Brain systems

Different Meditation Styles Affect the Medial Frontal Brain Network Differently

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Different Meditation Styles Affect the Medial Frontal Brain Network Differently

 

By John M. de Castro, Ph.D.

 

“meditation has a variety of neurological benefits, from changes in brain volume to decreasing activity in parts of the brain involved with stress.” – Ashley Welch

 

Mindfulness training has been shown to improve health and well-being. It has also been found to be effective for a large array of medical and psychiatric conditions, either stand-alone or in combination with more traditional therapies. How exactly mindfulness practices produce their benefits is unknown. But it is known that meditation practice alters brain activity.

 

There are a number of different types of meditation. Classically they’ve been characterized on a continuum with the degree and type of attentional focus. In focused attention meditation, the individual practices paying attention to a single meditation object, usually the breath. In open monitoring meditation, the individual opens up awareness to everything that’s being experienced including thoughts regardless of its origin. In Loving Kindness Meditation the individual

systematically pictures different individuals from self, to close friends, to enemies and wishes them happiness, well-being, safety, peace, and ease of well-being. It is suspected but not known that different forms of meditation practice can produce different changes in brain activity.

 

One way is to measure changes in the electroencephalogram (EEG), the rhythmic electrical activity that can be recorded from the scalp. In today’s Research News article “Attentional and cognitive monitoring brain networks in long-term meditators depend on meditation states and expertise.” (See summary below or view the full text of the study at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7921394/ )  Yordanova and colleagues recruited highly experienced meditators who practiced focused attention meditation, open monitoring meditation, and Loving Kindness Meditation in a balanced way. They had their electroencephalograms (EEG) recorded while at rest and while performing the 3 meditation types for 3 minutes each.

 

They found that the Frontal-Parietal network, that is thought to underlie attentional mechanisms did not differ between meditation types. But there was increased connectivity between the right hemisphere frontal and left hemisphere parietal areas. On the other hand, the Medial Frontal network that is thought to underlie cognitive control and monitoring mechanisms had different activity patterns with the different meditation types. During focused attention meditation was increased synchronization in the parietal regions whereas during Loving Kindness Meditation it increased in the right frontal regions.

 

These are interesting findings that demonstrate that highly experienced meditators have distinct changes in the activity of their brains during meditation regardless of type. But in areas associated with cognitive monitoring mechanisms, difference appear. During focused attention meditation and Loving Kindness Meditation there are different patterns of activity. To some extent this is not surprising in that the two meditation types involve specific focuses. But Loving Kindness Meditation is emotionally focused while focused attention meditation is breath sensation focused and these require different kinds of cognitive control. These differences may underlie the different medial frontal activities.

 

It should be noted that these patterns are quite different from those of inexperienced meditators and that the greater the amount of practice the greater the neural activations. It would be expected that highly experienced meditators would have greater focus and much less mind wandering during meditation than inexperience meditators and this would produce different patterns of neural activation.

 

So, different meditation styles affect the medial frontal brain network differently.

 

“Meditation benefits for the brain are abundant. Meditating strengthens neural connections and can literally change the configuration of these networks. With regular practice, you can cultivate a more resilient neurobiology.” – Ask the Scientists

 

CMCS – Center for Mindfulness and Contemplative Studies

 

This and other Contemplative Studies posts are also available on Google+ https://plus.google.com/106784388191201299496/posts and on Twitter @MindfulResearch

 

Study Summary

 

Yordanova, J., Kolev, V., Nicolardi, V., Simione, L., Mauro, F., Garberi, P., Raffone, A., & Malinowski, P. (2021). Attentional and cognitive monitoring brain networks in long-term meditators depend on meditation states and expertise. Scientific reports, 11(1), 4909. https://doi.org/10.1038/s41598-021-84325-3

 

Abstract

Meditation practice is suggested to engage training of cognitive control systems in the brain. To evaluate the functional involvement of attentional and cognitive monitoring processes during meditation, the present study analysed the electroencephalographic synchronization of fronto-parietal (FP) and medial-frontal (MF) brain networks in highly experienced meditators during different meditation states (focused attention, open monitoring and loving kindness meditation). The aim was to assess whether and how the connectivity patterns of FP and MF networks are modulated by meditation style and expertise. Compared to novice meditators, (1) highly experienced meditators exhibited a strong theta synchronization of both FP and MF networks in left parietal regions in all mediation styles, and (2) only the connectivity of lateralized beta MF networks differentiated meditation styles. The connectivity of intra-hemispheric theta FP networks depended non-linearly on meditation expertise, with opposite expertise-dependent patterns found in the left and the right hemisphere. In contrast, inter-hemispheric FP connectivity in faster frequency bands (fast alpha and beta) increased linearly as a function of expertise. The results confirm that executive control systems play a major role in maintaining states of meditation. The distinctive lateralized involvement of FP and MF networks appears to represent a major functional mechanism that supports both generic and style-specific meditation states. The observed expertise-dependent effects suggest that functional plasticity within executive control networks may underpin the emergence of unique meditation states in expert meditators.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7921394/

 

Meditation Changes the Brain Areas Underlying Executive Function and Mind Wandering

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Meditation Changes the Brain Areas Underlying Executive Function and Mind Wandering

 

By John M. de Castro, Ph.D.

 

“meditation nurtures the parts of the brain that contribute to well-being. Furthermore, it seems that a regular practice deprives the stress and anxiety-related parts of the brain of their nourishment.” – Mindworks

 

Mindfulness training has been shown to improve health and well-being. It has also been found to be effective for a large array of medical and psychiatric conditions, either stand-alone or in combination with more traditional therapies. There are a number of ways that mindfulness practices produce these benefits, including changes to the brain and physiology. The nervous system is a dynamic entity, constantly changing and adapting to the environment. It will change size, activity, and connectivity in response to experience. These changes in the brain are called neuroplasticity. Over the last decade neuroscience has been studying the effects of contemplative practices on the brain and has identified neuroplastic changes in widespread areas. In other words, mindfulness practice appears to mold and change the brain, producing psychological, physical, and spiritual benefits.

 

In today’s Research News article “Resting State Functional Connectivity Associated With Sahaja Yoga Meditation.” (See summary below or view the full text of the study at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8007769/ )  Barrós-Loscertales and colleagues recruited healthy adult non-meditators and long-term practitioners of Sahaja Yoga Meditation. They were measured for impulsiveness and cognitive control and response inhibition with a go/no-go task in which the participants had to respond to a target stimulus and withhold responding to another stimulus and a Simon task in which they had to respond to a target stimulus pointing in the same direction as its location and withhold responding to another stimulus pointing in a different direction than its location. The participants also had their brains scanned with functional Magnetic Resonance Imaging (fMRI).

