Yoga Reduces Inflammation in Breast Cancer Patients

psyjdc Leave a comment

Living Beyond Breast Cancer Yoga Series Part 1By John M. de Castro, Ph.D.

 

In today’s Research News article “Yoga Intervention and Inflammatory Homoeostasis in Breast Cancer Patients” (See summary below or view the full text of the study at: https://pmc.ncbi.nlm.nih.gov/articles/PMC11866663/ ) Kaje and colleagues provided a 3-days yoga intervention to patients undergoing chemotherapy for breast cancer. They found that the yoga practice reduced the levels of inflammatory markers in the patients.

 

Yoga decreased inflammation in patients undergoing chemotherapy for breast cancer.

 

CMCS – Center for Mindfulness and Contemplative Studies

 

This and other Contemplative Studies posts are also available on the Contemplative Studies Blog  http://contemplative-studies.org

 

Study Summary

 

Kaje KC, Dsilva F, Shetty PK, Mohan R, Kumar S, Dsouza N, D’souza C, Kalladka SS, Alagundagi DB, Kalladka K. Yoga Intervention and Inflammatory Homoeostasis in Breast Cancer Patients. Indian J Palliat Care. 2025 Jan-Mar;31(1):1–7. doi: 10.25259/IJPC_181_2024. Epub 2025 Feb 15. PMCID: PMC11866663.

Abstract

Objectives:

Yoga, renowned for its ability to maintain physical, mental and spiritual well-being, has recently gained prominence as a supportive therapy during conventional breast cancer (BC) treatment. This paradigm shift reflects a growing trend of people embracing yoga to enhance their overall health and aid in managing BC. The objective of this study was to determine the yoga intervention and inflammatory homoeostasis in newly diagnosed BC patients.

Materials and Method:

This study recruited 44 newly diagnosed BC patients at stages II, III and IV (without distant metastasis or other inflammatory diseases), all admitted for neoadjuvant chemotherapy followed by surgery. A prospective non-randomised control design was employed. Baseline assessments were conducted before the first chemotherapy cycle, with follow-ups before the 2nd and 3rd chemotherapy cycles, before surgery, and 2 months post-surgery. The outcome was compared with the control group.

Results:

The study showed significant within-subject effects in the yoga intervention group on serum tumour necrosis factor-alpha, interleukin (IL)-1-beta and IL-6 levels, while no significant changes were observed in the control group. Although between groups did not show statistically significant, the mean values indicated a consistent downregulation of proinflammatory markers over time in the yoga group.

Conclusion:

Incorporating yoga as a complementary therapy alongside conventional BC treatment significantly improved the health outcomes of BC patients by modulating proinflammatory markers.

 

Mindfulness Training Decreases Stress and Depression in Older Adults

psyjdc Leave a comment

Improve Mental Health in Older Adults with Online Meditation Practice | Contemplative Studies

By John M. de Castro, Ph.D.

 

In today’s Research News article “Effectiveness of an age-modified mindfulness-based cognitive therapy (MBCT) in improving mental health in older people with depressive symptoms: a non-randomised controlled trial” (See summary below or view the full text of the study at: https://pmc.ncbi.nlm.nih.gov/articles/PMC11863447/ ) Wang and colleagues investigated the effectiveness of Mindfulness-Based Cognitive Therapy (MBCT) on the mental health of older adults (>60 yrs.) compared to usual care. They found that MBCT produced significant reductions in perceived stress and depression.

 

So, improve the mental health of older adults with mindfulness training.

 

CMCS – Center for Mindfulness and Contemplative Studies

 

This and other Contemplative Studies posts are also available on the Contemplative Studies Blog  http://contemplative-studies.org

 

Study Summary

 

Wang YH, Wang YL, Leung DKY, Ng ZLY, Chan OLH, Wong SMY, Chan RCL, Liu T, Wong GHY, Lum TYS. Effectiveness of an age-modified mindfulness-based cognitive therapy (MBCT) in improving mental health in older people with depressive symptoms: a non-randomised controlled trial. BMC Complement Med Ther. 2025 Feb 26;25:81. doi: 10.1186/s12906-025-04781-6. PMCID: PMC11863447.

 

Abstract

Background

Emerging evidence has shown that mindfulness-based cognitive therapy (MBCT) is effective in improving depressive symptoms in the older population. However, the accessibility to MBCT is limited by the shortage of psychotherapists or mindfulness teachers. One potential solution is to involve social workers, who have the knowledge and skills to promote individual and community well-being in various settings, in delivering modified MBCT to enhance its accessibility and sustainability. This study examined the effectiveness of an eight-week age-modified MBCT led by different mental health professionals (mindfulness teacher only vs. mindfulness teacher and social worker) in improving mental health outcomes as compared with a control group.

Methods

Older adults (N = 112) were recruited through five community-based centres for older adults and mental wellness in Hong Kong. Participants were allocated to one of three groups: (1) mindfulness teacher-led modified MBCT, (2) social worker/teacher co-led modified MBCT (50% led by social workers and 50% led by mindfulness teacher), or (3) control (care as usual). The age-modified MBCT consisted of eight weekly sessions, with age-related modifications including more sitting meditation, shortened duration of each session, and the removal of the retreat. Outcome variables (i.e., depressive symptoms, anxiety symptoms, perceived stress, and mindfulness) were assessed at baseline (T0), after the intervention (T1), and four weeks after the intervention (T2), through self-reported questionnaires. Linear mixed models were performed while controlling for demographic variables to examine changes in outcome variables between the groups.

Results

Participants from the age-modified MBCT intervention groups (teacher-led and social worker/teacher co-led) showed significantly greater reductions in depressive symptoms and stress, as well as greater increase in mindful non-reactivity, compared to the control group post-intervention. No significant interaction effect of time and group was found for anxiety and both overall mindfulness and its other facets. The improvements in mental health and mindfulness outcomes post-intervention were not significantly different between the teacher-led and social worker/teacher co-led MCBT groups.

Discussion

Age-modified MBCT is beneficial in managing depressive and stress symptoms and in improving mindful non-reactivity among older adults at risk for depression. The findings support the feasibility and effectiveness of partial task-shifting in the delivery of MBCT to trained social workers. Future studies may explore the possibility for social workers in leading MBCTs independently to further improve its scalability and service accessibility for older adults in the community.

 

Mindfulness Meditation Alters the Brain to Accentuate Sensory Information Processing

psyjdc Leave a comment

Figure 3

By John M. de Castro, Ph.D.

 

In today’s Research News article “Long-term mindfulness meditation increases occurrence of sensory and attention brain states” (See summary below or view the full text of the study at: https://pmc.ncbi.nlm.nih.gov/articles/PMC11743700/ ) Panitz and colleagues examined the activity of brain systems in experienced mindfulness meditators in comparison to non-meditators and found that experienced meditators had greater activity in brain systems associated with sensory processing and lower activity in systems associated with cognitive processing, This suggests that mindfulness meditation practice alters brain activity to accentuate immediate sensations.

 

Mindfulness meditation increases brain sensory processing while decreasing brain cognitive processing.

 

CMCS – Center for Mindfulness and Contemplative Studies

 

This and other Contemplative Studies posts are also available on the Contemplative Studies Blog  http://contemplative-studies.org

 

Study Summary

 

Panitz DY, Mendelsohn A, Cabral J, Berkovich-Ohana A. Long-term mindfulness meditation increases occurrence of sensory and attention brain states. Front Hum Neurosci. 2025 Jan 6;18:1482353. doi: 10.3389/fnhum.2024.1482353. PMID: 39834400; PMCID: PMC11743700.

 

Abstract

Interest has been growing in the use of mindfulness meditation (MM) as a therapeutic practice, as accumulating evidence highlights its potential to effectively address a range of mental conditions. While many fMRI studies focused on neural activation and functional connectivity during meditation, the impact of long-term MM practice on spontaneous brain activity, and on the expression of resting state networks over time, remains unclear. Here, intrinsic functional network dynamics were compared between experienced meditators and meditation-naïve participants during rest. Our analysis revealed that meditators tend to spend more time in two brain states that involve synchrony among cortical regions associated with sensory perception. Conversely, a brain state involving frontal areas associated with higher cognitive functions was detected less frequently in experienced meditators. These findings suggest that, by shifting attention toward enhanced sensory and embodied processing, MM effectively modulates the expression of functional network states at rest. These results support the suggested lasting effect of long-term MM on the modulation of resting-state networks, reinforcing its therapeutic potential for disorders characterized by imbalanced network dynamics. Moreover, this study reinforces the utility of analytic approaches from dynamical systems theory to extend current knowledge regarding brain activity and evaluate its response to interventions.

 

Tai Chi Improves Balance and Movement in patients with Parkinson’s Disease

psyjdc Leave a comment

Tai Chi and Parkinson's disease - Parkinson's Nebraska

By John M. de Castro, Ph.D.

 

In today’s Research News article “Tai Chi improves balance, mobility and gait function of the lower limbs in patients with Parkinson’s disease: a systematic review and meta-analysis” (See summary below or view the full text of the study at: https://pmc.ncbi.nlm.nih.gov/articles/PMC11831811/ ) Lou and colleagues review and summarize the published research studies of the effectiveness of Tai Chi practice for the motor functions of patients with Parkinson’s Disease. They report that the published research found that Tai Chi practice improves balance, mobility, and gait speed in patients with Parkinson’s Disease compared to patients undergoing conventional therapies.

 

Tai Chi practice improves motor function in patients with Parkinson’s Disease.

 

CMCS – Center for Mindfulness and Contemplative Studies

 

This and other Contemplative Studies posts are also available on the Contemplative Studies Blog  http://contemplative-studies.org

 

Study Summary

 

Lou L, Xiang C, Hu Y, Yang J. Tai Chi improves balance, mobility and gait function of the lower limbs in patients with Parkinson’s disease: a systematic review and meta-analysis. Eur J Med Res. 2025 Feb 17;30(1):107. doi: 10.1186/s40001-024-02151-5. PMID: 39962570; PMCID: PMC11831811.

 

Abstract

Objective

This study aimed to systematically evaluate the effect of Tai Chi on the balance function, mobility function, and gait function (including gait endurance, gait amplitude, and gait speed) of the lower limbs in patients with Parkinson’s disease.

Methods

The “PICOS” principle was used to search seven English and six Chinese databases. Search for relevant studies published up to September 11, 2023, from the date of database creation. Two authors independently screened all eligible studies. The included studies were assessed for risk of bias based on the criteria outlined in Cochrane Handbook 5.1.0. Quantitative statistics and meta-analyses were conducted using Review Manager 5.4 software.

Results

Th 18 studies that met the inclusion criteria, 16 of which were included in the meta-analysis, included a sample of 963 cases from four countries. The meta-analysis revealed that Tai Chi was effective compared with conventional medication in improving balance function (MD = 2.06, 95% CI [1.35, 2.78], P < 0.00001, I2 =0%), mobility function (MD = − 1.59, 95% CI [− 2.28, − 0.91], P < 0.00001, I2 =14%), and gait speed (SMD =0.59, 95% [0.28, 0.91], P = 0.0002, I2 =29%). However, there was no significant improvement in gait endurance (SMD = 0.14, 95% CI [−0.41, 0.68], P =0.62, I2 = 0%) or gait amplitude (SMD =0.30 , 95% CI [− 0.00, 0.61], P = 0.05, I2 =0%). Compared with other exercise therapies, Tai Chi was significantly superior in improving balance function (MD = 3.05, 95% CI [1.94, 4.16], P <0.00001, I2 = 38%), mobility function (MD =−0.70, 95%CI [− 1.23, − 0.17], P = 0.01, I2 = 0%), and gait range (SMD = 0.36, 95% CI [0.14, 0.58], P = 0.002, I2 = 45%). However, the advantage of improving gait speed (SMD =0.00, 95% CI [− 0.28, 0.29], P = 0.98, I2 =0%) was uncertain.

Conclusion

Tai chi is a safe and effective rehabilitation intervention that can enhance the balance and mobility functions of the lower limbs in patients with Parkinson’s disease.

Online Yoga Improves the Psychological Health of Cancer Patients

psyjdc Leave a comment

The pros and cons of online yoga - Ekhart Yoga

By John M. de Castro, Ph.D.

 

In today’s Research News article “The Effects of Online Yoga Practice on Cancer Patients: A Systematic Review” (See summary below or view the full text of the study at: https://pmc.ncbi.nlm.nih.gov/articles/PMC11817149/ ) Gatti and colleagues reviewed and summarized the published research studies on the effectiveness of yoga practice presented online to alleviate the psychological sequala of a cancer diagnosis. They report that online yoga significantly increases sleep quality and quality of life and reduces stress, anxiety, depression, and fatigue in patients with a diagnosis of cancer.

 

Yoga practice improves the psychological health of cancer patients.

 

CMCS – Center for Mindfulness and Contemplative Studies

 

This and other Contemplative Studies posts are also available on the Contemplative Studies Blog  http://contemplative-studies.org

 

Study Summary

 

Gatti F, Perego G, Milano F, Calleri G, Giurioli B, Di Mattei VE. The Effects of Online Yoga Practice on Cancer Patients: A Systematic Review. Healthcare (Basel). 2025 Jan 23;13(3):225. doi: 10.3390/healthcare13030225. PMID: 39942415; PMCID: PMC11817149.

 

Abstract

Background: Cancer remains a leading cause of death, with 9.7 million deaths in 2022. Despite advancements in diagnosis and treatment, many cancer patients experience side effects that significantly impact their quality of life, including chronic pain, anxiety, depression, sleep disturbances, and cancer-related fatigue. Non-pharmacological interventions, such as yoga, have gained attention for their potential to reduce stress and improve overall well-being. However, barriers such as fatigue, pain, and transportation issues limit access to in-person yoga, leading to the growing adoption of online yoga as a viable alternative. Objective: This systematic review synthesizes research on the effectiveness of online yoga for cancer patients. A comprehensive search was conducted across Medline, PsycINFO, and Scopus databases on 24 October 2024. The methodological quality of the studies was assessed using the CASP Checklist. Of 6266 articles initially identified, 14 studies met the inclusion criteria, comprising qualitative (n = 4) and quantitative (n = 10) studies. Results: The results suggest that online yoga can improve stress and sleep quality, with moderate effects on anxiety, depression, and fatigue. However, variability in study designs and methodological limitations complicate the evaluation of its overall effectiveness. Conclusions: Online yoga offers a practical, accessible option for cancer patients unable to attend in-person sessions, showing the potential to enhance mental and physical health outcomes. Nevertheless, the variability in study methodologies highlights the need for more standardized research to establish its role as a supportive intervention in oncology care.

 

Meditation is Associated with a Reduction in Brain Aging Indicators

psyjdc Leave a comment

Figure 2

By John M. de Castro, Ph.D.

 

In today’s Research News article “Meditation Linked to Enhanced MRI Signal Intensity in the Pineal Gland and Reduced Predicted Brain Age” (See summary below or view the full text of the study at: https://pmc.ncbi.nlm.nih.gov/articles/PMC11822093/ ) Plini and colleagues examined the brains of long-term meditators and found that the activity of their Pineal Glands was enhanced and an indicator of brain aging was reduced. This suggests that meditation leads to less aging of the brain. This could be a mechanism whereby meditation reduces cognitive decline with aging.

 

Reduce brain aging with meditation.

 

CMCS – Center for Mindfulness and Contemplative Studies

 

This and other Contemplative Studies posts are also available on the Contemplative Studies Blog  http://contemplative-studies.org

 

Study Summary

 

Plini ERG, Melnychuk MC, Dockree PM. Meditation Linked to Enhanced MRI Signal Intensity in the Pineal Gland and Reduced Predicted Brain Age. J Pineal Res. 2025 Mar;77(2):e70033. doi: 10.1111/jpi.70033. PMID: 39940075; PMCID: PMC11822093.

 

ABSTRACT

Growing evidence demonstrates that meditation practice supports cognitive functions, including attention and interoceptive processing, and is associated with structural changes across cortical networks, including prefrontal regions and the insula. However, the extent of subcortical morphometric changes linked to meditation practice is less appreciated. A noteworthy candidate is the pineal gland, a key producer of melatonin, which regulates circadian rhythms that augment sleep‐wake patterns and may also provide neuroprotective benefits to offset cognitive decline. Increased melatonin levels, as well as increased fMRI BOLD signal in the pineal gland, have been observed in meditators versus controls. However, it is not known if long‐term meditators exhibit structural changes in the pineal gland linked to the lifetime duration of practice. In the current study, we performed voxel‐based morphometry (VBM) analysis to investigate: (1) whether long‐term meditators (LTMs) (n = 14) exhibited greater pineal gland MRI‐derived signal intensity compared to a control group (n = 969), (2) a potential association between the estimated lifetime hours of meditation (ELHOM) and pineal gland signal intensity, and (3) whether LTMs show greater grey matter (GM) maintenance (BrainPAD) that is associated with pineal gland signal intensity. The results revealed greater pineal gland signal intensity and lower BrainPAD scores (younger brain age) in LTMs compared to controls. Exploratory analysis revealed a positive association between ELHOM and greater signal intensity in the pineal gland but not with GM maintenance as measured by BrainPAD score. However, greater pineal signal intensity and lower BrainPAD scores were correlated in LTMs. The potential mechanisms by which meditation influences pineal gland function, hormonal metabolism, and GM maintenance are discussed – in particular, melatonin’s roles in sleep, immune response, inflammation modulation, and stem cell and neural regeneration.

 

Mindfulness Training Promotes Perinatal Mental Health

psyjdc Leave a comment

How New Moms Can Have a Positive, Mindful Postpartum JourneyBy John M. de Castro, Ph.D.

 

In today’s Research News article “Development and Evaluation of a Mindfulness-Based Mobile Intervention for Perinatal Mental Health: Randomized Controlled Trial” (See summary below or view the full text of the study at: https://pmc.ncbi.nlm.nih.gov/articles/PMC11786135/ ) Park and colleagues performed a randomized clinical trial comparing the effectiveness of a 4-week smartphone-based mindfulness program to a wait-list control condition on the mental health of pregnant women. They found that mindfulness training produced significant reductions in anxiety and increases in emotional well-being, mindfulness, and maternal-fetal attachment.

 

So, mindfulness training improves the mental health of pregnant women.

 

CMCS – Center for Mindfulness and Contemplative Studies

 

This and other Contemplative Studies posts are also available on the Contemplative Studies Blog  http://contemplative-studies.org

 

Study Summary

 

Park S, Cho HY, Park JY, Chung K, Jhung K. Development and Evaluation of a Mindfulness-Based Mobile Intervention for Perinatal Mental Health: Randomized Controlled Trial. J Med Internet Res. 2025 Jan 17;27:e56601. doi: 10.2196/56601. PMID: 39823585; PMCID: PMC11786135.

 

Abstract

Background

Perinatal mental health problems, such as anxiety, stress, and depression, warrant particularly close monitoring and intervention, but they are often unaddressed in both obstetric and psychiatric clinics, with limited accessibility and treatment resources. