Psychedelics

Psilocybin in Combination with Meditation Practice Improves Psychological Functioning

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Psilocybin in Combination with Meditation Practice Improves Psychological Functioning

 

By John M. de Castro, Ph.D.

 

“The ingestion of psilocybin, brought on “mystical” experiences that reduced illness-related anxiety and depression in nearly 80 percent of subjects studied in research trials.” – Andrew McCarron

 

Psychedelic substances have been used almost since the beginning of recorded history to alter consciousness and produce spiritually meaningful experiences. Psychedelics produce effects that are similar to those that are reported in spiritual awakenings. They report a loss of the personal self. They experience what they used to refer to as the self as just a part of an integrated whole. They report feeling interconnected with everything else in a sense of oneness with all things. They experience a feeling of timelessness where time seems to stop and everything is taking place in a single present moment. They experience ineffability, being unable to express in words what they are experiencing and as a result sometimes producing paradoxical statements. And they experience a positive mood, with renewed energy and enthusiasm.

 

It is easy to see why people find these experiences so pleasant and eye opening. They often report that the experiences changed them forever. Even though the effects of psychedelic substances have been experienced and reported on for centuries, only very recently have these effects come under rigorous scientific scrutiny.

 

Psilocybin is a psychedelic substance that is found naturally in a number of varieties of mushrooms. It has been used for centuries particularly by Native Americans for their spiritual practices. When studied in the laboratory under double blind conditions, Psilocybin has been shown to “reliably occasion deeply personally meaningful and often spiritually significant experiences (e.g. mystical-type experiences).” How lasting the changes are has not been systematically studied in controlled research studies.

 

In today’s Research News article “Psilocybin-occasioned mystical-type experience in combination with meditation and other spiritual practices produces enduring positive changes in psychological functioning and in trait measures of prosocial attitudes and behaviors.” (See summary below or view the full text of the study at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5772431/ ), Griffiths and colleagues examine the duration of Psilocybin effects when administered under laboratory conditions. They recruited participants from the community who were not experienced with either psychedelics or meditation and randomly assigned to one of three groups; very low Psilocybin dose – standard spiritual support, high Psilocybin dose – standard spiritual support, or high Psilocybin dose – high spiritual support. Participants and researchers who interacted with them were not informed as to the dosing conditions.

 

Psilocybin was administered in capsule form in the morning and the participants remained in the laboratory and were measured until Psilocybin immediate effects were gone 7 hours later. One month later the participants returned for a second similar Psilocybin session. For the standard support conditions, the participants met with “guides” for five 1 to 2-hour sessions and a couple of days after Psilocybin administration for another 1-hour session, followed up later with a 10-minute teleconference. Sessions consisted of instruction and support for their usual spiritual practices. For the high support conditions, participants met on a similar schedule and dad additional sessions approximately monthly thereafter. The “spiritual practice suggestions had three primary elements: meditation (10 to 30 minutes of sitting meditation daily); daily awareness practice (use of mantra and one-pointed attention in daily activities); and daily self-reflective journaling of insights, benefits, and challenges of spiritual practice in daily life.”

 

They found that the high Psilocybin dose administration during the 7-hour post-administration period produced hallucinations and illusions, feelings of transcendence, grief, joy, and/or anxiety, and a sense of meaning and insight. These effects were significantly greater in the high spiritual support group. At the 6-month follow up they found that the high Psilocybin dose group in comparison the very low dose group had significantly improves attitudes about life and self, improved mood, increased altruism and spirituality, and significantly greater personal meaning, spiritual significance, and change in well-being. Again, in the high spiritual support group had significantly greater effects. Virtually all of the participants in the high Psilocybin dose conditions reported that this was among the greatest spiritual experiences of their lives.

 

These results are striking and important. Administration of the psychedelic substance, Psilocybin, produced consistently positive personal and spiritual effects immediately and the effects appeared to be relatively permanent, still present after 6 months. In addition, engaging in spiritual meditative practices appeared to heighten these effects. The use of psychedelic substances is extremely controversial and for the most part illegal. But, the present findings suggest that at least under controlled circumstances, they may have positive and lasting, effects on the individual and their spirituality. Further research should explore the use of Psilocybin for the treatment of mental illness and the promotion of human well-being.

 

So, psilocybin in combination with meditation practice improves psychological functioning.

