inflammatory response

Reduce Interpersonal Trauma Symptoms with Mindfulness

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Reduce Interpersonal Trauma Symptoms with Mindfulness

 

By John M. de Castro, Ph.D.

 

“mindfulness meditation training improves your brain’s ability to help you manage stress, and these changes improve a broad range of stress-related health outcomes, such as your inflammatory health,” David Creswell

 

Experiencing trauma is quite common. It has been estimated that 60% of men and 50% of women will experience a significant traumatic event during their lifetime. Trauma produced by one person on another, interpersonal trauma, frequently involves intimate partners and can occur as personal assault, sexual assault, witnessing family violence, and sudden loss of a loved one. This is common particularly with low income women. The psychological consequences can be profound and endure over a lifetime, and can result in Post-Traumatic Stress Disorder (PTSD).

 

Another common consequence of the stress produced by trauma is an increase in inflammation. The immune system is designed to protect the body from threats like stress, infection, injury, and toxic chemicals. One of its tools is the inflammatory response. This response works quite well for short-term infections and injuries. But when inflammation is protracted and becomes chronic, such as can occur with trauma, it can itself become a threat to health. It can produce autoimmune diseases such as colitis, Chron’s disease, arthritis, heart disease, increased cancer risk, lung disease, sleep disruption, gum disease, decreased bone health, and psoriasis. Indeed, the presence of chronic inflammation is associated with reduced longevity. In addition, it can exacerbate the psychological issues produced by trauma including increasing the severity depression.

 

Mindfulness training has been shown to both help improve the symptoms of trauma and to reduce the inflammatory response. So, it would be reasonable to predict that mindfulness training would be useful in reducing the inflammation resulting from interpersonal trauma in women. In today’s Research News article “Mindfulness-Based Stress Reduction to Enhance Psychological Functioning and Improve Inflammatory Biomarkers in Trauma-Exposed Women: A Pilot Study.” See:

https://www.facebook.com/ContemplativeStudiesCenter/photos/a.628903887133541.1073741828.627681673922429/1462456350444953/?type=3&theater

or see summary below or view the full text of the study at:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4624080/

Gallegos and colleagues recruited low-income women who had experienced interpersonal trauma and provided them with an 8-week Mindfulness-Based Stress Reduction (MBSR) treatment. Measurements were taken before, during (4th week), and immediately after treatment, and 4 weeks later of traumatic events, cognitive performance, perceived stress, anxiety, emotion regulation, PTSD symptoms, and mindfulness. In addition, blood was drawn and assayed for markers of inflammation.

 

They found that the MBSR treatment significantly increased mindfulness and emotion regulation and decreased perceived stress, anxiety, depression, and PTSD symptoms. In addition, attendance at MBSR sessions was significantly related to decreases in IL-6 levels, a marker of inflammation. All of these improvements were maintained 4-weeks after the end of MBSR training. Hence Mindfulness-Based Stress Reduction (MBSR) produced significant and lasting improvement in both the psychological and inflammatory effects of interpersonal trauma. It should be kept in mind that no control condition was employed. So, the results could have been produced by a placebo effect and any form of treatment might have produced comparable improvements. A controlled clinical trial is needed to confirm that MBSR was responsible for the effects.

 

It comes as no surprise that mindfulness training had these effects in women who experienced interpersonal trauma as mindfulness training has been previously been shown with other groups to produce improvement in mindfulness, emotion regulation, perceived stress, anxiety, depression, PTSD symptoms, and inflammation. What the present study contributes is a demonstration that these benefits also occur in women who have experienced interpersonal trauma.

 

So, reduce interpersonal trauma symptoms with mindfulness.

 

“Mindfulness meditation reduces levels of interleukin 6 by altering patterns of functional connectivity: communication between different regions of the brain. “By modulating functional connectivity, you’re affecting the cell groups that influence the release of inflammatory markers and stress hormones,”  –  Adrienne Taren

 

CMCS – Center for Mindfulness and Contemplative Studies

 

This and other Contemplative Studies posts are also available on Google+ https://plus.google.com/106784388191201299496/posts

 

Study Summary

Gallegos, A. M., Lytle, M. C., Moynihan, J. A., & Talbot, N. L. (2015). Mindfulness-Based Stress Reduction to Enhance Psychological Functioning and Improve Inflammatory Biomarkers in Trauma-Exposed Women: A Pilot Study. Psychological Trauma : Theory, Research, Practice and Policy, 7(6), 525–532. http://doi.org/10.1037/tra0000053

 

Abstract

This study examined the effects of a Mindfulness-Based Stress Reduction (MBSR) program on psychological functioning and inflammatory biomarkers in women with histories of interpersonal trauma. The 8-week MBSR program was conducted at a community-based health center and participants (N = 50) completed several measures of psychological functioning at study entry as well as 4 weeks, 8 weeks, and 12 weeks later. Inflammatory biomarkers were assayed from blood collected at each assessment. A series of linear mixed model analyses were conducted to measure the effect of attendance and time on the dependent variables. Time was associated with significant decreases in perceived stress, depression, trait and state anxiety, emotion dysregulation, and post-traumatic stress symptoms as well as increases in mindfulness. Session attendance was associated with significant decreases in interleukin (IL)-6 levels. This pilot study demonstrated the potential beneficial effects of MBSR on psychological functioning and the inflammatory biomarker IL-6 among trauma-exposed and primarily low-income women. Decreases in inflammation have implications for this population, as interpersonal trauma can instigate chronic physiological dysregulation, heightened morbidity, and premature death. This study’s preliminary results support efforts to investigate biological remediation with behavioral interventions in vulnerable populations.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4624080/

 

Strengthen the Immune System with Mindfulness

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By John M. de Castro, Ph.D.

 

“Stress is immunosuppressive. Research into this pernicious relationship between stress and disease has piqued interest in the ways that contemplative practices might positively influence the immune system. According to a large body of evidence, meditation appears to have profound effects on immune function in health and disease because of its ability to reduce stress.” – David Vago

 

Contemplative practices have been found to improve the physical and psychological well-being of practitioners and to relieve the symptoms of a large number of mental and physical diseases. How these practices might have such widespread benefits is not precisely known. In fact, there may not be one mechanism but many. One important benefit of mindfulness practices appears to be a strengthening of the immune system, the body’s primary defense against disease. Through a series of steps called the immune response, this system attacks organisms and substances that invade body systems and cause disease. It is important that it be properly tuned as too weak of an immune response can allow diseases to develop while too strong of a response can result in autoimmune diseases.

 

In today’s Research News article “Mindfulness meditation and the immune system: a systematic review of randomized controlled trials.” See:

https://www.facebook.com/ContemplativeStudiesCenter/photos/a.628903887133541.1073741828.627681673922429/1387898754567380/?type=3&theater

or see summary below. Black and Slavich review the published research literature on the effects of mindfulness meditation on immune system function. They found and summarized twenty randomized controlled studies that administered mindfulness meditation and measured objective biomarkers of immune system activity, usually in the blood. All but three of the studies used a Mindfulness Based Stress Reduction (MBSR) or similar programs. MBSR includes a combination of meditation, body scan, and yoga practices. They found the published research reported that mindfulness meditation produced a reduction in biomarkers of inflammation including cellular transcription factor NF-κB and liver-derived C-reactive protein, CRP, and increases in cell-mediated immunity, CD4+ T cell count, and increases in telomerase activity indicating decreased biological aging.

 

These are remarkable findings suggesting that mindfulness meditation practice improves immune system function and reduces the processes of cellular aging. The reduction in the inflammatory response is significant as the inflammatory response which works quite well for short-term infections and injuries can, if protracted, itself become a threat to health, producing autoimmune diseases. Indeed, chronic inflammation is associated with reduced longevity. The improvements in cellular immunity suggest that meditation practice improves the ability of the body to fend off disease by destroying cells that have been infected, an important protection against the spread of disease through the body. Finally, the findings that mindfulness meditation practices increase telomerase activity is very exciting. The telomere is attached to the ends of the DNA molecule. As we age the telomere shortens, resulting in difficulty with cells reproducing, producing more defective cells. The enzyme telomerase helps to prevent shortening of the telomere and thereby slow the aging process.  It appears that mindfulness meditation increases telomerase activity and thereby slow the aging process.

 

Hence, accumulating scientific evidence suggests that mindfulness meditation has very positive effects on the immune system which improve health and longevity. It is not known exactly how these practices do this, but it is likely that the ability of mindfulness meditation to reduce the physical and psychological responses to stress is responsible. Chronic stress is known to impair immune system function, so its reduction may be responsible to the improved function of this system. Regardless of the mechanism, it is clear that mindfulness meditation is good for health, improving the systems that help to maintain it.

 

Strengthen the immune system with mindfulness.

 

“We still don’t know the precise mechanism by which control of attention or meditation acts this way on the immune system. It’s likely that a more “distant” and serene outlook, which is common during periods of meditation (and also between meditation sessions) gives rise to a weaker secretion of adrenaline and cortisol, and that this allows the immune cells to remain more active.” – David Servan-Schreiber

 

CMCS – Center for Mindfulness and Contemplative Studies

 

This and other Contemplative Studies posts are also available on Google+ https://plus.google.com/106784388191201299496/posts

 

Study Summary

Black, D. S. and Slavich, G. M. (2016), Mindfulness meditation and the immune system: a systematic review of randomized controlled trials. Ann. N.Y. Acad. Sci., 1373: 13–24.

 

Abstract

Mindfulness meditation represents a mental training framework for cultivating the state of mindful awareness in daily life. Recently, there has been a surge of interest in how mindfulness meditation improves human health and well-being. Although studies have shown that mindfulness meditation can improve self-reported measures of disease symptomatology, the effect that mindfulness meditation has on biological mechanisms underlying human aging and disease is less clear. To address this issue, we conducted the first comprehensive review of randomized controlled trials examining the effects of mindfulness meditation on immune system parameters, with a specific focus on five outcomes: (1) circulating and stimulated inflammatory proteins, (2) cellular transcription factors and gene expression, (3) immune cell count, (4) immune cell aging, and (5) antibody response. This analysis revealed substantial heterogeneity across studies with respect to patient population, study design, and assay procedures. The findings suggest possible effects of mindfulness meditation on specific markers of inflammation, cell-mediated immunity, and biological aging, but these results are tentative and require further replication. On the basis of this analysis, we describe the limitations of existing work and suggest possible avenues for future research. Mindfulness meditation may be salutogenic for immune system dynamics, but additional work is needed to examine these effects.

Improve Metabolism and Reduce the Inflammatory Response with Yoga

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By John M. de Castro, Ph.D.

 

“Kick-start your sluggish metabolism by engaging in physical exercise. Yoga moves and poses can help increase your metabolism and help you be more fit.” – Robin Reichert

 

Metabolic Syndrome is a major risk factor for cardiovascular disease and diabetes. It generally results from overweight and abdominal obesity and includes high blood pressure, insulin resistance and elevation of plasma cholesterol and triglycerides. It is an important risk factor as it increases the risk of developing type-2 diabetes five-fold and heart attack or stroke three-fold. Metabolic Syndrome incidence has been rising rapidly and it currently affects 34% of U.S. adults. Needless to say this is a major health problem. The good news is that timely treatment can prevent or reverse the risk. The simplest treatment is simply exercise and weight loss.

 

The immune system is designed to protect the body from threats like stress, infection, injury, and toxic chemicals. One of its tools is the Inflammatory response. This response works quite well for short-term infections and injuries. But when inflammation is protracted and becomes chronic, it can itself become a threat to health. It can produce autoimmune diseases such as colitis, Chron’s disease, arthritis, heart disease, increased cancer risk, lung disease, sleep disruption, gum disease, decreased bone health, psoriasis, and depression. Needless to say chronic inflammation can create major health problems. Indeed, the presence of chronic inflammation is associated with reduced longevity. So, it is important for health to control the inflammatory response, allowing it to do its job in fighting off infection but reducing its activity when no external threat is apparent.

 

Of course it is far better to prevent Metabolic Syndrome and chronic inflammation in the first place than to treat them later. Exercise can counteract their development and their consequent risks of disease. Yoga has been used to promote health and well-being for thousands of years. It has also been shown to be effective in treating Metabolic Syndrome. Mind-body techniques such as yoga, Tai Chi and meditation have been shown to adaptively reduce the inflammatory response. Most of these results were obtained from treating diseased individuals. It is important to establish if yoga can be effective in preventing Metabolic Syndrome and chronic inflammation through practice by healthy individuals.

 

In today’s Research News article “Effects of 8-Week Hatha Yoga Training on Metabolic and Inflammatory Markers in Healthy, Female Chinese Subjects: A Randomized Clinical Trial.” See:

https://www.facebook.com/ContemplativeStudiesCenter/photos/a.628903887133541.1073741828.627681673922429/1339638822726707/?type=3&theater

or see summary below or view the full text of the study at:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4987461/

Chen and colleagues recruited healthy women and randomly assigned them to either receive Hatha yoga practice for 8-weeks, twice a week for 60 minutes, or a control condition. Before and after the 8-week practice they had fasting blood drawn and clinical markers of insulin, glucose, triacylglycerol, HDL-cholesterol, LDL-cholesterol, and total cholesterol, and inflammation markers of plasma cytokines and endothelial microparticles measured.

 

They found that yoga practice produced a significant reduction in Metabolic Syndrome indicators; plasma insulin, total cholesterol, and LDL-C, and insulin resistance levels, and also inflammation indicators; endothelial microparticles, proinflammatory cytokines, and inflammatory signaling proteins. Thus, yoga practice appears to reduce circulating markers of Metabolic Syndrome and also the inflammatory response.

 

These are exciting and significant results. Keep in mind that the intervention consisted of a total of only 16 hours of gentle Hatha yoga over 8 weeks. So, it doesn’t seem to require intensive long-term practice to produce these benefits. Yet, the yoga improved markers that indicate a significant reduction in the risk of Metabolic Syndrome and a reduction in chronic inflammation. This suggests that yoga practice can prevent physiological reactions that lead to disease and thus could promote health and well-being.

 

So, improve health by improving metabolism and reducing the inflammatory response with yoga.

 

“We think improved sleep could be part of the mechanism of what we were seeing. When women were sleeping better, inflammation could have been lowered by that. Reducing fatigue enables women to engage in other activities over time. So yoga may have offered a variety of benefits in addition to the yoga exercises themselves.” – Janice Kiecolt-Glaser

 

CMCS – Center for Mindfulness and Contemplative Studies

 

This and other Contemplative Studies posts are also available on Google+ https://plus.google.com/106784388191201299496/posts

 

Study Summary

Chen, N., Xia, X., Qin, L., Luo, L., Han, S., Wang, G., … Wan, Z. (2016). Effects of 8-Week Hatha Yoga Training on Metabolic and Inflammatory Markers in Healthy, Female Chinese Subjects: A Randomized Clinical Trial. BioMed Research International, 2016, 5387258. http://doi.org/10.1155/2016/5387258

 

Abstract

We aimed to determine the effects of an 8 wk Hatha yoga training on blood glucose, insulin, lipid profiles, endothelial microparticles (EMPs), and inflammatory status in healthy, lean, and female Chinese subjects. A total of 30 healthy, female Chinese subjects were recruited and randomized into control or yoga practice group. The yoga practice included 8 wks of yoga practice (2 times/wk) for a total of 16 times. Fasting blood samples were collected before and after yoga training. Plasma was isolated for the measurement of lipid profiles, glucose, insulin, EMPs, and inflammatory cytokines. Whole blood was cultured ex vivo and stimulated with lipopolysaccharide (LPS) and Pam3Cys-SK4. Peripheral blood mononuclear cells (PBMCs) were isolated for the measurement of TLR2 and TLR4 protein expression. Yoga practice significantly reduced plasma cholesterol, LDL-cholesterol, insulin levels, and CD31+/CD42b− EMPs. Cultured whole blood from the yoga group has reduced proinflammatory cytokines secretion both at unstimulated condition and when stimulated with Pam3Cys-SK4; this might be associated with reduced TLR2 protein expression in PBMCs after yoga training. Hatha yoga practice in healthy Chinese female subjects could improve hallmarks related to MetS; thus it can be considered as an ancillary intervention in the primary MetS prevention for the healthy population.

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4987461/

 

Reduce Inflammation and Depression with Mindfulness

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By John M. de Castro, Ph.D.

 

“Mindfulness is a valuable practice for improving the cognitive symptoms of depression, such as distorted thinking and distractibility. It helps individuals recognize these more subtle symptoms, realize that thoughts are not facts and refocus their attention to the present.” –  Margarita Tartakovsky

 

Major depression is one of the most common mental disorders. In 2014, an estimated 15.7 million adults aged 18 or older in the United States had at least one major depressive episode in the past year. This number represented 6.7% of all adults. In addition, major depression carries the heaviest burden of disability among mental and behavioral disorders. It is most frequently treated with anti-depressive drugs. But, these frequently do not work or lose effectiveness over time and have many troublesome side effects. So, there is a need for better treatment methods.

 

Depression has been linked to chronic inflammation. Patients with major depressive disorder exhibit all of the cardinal features of an inflammatory response, including increased expression of pro-inflammatory cytokines and their receptors. In addition, administration of inflammatory cytokines to otherwise non-depressed individuals cause symptoms of depression. This suggests that chronic inflammation may be a contributing factor to the development, promotion, or maintenance of depression.

