Anxiety

Improve Food Related Cognitive Processing in Patients with Eating Disorders with Mindfulness

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Improve Food Related Cognitive Processing in Patients with Eating Disorders with Mindfulness

 

By John M. de Castro, Ph.D.

 

“Practicing mindfulness techniques has proven to be extremely helpful in aiding individuals to understand the driving forces behind their eating disorder.” – Greta Gleissner

 

Around 30 million people in the United States of all ages and genders suffer from an eating disorder: either anorexia nervosa, bulimia, or binge eating disorder. 95% of those who have eating disorders are between the ages of 12 and 26. Eating disorders are not just troubling psychological problems, they can be deadly, having the highest mortality rate of any mental illness. Two example of eating disorders are binge eating disorder (BED) and bulimia nervosa (BN). BED involves eating a large amount of food within a short time-period while experiencing a sense of loss of control over eating. BN involves binge-eating and purging (e.g., self-induced vomiting, compensatory exercise).

 

Eating disorders can be difficult to treat because eating is necessary and cannot be simply stopped as in smoking cessation or abstaining from drugs or alcohol. One must learn to eat appropriately not stop. So, it is important to find methods that can help prevent and treat eating disorders. Contemplative practices, mindfulness, and mindful eating have shown promise for treating eating disorders. It is not known however, what processes are affected by mindfulness training to improve eating disorders.

 

In today’s Research News article “Mindfulness-based cognitive therapy added to usual care improves eating behaviors in patients with bulimia nervosa and binge eating disorder by decreasing the cognitive load of words related to body shape, weight, and food.” (See summary below or view the full text of the study at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8668447/ ) Sala and colleagues recruited adult participants who were diagnosed with either bulimia nervosa or binge eating disorder. They were on a wait-list for 8 weeks and then received weekly 2-hour sessions over 8 weeks of Mindfulness-Based Cognitive Therapy (MBCT).  MBCT involves mindfulness training, containing sitting and walking meditation and body scan, and cognitive therapy to alter how the patient relates to the thought processes that often underlie and exacerbate psychological symptoms. They were measured before and after therapy for mindfulness, eating behaviors, anxiety, and depression. In addition, the participants were presented cards printed in various colors with either neutral words or food related words and asked to name the color of the word as quickly as possible.

 

After Mindfulness-Based Cognitive Therapy (MBCT) there were significant improvements in mindfulness, anxiety, depression and eating behaviors, including nonreactivity, cognitive restraint, disinhibition, and hunger. In addition, the reaction times to food-related words was significantly shorter after MBCT. Path analysis revealed that MBCT affected eating behavior indirectly by altering the responses to the food-related words.

 

These results are interesting, but the study lacked a comparison (control) condition limiting the strength of the conclusions. But previous controlled research has demonstrated that mindfulness training improves eating disorders. So, the present results are likely due to the effects of Mindfulness-Based Cognitive Therapy (MBCT) and not to potential confounding variables.

 

The present study, though, has an interesting new finding. Mindfulness-Based Cognitive Therapy (MBCT) appears to affect the cognitive processing involved with eating. This includes nonreactivity, cognitive restraint, disinhibition, and hunger. These changes predict more healthful eating behavior and a reduction in disordered eating. In addition, MBCT affected these cognitive processes only indirectly by altering responses to food-related cues (words). This suggests that MBCT improves eating disorders by changing the thought processes in response to food cues. In other words, mindfulness improves eating disorders by altering how the individual processes information related to food. This interesting finding needs further research.

 

So, improve food related cognitive processing in patients with eating disorders with mindfulness.

 

“increasing mindful awareness of internal experiences and automatic patterns could be effective for the improvement of self-acceptance and emotional regulation, thereby reducing the problematic eating behaviors.” – Jinyue Yu

 

CMCS – Center for Mindfulness and Contemplative Studies

 

This and other Contemplative Studies posts are available on Twitter @MindfulResearch

 

Study Summary

 

Sala, L., Gorwood, P., Vindreau, C., & Duriez, P. (2021). Mindfulness-based cognitive therapy added to usual care improves eating behaviors in patients with bulimia nervosa and binge eating disorder by decreasing the cognitive load of words related to body shape, weight, and food. European psychiatry : the journal of the Association of European Psychiatrists, 64(1), e67. https://doi.org/10.1192/j.eurpsy.2021.2242

 

Abstract

Background

This study aimed to investigate the effectiveness of mindfulness-based cognitive therapy (MBCT) as a complementary approach in patients with bulimia nervosa (BN) or binge eating disorder (BED), and to assess how the reduction of the cognitive load of words related to eating disorders (ED) could constitute an intermediate factor explaining its global efficacy.

Methods

Eighty-eight women and men participated in clinical assessments upon inscription, prior to and following 8-week group MBCT. Mindfulness skills were assessed using the five facet mindfulness questionnaire; eating behaviors were assessed using the Three Factor Eating Questionnaire (TFEQ); comorbid pathologies were assessed using the beck depression index and the state-trait anxiety inventory. The cognitive load of words associated with ED was assessed through a modified version of the Stroop color naming task.

Results

Mindfulness skills improved significantly (p < .05) after group MBCT. The improvement of TFEQ scores was accompanied by reduced levels of depressive mood and trait anxiety. The positive impact of MBCT on TFEQ score was directly related to an improvement of the performance in the Stroop task.

Conclusions

MBCT represents an interesting complementary therapy for patients with either BN or BED, at least when cognitive and behavioral domains are concerned. Such efficacy seems to be mediated by the reduction of the cognitive load associated with ED stimuli, which offers a possible explanation of how MBCT could reduce binge-eating behaviors. Other studies are needed, in independent centers, to focus more directly on core symptoms and long-term outcome.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8668447/

 

Effectiveness of Mindfulness Training on Stress Depends Upon Baseline Levels of Anxiety and Sleep Disruption

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Effectiveness of Mindfulness Training on Stress Depends Upon Baseline Levels of Anxiety and Sleep Disruption

 

By John M. de Castro, Ph.D.

 

“Chronic stress can impair the body’s immune system and make many other health problems worse. By lowering the stress response, mindfulness may have downstream effects throughout the body.” – American Psychological Association

 

Mindfulness training has been shown to improve health and well-being in healthy individuals. It has also been found to be effective for a large array of medical and psychiatric conditions, either stand-alone or in combination with more traditional therapies. One of the primary effects of mindfulness that may be responsible for many of its benefits is that it improves the physiological and psychological responses to stress. But there are large individual differences in the effectiveness of mindfulness training for reduction in stress and its effects. Hence, there is a need to investigate what individual characteristics may predict the positive benefits of mindfulness training.

