based Intervention Among Young Adults with a History of Childhood Maltreatment. Mindfulness, 11(4), 975–990. https://doi.org/10.1007/s12671-020-01322-9

Abstract

Objectives:

Individuals with a childhood maltreatment history tend to have various psychological symptoms and impaired social functioning. This study aimed to investigate the related therapeutic effects of a mindfulness-based intervention in this population.

Methods:

We analyzed self-report questionnaire scores of the Mindful Attention Awareness Scale (MAAS), Non-Attachment Scale (NAS), Adult Rejection Sensitivity Questionnaire (A-RSQ), Interpersonal Reactivity Index (IRI), PTSD CheckList (PCL), and Anxiety Sensitivity Index (ASI), from 16 (3 males) young adults (age range 22–29) with mild to moderate childhood maltreatment, compared to 18 matched participants (6 males) on a waiting list, during both pre- and post-intervention/waiting periods. Analyses were conducted with linear mixed effects models, partial correlation analyses and t-tests.

Results:

There were group by time interaction effects with the scores of MAAS, NAS, PCL, IRI-Fantasy, and A-RSQ (p < .05). The mindfulness group had significant increase in MAAS (17.325%) and NAS (8.957%) scores, as well as reduction in PCL (15.599%) and A-RSQ (23.189%) scores (p < .05). Changes in non-attachment, but not mindfulness, had significant contributions to the score changes of PCL (16.375%), ASI (36.244%), IRI-Personal Distress (24.141%), IRI-Empathic Concern (16.830%), and A-RSQ (10.826%) (p < .05). The number of intervention sessions attended was correlated with score changes of NAS (r = .955, p < .001), and ASI (r = −.887, p < .001), suggesting a dose-dependent effect.

Conclusions:

Findings from this pilot study suggest that the mindfulness-based intervention improved mindfulness, non-attachment and empathy, which contributed to reduced interpersonal distress, rejection sensitivity and other psychological symptoms.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7205188/

Improve Emotion Regulation and Well-Being During Covid-19 with Mindfulness

March 4, 2022March 4, 2022 psyjdc Leave a comment

Improve Emotion Regulation and Well-Being During Covid-19 with Mindfulness

By John M. de Castro, Ph.D.

“A mindfulness practice can help us connect with awareness and let things come and go without our attention getting stuck on it. It can also help us make better choices. Between the emotion and the action, there is a choice, so this can help you to respond rather than to react.” – Anne Dutton

Mindfulness is known to decrease the psychological and physical responses to stress. So, mindfulness training may be helpful in coping with the mental and physical challenges resulting from the COVID-19 pandemic. But exposure to others during a pandemic is very dangerous. So, providing mindfulness training online is a preferred method. Mindfulness-Based Stress Reduction (MBSR) is a well-established and heavily used mindfulness training technique that employs meditation, body scan, yoga, group discussion and homework. It has been successfully implemented online. But it’s efficacy during a Covid-19 lockdown is not well established.

In today’s Research News article “Mindfulness-Based Stress Reduction Increases Mental Wellbeing and Emotion Regulation During the First Wave of the COVID-19 Pandemic: A Synchronous Online Intervention Study.” (See summary below or view the full text of the study at: https://www.frontiersin.org/articles/10.3389/fpsyg.2021.720965/full?utm_source=F-AAE&utm_medium=EMLF&utm_campaign=MRK_1778822_a0P58000000G0YfEAK_Psycho_20211123_arts_A ) Sanilevici and colleagues during the first wave Covid-19 lockdown recruited adult participants who enrolled in an online Mindfulness-Based Stress Reduction (MBSR) course and a control group who expressed interest in the online program but who were unable to participate. MBSR was administered in 8 weekly, 2.5 hour online meetings along with 30 minutes of daily home practice. The groups were measured before and after MBSR and 1 month later for mindfulness, anxiety, perceived stress, emotion regulation, intolerance of uncertainty, and loneliness.

At baseline they found that the higher the levels of mindfulness the lower the levels of anxiety, perceived stress, intolerance of uncertainty, and loneliness and the higher the levels of emotion regulation. They also found that in comparison to baseline and the control group, the group that completed the online Mindfulness-Based Stress Reduction (MBSR) course had significantly lower levels of anxiety and perceived stress and significantly higher levels of emotion regulation. Finally, they found that MBSR lowered anxiety and perceived stress directly and also indirectly by increasing emotion regulation which in turn lowered anxiety and perceived stress. These benefits were still significant one month after the completion of MBSR.

Previous research by others has established that mindfulness training reduces anxiety and perceived stress and improves emotion regulation. The present findings suggest that a Mindfulness-Based Stress Reduction (MBSR) course can be successfully implemented online, improving the psychological well-being of individuals during an extremely stressful time. They further demonstrate that MBSR improved psychological well-being directly and through improving emotion regulation. These findings are important as during a pandemic it is not feasible to provide mindfulness-based therapy in person. So, the findings that mindfulness training can be implemented successfully online improving the psychological well-being of individuals in the real world provides a means to help individuals cope with the pandemic and the lockdown.

So, improve emotion regulation and well-being during Covid-19 with mindfulness.

“Mindfulness practice . . . can bring about an understanding and acceptance of transient and ever-changing nature of all our experiences, whether mental (thoughts, emotions, body sensations) or physical (events, things, relationships). This experiential understanding of all phenomena as being “impermanent” might prove to be an important mechanism for promoting positive adaptation to a highly unpredictable and constantly changing landscape of COVID-19 pandemic.” – Elena Antonova

CMCS – Center for Mindfulness and Contemplative Studies

This and other Contemplative Studies posts are available on Twitter @MindfulResearch

Study Summary

Sanilevici M, Reuveni O, Lev-Ari S, Golland Y and Levit-Binnun N (2021) Mindfulness-Based Stress Reduction Increases Mental Wellbeing and Emotion Regulation During the First Wave of the COVID-19 Pandemic: A Synchronous Online Intervention Study. Front. Psychol. 12:720965. doi: 10.3389/fpsyg.2021.720965

The COVID-19 pandemic imposed extreme living conditions of social distancing, which triggered negative mental health problems and created challenges in seeking mental health support. Mindfulness-based interventions (MBIs) have been found to enhance wellbeing and mental health by reducing stress and anxiety and improving emotion regulation. Preliminary evidence suggests that online, synchronous MBIs may produce beneficial effects similar to face-to-face programs. However, the effectiveness of such online-MBIs to support mental health in highly stressful times, such as a global pandemic, requires further study. To this end, we investigated the effect of an online 8-week Mindfulness-Based Stress Reduction (MBSR) program on aspects of mental health during the first wave of the COVID-19 pandemic. Participants (N=92) who expressed interest in discounted online-MBSR programs were recruited for the study. The division into experimental and control groups was based on actual enrollment to the courses. Those who enrolled in a program were assigned to the experimental condition and those who decided not to enroll served as controls. Participants were assessed pre-intervention, post-intervention, and 1-month post-intervention for levels of mindfulness, perceived stress, anxiety, emotion regulation, and intolerance of uncertainty. Differences between the groups were tested using the general linear mixed effects model (GLMM) and Individual Growth Curve Models (IGCM) in intent to treat analysis. The findings indicated that, relative to the control group, MBSR improved mindfulness abilities (p <0.001), decreased anxiety (p <0.001), and stress (p <0.001) and increased emotion regulation (p <0.001). These effects were found to persist 1 month after the end of the program, despite the increased governmental public-health restrictions due to COVID-19 at that time. The ability to tolerate uncertainty, a central characteristic of the pandemic, was not found to be affected by the program. A mediation analysis revealed that the effect of the intervention on mental health improvement was partially mediated by the improvement in emotion regulation. Overall, the findings provide positive evidence for the feasibility of an online-MBSR program to support the mental health of individuals from the general population through the mediation of emotion regulation in challenging times, such as a global pandemic.

https://www.frontiersin.org/articles/10.3389/fpsyg.2021.720965/full?utm_source=F-AAE&utm_medium=EMLF&utm_campaign=MRK_1778822_a0P58000000G0YfEAK_Psycho_20211123_arts_A

Mindfulness Improves Cognitive Function in Older Adults by Altering Brain Gene Expression

February 24, 2022 psyjdc Leave a comment

Mindfulness Improves Cognitive Function in Older Adults by Altering Brain Gene Expression

By John M. de Castro, Ph.D.

“mindfulness may target inflammation, stress-related pathways, and neuroplasticity, thus reducing the risk of developing cerebrovascular disease and age-related neurodegeneration that could lead to the development of dementia.” – Ted Kheng Siang Ng

The aging process involves a systematic progressive decline in every system in the body, the brain included. The elderly frequently have problems with attention, thinking, and memory abilities, known as mild cognitive impairment. An encouraging new development is that mindfulness practices such as meditation training and mindful movement practices can significantly reduce these declines in cognitive ability. In addition, it has been found that

mindfulness practices reduce the deterioration of the brain that occurs with aging restraining the loss of neural tissue. Indeed, the brains of practitioners of meditation have been found to degenerate less with aging than non-practitioners. The mechanisms by which mindfulness affects the brain and reduces cognitive decline need to be investigated.

In today’s Research News article “Mindfulness intervention improves cognitive function in older adults by enhancing the level of miRNA-29c in neuron-derived extracellular vesicles.” (See summary below or view the full text of the study at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8575875/ ) Hashizume and colleagues recruited healthy elderly adults aged 65 and over and administered either 4 weeks , 3 times per week for 60 minutes of Mindfulness-Based Stress Reduction (MBSR) or a no-treatment wait-list condition. They were measured before and after treatment for cognitive function including delayed recall, visuospatial/executive function, attention, abstraction, language, naming, and orientation tasks. They also had blood drawn and assayed for extracellular vesicles and mRNA in the vesicles.

They found that in comparison to baseline and the wait list control, after Mindfulness-Based Stress Reduction (MBSR) there were significant improvement in cognitive function including delayed recall, visuospatial/executive function, attention, naming, and orientation tasks. The blood assays revealed that in comparison to baseline and the wait list control, after MBSR there were significant reductions in miR-29c in the extracellular vesicles and decreased expression of the genes DNMT3A, DNMT3B, and BACE1 in in the extracellular vesicles. In another study with mice they found that injection into the brain ventricles of miR-29c prevented cognitive decline in the animals.

The results suggest that mindfulness training improves cognitive function in the elderly. These improvements in cognition have been previously observed by other researchers. The new findings in the present research are the changes in the extracellular vesicles found in the plasma. The expression of the mRNA miR-29c controls the gene expressions of DNMT3A, DNMT3B, and BACE1. These genes are associated with the loss of neurons in the brain. With aging there is a degeneration of the brain including losses of neurons. Reductions in the expression of the genes that tend to produce neuronal loss after Mindfulness-Based Stress Reduction (MBSR) suggests that the training protects the brain from the loss of neurons. This may represent the mechanism by which mindfulness training protects the brain in aging individual which results in improved cognitive function. It may be how mindfulness training stops cognitive decline in the elderly.

So, mindfulness improves cognitive function in older adults by altering brain gene expression.

“an 8-week mindfulness-based training program improved cognition . . . in cognitively normal older adults, and that these improvements were associated with increased intrinsic connectivity within the default mode network.” – Gunes Sevinc

CMCS – Center for Mindfulness and Contemplative Studies

This and other Contemplative Studies posts are available on Twitter @MindfulResearch

Study Summary

Hashizume, S., Nakano, M., Kubota, K., Sato, S., Himuro, N., Kobayashi, E., Takaoka, A., & Fujimiya, M. (2021). Mindfulness intervention improves cognitive function in older adults by enhancing the level of miRNA-29c in neuron-derived extracellular vesicles. Scientific reports, 11(1), 21848. https://doi.org/10.1038/s41598-021-01318-y

Abstract

Although mindfulness-based stress reduction (MBSR) improves cognitive function, the mechanism is not clear. In this study, people aged 65 years and older were recruited from elderly communities in Chitose City, Japan, and assigned to a non-MBSR group or a MBSR group. Before and after the intervention, the Japanese version of the Montreal Cognitive Assessment (MoCA-J) was administered, and blood samples were collected. Then, neuron-derived extracellular vesicles (NDEVs) were isolated from blood samples, and microRNAs, as well as the target mRNAs, were evaluated in NDEVs. A linear mixed model analysis showed significant effects of the MBSR x time interaction on the MoCA-J scores, the expression of miRNA(miR)-29c, DNA methyltransferase 3 alpha (DNMT3A), and DNMT3B in NDEVs. These results indicate that MBSR can improve cognitive function by increasing the expression of miR-29c and decreasing the expression of DNMT3A, as well as DNMT3B, in neurons. It was also found that intracerebroventricular injection of miR-29c mimic into 5xFAD mice prevented cognitive decline, as well as neuronal loss in the subiculum area, by down-regulating Dnmt3a and Dnmt3b in the hippocampus. The present study suggests that MBSR can prevent neuronal loss and cognitive impairment by increasing the neuronal expression of miR-29c.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8575875/

Improve Anxiety Disorders with Mindfulness

February 23, 2022 psyjdc Leave a comment

Improve Anxiety Disorders with Mindfulness

By John M. de Castro, Ph.D.