 

Mindfulness practice has been shown to be effective in the treatment of chronic depression. It has also been shown to reduce inflammation and the inflammatory cytokines. So, it would make sense to study the relationship of mindfulness training to depression and the inflammatory response in depressed individuals. In today’s Research News article “Brief Mindfulness Training Reduces Salivary IL-6 and TNF-α in Young Women with Depressive Symptomatology.” See:

https://www.facebook.com/ContemplativeStudiesCenter/photos/a.628903887133541.1073741828.627681673922429/1270480726309184/?type=3&theater

or below,

Walsh and colleagues do just that. They recruited female college students who had mild to moderate depression and assigned them to either a mindfulness training group or a contact control group. Mindfulness training was modelled after a Mindfulness Based Stress Reduction (MBSR) program and included meditation, body scan, and yoga, but the program was conducted over only 4 weeks rather than the customary 8 weeks. The contact control group met in a group on a similar schedule but simple filled out questionnaires. The participants were measured for salivary inflammatory cytokine levels, depression, and other mental issues both before and training and 3 months later.

 

They found that mindfulness training decreased the levels of the inflammatory cytokines IL-6 and TNF-α between 59% to 76% and this decrease was maintained at the 3 month follow up. There was also a significant decrease in depression but this was true for both the mindfulness and contact groups. The higher the levels of baseline depression the greater the effect of mindfulness training on reducing inflammatory cytokines. These results suggest that mindfulness training is effective in reducing the inflammatory response and that the more depressed the individual is the greater the benefit.

 

These are exciting findings. They suggest that mindfulness training reduces chronic inflammation in depressed women. The fact that the depression levels were low to start with may have produced a floor effect making it impossible to detect a benefit of mindfulness training on the levels of depression. This prohibits and analysis of the relationship of the reduction in the inflammatory cytokines to the reduction in depression. But, the results are suggestive of a potential effect in that the most depressed women showed the greatest reductions in the inflammatory response. It will require further work with women exhibiting higher levels of depression and perhaps with a longer treatment period to conclusively demonstrate whether there’s a causal connection between the two.

 

Mindfulness training has a number of known effects that may underlie its ability to reduce depression and inflammation. In particular mindfulness training has been shown to reduce the psychological and physiological responses to stress. This decreased stress response may be responsible for the reduction in inflammation. In addition, mindfulness training is known to improve focus on the present moment and thereby reduce rumination about the past or worry about the future, both of which are characteristic of depression. This may well underlie the ability of mindfulness training to reduce depression.

 

So, reduce inflammation and depression with mindfulness.

 

CMCS – Center for Mindfulness and Contemplative Studies

 

“Everyone can benefit from mindfulness meditation, but some can more than others.  There are no negative side effects of mindfulness, and there are the positive benefits of stress reduction and relaxation.  Reducing inflammation and boosting immune health can help fight a broad range of ailments, from a stubbed toe to chronic inflammatory conditions.” – Amanda Page

 

This and other Contemplative Studies posts are also available on Google+ https://plus.google.com/106784388191201299496/posts

 

Study Summary

Walsh, E., Eisenlohr-Moul, T., & Baer, R. (2016). Brief Mindfulness Training Reduces Salivary IL-6 and TNF-α in Young Women with Depressive Symptomatology. Journal of Consulting and Clinical Psychology, doi:10.1037/ccp0000122

 

Abstract

OBJECTIVE: Pro-inflammatory cytokines have been implicated in the pathophysiology and maintenance of depression. This study investigated the effects of a brief mindfulness intervention on salivary pro-inflammatory correlates of depression (IL-6, TNF-α) and self-reported symptoms of depression in college women.

METHODS: Sixty-four females with a cut score of ≥16 on the Center for Epidemiological Studies for Depression Scale (CES-D) were assigned to a 4-week mindfulness-based intervention (MBI; N = 31) or a contact-control group (N = 33). For both groups, salivary cytokines and depressive symptoms were assessed at baseline and posttreatment. For the mindfulness group only, salivary cytokines were also assessed at a 3-month follow-up.

RESULTS: Both groups showed similar reductions in depression. However, MBI (vs. control) predicted greater reductions in IL-6 and TNF-α; changes in IL-6 were sustained at 3-month follow-up. Higher baseline depressive symptoms predicted greater reductions in inflammation in the mindfulness group.

CONCLUSION: MBIs may reduce inflammatory immune markers commonly implicated in depression. Individuals with greater depressive symptoms may benefit more from mindfulness training. Although reductions in salivary cytokines in the mindfulness condition were not attributable to changes in depressive symptoms, future work should examine the possibility that such reductions are protective against the development of future depressive episodes.

http://eds.a.ebscohost.com.ezproxy.shsu.edu/ehost/pdfviewer/pdfviewer?vid=5&sid=911f511a-9143-4771-8f7c-e876dcfe165f%40sessionmgr4005&hid=4208

 

Improve Symptoms in Breast Cancer Survivors with Mindfulness

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By John M. de Castro, Ph.D.

 

“The mindfulness elements of accepting things as they are, turning towards rather than away from difficult emotional experience, and embracing change as a constant are helpful antidotes to these difficult realities. The emotion-regulation strategies practiced in mindfulness-based interventions help to prevent worry about the future and rumination over past events, and allow people to live more fully in the present moment, regardless of what lies ahead. The inevitability of loss, change and eventual death are helpful to face in general, but are both more challenging and more powerful for people directly facing a life threat like cancer.” – Linda Carlson

 

About 12.5% of women in the U.S. develop invasive breast cancer over their lifetimes and every year about 40,000 women die. Indeed, more women in the U.S. die from breast cancer than from any other cancer, besides lung cancer. Breast cancer diagnosis, however, is not a death sentence. It is encouraging that the death rates have been decreasing for decades from improved detection and treatment of breast cancer. Five-year survival rates are now at around 95%.

 

The improved survival rates mean that more women are now living with cancer. Surviving cancer, however, carries with it a number of problems. “Physical, emotional, and financial hardships often persist for years after diagnosis and treatment. Cancer survivors are also at greater risk for developing second cancers and other health conditions.” National Cancer Survivors Day. In addition, breast cancer survivors can have to deal with the consequences of chemotherapy, and often experience increased fatigue, pain, and bone loss, reduced fertility, difficulty with weight maintenance, damage to the lymphatic system, heightened fear of reoccurrence, and an alteration of their body image. With the loss of a breast or breasts, scars, hair shedding, complexion changes and weight gain or loss many young women feel ashamed or afraid that others will reject or feel sorry for them. As a result, survivors often develop psychological symptoms of stress, anxiety, depression, and impaired cognitive functioning.

Psychologically, cancer survivors frequently suffer from anxiety, depression, mood disturbance, Post-Traumatic Stress Disorder (PTSD), sleep disturbance, fatigue, sexual dysfunction, loss of personal control, impaired quality of life, and psychiatric symptoms which have been found to persist even ten years after remission.

 

Unfortunately, most of these residual problems often go untreated. So, safe and effective treatments for the residual symptoms in breast cancer survivors are needed. Mindfulness training has been shown to help with cancer recovery and help to alleviate many of the residual psychological symptoms and improve cognitive function. Most of the research, however, has been performed with postmenopausal women. But, 25% of breast cancer survivors are younger and premenopausal. In today’s Research News article “Mindfulness meditation for younger breast cancer survivors: A randomized controlled trial.” See:

https://www.facebook.com/ContemplativeStudiesCenter/photos/a.628903887133541.1073741828.627681673922429/1252924528064804/?type=3&theater

or below or view the full text of the study at:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4393338/

Bower and colleagues examine the efficacy of mindfulness training for premenopausal breast cancer survivors. They recruited premenopausal breast cancer survivors who had completed primary treatment at least 3 months prior to participation and randomly assigned them to either receive a 6-week Mindful Awareness Practice program or to a wait-list control group. The participants were assessed with a battery of psychological tests. They also measured a set of genetic markers of inflammation. Assessments were performed before and 1-2 weeks after treatment and also 3 months later.

 

They found that mindfulness training produced significant improvements in the patients’ psychological state. In comparison to control participants, the mindfulness training group had significant decreases in perceived stress, depression, fatigue, subjective sleep disturbance, and hot flashes/night sweats, and significant increases in positive emotions, peace and meaning. For the most part the effects were not maintained at 3-month follow-up. In addition, the mindfulness training appeared to decrease inflammation as the mindfulness trained group showed a reduction in pro-inflammatory genetic markers and an increase in anti-inflammatory genetic markers.

 

These results are encouraging and suggest that the psychological well-being and inflammation can be improved with mindfulness training for premenopausal breast cancer survivors. Previous studies have demonstrated that mindfulness training with healthy individuals improves their psychological and emotional state and reduces inflammation. These results suggest that breast cancer survivors benefit as well. These improvements are particularly important for the breast cancer survivors as they are generally struggling with the psychological, emotions, and physical ramifications of their diagnosis and treatment. It is reassuring that mindfulness training can help.

 

Of concern is the fact that the psychological treatment effects were not maintained 3-months later. It is unclear if the women maintained their mindfulness practices following training as they were encouraged to do. It is possible that more encouragement and perhaps booster sessions may be needed to maintain the benefits.

 

Regardless, improve symptoms in breast cancer survivors with mindfulness.

 

“We already know that psychosocial interventions like mindfulness meditation will help you feel better mentally, but now for the first time we have evidence that they can also influence key aspects of your biology.”  – Dr. Linda Carlson

 

CMCS – Center for Mindfulness and Contemplative Studies

 

This and other Contemplative Studies posts are also available on Google+ https://plus.google.com/106784388191201299496/posts

 

Study Summary

Bower, J. E., Crosswell, A. D., Stanton, A. L., Crespi, C. M., Winston, D., Arevalo, J., … Ganz, P. A. (2015). Mindfulness meditation for younger breast cancer survivors: A randomized controlled trial. Cancer, 121(8), 1231–1240. http://doi.org/10.1002/cncr.29194

 

Abstract

Purpose: Premenopausal women diagnosed with breast cancer are at risk for psychological and behavioral disturbances after cancer treatment. Targeted interventions are needed to address the needs of this vulnerable group.

Methods: This randomized trial provided the first evaluation of a brief mindfulness-based intervention for younger breast cancer survivors designed to reduce stress, depression, and inflammatory activity. Women diagnosed with early-stage breast cancer before age 50 who had completed cancer treatment were randomly assigned to a 6-week Mindful Awareness Practices (MAPS) intervention (n = 39) or wait-list control (n = 32). Participants completed questionnaires at pre- and post-intervention to assess stress and depressive symptoms (primary outcomes) as well as physical symptoms, cancer-related distress, and positive outcomes. Blood samples were collected to examine genomic and circulating markers of inflammation. Participants also completed questionnaires at a three-month follow-up.

Results: In linear mixed models, the MAPS intervention led to significant reductions in perceived stress (P = .004) and marginal reductions in depressive symptoms (P = .094), as well as significant reductions in pro-inflammatory gene expression (P = .009) and inflammatory signaling (P = .001) at post-intervention. Improvements in secondary outcomes included reduced fatigue, sleep disturbance, and vasomotor symptoms and increased peace and meaning and positive affect (Ps < .05). Intervention effects on psychological and behavioral measures were not maintained at three-month follow-up, though reductions in cancer-related distress were observed at this assessment.

Conclusions: A brief mindfulness-based intervention showed preliminary short-term efficacy in reducing stress, behavioral symptoms, and pro-inflammatory signaling in younger breast cancer survivors.

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4393338/

 

Help Cancer Treatment with Qigong

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By John M. de Castro, Ph.D.

 

“Qigong is a viable and essential practice for enhancing everyday life, as well as an effective factor in mainstream health care.“ – Sifu Wong

 

Qigong has been practiced for thousands of years with benefits for health and longevity. Qigong training is designed to enhance function and regulate the activities of the body through regulated breathing, mindful concentration, and gentle movements. Only recently though have the effects of qigong practice been scrutinized with empirical research. It has been found to be effective for an array of physical and psychological issues. It appears to strengthen the immune system, reduce inflammation and increase the number of cancer killing cells in the bloodstream. All of these effects suggest that Qigong may be effective for cancer survivors.

 

Modern medicine has improved markedly in treating cancer. But, the treatments themselves can be difficult on the patient and produce great discomfort and suffering. In addition, if the treatment is successful, the cancer survivor is left with a whole different set of challenges. Fatigue accompanies cancer and its treatment in from half to all cancer patients depending upon the type of cancer and treatment regimen. The fatigue can continue even after completion of successful treatment. The patient feels weak, tired, weary, or exhausted all of the time and sleep does not relieve the tiredness. Symptoms can include prolonged, extreme tiredness following an activity, arms and legs feeling heavy and hard to move, lack of engagement in normal daily activities, trouble concentrating, thinking clearly, or remembering, feeling frustrated, irritable, and upset, putting less energy into personal appearance, and spending more time in bed or sleeping. It is easy to confuse cancer-related fatigue with depression. The cause of cancer-related fatigue is unknown.

 

The best treatment for cancer-related fatigue appears to be encouragement to engage in moderate exercise along with relaxation and body awareness training. The ancient Chinese practice of Qigong has all of these properties. It’s a light exercise that produces relaxation and body awareness. So, it would seem reasonable to expect that Qigong practice would be effective in treating cancer patients.

 

In today’s Research News article “Qigong in cancer care: a systematic review and construct analysis of effective Qigong therapy.” See:

https://www.facebook.com/ContemplativeStudiesCenter/photos/a.628903887133541.1073741828.627681673922429/1225696334120957/?type=3&theater

or see below

Klein and colleagues review the published research literature on the application of Qigong for the treatment of cancer patients. They report that a significant number of controlled studies report that Qigong has positive effects on the cancer-specific quality of life, improving the overall well-being of the patients. In this regard, it is effective for reducing fatigue, which by itself will improve quality of life. Importantly for fighting cancer, Qigong improves immune function, reduces the inflammatory response, and the stress levels of individuals with cancer, as referenced by decreased cortisol levels. These latter findings suggest that Qigong can not only improve the quality of life but also help in fighting the cancer itself.

 

These findings are very exciting. They suggest that Qigong practice may be a tremendous help in treating cancer and for the patients coping with the consequences of cancer and its treatment. Qigong is a light exercise as well as a mindfulness practice. Because of its gentle nature it is appropriate for individuals weakened by disease or for the elderly. The exercise component may be essential for improving the individual’s ability to fight cancer. The mindfulness component is also important as mindfulness practices, in general, have been found to be effective in improving health and fighting disease. So, the combination of gentle exercise along with mindfulness training suggests that Qigong is a potent mixture to assist cancer patients.

 

So, help cancer treatment with qigong.

 

“Qigong is clearly not for those who would like to take a pill and wait for the next instruction from the oncologist. But for anyone who has found their diagnosis has led them to a deeper enquiry into the subtler energetic levels of health and healing, this practice has a proven track record and can provide excellent results for those with the discipline for daily practice.” – Donatus Roobeek

 

CMCS – Center for Mindfulness and Contemplative Studies

 

Study Summary

Klein PJ, Schneider R, Rhoads CJ. Qigong in cancer care: a systematic review and construct analysis of effective Qigong therapy. Support Care Cancer. 2016 Apr 5. [Epub ahead of print] Review.

PMID: 27044279

 

Abstract

Purpose: This review (a) assesses the strength of evidence addressing Qigong therapy in supportive cancer care and (b) provides insights for definition of effective Qigong therapy in supportive cancer care.

Methods: This mixed-methods study includes (a) a systematic review of randomized clinical trials (RCTs) following PRISMA guidelines and (b) a constant-comparative qualitative analysis of effective intervention protocols.

Results: Eleven published randomized clinical trials were reviewed. A total of 831 individuals were studied. Geographic settings include the USA, Australia, China, Hong Kong, and Malaysia. Qigong therapy was found to have positive effects on the cancer-specific QOL, fatigue, immune function, and cortisol levels of individuals with cancer. Qigong therapy protocols varied supporting a plurality of styles. Qualitative analyses identified common programming constructs. Content constructs included exercise (gentle, integrated, repetitious, flowing, weight-bearing movements), breath regulation, mindfulness and meditation, energy cultivation including self-massage, and emphasis on relaxation. Logistic constructs included delivery by qualified instructors, home practice, and accommodation for impaired activity tolerance.

Conclusions: There is global interest and a growing body of research providing evidence of therapeutic effect of Qigong therapy in supportive cancer care. While Qigong therapy protocols vary in style, construct commonalities do exist. Knowledge of the common constructs among effective programs revealed in this research may be used to guide future research intervention protocol and community programming design and development.

 

Mindfully Control Inflammation

psyjdc 2 Comments

 

“I don’t think anybody would argue that fact that we know inflammation in the body, which comes from a lot of different sources, is the basis for a lot of chronic health problems, so by controlling that, we would expect to see increased life expectancy … but if we’re not changing those things and just taking ibuprofen, I don’t know if we’re really going to make any headway in that, I feel like there are probably a lot of factors that we could change without medicating with risk.”– Josie Znidarsic

 

The immune system is designed to protect the body from threats like stress, infection, injury, and toxic chemicals. One of its tools is the Inflammatory response. Its primary effect is to increase blood circulation around the infected area, dilating the blood vessels around the site of inflammation. It also produces gaps in the cell walls surrounding the infected area, allowing the larger immune cells, to pass. It also tends to increase body temperature to further fight infection. This response works quite well for short-term infections and injuries and as such is an important defense mechanism for the body. But when inflammation is protracted and becomes chronic, it can itself become a threat to health.

 

Chronic inflammation can produce autoimmune diseases such as colitis, Chron’s disease, arthritis, heart disease, increased cancer risk, lung disease, sleep disruption, gum disease, decreased bone health, psoriasis, and depression. Needless to say chronic inflammation can create major health problems. Indeed, the presence of chronic inflammation is associated with reduced longevity. So, it is important for health to control the inflammatory response, allowing it to do its job in fighting off infection but then reducing its activity when no external threat is apparent.