 

They found that the meditators had increased functional connectivity between the ventrolateral prefrontal cortex and the dorsolateral prefrontal cortex and decreased functional connectivity between the left insula and mid-cingulate cortex and between the right angular gyrus and precuneus. They also found that the meditators had significantly less response interference and the greater the amount of response interference the lower the functional connectivity between the left insula and the mid-cingulate.

 

The ventrolateral prefrontal cortex and the dorsolateral prefrontal cortex have been found to be involved in attention, cognitive control, and conflict resolution. The increased connectivity suggests that the meditators had higher levels of executive function. The insula, cingulate cortex, angular gyrus, and precuneus are all components of the default mode network that has been shown to be involved with mind wandering and self-referential thinking. The decreased functional connectivity between these areas suggests reductions in these processes.

 

It should be kept in mind that the meditation and non-meditation groups self-selected whether they meditated or not and thus may be systematically different people. So, causation cannot be determined. Nevertheless, these results suggest that the meditators had more active attention and executive control networks and less active mind-wandering networks. These results replicate previous research that demonstrated that contemplative practices like meditation produce improvements in cognition and reductions in mind wandering.  So, the connectivity differences seen in the present study appear to show the neural mechanisms underlying the differences in thought processes.

 

So, meditation changes the brain areas underlying executive function and mind wandering.

 

“It seems the longer you do meditation, the better your brain will be at self-regulation. You don’t have to consume as much energy at rest and you can more easily get yourself into a more relaxed state.” – Bin He

 

CMCS – Center for Mindfulness and Contemplative Studies

 

This and other Contemplative Studies posts are also available on Google+ https://plus.google.com/106784388191201299496/posts and on Twitter @MindfulResearch

 

Study Summary

 

Barrós-Loscertales, A., Hernández, S. E., Xiao, Y., González-Mora, J. L., & Rubia, K. (2021). Resting State Functional Connectivity Associated With Sahaja Yoga Meditation. Frontiers in human neuroscience, 15, 614882. https://doi.org/10.3389/fnhum.2021.614882

 

Abstract

Neuroscience research has shown that meditation practices have effects on brain structure and function. However, few studies have combined information on the effects on structure and function in the same sample. Long-term daily meditation practice produces repeated activity of specific brain networks over years of practice, which may induce lasting structural and functional connectivity (FC) changes within relevant circuits. The aim of our study was therefore to identify differences in FC during the resting state between 23 Sahaja Yoga Meditation experts and 23 healthy participants without meditation experience. Seed-based FC analysis was performed departing from voxels that had shown structural differences between these same participants. The contrast of connectivity maps yielded that meditators showed increased FC between the left ventrolateral prefrontal cortex and the right dorsolateral prefrontal cortex but reduced FC between the left insula and the bilateral mid-cingulate as well as between the right angular gyrus and the bilateral precuneus/cuneus cortices. It thus appears that long-term meditation practice increases direct FC between ventral and dorsal frontal regions within brain networks related to attention and cognitive control and decreases FC between regions of these networks and areas of the default mode network.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8007769/

 

Increase the Energy Metabolism of the Brain with Meditation

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Increase the Energy Metabolism of the Brain with Meditation

 

By John M. de Castro, Ph.D.

 

“As a form of mental training, meditation improves core physical and psychological assets, including energy, motivation, and strength. Studies on the neurophysiological concomitants of meditation have proved that commitment to daily practice can bring promising changes for the mind and the body.” –  Madhuleena Roy Chowdhury

 

Mindfulness training has been shown through extensive research to be effective in improving physical and psychological health and particularly with reducing the physical and psychological reactions to stress. There are a number of ways that meditation practices produce these benefits, including changes to the brain and physiology. The nervous system changes in response to how it is used and how it is stimulated in a process called neuroplasticity. Highly used areas grow in size, metabolism, and connectivity. Mindfulness practices in general are known to produce these kinds of changes in the structure and activity of the brain.

 

In today’s Research News article “Short-term meditation training influences brain energy metabolism: A pilot study on 31 P MR spectroscopy.” (See summary below or view the full text of the study at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7821578/ ) Gizewski and colleagues recruited healthy adult meditation naïve yoga students and provided them with 7 weeks of twice a week 45-minute training in Raja yoga meditation. This focused meditation training emphasizes the cessation of thinking and includes meditation and breathing exercises. They were measured before and after training for meditative depth, health history, lifestyle, anxiety, depression, and angst. Before and after training they also underwent brain scanning with structural Magnetic Resonance Imaging (MRI) and for brain energy metabolism (31P-MRS).

 

They found that in comparison to baseline after Raja yoga meditation training there were significant increases overall mental health and decreases in anxiety and dysthymia. There were also significant increases in brain energy metabolism particularly in the right hemisphere in the occipital and temporal lobes and the basal ganglia.

 

This study did not contain a comparison, control, condition which opens the results up to some alternative interpretations. But ignoring these possible contaminants, the study suggests that 7 weeks of meditation training can alter the brain. This has been demonstrated with numerous studies of changes in the structure, connectivity, and electrical activity of the brain produced by mindfulness training. The present study adds to this understanding by demonstrating the focused meditation training increases the energy metabolism in the brain particularly in the posterior cerebral cortex and the motor control areas. Meditation training is thought to be relaxing and the technique used here is one that emphasizes reduction in mental activity. But the present study suggests that the brain can get very active. This suggests that there is considerable mental activity going on during meditation.

 

So, increase the energy metabolism of the brain with meditation.

 

“Meditation is thought to work via its effects on the sympathetic nervous system, which increases heart rate, breathing, and blood pressure during times of stress. Yet meditating has a spiritual purpose, too. “True, it will help you lower your blood pressure, but so much more: it can help your creativity, your intuition, your connection with your inner self,” –  Burke Lennihan,

 

CMCS – Center for Mindfulness and Contemplative Studies

 

This and other Contemplative Studies posts are also available on Google+ https://plus.google.com/106784388191201299496/posts and on Twitter @MindfulResearch

 

Study Summary

 

Gizewski, E. R., Steiger, R., Waibel, M., Pereverzyev, S., Sommer, P., Siedentopf, C., Grams, A. E., Lenhart, L., & Singewald, N. (2021). Short-term meditation training influences brain energy metabolism: A pilot study on 31 P MR spectroscopy. Brain and behavior, 11(1), e01914. https://doi.org/10.1002/brb3.1914

 

Abstract

Background

Meditation is increasingly attracting interest among neuroimaging researchers for its relevance as a cognitive enhancement technique and several cross‐sectional studies have indicated cerebral changes. This longitudinal study applied a distinct and standardized meditative technique with a group of volunteers in a short‐term training program to analyze brain metabolic changes.