“[Anxiety Disorders] primarily involves unrelenting worry. With meditation, you can learn to accept those worries without letting them upset you, which is likely to diminish your stress.” – Arlin Cuncic

Anxiety disorders are the most common mental illness in the United States, affecting 40 million adults, or 18% of the population. A characterizing feature of anxiety disorders is that the sufferer overly identifies with and personalizes their thoughts. The sufferer has recurring thoughts, such as impending disaster, that they may realize are unreasonable, but are unable to shake. Anxiety disorders have generally been treated with drugs. But there are considerable side effects, and these drugs are often abused. There are several psychological therapies for anxiety. But, about 45% of the patients treated do not respond to the therapy. So, there is a need to develop alternative treatments. So, there is a need to develop alternative treatments. Recently, it has been found that mindfulness training can be effective for anxiety disorders. There has developed a considerable volume of research on the effectiveness of mindfulness-based therapies for anxiety disorders. So, it is reasonable to summarize what has been learned.

In today’s Research News article “A systematic review and meta-analysis of acceptance- and mindfulness-based interventions for DSM-5 anxiety disorders.” (See summary below or view the full text of the study at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8516851/ ) Haller and colleagues review, summarize, and perform a meta-analysis on the published research on the effectiveness of mindfulness-based therapies for anxiety disorders. They identified 23 randomized controlled trials including a total of 1815 patients with anxiety disorders; Generalized Anxiety Disorder, Social Anxiety Disorder, and mixed anxiety diagnoses. Twelve studies employed Acceptance and Commitment Therapy (ACT), 3 ones Mindfulness-Based Cognitive Therapy (MBCT), and 8 ones Mindfulness-Based Stress Reduction (MBSR).

They report that the published research studies found that Acceptance and Commitment Therapy (ACT), Mindfulness-Based Cognitive Therapy (MBCT), and Mindfulness-Based Stress Reduction (MBSR) in comparison to treatment as usual produced significant reduction in anxiety either based on clinician or patient reports and also depression in these patients. ACT appeared to have superior effects, followed by MBCT, and lastly MBSR. These effects, however, were no longer significant at follow up 6- and 12-months after the interventions.

This analysis of the published research suggests that mindfulness-based therapies are effective in relieving anxiety and depression in patients with anxiety disorders. But they appear to be only effective over the short term. More work needs to be done to optimize the effectiveness of these therapies and to identify how to make the effects longer lasting.

So, improve anxiety disorders with mindfulness.

“Mindfulness counters the overthinking and hypervigilance of anxiety. When we’re anxious, our minds are full of ruminations about the past and worries about the future, and the more anxiety pulls us away from the present moment, the more stressed and unhappy we are. . . mindfulness offers a break from the worries and fears of anxiety.” – Tanya Peterson

CMCS – Center for Mindfulness and Contemplative Studies

This and other Contemplative Studies posts are available on Twitter @MindfulResearch

Study Summary

Haller, H., Breilmann, P., Schröter, M., Dobos, G., & Cramer, H. (2021). A systematic review and meta-analysis of acceptance- and mindfulness-based interventions for DSM-5 anxiety disorders. Scientific reports, 11(1), 20385. https://doi.org/10.1038/s41598-021-99882-w

Abstract

This meta-analysis systematically reviewed the evidence on standardized acceptance-/mindfulness-based interventions in DSM-5 anxiety disorders. Randomized controlled trials examining Acceptance and Commitment Therapy (ACT), Mindfulness-Based Cognitive Therapy (MBCT), and Mindfulness-Based Stress Reduction (MBSR) were searched via PubMed, Central, PsycInfo, and Scopus until June 2021. Standardized mean differences (SMD) and 95% confidence intervals (CI) were calculated for primary outcomes (anxiety) and secondary ones (depression and quality of life). Risk of bias was assessed using the Cochrane tool. We found 23 studies, mostly of unclear risk of bias, including 1815 adults with different DSM-5 anxiety disorders. ACT, MBCT and MBSR led to short-term effects on clinician- and patient-rated anxiety in addition to treatment as usual (TAU) versus TAU alone. In comparison to Cognitive Behavioral Therapy (CBT), ACT and MBCT showed comparable effects on both anxiety outcomes, while MBSR showed significantly lower effects. Analyses up to 6 and 12 months did not reveal significant differences compared to TAU or CBT. Effects on depression and quality of life showed similar trends. Statistical heterogeneity was moderate to considerable. Adverse events were reported insufficiently. The evidence suggests short-term anxiolytic effects of acceptance- and mindfulness-based interventions. Specific treatment effects exceeding those of placebo mechanisms remain unclear.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8516851/