 

CMCS – Center for Mindfulness and Contemplative Studies

 

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Study Summary

 

Roland R Griffiths, Matthew W Johnson, William A Richards, Brian D Richards, Robert Jesse, Katherine A MacLean, Frederick S Barrett, Mary P Cosimano, Maggie A Klinedinst. Psilocybin-occasioned mystical-type experience in combination with meditation and other spiritual practices produces enduring positive changes in psychological functioning and in trait measures of prosocial attitudes and behaviors. J Psychopharmacol. 2018 Jan; 32(1): 49–69. Published online 2017 Oct 11. doi: 10.1177/0269881117731279

 

Abstract

Psilocybin can occasion mystical-type experiences with participant-attributed increases in well-being. However, little research has examined enduring changes in traits. This study administered psilocybin to participants who undertook a program of meditation/spiritual practices. Healthy participants were randomized to three groups (25 each): (1) very low-dose (1 mg/70 kg on sessions 1 and 2) with moderate-level (“standard”) support for spiritual-practice (LD-SS); (2) high-dose (20 and 30 mg/70 kg on sessions 1 and 2, respectively) with standard support (HD-SS); and (3) high-dose (20 and 30 mg/70kg on sessions 1 and 2, respectively) with high support for spiritual practice (HD-HS). Psilocybin was administered double-blind and instructions to participants/staff minimized expectancy confounds. Psilocybin was administered 1 and 2 months after spiritual-practice initiation. Outcomes at 6 months included rates of spiritual practice and persisting effects of psilocybin. Compared with low-dose, high-dose psilocybin produced greater acute and persisting effects. At 6 months, compared with LD-SS, both high-dose groups showed large significant positive changes on longitudinal measures of interpersonal closeness, gratitude, life meaning/purpose, forgiveness, death transcendence, daily spiritual experiences, religious faith and coping, and community observer ratings. Determinants of enduring effects were psilocybin-occasioned mystical-type experience and rates of meditation/spiritual practices. Psilocybin can occasion enduring trait-level increases in prosocial attitudes/behaviors and in healthy psychological functioning.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5772431/

Psychedelic Drugs and Spirituality

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“In history, psychedelic plants were used by priests and shamans with a desire to discover the interior.” – Alejandro Jodorowsky

 

Psychedelic substances have been used almost since the beginning of recorded history to alter consciousness and produce spiritually meaningful experiences. Psychedelics produce effects that are similar to those that are reported in spiritual awakenings. They report a loss of the personal self. They experience what they used to refer to as the self as just a part of an integrated whole. They report feeling interconnected with everything else in a sense of oneness with all things. They experience a feeling of timelessness where time seems to stop and everything is taking place in a single present moment. They experience ineffability, being unable to express in words what they are experiencing and as a result sometimes producing paradoxical statements. And they experience a positive mood, with renewed energy and enthusiasm.

 

It is easy to see why people find these experiences so pleasant and eye opening. They often report that the experiences changed them forever. Even though the effects of psychedelic substances have been experienced and reported on for centuries, only very recently have these effects come under rigorous scientific scrutiny. One deterrent to the research is the legal prohibitions for the possession and use of these substances. One way around this problem is to take advantage of natural groupings of individuals who regularly use psychedelic substances.

 

In today’s Research News article “Long-term use of psychedelic drugs is associated with differences in brain structure and personality in humans.”

https://www.facebook.com/ContemplativeStudiesCenter/photos/a.628903887133541.1073741828.627681673922429/1110584015632190/?type=3&theater

Bouso and colleagues took advantage of the fact that a substantial number of Brazilian religious groups ingest the natural psychedelic substance ayahuasca on a regular basis for ritual purposes. These groups, like many users of psychedelic substances, employ them to develop spirituality and self-transcendence. The investigators used neuroimaging to investigate the differences in brain structure between long-term (at least 50 uses) users of ayahuasca and matched control participants.

 

Bouso and colleagues found that the ayahuasca users had a thinning of a number of midline structures of the brain especially the posterior cingulate cortex.in addition, the amount of this thinning was positively related to the length of time that the individual had been using ayahuasca. The thinning suggests that there is a eduction in the use and importance of the structures. Importantly, the ayahuasca users did not differ from controls in the incidence of psychological problems or neuropsychological function. This suggests that the use of ayahuasca does not produce psychological or cognitive harm.

 

One of the most interesting findings was a significant increase in self-transcendence in the ayahuasca users. This included and increase in self-forgetfulness, which represents a decrease in self-conscious experience, transpersonal identification, which is seeing oneself as not isolated but merely a part of an integrated whole, and spiritual acceptance, which is an increase in viewing life as beyond the physical. Hence this self-transcendence is an indicator of increased spirituality and loss of the personal ego.

 

It is interesting that the midline structures including posterior cingulate cortex that are thinned with ayahuasca use are considered key elements of what’s termed the default mode network. This is an interconnected set of neural structures that becomes most active when the individual is lost in thought, day dreaming, and involved in self-referential thinking. In other words this system becomes active when the individual has lost touch with the present moment and his/her thoughts are referenced to a separate self.

 

So, the anatomical findings correlate nicely with the psychological findings for the ayahuasca users and suggest that the use of this psychedelic appears to be psychologically relatively harmless and appear to accentuate experiences that are virtually identical to those occurring in spiritual awakenings. This may suggest that spiritual awakening and psychedelic substance effects work through the same neural mechanisms.

 

“Through all of history mankind has ingested psychedelic substances. Those substances exist to put you in touch with spirits beyond yourself, with the creator, with the creative impulse of the planet.” – Ray Manzarek
CMCS – Center for Mindfulness and Contemplative Studies