Methods

The effect of 7 weeks of meditation exercises (focused attention meditation, FAM) was assessed on 27 healthy volunteers. Changes in cerebral energy metabolism were investigated using 31P‐MR spectroscopy. Metabolite ratios were compared before (T1) and after training (T2). Additional questionnaire assessments were included.

Results

The participants performed FAM daily. Depression and anxiety scores revealed a lower level of state anxiety at T2 compared to T1. From T1 to T2, energy metabolism ratios showed the following differences: PCr/ATP increased right occipitally; Pi/ATP decreased bilaterally in the basal ganglia and temporal lobe on the right; PCr/Pi increased in occipital lobe bilaterally, in the basal ganglia and in the temporal lobe on the right side. The pH decreased temporal on the left side and frontal in the right side. The observed changes in the temporal areas and basal ganglia may be interpreted as a higher energetic state, whereas the frontal and occipital areas showed changes that may be related to a down‐regulation in ATP turnover, energy state, and oxidative capacity.

Conclusions

The results of the current study indicate for the first time in a longitudinal study that even short‐term training in FAM may have considerable effects on brain energy state with different local energy management in specific brain regions. Especially higher energetic state in basal ganglia may represent altered function in their central role in complex cerebral distributed networks including frontal and temporal areas. Further studies including different forms of relaxation techniques should be performed for more specific and reliable insights.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7821578/

 

Improve Brain Function and Mental Health in Chronic Pain Patients with Mindfulness

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Improve Brain Function and Mental Health in Chronic Pain Patients with Mindfulness

 

By John M. de Castro, Ph.D.

 

“With the ACT approach, learning to let go of behaviors, memories, thoughts, and emotions creates space to explore new experiences, including acceptance of chronic pain sensations.” – Rosemary Black

We all have to deal with pain. It’s inevitable, but hopefully it’s mild and short lived. For a wide swath of humanity, however, pain is a constant in their lives. At least 100 million adult Americans have chronic pain conditions. The most common treatment for chronic pain is drugs. These include over-the-counter analgesics and opioids. But opioids are dangerous and highly addictive. Prescription opioid overdoses kill more than 14,000 people annually. So, there is a great need to find safe and effective ways to lower the psychological distress and improve the individual’s ability to cope with the pain.

 

Hence, it is important to find an effective method to treat Chronic pain. There is an accumulating volume of research findings to demonstrate that mindfulness practices, in general, are effective in treating pain. Acceptance and Commitment Therapy (ACT) is a mindfulness-based psychotherapy technique that is employs many of the techniques of Cognitive Behavioral Therapy (CBT). ACT focuses on the individual’s thoughts, feelings, and behavior and how they interact to impact their psychological and physical well-being. It then works to change thinking to alter the interaction and produce greater life satisfaction. ACT employs mindfulness practices to increase awareness and develop an attitude of acceptance and compassion in the presence of painful thoughts and feelings. ACT teaches individuals to “just notice”, accept and embrace private experiences and focus on behavioral responses that produce more desirable outcomes.

 

Pain experiences are processed in the nervous system. So, it’s likely that mindfulness practices somehow alter the brain’s processing of pain. So, it makes sense to study the how Acceptance and Commitment Therapy (ACT) may affect the brain to improve the mental health of chronic pain patients.

 

In today’s Research News article “Neural Mechanisms of Acceptance and Commitment Therapy for Chronic Pain: A Network-Based fMRI Approach.” (See summary below or view the full text of the study at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7892587/ ) Aytur and colleagues recruited with musculoskeletal pain who did not abuse opioids. They completed 2 sessions per week for 4 weeks of Acceptance and Commitment Therapy (ACT). Before and after therapy they were measured for acceptance, chronic pain acceptance, quality of life, pain interference, and depression. Brain systems were measured before and after therapy with functional Magnetic Resonance Imaging (fMRI).

 

They found that in comparison to baseline after Acceptance and Commitment Therapy (ACT) the participants had significant increases in acceptance, chronic pain acceptance, quality of life and significant decreases in pain interference, and depression. In the fMRIs they also observed significant decreases in activation and connectivity in the Default Mode Network (DMN), Salience Network (SN), and Frontal-Parietal Network (FPN) networks of the brain. In addition, they observed that changes in the connectivity between these networks were correlated with decreases in depression and pain interference, and increases in quality of life.

 

These are interesting results that need to be interpreted with caution as there wasn’t a control, comparison condition present opening the findings up to alternative confounded interpretations. But the results replicate previous findings with controlled designs that Acceptance and Commitment Therapy (ACT) produces improvements in depression, pain, and quality of life. So, the improvements observed in the present study are likely due to causal effects of ACT.

 

These results also show that the psychological improvements produced by Acceptance and Commitment Therapy (ACT) are related to changes in the activity and connectivity within and between significant brain networks. This suggests that these neural alterations may underly the improvements in mental health of chronic pain patients produced by ACT. It remains for future studies to unravel the cause effect relationships.

 

So, improve brain function and mental health in chronic pain patients with mindfulness.

 

“ACT can help us to break out of that box that we have created for ourselves. To understand that the key to living with our condition is not to limit our lives and miss out on experiences, but instead to face things head on and be dedicated to working with our pain and doing things that bring us joy. ACT’s goal is not necessarily to reduce the pain but to help you to live your life with it, to feel more confident in engaging in activities that you might have otherwise swayed away from.” – Ann-Marie D’arcy-Sharpe

 

CMCS – Center for Mindfulness and Contemplative Studies

 

This and other Contemplative Studies posts are also available on Google+ https://plus.google.com/106784388191201299496/posts and on Twitter @MindfulResearch

 

Study Summary

 

Aytur, S. A., Ray, K. L., Meier, S. K., Campbell, J., Gendron, B., Waller, N., & Robin, D. A. (2021). Neural Mechanisms of Acceptance and Commitment Therapy for Chronic Pain: A Network-Based fMRI Approach. Frontiers in human neuroscience, 15, 587018. https://doi.org/10.3389/fnhum.2021.587018

 