 

Contemplative practices appear to relax the physical systems of the body including the immune system, reducing inflammation. Mind-body techniques such as yoga, Tai Chi and meditation have been shown to adaptively reduce the inflammatory response (see http://contemplative-studies.org/wp/index.php/category/research-news/inflammatory-response/). In today’s Research News article “Mind-body therapies and control of inflammatory biology: A descriptive review”

https://www.facebook.com/ContemplativeStudiesCenter/photos/a.628903887133541.1073741828.627681673922429/1157023674321557/?type=3&theater

Bower and colleagues review the published research literature on the effects of mind-body practices on the inflammatory response. They found mixed and inconclusive results for circulating and cellular markers of inflammation but consistent findings for gene expression inflammatory pathways. These studies consistently demonstrated that mind-body practices including tai chi, yoga, and meditation produced a decrease in inflammatory gene expressions and does so in diverse populations of practitioners.

 

Bower and colleagues suggest that mind-body practices alter gene expression through their well-documented effects on the neuroendocrine system. These techniques are known to reduce the activity of the activating portion of the peripheral nervous system, the sympathetic system, to reduce the release of stress hormones, particularly cortisol, and to lower perceived stress (see http://contemplative-studies.org/wp/index.php/category/research-news/stress/).  Mind-body practices are also known to improve emotion regulation (see http://contemplative-studies.org/wp/index.php/category/research-news/emotions/) and reduce depression (see http://contemplative-studies.org/wp/index.php/category/research-news/depression/), and anxiety (see http://contemplative-studies.org/wp/index.php/2016/01/02/distress-produces-less-stress-with-mindfulness/). All of these effects occur via alterations of the nervous system by mind-body practices. The reduced activation and heightened relaxation then reduce the inflammatory response.

 

Regardless of the explanation, it is clear that mindfulness practices reduce potentially harmful inflammatory responses. So, mindfully control inflammation.

 

 

“The mindfulness-based approach to stress reduction may offer a lower-cost alternative or complement to standard treatment, and it can be practiced easily by patients in their own homes, whenever they need.” – Melissa Rosenkranz

 

CMCS – Center for Mindfulness and Contemplative Studies

 

Mind-body Practices Promote Health and Well-being by Changing Gene Expression

psyjdc 3 Comments

 

“We can’t any longer have the conventional understanding of genetics which everybody peddles because it is increasingly obvious that epigenetics – actually things which influence the genome’s function – are much more important than we realised.” – Robert Winston

 

There is an accumulating volume of research findings to demonstrate that Mind-body therapies have highly beneficial effects on the health and well-being of humans. These include meditation, yoga, tai chi, qigong, biofeedback, progressive muscle relaxation, guided imagery, hypnosis, and deep breathing exercises. Because of their proven benefits the application of these practices to relieving human suffering has skyrocketed.

 

It is clear that Mind-body therapies affect the physiology. In other words, the mind can alter the body. In turn, the genes can affect our minds. In fact, the genes have been shown to affect an individual’s inherent level of mindfulness (see http://contemplative-studies.org/wp/index.php/category/research-news/genetics/). These interactions are well documented. The mechanisms by which they occur, however, are not well understood. It has been shown that contemplative practices help create balance in the inflammatory response (see http://contemplative-studies.org/wp/index.php/category/research-news/inflammatory-response/) which is very beneficial for health. But, the mechanism through which contemplative practices affect the immune system is not known.

 

The genes dictate all of the chemical processes in our bodies including immune and inflammatory responses. So, it would seem reasonable to investigate whether alterations in gene expressions might be the intermediary between mind-body therapies and health. In today’s Research News article “Functional Genomics in the Study of Mind-Body Therapies”

https://www.facebook.com/ContemplativeStudiesCenter/photos/a.628903887133541.1073741828.627681673922429/1140382739318984/?type=3&theater

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4295747/

Niles and colleagues review the literature on the effects of mind-body therapies on the functional expression of the genes. Out of the vast number of genomic pathways that can be affected, they found one which appears to be altered by mind-body therapies in general. This was a reduction in activity (downregulation) of the expression of genes that elicit the inflammatory response. In other words mindfulness practices reduce inflammation by reducing the activity of the genes that produce it.

 

This finding is extremely important as an overactive inflammatory system underlies many chronic diseases. Inflammation is a normal response of the body to outside threats like stress, infection, injury, and toxic chemicals. It is designed to protect the body and ward off these threats. It works quite well for short-term infections and injuries and as such is an important defense mechanism for the body. But when inflammation is protracted and becomes chronic, it can itself become a threat to health. Chronic inflammation can produce autoimmune diseases such as colitis, Chron’s disease, arthritis, heart disease, increased cancer risk, lung disease, sleep disruption, gum disease, decreased bone health, psoriasis, and depression. Needless to say chronic inflammation can create major health problems. Indeed, the presence of chronic inflammation is associated with reduced longevity. So, it is important for health to control the inflammatory response, allowing it to do its job in fighting off infection but then reducing its activity when no external threat is apparent. Mind-body therapies appear to do just that by reducing the expression of the genes that produce inflammation.

 

Niles and colleagues also found that a number of mind-body therapies increase the activity of telomerase, an enzyme that protects the genes from deterioration, particularly during aging. Hence, mind-body therapies appear to have anti-aging properties by increasing the activity of genes the reduce age related deterioration (see http://contemplative-studies.org/wp/index.php/2015/07/17/aging-healthily-yoga-and-cellular-aging/).

 

All of these results suggest that mind-body therapies promote health and well-being by altering gene expression. This is interesting and important. The next question is what are the mechanisms by which these practices affect gene expressions? It will be up to future research to investigate this link in the causal chain from mind-body therapies to the promotion of health and well-being.

 

So engage in mind-body practices, change gene expression and promote health and well-being.

 

“Our genes are quite dynamic in their expression and …. the calmness of our mind can actually have a potential influence on their expression.” – Richard Davidson

 

CMCS – Center for Mindfulness and Contemplative Studies

 

 

 

Strengthen the Immune System with Qigong

psyjdc 18 Comments

Qi gong is one modality of traditional Chinese medicine (TCM) believed to be at least 4,000 years-old. Written records referring to Qi and its effects are thought to be as old as 3,300 years (Shang dynasty oracle bones, Zhou dynasty inscriptions).

 

Qigong has been practiced for thousands of years with purported benefits for health and longevity. Qigong training is designed to enhance function and regulate the functional activities of the body through regulated breathing, mindful concentration, and gentle movements. Only recently though have the effects of qigong practice been scrutinized with empirical research. It has been found to be effective for an array of physical and psychological issues (See links below).

 

There is evidence that Qigong practice strengthens the immune system and lowers the incidence of upper respiratory infections (colds and flu). The state of the immune system is an indicator of the state of health of the individual. Chronic inflammation is associated with a number of diseases and what’s called the innate immune response involving high levels of Natural Killer (NK) cells. On the other hand, the ability of the body to detect and fight of infections is indicated by what’s termed the adaptive immune response and involves both T and B cells lymphocytes. It follows then that if qigong practice improves general health and fights off infection and inflammation, that practice should increase T and B lymphocytes and decrease NK cells.

 

In today’s Research News article “Effects on the Counts of Innate and Adaptive Immune Response Cells after 1 Month of Taoist Qigong Practice”

https://www.facebook.com/ContemplativeStudiesCenter/photos/a.628903887133541.1073741828.627681673922429/1109601799063745/?type=3&theater

Vera and colleagues studied the effect of one month of qigong practice on plasma levels of T, B, and NK cells. They found that qigong practice, in comparison to control participants, increased the levels of T and B lymphocytes and decreased the levels of NK cells. This indicates that engaging in qigong practice strengthens the immune system and reduces inflammation.

 

These results help to explain why qigong practice appears to be so beneficial for health. It strengthens the body’s critical defenses against disease and reduces the maladaptive over-activity in this system as reflected in chronic inflammation. Importantly, qigong does this with a practice that is safe, simple, easily scalable to large numbers of people, very inexpensive, and applicable to all age groups and to both healthy and ill individuals.

 

So, practice qigong and strengthen the immune system.

 

“Tai chi is often described as “meditation in motion,” but it might well be called “medication in motion.” There is growing evidence that this mind-body practice… has value in treating or preventing many health problems.” ~Harvard Women’s Health Watch

 

CMCS – Center for Mindfulness and Contemplative Studies

 

Qigong Links

It has been shown to improve cardiac health (see http://contemplative-studies.org/wp/index.php/2015/09/02/heart-health-with-tai-chi/), reduce the risk for strokes (see http://contemplative-studies.org/wp/index.php/2015/09/18/dont-get-stroked-practice-tai-chi/), reduce the physical and psychological responses to stress (see http://contemplative-studies.org/wp/index.php/2015/09/28/age-healthily-with-qigong-soothing-stress-responses/), improved sleep in people suffering from insomnia (see http://contemplative-studies.org/wp/index.php/2015/07/17/aging-healthily-sleeping-better-with-mindful-movement-practice/ and  http://contemplative-studies.org/wp/index.php/2015/08/06/age-healthily-treating-insomnia-and-inflammation/), helped with recovery from cancer (see http://contemplative-studies.org/wp/index.php/2015/07/17/age-healthily-mindful-movement-and-cancer-recovery/) and reduced chronic inflammation (see http://contemplative-studies.org/wp/index.php/category/contemplative-practice/tai-chi-qigong/)

Reduce Inflammation with Yoga

psyjdc 1 Comment

“You can’t live without inflammation, but it can also be hazardous to your health.”

 

Inflammation is a normal response of the body to outside threats like stress, infection, injury, and toxic chemicals. It is a response of the immune system that is designed to protect the body and ward off these threats. It works quite well for short-term infections and injuries and as such is an important defense mechanism for the body.. But when inflammation is protracted and becomes chronic, it can itself become a threat to health.

 

Chronic inflammation can produce autoimmune diseases such as colitis, Chron’s disease, arthritis, heart disease, increased cancer risk, lung disease, sleep disruption, gum disease, decreased bone health, psoriasis, and depression. Needless to say chronic inflammation can create major health problems. Indeed, the presence of chronic inflammation is associated with reduced longevity. So, it is important for health to control the inflammatory response, allowing it to do its job in fighting off infection but then reducing its activity when no external threat is apparent.

 

Contemplative practices appear to relax the physical systems of the body including the immune system, reducing inflammation. Mind body techniques such as the ancient practice of Tai Chi http://contemplative-studies.org/wp/index.php/2015/08/06/age-healthily-treating-insomnia-and-inflammation/ and meditation  (LINK TO “Control Inflammation with Mind-Body Practices – with RN Bower 2015”) have been shown to reduce inflammation. In addition, yoga practice has been found to reduce the inflammatory response in industrial workers http://contemplative-studies.org/wp/index.php/2015/07/17/healthy-balance-through-yoga/.

 

In today’s Research News article “Effect of Yoga Practice on Levels of Inflammatory Markers after Moderate and Strenuous Exercise”

https://www.facebook.com/ContemplativeStudiesCenter/photos/a.628903887133541.1073741828.627681673922429/1086016591422266/?type=1&theater

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4525504/

Vijayaraghava and colleagues found that yoga practitioners had lower levels of immune system agents that are associated with inflammation, Tumour Necrosis Factor alpha (TNF-α), Interleukin-6 (IL-6). Additionally, they found that when exposed to strenuous exercise there was less of an increase in these agents than in participants who did not practice yoga. These results suggest that yoga practice reduces chronic inflammation and also blunts the inflammatory response to exercise.

 

Yoga is both a mind-body relaxation technique and a mild exercise. Both of these aspects of yoga practice may be involved in reducing the inflammatory response. This may occur by creating an overall state of physical and psychological relaxation, by reducing the the response to stress, and by exercise moderating pro-inflammatory cytokines.

 

Regardless of the mechanisms involved, these results are exciting and indicate that the relatively safe practice of yoga can be very good for health by reducing chronic inflammation. This may be one of the reasons that yoga practitioners appear to be healthier and live longer.

 

So, practice yoga, reduce inflammation, and be healthier.

 

“I don’t think anybody would argue that fact that we know inflammation in the body, which comes from a lot of different sources, is the basis for a lot of chronic health problems, so by controlling that, we would expect to see increased life expectancy.”. – Josie Znidarsic

 

CMCS – Center for Mindfulness and Contemplative Studies