 

In today’s Research News article “Do gender, anxiety, or sleep quality predict mindfulness-based stress reduction outcomes?.” (See summary below or view the full text of the study at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7814316/ ) Brown and colleagues recruited adult participants in an 8-week Mindfulness-Based Stress Reduction (MBSR) program. the program consists of weekly training meetings that include meditation, yoga, and body scan along with group discussion and daily home practice. The participants were measured before and after the program for anxiety. depression, sleep quality, stress-related symptoms, and emotion regulation.

 

They found that in comparison to baseline after the Mindfulness-Based Stress Reduction (MBSR) program there was a significant decrease in stress-related symptoms and emotion suppression and a significant increase in cognitive reappraisal. Participants who were high in anxiety and sleep disruptions at baseline had significantly greater reductions in stress-related symptoms and greater increases in cognitive reappraisal after MBSR. In addition, men had significantly greater decreases in emotion suppression after MBSR than women.

 

This study lacked a control (comparison condition). So, caution must be exercised in reaching definitive conclusions. But previous controlled studies have demonstrated that mindfulness training results in significant decreases in the physiological and psychological responses to stress and improvements in emotion regulation. So, the present findings are likely due to the impact of the Mindfulness-Based Stress Reduction (MBSR) program.

 

The study demonstrates that the characteristics of the participants at the beginning of the Mindfulness-Based Stress Reduction (MBSR) program predict it’s impact. Participants who are highly anxious and have troubled sleep at the start tend to benefit the most. Since anxiety and sleep disruption tend to contribute to stress and mindfulness training has been shown to decrease anxiety and improve sleep, it is not surprising that they would be predictive of greater reduction in stress-related symptoms. Nevertheless, the results suggest that MBSR should be employed particularly for anxious individuals and those with troubled sleep.

 

So, effectiveness of mindfulness training on stress depends upon baseline levels of anxiety and sleep disruption.

 

“The benefits of mindfulness training may persist for years, because learning to be mindful is something that can be applied to your daily routine.” – Arielle Silverman

 

CMCS – Center for Mindfulness and Contemplative Studies

 

This and other Contemplative Studies posts are available on Twitter @MindfulResearch

 

Study Summary

 

Brown, M. M., Arigo, D., Wolever, R. Q., Smoski, M. J., Hall, M. H., Brantley, J. G., & Greeson, J. M. (2021). Do gender, anxiety, or sleep quality predict mindfulness-based stress reduction outcomes?. Journal of health psychology, 26(13), 2656–2662. https://doi.org/10.1177/1359105320931186

 

Abstract

Although mindfulness-based stress reduction (MBSR) can improve health and well-being, less is known about factors that predict outcomes. This prospective observational study examined gender and baseline anxiety and sleep quality as predictors of change in emotion regulation and stress symptoms following an 8-week MBSR program. Women and men reported similar improvement in stress symptoms and cognitive reappraisal, whereas men improved more in emotion suppression. Individuals with higher anxiety and worse sleep pre-treatment benefited most in terms of decreased stress. Evaluating pre-treatment characteristics could help determine optimal candidates for MBSR training and could optimize outcomes for both women and men.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7814316/

Improve the Psychological Well-Being of Opioid Users Undergoing Medicinal Therapy with Mindfulness

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Improve the Psychological Well-Being of Opioid Users Undergoing Medicinal Therapy with Mindfulness

 

By John M. de Castro, Ph.D.

 

“As individuals with [Substance Use Disorders] engage in mindfulness practices within [Mindfulness-Based Interventions], they learn to cultivate trait mindfulness, providing a bulwark against substance use and relapse.” – Sarah E Priddy

 

Substance abuse is a major health and social problem. There are estimated 22.2 million people in the U.S. with substance dependence. It is estimated that worldwide there are nearly ¼ million deaths yearly as a result of illicit drug use which includes unintentional overdoses, suicides, HIV and AIDS, and trauma. Obviously, there is a need to find effective methods to prevent and treat substance abuse. There are a number of programs that are successful at stopping the drug abuse, including the classic 12-step program emblematic of Alcoholics Anonymous. Unfortunately, the majority of drug and/or alcohol abusers’ relapse and return to substance abuse.

 

Hence, it is important to find an effective method to treat substance abuse and prevent relapse, but an effective treatment has been elusive. Most programs and therapies to treat addictions have poor success rates. Recently, mindfulness training has been found to be effective in treating addictions and preventing relapses. Medicinal therapies with drugs such as buprenorphine/naloxone have also been effective. But there is a need to study the effectiveness of mindfulness training in combination with medicinal therapy on relapse prevention.

 

In today’s Research News article “Testing Mindfulness-Based Relapse Prevention with Medications for Opioid Use Disorder Among Adults in Outpatient Therapy: a Quasi-experimental Study.” (See summary below or view the full text of the study at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8504564/ ) Zullig and colleagues recruited patients who were addicted to opioids and after treatment had been opioid free for at least 90 days. They continued on receiving treatment with daily injections of buprenorphine/naloxone and attending Narcotics Anonymous meetings. Patients who volunteered underwent additional 24 weeks of twice weekly 60-minute sessions of Mindfulness-Based Relapse Prevention (MBRP) treatment. The participants were measured before, at midpoint, and after treatment and 12 weeks later for relapse, craving symptoms, anxiety, depression, and mindfulness.

 

They found that 73% of the participants were retained through the entire 36 weeks with no differences between groups. Relapse occurred in 45% of the participants but there were no differences between groups. Cravings declined throughout the 36 weeks but again there were no differences between groups. On the other hand, the decline in anxiety and depression and increase in mindfulness was significantly greater for the group that received Mindfulness-Based Relapse Prevention (MBRP).

 

The findings suggest that adding Mindfulness-Based Relapse Prevention (MBRP) to medicinal therapy for opioid relapse prevention produced significantly lower levels of anxiety and depression in the patients. But it did not appear to improve relapses or cravings. More research is needed to ascertain whether the additional cost and staff support involved in implementing MBRP is justified by the additional improvements in psychological well-being.

 

So, improve the psychological well-being of opioid users undergoing medicinal therapy with mindfulness.

 

“Mindfulness-Based Relapse Prevention (MBRP) has been shown to help with physical and psychological well-being, reduce craving, and help with anxiety and depression.” – Keith Zullig

 

CMCS – Center for Mindfulness and Contemplative Studies

 

This and other Contemplative Studies posts are available on Twitter @MindfulResearch

 

Study Summary

 

Zullig, K. J., Lander, L. R., Tuscano, M., Garland, M., Hobbs, G. R., & Faulkenberry, L. (2021). Testing Mindfulness-Based Relapse Prevention with Medications for Opioid Use Disorder Among Adults in Outpatient Therapy: a Quasi-experimental Study. Mindfulness, 1–11. Advance online publication. https://doi.org/10.1007/s12671-021-01763-w

 

Abstract

Objectives

This study aimed to explore the effectiveness of mindfulness-based relapse prevention (MBRP) with individuals receiving medication for opioid use disorder (MOUD) in a naturalistic, open-ended outpatient group treatment setting.

Methods

Eighty participants (mean age 36.3) who had at least 90 consecutive days substance free self-selected into treatment (MBRP, n = 35) or comparison groups (treatment as usual, TAU, n = 45). Outcomes tracked included treatment retention and relapse, and self-reported craving, anxiety, depression, and mindfulness at baseline, 12 weeks, 24 weeks, and 36 weeks post-recruitment. MBRP group participants attended biweekly 60-min sessions for 24 weeks. A linear mixed model analysis of variance determined the significance of the MBRP intervention on changes in craving, anxiety, depression, and mindfulness.

Results

No significant differences in sex, education level, insurance status, relationship status, or employment status were detected at baseline between groups. The 36-week retention (74%, MBRP/MOUD; 71%, TAU/MOUD) and relapse rates (43%, MBRP/MOUD; 47%, TAU/MOUD) were similar for the groups. There were only four relapses on opioids. Significant reductions (p < .05) were observed in the MBRP/MOUD group for craving, anxiety, and depression in addition to significant increases in mindfulness compared to those in TAU/MOUD.

Conclusions

Although state and federal resources are available to expand MOUD, no standard of behavioral therapy has been established as most complimentary to MOUD. The current study results suggest MBRP can be implemented as an outpatient therapy for individuals in MOUD.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8504564/

 

Improved Psychological Well-Being and Cognition is Reported by Adult who Engage in Microdosing of Psychedelic Substances

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Improved Psychological Well-Being and Cognition is Reported by Adult who Engage in Microdosing of Psychedelic Substances

 

By John M. de Castro, Ph.D.

 

“After a 40-year moratorium, the psychedelic renaissance has begun: rigorous scientific methods can now be used to investigate psychedelics as potential medicines and for “the betterment of well people”. – Thomas Anderson

 

Psychedelic substances such as peyote, mescaline, LSD, Bufotoxin, ayahuasca and psilocybin 

have been used almost since the beginning of recorded history to alter consciousness and produce spiritually meaningful experiences. More recently hallucinogenic drugs such as MDMA (Ecstasy) and Ketamine have been similarly used. People find the experiences produced by these substances extremely pleasant. eye opening, and even transformative. They often report that the experiences changed them forever. Psychedelics and hallucinogens have also been found to be clinically useful as they markedly improve mood, increase energy and enthusiasm and greatly improve clinical depression.

 

Recently doses of psychedelic substances that are small enough that they do not produce psychedelic effects (microdoses) have been employed repeatedly in real world settings. They have been reported to produce reductions in the symptoms of depression and anxiety, improve cognitive function, and promote social interaction. But there is little systematic research on the effects of repeated psychedelic microdosing.

 

In today’s Research News article “Psychedelic Microdosing: Prevalence and Subjective Effects.” (See summary below or view the full text of the study at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7282936/ ) Cameron and colleagues recruited adult volunteers to complete an anonymous online survey of “Recreational Drug and Alcohol Use”. The survey requested information regarding familiarity with psychedelic microdosing. personal practices, drugs used, and any changes observed in depression, anxiety, memory, sociability, focus/attention, and physical health.

 

They found that of the 2347 respondents the majority (59%) were familiar with psychedelic microdosing but only 13 % ever practiced it and only 4% were currently practicing. LSD and Psilocybin were the most common drugs used in microdosing. Males, veterans, and less educated participants were significantly more likely to practice psychedelic microdosing.

 

In comparison to participants who did not microdose, those that did reported significantly greater reductions in depression anxiety and greater improvements in memory, attention, and sociability. Males again reported the greatest improvements. The majority of the participants who stopped microdosing attributed it to difficulty in obtaining the drugs and their legal riskiness.

 

These results were produced by an anonymous survey and there was no way to ascertain the veracity of the responses. In addition, there were no comparison to other spontaneously used drugs to determine demand characteristics or placebo effects. Hence, the results are from a self-selected sample, have strong expectancy effect, and with no objective verification of the responses. So, these results must be viewed as preliminary. Nevertheless, the findings suggest that psychedelic microdosing is viewed by those engaging in it as beneficial for their psychological well-being and cognitive ability. These are interesting results that suggest that further investigation in warranted to determine if this practicemay be useful in improving well-being.

 

So, improved psychological well-being and cognition is reported by adult who engage in microdosing of psychedelic substances.

 

“We have an epidemic of mental health problems, with existing treatments that don’t work for everyone. We need to follow the lead of patients who are taking these initiatives to improve their wellbeing and reduce suffering.” – Zach Walsh

 

CMCS – Center for Mindfulness and Contemplative Studies

 

This and other Contemplative Studies posts are available on Twitter @MindfulResearch

 

Study Summary

 

Cameron, L. P., Nazarian, A., & Olson, D. E. (2020). Psychedelic Microdosing: Prevalence and Subjective Effects. Journal of psychoactive drugs, 52(2), 113–122. https://doi.org/10.1080/02791072.2020.1718250

 

Abstract

Anecdotal reports suggest that the administration of sub-hallucinogenic doses of psychedelic compounds on a chronic, intermittent schedule—a practice known as psychedelic microdosing—is becoming increasingly popular among young adults due to its purported ability to reduce symptoms of depression and anxiety while improving cognitive function and promoting social interaction. Using an anonymous online survey, we collected data from 2347 people to 1) assess the prevalence of psychedelic microdosing and characterize the demographics of microdosers, 2) determine whether microdosers associate the practice with changes in mood, cognitive function, social interaction, or physiology, and 3) investigate frequent motives for discontinuing the practice. Fifty-nine percent of respondents (NT = 2183) reported familiarity with the concept of psychedelic microdosing, with 17% (383 respondents, NT=2200) having engaged in this practice. Microdosers attributed psychedelic microdosing with improving their mood, decreasing their anxiety, and enhancing their memory, attention, and sociability. The most frequently cited reasons for quitting microdosing (NT = 243) were the risks associated with taking an illegal substance (24.28%) and the difficulty of obtaining psychedelic compounds (22.63%). Overall, our findings suggest that psychedelic microdosing is relatively common and is subjectively associated with a broad spectrum of socio-affective, cognitive, and physical outcomes.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7282936/

Improve Education Students Psychological Well-Being with Mindfulness

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Improve Education Students Psychological Well-Being with Mindfulness

 

By John M. de Castro, Ph.D.

 

“Mindfulness practices help anchor the mind, creating space to become aware of our thoughts and feelings, and keeps us in the present moment, all of which helps reduce stress and anxiety and boosts levels of attention and concentration.” – Rebecca Enderby 

 

In the modern world education is a key for success. There is a lot of pressure on university students to excel so that they can get the best jobs after graduation. The pressure can lead to stress, anxiety, and depression which can impede the student’s mental health, well-being, and school performance. But it is, for the most part, beyond the ability of the individual to change the environment to reduce stress, so it is important that methods be found to reduce the college students’ responses to stress; to make them more resilient when high levels of stress occur. Contemplative practices including meditation, mindfulness training, exercise, Tai Chi and Qigong, and yoga practice have been shown to reduce the psychological and physiological responses to stress, relieve anxiety, and reduce depression 

 

In today’s Research News article “The Effects of a Mindfulness Program on Mental Health in Students at an Undergraduate Program for Teacher Education: A Randomized Controlled Trial in Real-Life.” (See summary below or view the full text of the study at: https://www.frontiersin.org/articles/10.3389/fpsyg.2021.722771/full?utm_source=F-AAE&utm_medium=EMLF&utm_campaign=MRK_1790561_a0P58000000G0YfEAK_Psycho_20211214_arts_A ) Juul and colleagues recruited teacher education college students and randomly assigned them to a wait-list control condition or to receive 8 weekly 2.5 hour sessions of the Mindfulness-Based Stress Reduction (MBSR) program. The program consists of training in meditation, body scan, and yoga, group discussion, and daily home practice. They were measured before and after training and 3 months later for perceived stress, anxiety, depression, well-being, resilience, mindfulness, and resting state cognitive activity.

 

They found that in comparison to baseline and the wait-list control group, the group that received Mindfulness-Based Stress Reduction (MBSR) had significantly higher well-being and significantly lower levels of perceived stress, anxiety, depression, and resting state cognitive activity of distracting thoughts, thoughts of self and comfort. In addition, they found that the effect of MBSR on perceived stress was in part mediated by resting state cognitive activity of distracting thoughts and comfort and by thoughts of self on anxiety and depression. These effects were still present at the 3-month follow-up measurement.

 

The study demonstrates that mindfulness training improves the mental health of stresses teacher education college students. It has been routinely shown in previous research with a variety of groups that mindfulness training produces reduced levels of perceived stress, anxiety, and depression and increased levels of well-being. The new finding is that these improvements in mental health produced by the mindfulness training appear to be in part mediated by changes in the students’ resting state cognitive activity. In other words, the training appears to alter the mental contents of the students which in turn improves their mental health. The mindfulness trained students appear to have fewer distracting thoughts, thoughts of self and comfort and these reductions appear to improve their psychological well-being.

 

So, improve education students psychological well-being with mindfulness.

 

“It’s no secret that college can quickly become a major stressor for many students. Balancing multiple classes on top of work, a social life, and a million other things is a lot to take on at once. Don’t let yourself become too overwhelmed with everything. Instead, try . . . mindfulness.” – Savannah Byers

 

CMCS – Center for Mindfulness and Contemplative Studies

 

This and other Contemplative Studies posts are available on Twitter @MindfulResearch

 

Study Summary

 

Juul L, Brorsen E, Gøtzsche K, Nielsen BL and Fjorback LO (2021) The Effects of a Mindfulness Program on Mental Health in Students at an Undergraduate Program for Teacher Education: A Randomized Controlled Trial in Real-Life. Front. Psychol. 12:722771. doi: 10.3389/fpsyg.2021.722771

 

Background: In this study, we aimed to investigate the effects of a mindfulness program including Mindfulness-Based Stress Reduction (MBSR) on the mental health of student teachers when offered at their educational institution in a real-life context.

Methods: A parallel randomized controlled trial (RCT) was conducted among self-selected student teachers at a Danish undergraduate program for teacher education in the autumns of 2019 and 2020. Participation was not recommended in case of (1) clinical depression or a diagnosis of psychosis or schizophrenia, (2) abuse of alcohol, drugs, and/or medicine. Randomization was performed by a Statistician who was blinded to the identity of the students. Data was collected using self-reported questionnaires. The primary outcome was a change in perceived stress 3 months from baseline. Secondary outcome measures were symptoms of anxiety and depression, well-being, resilience, mindfulness, and thoughts and feelings during rest. The effects were analyzed according to the intention-to-treat principle using mixed-effect linear regression models. Mediating effects of mindfulness skills on the mental health outcomes were explored using structural equation modeling.

Results: The study group included 67 student teachers with 34 allocated to the intervention group (median age: 25 years; women: n = 24, 71%); and 33 students (median age: 25 years; women: n = 25, 76%) allocated to a waiting list control group. At baseline, mean Perceived Stress Scale (PSS) scores were 18.88 (SD: 5.75) in the intervention group and 17.91 (SD: 6.36) in the waiting list control group. A total of 56 students completed the questionnaire at a 3-month follow-up (28 in both the intervention- and the control group). Statistically significant effects of the intervention were found on perceived stress, symptoms of anxiety and depression, well-being, and on three of seven resting-state dimensions. No effects were found on resilience or mindfulness. Statistically significant mediated effects via resting-state dimensions were found.

Conclusion The findings suggested that offering a mindfulness program at an undergraduate program for teacher education could significantly improve the mental health among self-selected students within 3 months. Results of mediation analysis supported the hypothesis that some of the effects might be explained by reduced distracting thoughts.

https://www.frontiersin.org/articles/10.3389/fpsyg.2021.722771/full?utm_source=F-AAE&utm_medium=EMLF&utm_campaign=MRK_1790561_a0P58000000G0YfEAK_Psycho_20211214_arts_A

 

Improve Adolescent Psychological Well-Being with Tai Chi or Qigong

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Improve Adolescent Psychological Well-Being with Tai Chi or Qigong

 

By John M. de Castro, Ph.D.

 

“Qigong was able to improve attention in adolescents after 4 weeks of practice, leading us to conclude that it may be a useful tool when integrated into physical education classes.” – Leonel Duarte

 

Adolescence is a time of mental, physical, social, and emotional growth. It is during this time that higher levels of thinking, sometimes called executive function, develops. But adolescence can be a difficult time, fraught with challenges. During this time the child transitions to young adulthood; including the development of intellectual, psychological, physical, and social abilities and characteristics. There are so many changes occurring during this time that the child can feel overwhelmed and unable to cope with all that is required. This can lead to emotional and behavioral problems.

 

Indeed, up to a quarter of adolescents suffer from depression or anxiety disorders, and an even larger proportion struggle with subclinical symptoms. Mindfulness training in adults has been shown to reduce anxiety and depression levels and improve resilience and emotional regulation. In addition, in adolescents it has been shown to improve emotion regulation and to benefit the psychological and emotional health.

 

Tai Chi and Qigong are ancient mindfulness practices involving slow prescribed movements. They are gentle and completely safe, are inexpensive to administer, can be performed in groups or alone, at home or in a facility or even public park. There has been accumulating research on the effects of Tai Chi and Qigong training on the psychological well-being of adolescents. So, it makes sense to summarize what has been learned.

 

In today’s Research News article “The Effects of Tai Chi and Qigong Exercise on Psychological Status in Adolescents: A Systematic Review and Meta-Analysis.” (See summary below or view the full text of the study at: https://www.frontiersin.org/articles/10.3389/fpsyg.2021.746975/full?utm_source=F-AAE&utm_medium=EMLF&utm_campaign=MRK_1784429_a0P58000000G0YfEAK_Psycho_20211202_arts_A  ) Liu and colleagues review, summarize, and perform a meta-analysis of the published controlled research studies effects of Tai Chi and Qigong training on the psychological well-being of adolescents (aged 12 to 18 years).

 

They identified 10 published research studies with a total of 1244 participants. They report that the published research studies found that Tai Chi or Qigong practice produced significant reductions in anxiety, depression, and blood cortisol levels (stress marker) and significant improvements in self-concept and general mental health. Adolescence is a turbulent and stressful time. The published research suggests that practicing Tai Chi or Qigong helps reduce the mental turbulence and may help the youths navigate adolescence and in their transition to adulthood.

 

So, improve adolescent psychological well-being with Tai Chi or Qigong.

 

“Teens . . . who had taken the Tai Chi Chuan classes showed markedly less stress and psychological distress and enjoyed a much better self-image.” – Jeff Paterson

 

CMCS – Center for Mindfulness and Contemplative Studies

 

This and other Contemplative Studies posts are available on Twitter @MindfulResearch

 

Study Summary

 

Liu X, Li R, Cui J, Liu F, Smith L, Chen X and Zhang D (2021) The Effects of Tai Chi and Qigong Exercise on Psychological Status in Adolescents: A Systematic Review and Meta-Analysis. Front. Psychol. 12:746975. doi: 10.3389/fpsyg.2021.746975

 

Background: The purpose of this study was to systematically review the effectiveness of Tai Chi and Qigong exercise on adolescents’ symptoms of depression and anxiety, and psychological status based on clinical evidences, and to calculate the pooled results using meta-analysis.

Methods: A systematic search using seven English and three Chinese databases was initiated to identify randomized controlled trials (RCT) and non-randomized comparison studies (NRS) assessing the effect of Tai Chi and Qigong exercise on psychological status among adolescents. Standardized mean differences (SMD) and their 95% confidence intervals (CI) were used to determine the pooled effect of the intervention. Study quality was evaluated using a Checklist to Evaluate a Report of a Non-pharmacological Trial (CLEAR-NPT) designed for non-pharmacological trials.

Results: Four RCTs and six NRS were identified, including 1,244 adolescents. The results suggested a potential beneficial effect of Tai chi and Qigong exercise on reducing anxiety (SMD = 0.386, 95 CI% [0.233, 0.538]) and depression (SMD = 1.937 [95 CI%, 1.392–2.546]) symptoms, and reducing cortisol level (SMD = 0.621 [95 CI%, 0.18–1.062]) in adolescents. Conversely, non-significant effects were found for stress, mood, and self-esteem.

Conclusions: The findings of this review suggest Qigong appears to be an effective therapeutic modality to improve psychological well-being in adolescents. Hope future studies will have rigorously designed, well-controlled randomized trials with large sample sizes in order to confirm these findings.

https://www.frontiersin.org/articles/10.3389/fpsyg.2021.746975/full?utm_source=F-AAE&utm_medium=EMLF&utm_campaign=MRK_1784429_a0P58000000G0YfEAK_Psycho_20211202_arts_A

 

Improve Parkinson’s Disease Psychological Symptoms with Mindfulness

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Improve Parkinson’s Disease Psychological Symptoms with Mindfulness

 

By John M. de Castro, Ph.D.

 

“[Parkinson’s Disease] patients experience greater levels of stress than controls, and that stress worsens both motor and non-motor symptoms. Mindfulness may improve [Parkinson’s Disease] symptom severity, with the strongest effects on anxiety and depressed mood.” – Anouk van der Heide

 

Parkinson’s Disease (PD) is an incurable progressive degenerative disease of the central nervous system. The condition is caused by the death of nerve cells in the brain that produce the neurotransmitter dopamine. There are around seven million people worldwide and one million people in the U.S. living with PD and about 60,000 people are diagnosed with PD every year. PD is associated with aging as the vast majority of patients are diagnosed after age 50. In fact, it has been speculated that everyone would eventually develop PD if they lived long enough.

 

Its physical symptoms include resting tremor, slow movements, muscle rigidity, problems with posture and balance, loss of automatic movements, and slurring of speech. PD itself is not fatal but is often associated with related complications which can reduce life expectancy, such as falls, choking, and cardiovascular problems. PD also has psychological effects, especially cognitive decline, anxiety, and depression. Balance is a particular problem as it effects mobility and increases the likelihood of falls, restricting activity and reducing quality of life.

 

There are no cures for Parkinson’s Disease (PD) or even treatments to slow its progression. There are only treatments that can produce symptomatic relief. So, there is a need to discover new and different treatments. Mindfulness training has been found to improve the psychological symptoms and the quality of life with PD patients. PD patients often develop an unawareness of their motor symptoms. It is not known if mindfulness training may help make the patients more aware of their symptoms.

 

In today’s Research News article “Pilot Study of Mindfulness Training on the Self-Awareness of Motor Symptoms in Parkinson’s Disease – A Randomized Controlled Trial.” (See summary below or view the full text of the study at: https://www.frontiersin.org/articles/10.3389/fpsyg.2021.763350/full?utm_source=F-AAE&utm_medium=EMLF&utm_campaign=MRK_1784429_a0P58000000G0YfEAK_Psycho_20211202_arts_A ) Buchwitz and colleagues recruited otherwise healthy patients diagnosed with Parkinson’s Disease (average 64 years) and randomly assigned them to either a wait-list control condition or to receive 8 weekly 2-hour sessions of mindfulness training tailored for Parkinson’s Disease patients. Before and after training and 8 weeks later they were measured for awareness of their motor symptoms, cognitive ability, and Parkinson’s Disease symptoms.

 

They found that there was no improvement in general cognitive ability, motor performance, or awareness of motor symptoms by either group. But the mindfulness trained group had significant improvement in mindfulness, sleep quality, attentional ability, and language performance and reductions in anxiety, apathy, and impulsivity of eating behavior.

 

The findings are similar to those of others that mindfulness training improves the psychological well-being of patients diagnosed with Parkinson’s Disease. But it did not improve motor symptoms or the awareness of those motor symptoms. This suggests that mindfulness training should be incorporated into the routine treatment program for Parkinson’s Disease patients.

 

So, improve Parkinson’s Disease psychological symptoms with mindfulness

 

 

“mindfulness training for people with [Parkinson’s Disease] found significant reductions in anxiety, depression and distress about symptoms, along with improvements in memory and verbal fluency.” – Emily Delzell

 

 

CMCS – Center for Mindfulness and Contemplative Studies

 

This and other Contemplative Studies posts are available on Twitter @MindfulResearch

 

Study Summary

 

Buchwitz TM, Maier F, Greuel A, Thieken F, Steidel K, Jakobs V and Eggers C (2021) Pilot Study of Mindfulness Training on the Self-Awareness of Motor Symptoms in Parkinson’s Disease – A Randomized Controlled Trial. Front. Psychol. 12:763350. doi: 10.3389/fpsyg.2021.763350

 

ABSTRACT

Objective: This study aims to evaluate feasibility and effects of a newly developed mindfulness intervention tailored to specific needs of patients with Parkinson’s disease (PD).

Background: The phenomenon of impaired self-awareness of motor symptoms (ISAm) in PD might be reduced by increasing patients’ mindfulness. A PD-specific mindfulness intervention has been developed and evaluated as a potential treatment option: IPSUM (“Insight into Parkinson’s Disease Symptoms by using Mindfulness”).

Methods: IPSUM’s effectiveness is evaluated by comparing an intervention with a waitlist-control group. Applying a pre-post design, patients were assessed before, directly after and 8weeks after treatment. The primary outcome was the change in a quantitative ISAm score from baseline to post-assessment. Secondary outcome measures were PD-related affective changes and neuropsychological test performance. Feasibility was evaluated via feedback forms.

Results: In total, 30 non-depressed and non-demented PD patients were included (intervention: n=14, waitlist-control: n=16). ISAm score did not change significantly, but the training group showed greater performance in sustained attention and language tasks over time. Additional changes included greater mindfulness as well as less sleeping problems and anxiety. Cognitive disturbances, apathy, and sleeping problems worsened only in the waitlist-control group. Patients’ feedback regarding the training concept and material was excellent.

Conclusion: Insight into Parkinson’s Disease Symptoms by using Mindfulness has not been capable of reducing ISAm in PD patients but appears to be a feasible and effective concept to, among others, support mental health in the mid-term. It has to be noted though that the study was stopped beforehand because of the SARS CoV-2 pandemic. The lack of findings might therefore be caused by a lack of statistical power. The need for further research to better understand the mechanisms of ISAm and its connection to mindfulness in PD is highlighted.

https://www.frontiersin.org/articles/10.3389/fpsyg.2021.763350/full?utm_source=F-AAE&utm_medium=EMLF&utm_campaign=MRK_1784429_a0P58000000G0YfEAK_Psycho_20211202_arts_A

 

Improve Well-Being in Adults who Experienced Childhood Maltreatment with Mindfulness

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Improve Well-Being in Adults who Experienced Childhood Maltreatment with Mindfulness

 

By John M. de Castro, Ph.D.

 

“mindfulness-based interventions can be beneficial for childhood maltreatment survivors to alleviate psychological symptoms including stress, anxiety, recurrent depression, substance use, and post-traumatic stress.” – Diane Joss

 

Childhood trauma can leave in its wake symptoms which can haunt the victims for the rest of their lives. These include persistent recurrent re-experiencing of the traumatic event, including flashbacks and nightmares, loss of interest in life, detachment from other people, increased depression, anxiety and emotional arousal, including outbursts of anger, difficulty concentration, and jumpiness, startling easily. Unfortunately, childhood maltreatment can continue to affect mental and physical health throughout the individual’s life. How individuals cope with childhood maltreatment helps determine the effects of the maltreatment on their mental health.

 

It has been found that experiencing the feelings and thoughts produced by trauma completely, allows for better coping. This can be provided by mindfulness. Indeed, mindfulness has been found to be effective for relieving trauma symptoms. But it is not known how mindfulness works to impact the psychological well-being of adults who experienced childhood maltreatment.

 

In today’s Research News article “Nonattachment Predicts Empathy, Rejection Sensitivity, and Symptom Reduction After a Mindfulness-Based Intervention Among Young Adults with a History of Childhood Maltreatment.” (See summary below or view the full text of the study at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7205188/ ) Joss and colleagues recruited patience with a history of childhood maltreatment including physical and emotional abuse or neglect, and sexual abuse, verbal abuse, witnessing violence between parents or physical abuse of siblings.

 

They were assigned to either a wait-list control condition or to receive mindfulness training. The training was modelled after the Mindfulness-Based Stress Reduction (MBSR) program and met once a week for eight weeks along with daily home practice and contained “breath awareness meditation, body scan meditation, mindful yoga, open awareness meditation, loving-kindness meditation, walking meditation, mountain meditation, mindful eating as well as noticing mindful moments in daily lives”. They were measured before and after training for mindfulness, childhood trauma, adverse childhood experiences, anxiety sensitivity, PTSD symptoms, rejection sensitivity, nonattachment, and interpersonal reactivity.

 

They found that in comparison to baseline and the wait-list control group, the group that received mindfulness training had significantly higher levels of mindfulness and nonattachment and significantly lower levels of PTSD symptoms, rejection sensitivity, and interpersonal reactivity. In addition, the greater the attendance at the mindfulness training sessions the greater the increases in mindfulness and nonattachment and decreases in personal distress and anxiety sensitivity. Further they found that mindfulness was associated with reduced rejection sensitivity indirectly by being associated with higher levels of nonattachment and empathy which were in turn associated with lower levels of rejection sensitivity.

 

The results suggest that mindfulness training improves the psychological well-being of young adults who had experienced childhood maltreatment in a dose dependent way. Nonattachment is a “flexible way of relating to one’s experiences without clinging to or suppressing them” and is increased by mindfulness training. In addition, empathy is “the capacity to understand others’ perspectives and to feel and share others’ feelings” and is increased by mindfulness training. These factors in turn appear to be important for the improvement in psychological well-being. In other words, mindfulness increases the ability to let go of experiences and not ruminate or worry about them and improves empathy and these factors improve the well-being of young adults who had experienced childhood maltreatment. All this suggests that mindfulness training should be recommended for people who experienced childhood maltreatment to reduce the impact of the trauma and improve psychological well-being.

 

So, improve well-being in adults who experienced childhood maltreatment with mindfulness.

 

“Mindfulness skills tend to be lower among adolescents and adults exposed to various forms of childhood maltreatment.” – Alan R. King

 

CMCS – Center for Mindfulness and Contemplative Studies

 

This and other Contemplative Studies posts are available on Twitter @MindfulResearch

 

Study Summary

 

Joss, D., Lazar, S. W., & Teicher, M. H. (2020). Nonattachment Predicts Empathy, Rejection Sensitivity, and Symptom Reduction After a Mindfulness-Based Intervention Among Young Adults with a History of Childhood Maltreatment. Mindfulness, 11(4), 975–990. https://doi.org/10.1007/s12671-020-01322-9

 

Abstract

Objectives:

Individuals with a childhood maltreatment history tend to have various psychological symptoms and impaired social functioning. This study aimed to investigate the related therapeutic effects of a mindfulness-based intervention in this population.

Methods:

We analyzed self-report questionnaire scores of the Mindful Attention Awareness Scale (MAAS), Non-Attachment Scale (NAS), Adult Rejection Sensitivity Questionnaire (A-RSQ), Interpersonal Reactivity Index (IRI), PTSD CheckList (PCL), and Anxiety Sensitivity Index (ASI), from 16 (3 males) young adults (age range 22–29) with mild to moderate childhood maltreatment, compared to 18 matched participants (6 males) on a waiting list, during both pre- and post-intervention/waiting periods. Analyses were conducted with linear mixed effects models, partial correlation analyses and t-tests.

Results:

There were group by time interaction effects with the scores of MAAS, NAS, PCL, IRI-Fantasy, and A-RSQ (p < .05). The mindfulness group had significant increase in MAAS (17.325%) and NAS (8.957%) scores, as well as reduction in PCL (15.599%) and A-RSQ (23.189%) scores (p < .05). Changes in non-attachment, but not mindfulness, had significant contributions to the score changes of PCL (16.375%), ASI (36.244%), IRI-Personal Distress (24.141%), IRI-Empathic Concern (16.830%), and A-RSQ (10.826%) (p < .05). The number of intervention sessions attended was correlated with score changes of NAS (r = .955, p < .001), and ASI (r = −.887, p < .001), suggesting a dose-dependent effect.

Conclusions:

Findings from this pilot study suggest that the mindfulness-based intervention improved mindfulness, non-attachment and empathy, which contributed to reduced interpersonal distress, rejection sensitivity and other psychological symptoms.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7205188/

 

Reduce Stress and Improve Well-Being in Nursing Students with Mindfulness

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Reduce Stress and Improve Well-Being in Nursing Students with Mindfulness

 

By John M. de Castro, Ph.D.

 

“mindfulness meditation has a positive impact on nurses’ and nursing students’ stress, anxiety, depression, burnout, sense of well-being and empathy.” – Pamela van der Riet

 

Stress is epidemic in the western workplace with almost two thirds of workers reporting high levels of stress at work. In high stress occupations, like healthcare, burnout is all too prevalent. It is estimated that over 45% of healthcare workers experience burnout. Burnout not only affects the healthcare providers personally, but also the patients, as it produces a loss of empathy and compassion. So, preventing burnout has to be a priority.

 

It is important that methods be found to reduce the individual’s responses to stress and to improve their resilience. Contemplative practices have been shown to reduce the psychological and physiological responses to stress. Indeed, mindfulness has been shown to be helpful in treating and preventing burnout, increasing resilience, and improving sleep. Developing mindfulness early in healthcare careers could work to prevent later burnout. There has been considerable research on this topic. So, it makes sense to summarize what has been learned regarding the effects of mindfulness training for nursing students.

 

In today’s Research News article “Mindfulness-Based Interventions for Undergraduate Nursing Students in a University Setting: A Narrative Review.” (See summary below or view the full text of the study at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8621067/ ) McVeigh and colleagues review and summarize the published research on the effectiveness of mindfulness training on the psychological well-being of nursing students. They identified 15 published research studies.

 

They report that the published research found that mindfulness training for nursing students resulted in significant decreases in anxiety, depression, perceived stress, and negative coping strategies, and significant increases in mindfulness, self-efficacy, emotion regulation, and self-awareness. These benefits accrued regardless of the type and form of mindfulness training from meditation, to Mindfulness-Based Stress Reduction (MBSR), to mindful movement practice.

 

These results are very promising. Mindfulness training of nursing students appears to markedly improve their psychological well-being. There was no long-term follow-up reported. So, it is not known whether the training has lasting effects and potentially improve resilience to later career stresses and reduce burnout. Future research needs to follow-up to identify whether the effects of this early intervention might assist the nurses in their later careers.

 

So, reduce stress and improve well-being in nursing students with mindfulness.

 

“Mindfulness practices have been found beneficial for nurses. The program has been found to increase self-compassion, serenity, and empathetic concern as well as decrease burnout and self-reported distress “ – Sandra Bernstein

 

CMCS – Center for Mindfulness and Contemplative Studies

 

This and other Contemplative Studies posts are available at the Contemplative Studies Blog http://contemplative-studies.org/wp/ andon Twitter @MindfulResearch

 

Study Summary

 

McVeigh, C., Ace, L., Ski, C. F., Carswell, C., Burton, S., Rej, S., & Noble, H. (2021). Mindfulness-Based Interventions for Undergraduate Nursing Students in a University Setting: A Narrative Review. Healthcare, 9(11), 1493. https://doi.org/10.3390/healthcare9111493

 

Abstract

(1) Introduction: Undergraduate (UG) nursing students are vulnerable to stress throughout their education, known to result in burnout, with high attrition rates of up to 33%. There is a growing body of evidence to suggest that mindfulness-based interventions are effective for the management of anxiety, depression and wellbeing, thereby reducing stress in healthcare provider populations. The aim of this narrative review was to synthesize and provide a critical overview of the current evidence in relation to mindfulness-based interventions for UG nursing students in a university setting. (2) Methods: A review of the literature was conducted in March 2020 and updated in May 2021, utilising the databases CINAHL, Medline and PsycINFO. (3) Results: Fifteen studies were included in the review, with three common themes identified: (i) the positive impact of mindfulness on holistic wellbeing, (ii) mindfulness-based techniques as a positive coping mechanism within academic and clinical practice, and (iii) approaches to the delivery of mindfulness-based interventions. (4) Conclusions: Mindfulness-based interventions are effective strategies for the management of stress, development of self-awareness and enhanced academic and clinical performance in undergraduate nursing students. No ideal approach to delivery or duration of these interventions was evident from the literature. Best practice in relation to delivery of mindfulness-based interventions for nursing students is recommended for future studies.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8621067/

 

Placebo Effects are Strong in Research on the Effects of Psychedelic Drugs

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Placebo Effects are Strong in Research on the Effects of Psychedelic Drugs

 

By John M. de Castro, Ph.D.

 

“in the right context, some people may experience psychedelic-like effects from placebos alone.” – Science News

 

Psychedelic substances such as peyote, mescaline, LSD, Bufotoxin, ayahuasca and psilocybin 

have been used almost since the beginning of recorded history to alter consciousness and produce spiritually meaningful experiences. More recently hallucinogenic drugs such as MDMA (Ecstasy) and Ketamine have been similarly used. People find the experiences produced by these substances extremely pleasant. eye opening, and even transformative. They often report that the experiences changed them forever. Psychedelics and hallucinogens have also been found to be clinically useful as they markedly improve mood, increase energy and enthusiasm and greatly improve clinical depression.

 

Even though the effects of psychedelic substances have been experienced and reported on for centuries, only very recently have these effects come under rigorous scientific scrutiny. The setting in which psychedelic drugs are taken in the real world varies widely and there is little research on the effects of these settings on the experiences and their effects. The settings can set up strong participant expectancy (placebo) effects and there has been little research on the extent to which placebo effects can account for the reported benefits of psychedelic drug administration.

 

In today’s Research News article “A placebo-controlled study of the effects of ayahuasca, set and setting on mental health of participants in ayahuasca group retreats.” (See summary below or view the full text of the study at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8233273/ ) Uthaug and colleagues recruited adults attending a ayahuasca retreat where they repeatedly ingested ayahuasca. At one point in the retreat the participants were randomly administered either ayahuasca or a placebo in a capsule form. They were measured before and the morning after the test session for empathy, ego dissolution, altered states of consciousness, anxiety, depression, perceived stress, somatization, and mindfulness.

 

They found that following both ayahuasca  or the placebo there were significant reductions in anxiety, depression, and perceived stress. The groups did not differ in ego dissolution. For the altered states of consciousness measures the ayahuasca group had higher levels of oceanic boundlessness, visual restructuralization, and insightfulness. But only insightfulness was significantly greater for the ayahuasca group compared to the placebo group.

 

These findings suggest that the psychological and altered states of consciousness effects of ayahuasca may be due to placebo effects. The study, however, was small with only 14 and 16 participants in the ayahuasca and placebo groups respectively. This provided only modest statistical power. There were a number of marginal effects which may have been significant had larger groups been used. In addition, the participants had repeated exposure to ayahuasca in the retreat environment prior to the placebo controlled test. This provided considerable conditioning that may explain the responses to the placebo.

 

The study, though, raises the question as to how much are the reported significant responses to psychedelic drugs due to participant expectancy (placebo) effects. Placebo effects can be quite powerful. Obviously, much more research is needed, particularly with larger numbers of participants and with the first administration of the psychedelic.

 

So, placebo effects may be strong in research on the effects of psychedelic drugs.

 

“Microdosing is the practice of regularly using low doses of psychedelic drugs. Anecdotal reports suggest that microdosing enhances well-being and cognition; however . . . benefits of microdosing can be explained by the placebo effect.” – Balázs Szigeti

 

 

CMCS – Center for Mindfulness and Contemplative Studies

 

This and other Contemplative Studies posts are available on Twitter @MindfulResearch

 

Study Summary

 

Uthaug, M. V., Mason, N. L., Toennes, S. W., Reckweg, J. T., de Sousa Fernandes Perna, E. B., Kuypers, K., van Oorsouw, K., Riba, J., & Ramaekers, J. G. (2021). A placebo-controlled study of the effects of ayahuasca, set and setting on mental health of participants in ayahuasca group retreats. Psychopharmacology, 238(7), 1899–1910. https://doi.org/10.1007/s00213-021-05817-8

 

Abstract

Ayahuasca is a plant concoction containing N,N-dimethyltryptamine (DMT) and certain β-carboline alkaloids from South America. Previous research in naturalistic settings has suggested that ingestion of ayahuasca can improve mental health and well-being; however, these studies were not placebo controlled and did not control for the possibility of expectation bias. This naturalistic observational study was designed to assess whether mental health changes were produced by ayahuasca or by set and setting. Assessments were made pre- and post-ayahuasca sessions in 30 experienced participants of ayahuasca retreats hosted in the Netherlands, Spain, and Germany. Participants consumed ayahuasca (N = 14) or placebo (N = 16). Analysis revealed a main effect of time on symptoms of depression, anxiety, and stress. Compared to baseline, symptoms reduced in both groups after the ceremony, independent of treatment. There was a main treatment × time interaction on implicit emotional empathy, indicating that ayahuasca increased emotional empathy to negative stimuli. The current findings suggest that improvements in mental health of participants of ayahuasca ceremonies can be driven by non-pharmacological factors that constitute a placebo response but also by pharmacological factors that are related to the use of ayahuasca. These findings stress the importance of placebo-controlled designs in psychedelic research and the need to further explore the contribution of non-pharmacological factors to the psychedelic experience.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8233273/