Abstract

Over 100 million Americans suffer from chronic pain (CP), which causes more disability than any other medical condition in the United States at a cost of $560–$635 billion per year (Institute of Medicine, 2011). Opioid analgesics are frequently used to treat CP. However, long term use of opioids can cause brain changes such as opioid-induced hyperalgesia that, over time, increase pain sensation. Also, opioids fail to treat complex psychological factors that worsen pain-related disability, including beliefs about and emotional responses to pain. Cognitive behavioral therapy (CBT) can be efficacious for CP. However, CBT generally does not focus on important factors needed for long-term functional improvement, including attainment of personal goals and the psychological flexibility to choose responses to pain. Acceptance and Commitment Therapy (ACT) has been recognized as an effective, non-pharmacologic treatment for a variety of CP conditions (Gutierrez et al., 2004). However, little is known about the neurologic mechanisms underlying ACT. We conducted an ACT intervention in women (n = 9) with chronic musculoskeletal pain. Functional magnetic resonance imaging (fMRI) data were collected pre- and post-ACT, and changes in functional connectivity (FC) were measured using Network-Based Statistics (NBS). Behavioral outcomes were measured using validated assessments such as the Acceptance and Action Questionnaire (AAQ-II), the Chronic Pain Acceptance Questionnaire (CPAQ), the Center for Epidemiologic Studies Depression Scale (CES-D), and the NIH Toolbox Neuro-QoLTM (Quality of Life in Neurological Disorders) scales. Results suggest that, following the 4-week ACT intervention, participants exhibited reductions in brain activation within and between key networks including self-reflection (default mode, DMN), emotion (salience, SN), and cognitive control (frontal parietal, FPN). These changes in connectivity strength were correlated with changes in behavioral outcomes including decreased depression and pain interference, and increased participation in social roles. This study is one of the first to demonstrate that improved function across the DMN, SN, and FPN may drive the positive outcomes associated with ACT. This study contributes to the emerging evidence supporting the use of neurophysiological indices to characterize treatment effects of alternative and complementary mind-body therapies.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7892587/

 

Maintain Weight Loss with Mindfulness

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Maintain Weight Loss with Mindfulness

 

By John M. de Castro, Ph.D.

 

“Just as meditation can help us with stress, sleeping, focus, and much more, it can also have an impact on our relationship with eating and managing our weight.” – Headspace

 

Eating is produced by two categories of signals. Homeostatic signals emerge from the body’s need for nutrients, is associated with feelings of hunger, and usually work to balance intake with expenditure. Non-homeostatic eating, on the other hand, is not tied to nutrient needs or hunger but rather to the environment, to emotional states, and or to the pleasurable and rewarding qualities of food. These cues can be powerful signals to eat even when there is no physical need for food. External eating is non-homeostatic eating in response to the environmental stimuli that surround us, including the sight and smell of food or the sight of food related cause such as the time of day or a fast-food restaurant ad or sign.

 

Mindful eating involves paying attention to eating while it is occurring, including attention to the sight, smell, flavors, and textures of food, to the process of chewing and may help reduce intake. Indeed, high levels of mindfulness are associated with lower levels of obesity and mindfulness training has been shown to reduce binge eating, emotional eating, and external eating. The Mindfulness-Based Stress Reduction (MBSR) program is a mindfulness program including meditation, body scan, yoga, discussion and home practice. So, it makes sense to examine MBSR as a part of a weight loss program.

 

In today’s Research News article “Keeping weight off: Mindfulness-Based Stress Reduction alters amygdala functional connectivity during weight loss maintenance in a randomized control trial.” (See summary below or view the full text of the study at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7799782/ ) Chumachenko and colleagues recruited overweight adults (BMI>25) who had lost at least 5% of their body weight and wished to maintain it off. They were randomly assigned to receive 8, once a week for 1.5 hours, sessions of either a healthy living course or the Mindfulness-Based Stress Reduction (MBSR) program. They were measured before and after training and 6 months later for body size, perceived stress, depression, and eating disinhibition. Before and after training they also had their brains scanned with functional Magnetic Resonance Imaging (fMRI).

 

They found that after Mindfulness-Based Stress Reduction (MBSR) training there was a significant increase in the connectivity between the Amygdala and the ventromedial prefrontal cortex while this was decreased after completing the healthy living course. Over the 6-month follow-up period the MBSR participants did not gain weight while the healthy living course participants gained on average 5.9 pounds.

 

These results are interesting and important. There are many dietary programs that produce weight loss. But almost inevitably the weight is regained subsequently. Mindfulness-Based Stress Reduction (MBSR) training was found here to prevent that weight gain. Hence, MBSR may be an important ingredient in weight loss to help maintain the loss. The results also suggest that MBSR may alter the brain, increasing the functional connectivity in brain circuits that are thought to underlie emotion regulation. This fits with the prior findings that mindfulness training improves emotion regulation. This suggests that MBSR may prevent non-homeostatic, emotional, eating by strengthening emotion regulation and thereby prevent weight regain.

 

So, maintain weight loss with mindfulness.

 

“By itself, mindful eating is not a weight-loss cure, but as part of an approach or tool it can catapult healthy eating and weight loss,” – Josh Klapow

 

CMCS – Center for Mindfulness and Contemplative Studies

 

This and other Contemplative Studies posts are also available on Google+ https://plus.google.com/106784388191201299496/posts and on Twitter @MindfulResearch

 

Study Summary

 

Chumachenko, S. Y., Cali, R. J., Rosal, M. C., Allison, J. J., Person, S. J., Ziedonis, D., Nephew, B. C., Moore, C. M., Zhang, N., King, J. A., & Fulwiler, C. (2021). Keeping weight off: Mindfulness-Based Stress Reduction alters amygdala functional connectivity during weight loss maintenance in a randomized control trial. PloS one, 16(1), e0244847. https://doi.org/10.1371/journal.pone.0244847

 

Abstract

Obesity is associated with significant comorbidities and financial costs. While behavioral interventions produce clinically meaningful weight loss, weight loss maintenance is challenging. The objective was to improve understanding of the neural and psychological mechanisms modified by mindfulness that may predict clinical outcomes. Individuals who intentionally recently lost weight were randomized to Mindfulness-Based Stress Reduction (MBSR) or a control healthy living course. Anthropometric and psychological factors were measured at baseline, 8 weeks and 6 months. Functional connectivity (FC) analysis was performed at baseline and 8 weeks to examine FC changes between regions of interest selected a priori, and independent components identified by independent component analysis. The association of pre-post FC changes with 6-month weight and psychometric outcomes was then analyzed. Significant group x time interaction was found for FC between the amygdala and ventromedial prefrontal cortex, such that FC increased in the MBSR group and decreased in controls. Non-significant changes in weight were observed at 6 months, where the mindfulness group maintained their weight while the controls showed a weight increase of 3.4% in BMI. Change in FC at 8-weeks between ventromedial prefrontal cortex and several ROIs was associated with change in depression symptoms but not weight at 6 months. This pilot study provides preliminary evidence of neural mechanisms that may be involved in MBSR’s impact on weight loss maintenance that may be useful for designing future clinical trials and mechanistic studies.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7799782/

 

The Default Mode Network of the Brain Underlies Mind Wandering

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The Default Mode Network of the Brain Underlies Mind Wandering

 

By John M. de Castro, Ph.D.

 

“the brain appears to support mind wandering by disrupting some of the brain processes that are involved in responding to our surrounding external environment.” – Julia Kam

 

We spend a tremendous amount of waking time with our minds wandering and not on the present environment or the task at hand. We daydream, plan for the future, review the past, ruminate on our failures, exalt in our successes. In fact, we spend almost half of our waking hours off task with our mind wandering. A system of the brain known as the Default Mode Network (DMN) becomes active during wind wandering and relatively quiet during focused on task behavior. Meditation is known to reduce the size, connectivity, and activity of the Default Mode Network (DMN).

 

In today’s Research News article “Lesion network mapping demonstrates that mind-wandering is associated with the default mode network.” (See summary below or view the full text of the study at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7704688/ ) Philippi and colleagues recruited patients with circumscribed brain injuries (lesions) and age and education matched non-brain damaged comparison participants. They all underwent brain scanning with Magnetic Resonance Imaging (MRI). They completed a self-report measure of mind wandering.

 

They found that the brain damaged patients had lower frequencies of mind wandering than the healthy comparison participants. They then examined the specific brain areas damaged in the patients lesions and related it to their reduced mind wandering scores. They found that reduced mind wandering was associated with structures in the Default Mode Network (DMN), including the medial prefrontal cortex, parietal lobe, and inferior frontal gyrus.

 

The results are simple and straightforward and suggest that damage to the Default Mode Network (DMN) reduces mind wandering. This finding taken together with the findings that the DMN becomes more active during mind wandering makes a clear case that the DMN is responsible for mind wandering.

 

So, the default mode network of the brain underlies mind wandering.

 

“mind-wandering was associated with increased DMN activity and increased DMN-VS connectivity.“ – Xinqi Zhou

 

CMCS – Center for Mindfulness and Contemplative Studies

 

This and other Contemplative Studies posts are also available on Google+ https://plus.google.com/106784388191201299496/posts and on Twitter @MindfulResearch

 

Study Summary

 

Philippi, C. L., Bruss, J., Boes, A. D., Albazron, F. M., Deifelt Streese, C., Ciaramelli, E., Rudrauf, D., & Tranel, D. (2021). Lesion network mapping demonstrates that mind-wandering is associated with the default mode network. Journal of neuroscience research, 99(1), 361–373. https://doi.org/10.1002/jnr.24648

 

Abstract

Functional neuroimaging research has consistently associated brain structures within the default mode network (DMN) and frontoparietal network (FPN) with mind-wandering. Targeted lesion research has documented impairments in mind-wandering after damage to the medial prefrontal cortex (mPFC) and hippocampal regions associated with the DMN. However, no lesion studies to date have applied lesion network mapping to identify common networks associated with deficits in mind-wandering. In lesion network mapping, resting-state functional connectivity data from healthy participants are used to infer which brain regions are functionally connected to each lesion location from a sample with brain injury. In the current study, we conducted a lesion network mapping analysis to test the hypothesis that lesions affecting the DMN and FPN would be associated with diminished mind-wandering. We assessed mind-wandering frequency on the Imaginal Processes Inventory (IPI) in participants with brain injury (n = 29) and healthy comparison participants without brain injury (n = 19). Lesion network mapping analyses showed the strongest association of reduced mind-wandering with the left inferior parietal lobule within the DMN. In addition, traditional lesion symptom mapping results revealed that reduced mind-wandering was associated with lesions of the dorsal, ventral, and anterior sectors of mPFC, parietal lobule, and inferior frontal gyrus in the DMN (p < 0.05 uncorrected). These findings provide novel lesion support for the role of the DMN in mind-wandering and contribute to a burgeoning literature on the neural correlates of spontaneous cognition.

Significance

Adults spend up to 50% of their waking day mind-wandering, which is the process of turning one’s attention inward to focus on self-generated thoughts or feelings. Mind-wandering can have both costs and benefits, such as increased negative mood or enhanced creative problem-solving. In this study, we report novel findings linking reduced mind-wandering with brain injury located within the default mode network. This work is important because it can help us to determine which brain networks are necessary for self-generated cognition, which may improve our understanding of neuropsychiatric conditions associated with altered self-focused thought.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7704688/

 

Change the Brain to Improve Chronic Pain with Mindfulness

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Change the Brain to Improve Chronic Pain with Mindfulness

 

By John M. de Castro, Ph.D.

 

“we should consider one’s level of mindfulness when calculating why and how one feels less or more pain.” – Fadel Zeidan

 

We all have to deal with pain. It’s inevitable, but hopefully it’s mild and short lived. For a wide swath of humanity, however, pain is a constant in their lives. At least 100 million adult Americans have chronic pain conditions. The most common treatment for chronic pain is drugs. These include over-the-counter analgesics and opioids. But opioids are dangerous and highly addictive. Prescription opioid overdoses kill more than 14,000 people annually. So, there is a great need to find safe and effective ways to lower the psychological distress and improve the individual’s ability to cope with the pain.

 

There is an accumulating volume of research findings that demonstrate that mindfulness practices, in general, are effective in treating pain. Pain experiences are processed in the nervous system. The nervous system changes in response to how it is used and how it is stimulated in a process called neuroplasticity. Highly used areas grow in size, metabolism, and connectivity. So, the nervous system changes in response to chronic pain. Mindfulness practices in general are known to produce neuroplastic changes in the structure and activity of the brain. So, it’s likely that mindfulness practices somehow alter the brain’s processing of pain.

 

Acceptance and Commitment Therapy (ACT) is a mindfulness-based psychotherapy technique that is employs many of the techniques of Cognitive Behavioral Therapy (CBT). ACT focuses on the individual’s thoughts, feelings, and behavior and how they interact to impact their psychological and physical well-being. It then works to change thinking to alter the interaction and produce greater life satisfaction. ACT employs mindfulness practices to increase awareness and develop an attitude of acceptance and compassion in the presence of painful thoughts and feelings. ACT teaches individuals to “just notice”, accept and embrace private experiences and focus on behavioral responses that produce more desirable outcomes.

 

In today’s Research News article “Network Analysis of Induced Neural Plasticity Post-Acceptance and Commitment Therapy for Chronic Pain.” (See summary below or view the full text of the study at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7823706/ ) Meier and colleagues recruited adult female patients who were diagnosed with chronic musculoskeletal pain. They were provided a 4-week group program of Acceptance and Commitment Therapy (ACT). It met twice a week for 90 minutes. They were measured before and after ACT for pain intensity, pain interference, anxiety, depression, sleep, quality of life, and cognitive ability. ACT was previously found to improve these symptoms of chronic pain.

 

They also had their brains scanned with functional Magnetic Resonance Imaging (f-MRI). The researchers examined the functional connectivity in 4 brain systems; the pain network, default mode network, frontoparietal network, and salience network. They found that after Acceptance and Commitment Therapy (ACT) there were significant reductions in functional connectivity within all four networks.

 

Previous work revealed that the chronic pain patients had very high levels of connectivity in these 4 networks. This hyperconnectivity was interpreted as a neuroplastic change in the brain produced by chronic pain. The present findings that Acceptance and Commitment Therapy (ACT) reduces this connectivity suggest that ACT normalizes the connectivity in these networks, making it easier for the patients to cope with their pain. This, in turn, improves their mood and quality of life.

 

So, change the brain to improve chronic pain with mindfulness.

 

“Mindfulness meditation can be used as a tool to create more awareness of the sensation of pain itself, without the judgment or resistance, and the affective and cognitive evaluation that we often project upon it. When we impose a litany of negativity upon our pain, it only becomes worse, and potentially elicits other difficulties including depression and anxiety. When we become more aware of what we are actually experiencing, without the overlay of our judgment, the overall perception of pain is reduced.” – Jennifer Wolkin

 

CMCS – Center for Mindfulness and Contemplative Studies

 

This and other Contemplative Studies posts are also available on Google+ https://plus.google.com/106784388191201299496/posts and on Twitter @MindfulResearch

 

Study Summary

 

Meier, S. K., Ray, K. L., Waller, N. C., Gendron, B. C., Aytur, S. A., & Robin, D. A. (2020). Network Analysis of Induced Neural Plasticity Post-Acceptance and Commitment Therapy for Chronic Pain. Brain sciences, 11(1), 10. https://doi.org/10.3390/brainsci11010010

 

Abstract

Chronic musculoskeletal pain is a costly and prevalent condition that affects the lives of over 50 million individuals in the United States. Chronic pain leads to functional brain changes in those suffering from the condition. Not only does the primary pain network transform as the condition changes from acute to persistent pain, a state of hyper-connectivity also exists between the default mode, frontoparietal, and salience networks. Graph theory analysis has recently been used to investigate treatment-driven brain network changes. For example, current research suggests that Acceptance and Commitment Therapy (ACT) may reduce the chronic pain associated hyper-connectivity between the default mode, frontoparietal, and salience networks, as well as within the salience network. This study extended previous work by examining the associations between the three networks above and a meta-analytically derived pain network. Results indicate decreased connectivity within the pain network (including left putamen, right insula, left insula, and right thalamus) in addition to triple network connectivity changes after the four-week Acceptance and Commitment Therapy intervention.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7823706/

 

Mindful Attention Produces Different Responses to Sexual Orientation Consistent and Inconsistent Stimuli.

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Mindful Attention Produces Different Responses to Sexual Orientation Consistent and Inconsistent Stimuli.

 

By John M. de Castro, Ph.D.

 

“Sometimes people need to play around with the idea of [something] before they can really get a sense of whether this is something that they want to bring into their real-world sex life, so fantasy can be super helpful in that way,” Vanessa Marin

 

Sexual fantasies are nearly universal occurring in both men and women across cultures. But, the purpose of these fantasies or their effects upon sexual behavior and the well-being of the individual have not been well studied. Most heterosexual fantasies are orientation consistent involving fantasized interactions with members of the opposite sex. But occasionally orientation inconsistent fantasies occur involving fantasies about individuals of the same sex. It is not known what are the effects of these orientation consistent and inconsistent fantasies.

 

In today’s Research News article “Understanding heterosexual women’s erotic flexibility: the role of attention in sexual evaluations and neural responses to sexual stimuli.” (See summary below or view the full text of the study at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7308660/ ) Dickinson and colleagues recruited single heterosexual women between the ages of 18 to 35 years. The women evaluated 30 second film clips of male actors masturbating, female actors masturbating, male actors engaging in non-sexual activity and female actors engaging in non-sexual activity. After each clip they answered to what extent they found the clips sexually arousing and to what extent they felt distracted? They also underwent brain scanning with functional Magnetic Resonance Imaging (fMRI) while watching the videos with mindful attention and not.

 

They found that when practicing mindful attention, the women rated the orientation consistent images significantly more sexually arousing and they were less distracted than the neutral images. On the other hand, when practicing mindful attention, the women rated the orientation inconsistent images significantly less sexually arousing and they were more distracted. When viewing sexual stimuli, the women’s brains showed significant activation in brain areas that are involved in control of the physiology (autonomic nervous system), attention, appraisal, tactual sensitivity, and motor imagery.

 

The findings demonstrate that women react differently to orientation consistent erotic imagery that to orientation inconsistent imagery finding the consistent imagery more arousing and less distracting. These differences are amplified with mindful attention. They also show that the neural responses to the stimuli differ between consistent and inconsistent orientation stimuli suggesting that the attentional and visual processing areas of the women’s brains are activated by consistent but not inconsistent orientation erotic imagery.

 

These findings suggest that women are not erotically flexible. Erotic imagery consistent with their sexual orientation were found to be more arousing psychologically and in brain processing than erotic imagery inconsistent with their orientation. They also suggest that mindfulness amplifies their responses. These types of studies begin to unravel the physical and psychological responses underlying sexuality toward the opposite sex in heterosexual women. These types of responses may support human reproduction and perpetuation of the species.

 

So, mindful attention produces different responses to sexual orientation consistent and inconsistent stimuli.

 

“Sex therapists concur, encouraging lovers to observe their erotic thoughts and fantasies non-judgmentally, no matter what their content, and then gently let go of them as lovers return to focusing on giving and receiving pleasure. Just as random thoughts during meditation don’t mean anything, neither do the vast majority of thoughts and fantasies during sex.” – Michael Castleman

 

CMCS – Center for Mindfulness and Contemplative Studies

 

This and other Contemplative Studies posts are also available on Google+ https://plus.google.com/106784388191201299496/posts and on Twitter @MindfulResearch

 

Study Summary

Dickenson, J. A., Diamond, L., King, J. B., Jenson, K., & Anderson, J. S. (2020). Understanding heterosexual women’s erotic flexibility: the role of attention in sexual evaluations and neural responses to sexual stimuli. Social cognitive and affective neuroscience, 15(4), 447–465. https://doi.org/10.1093/scan/nsaa058

 

Abstract

Many women experience desires, arousal and behavior that run counter to their sexual orientation (orientation inconsistent, ‘OI’). Are such OI sexual experiences cognitively and neurobiologically distinct from those that are consistent with one’s sexual orientation (orientation consistent, ‘OC’)? To address this question, we employed a mindful attention intervention—aimed at reducing judgment and enhancing somatosensory attention—to examine the underlying attentional and neurobiological processes of OC and OI sexual stimuli among predominantly heterosexual women. Women exhibited greater neural activity in response to OC, compared to OI, sexual stimuli in regions associated with implicit visual processing, volitional appraisal and attention. In contrast, women exhibited greater neural activity to OI, relative to OC, sexual stimuli in regions associated with complex visual processing and attentional shifting. Mindfully attending to OC sexual stimuli reduced distraction, amplified women’s evaluations of OC stimuli as sexually arousing and deactivated the superior cerebellum. In contrast, mindfully attending to OI sexual stimuli amplified distraction, decreased women’s evaluations of OI stimuli as sexually arousing and augmented parietal and temporo-occipital activity. Results of the current study constrain hypotheses of female erotic flexibility, suggesting that sexual orientation may be maintained by differences in attentional processing that cannot be voluntarily altered.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7308660/

 

Change the Brain to Improve Emotion Regulation in Bereaved Individuals with Mindfulness

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Change the Brain to Improve Emotion Regulation in Bereaved Individuals with Mindfulness

 

By John M. de Castro, Ph.D.

 

“It takes a boat load of self-compassion to allow oneself to feel whatever it is you are feeling at any given time, without judgment, without comparison relative to another’s explicit portrayal of their own process. In this way, to grieve is to be mindful of our thoughts and feelings.” – Jennifer Wolkin

 

Grief is a normal, albeit complex, process that follows a loss of a significant person or situation in one’s life. This can involve the death of a loved one, a traumatic experience, termination of a relationship, relationship to a long-missing person, etc. Exactly what transpires depends upon the individual and the nature of the loss. It involves physical, emotional, psychological and cognitive processes. In about 15% of people grief can be overly intense or long and therapeutic intervention may become necessary.

 

Mindfulness practices have been found to help with coping with loss and its consequent grief.  Mindfulness-Based Cognitive Therapy (MBCT) was specifically developed to treat depression. MBCT involves mindfulness training, containing sitting, walking and body scan meditations, and cognitive therapy that is designed to alter how the patient relates to the thought processes that often underlie and exacerbate psychological symptoms. Mindfulness training has been shown to change the size, activity and connectivity of brain structures. Hence, MBCT may reduce grief by altering the brain.

 

In today’s Research News article “Mindfulness-based cognitive therapy on bereavement grief: Alterations of resting-state network connectivity associate with changes of anxiety and mindfulness.” (See summary below or view the full text of the study at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7775995/ ) Huang and colleagues recruited adults who had lost a first degree relative within the last 4 years and had unresolved grief. The patients received an 8-week program of Mindfulness-Based Cognitive Therapy (MBCT). They met weekly for 2.5 hours and were encouraged to practice for 45 minutes daily at home. They were measured before and after the training for grief, generalized anxiety, depression, emotion regulation, and mindfulness. After training they underwent brain functional Magnetic Resonance Imaging (fMRI) at rest and while viewing pictures of faces with either neutral or negative emotional expressions.

 

They found that in comparison to baseline, after Mindfulness-Based Cognitive Therapy (MBCT) the participants had significant increases in mindfulness, particularly the describing and non-reacting mindfulness facets, and emotion regulation and significant decreases in grief, anxiety, and depression. The brain connectivity as revealed in the fMRI scans changed after MBCT training with decreased connectivity within the Default Mode Network of the brain and connectivity between the Auditory, Visual, Salience, and frontal-parietal networks during rest but not emotion arousal. In addition, the connectivity between the subcortical caudate with the cortex correlated positively with mindfulness and emotion regulation and negatively with anxiety.

 

The Default Mode Network is thought to underly mind wandering and self-referential thinking. So, the decreases in connectivity may signal heightened present moment awareness. In addition, the changes in the connectivity between cortical areas were negatively related to emotion regulation while the connectivity between cortical and subcortical areas were positively related to emotion regulation. This suggests that MBCT training decreased effects of external perception on emotion regulation while increasing the effects of internal sensations.

 

It should be noted that there wasn’t a comparison, control, condition. So, the passage of time, participant expectancy effects, attentional effects, or experimenter bias may have been responsible for the observed changes. Nevertheless, the results suggest that MBCT training for bereaved patients improves their mental health and reduces grief. The brain scans suggest that the training altered the brain to increase present moment awareness and dependence of the person’s internal state in regulating emotions.

 

So, change the brain to improve emotion regulation in bereaved individuals with mindfulness.

 

“Mindfulness practice is not meant to minimize that pain or to convince people that everything is OK, but rather to help you recognize the reality of your circumstances, and to do so in a nonjudgmental and self-compassionate way.” – Stephanie Pritchard

 

CMCS – Center for Mindfulness and Contemplative Studies

 

This and other Contemplative Studies posts are also available on Google+ https://plus.google.com/106784388191201299496/posts and on Twitter @MindfulResearch

 

Study Summary

 

Huang, F. Y., Hsu, A. L., Chao, Y. P., Shang, C. M., Tsai, J. S., & Wu, C. W. (2020). Mindfulness-based cognitive therapy on bereavement grief: Alterations of resting-state network connectivity associate with changes of anxiety and mindfulness. Human brain mapping, 42(2), 510–520. Advance online publication. https://doi.org/10.1002/hbm.25240

 

Abstract

Bereavement, the experience of losing a loved one, is one of the most catastrophic but inevitable events in life. It causes grief and intense depression‐like sadness. Recent studies have revealed the effectiveness and proficiency of mindfulness‐based cognitive therapy (MBCT) in emotional regulation among bereavement populations. MBCT improves the well‐being of the bereaved by enhancing cognitive performances. Regarding the neural correlates of bereavement grief, previous studies focused on the alleviation of emotion–cognition interferences at specific brain regions. Here, we hypothesized that the bereavement grief fundamentally triggers global alterations in the resting‐state brain networks and part of the internetwork connectivity could be reformed after MBCT intervention. We recruited 19 bereaved individuals who participated the 8‐week MBCT program. We evaluated (a) the large‐scale changes in brain connectivity affected by the MBCT program; as well as (b) the association between connectivity changes and self‐rated questionnaire. First, after MBCT, the bereaved individuals showed the reduction of the internetwork connectivity in the salience, default‐mode and fronto‐parietal networks in the resting state but not under emotional arousal, implying the alleviated attention to spontaneous mind wandering after MBCT. Second, the alterations of functional connectivity between subcortical (e.g., caudate) and cortical networks (e.g., cingulo‐opercular/sensorimotor) were associated with the changes of the mindfulness scale, the anxiety and the emotion regulation ability. In summary, MBCT could enhance spontaneous emotion regulation among the bereaved individuals through the internetwork reorganizations in the resting state.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7775995/

 

Change the Brain to Improve Fibromyalgia with Tai Chi

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Change the Brain to Improve Fibromyalgia with Tai Chi

 

By John M. de Castro, Ph.D.

 

“tai chi appears to be as effective or better for managing fibromyalgia . . .  and patients are more likely to attend tai chi classes than aerobic exercise sessions.” – NCCIH

 

Fibromyalgia is a mysterious disorder whose causes are unknown. It is very common affecting over 5 million people in the U.S., about 2% of the population with about 7 times more women affected than men. It is characterized by widespread pain, abnormal pain processing, sleep disturbance, and fatigue that lead to psychological distress. Fibromyalgia may also have morning stiffness, tingling or numbness in hands and feet, headaches, including migraines, irritable bowel syndrome, sleep disturbances, thinking and memory problems, and painful menstrual periods. The symptoms are so severe and debilitating that about half the patients are unable to perform routine daily functions and about a third have to stop work. Although it is not itself fatal, suicide rates are higher in fibromyalgia sufferers. Clearly, fibromyalgia greatly reduces the quality of life of its’ sufferers.

 

There are no completely effective treatments for fibromyalgia. Symptoms are generally treated with pain relievers, antidepressant drugs and exercise. But these only reduce the severity of the symptoms and do not treat the disease directly. Mindfulness practices have also been shown to be effective in reducing pain from fibromyalgia. Tai Chi is an ancient Chinese practice involving mindfulness and gentle movements. They are easy to learn, safe, and gentle. So, it may be appropriate for patients with fibromyalgia where exercise can produce painful flares.

 

In general, mindfulness practices both produce psychological and physical benefits and also change the structure and connectivity of the brain. Indeed, Tai Chi practice has been shown to improve the symptoms of fibromyalgia. So, Tai Chi may be beneficial for fibromyalgia by altering the brain systems involved in the disorder.

 

In today’s Research News article “Altered resting state functional connectivity of the cognitive control network in fibromyalgia and the modulation effect of mind-body intervention.” (See summary below or view the full text of the study at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6214794/ ) Kong and colleagues recruited adult patients with fibromyalgia and a group of age, gender, and body size matched controls. The fibromyalgia patients received Tai Chi practice twice a week for 1-hour for 12 weeks. All participants underwent functional Magnetic Resonance Imaging (fMRI) of their brains before and after the 12-week period and also completed measures of depression, and fibromyalgia impact, including function, overall impact, and symptom severity.

 

They found that after Tai Chi training there was a significant improvement in the fibromyalgia patients’ depression, and fibromyalgia impact, including function, overall impact, and symptom severity. They examined a set of connected brain structures (frontal gyrus, parietal gyrus, and anterior cingulate cortex) called the cognitive control network. At baseline, the fibromyalgia patients had significantly greater levels of resting functional connectivity between the structures in this network. After 12 weeks of Tai Chi practice the functional connectivity between the structures in the cognitive control network were further significantly increased. In addition, they found that the greater the increase in functional connectivity the greater the improvement in overall fibromyalgia symptoms.

 

The ability of Tai Chi to improve the symptoms of fibromyalgia has been documented preciously. The contribution of the present study is to document the differences in the brains of fibromyalgia patients and healthy people and the changes in the brain of these patients that occur with Tai Chi practice. In particular the cognitive control network had increased functional connectivity in these patients and that connectivity increased significantly after Tai Chi practice. This may indicate the neural mechanism by which Tai Chi practice improves fibromyalgia symptoms. The fact that the amount of connectivity change was associated with the degree of improvement, supports this inference.

 

The baseline difference in connectivity may indicate that the way the patients’ brains adapted to help deal with the impact of fibromyalgia and Tai Chi practice further improved this adaptation. The cognitive control network is involved in high level thinking, attention, and executive control. Hence, these patients may be employing high level thought processes including the allocation of attention to help deal with the disease and Tai Chi practice further improves their ability to do this. It has been shown that attention to the pain in the present moment while not thinking about its past occurrences or worrying about the future reduces the severity of the pain. This may be what the brain is doing to help cope with fibromyalgia symptoms; using attention to mitigate the pain.

 

So, change the brain to improve fibromyalgia with Tai Chi

 

“subjects with fibromyalgia, reported benefits (compared with control groups or before/after comparisons) of Tai Chi in core symptom domains for this condition (pain, sleep, impact, physical function and mental function).” – Jana Sawynok

 

CMCS – Center for Mindfulness and Contemplative Studies

 

This and other Contemplative Studies posts are also available on Google+ https://plus.google.com/106784388191201299496/posts and on Twitter @MindfulResearch

 

Study Summary

 

Kong, J., Wolcott, E., Wang, Z., Jorgenson, K., Harvey, W. F., Tao, J., Rones, R., & Wang, C. (2019). Altered resting state functional connectivity of the cognitive control network in fibromyalgia and the modulation effect of mind-body intervention. Brain imaging and behavior, 13(2), 482–492. https://doi.org/10.1007/s11682-018-9875-3

 

Abstract

This study examines altered resting state functional connectivity (rsFC) of the cognitive control network (CCN) in fibromyalgia patients as compared to healthy controls, as well as how effective interventions, such as Tai Chi, can modulate the altered rsFC of the CCN. Patients with fibromyalgia and matched healthy subjects were recruited in this study. Fibromyalgia patients were scanned 12 weeks before and after intervention. The bilateral dorsolateral prefrontal cortex (DLPFC) was used as a seed to explore the rsFC of the CCN. Data analysis was conducted with 21 patients and 20 healthy subjects. Compared to healthy subjects, fibromyalgia patients exhibited increased rsFC between the DLPFC and the bilateral rostral anterior cingulate cortex (rACC) and medial prefrontal cortex (MPFC) at baseline. The rsFC between the CCN and rACC/MPFC further increased after Tai Chi intervention, and this increase was accompanied by clinical improvements. This rsFC change was also significantly associated with corresponding changes in the Overall Impact domain of the Revised Fibromyalgia Impact Questionnaire (FIQR). Further analysis showed that the rACC/MPFC rsFC with both the PAG and hippocampus significantly decreased following Tai Chi intervention. Our study suggests that fibromyalgia is associated with altered CCN rsFC and that effective treatment may elicit clinical improvements by further increasing this altered rsFC. Elucidating this mechanism of enhancing the allostasis process may deepen our understanding of the mechanisms underlying mind-body intervention non-pharmacological treatment of fibromyalgia and facilitate the development of new pain management methods.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6214794/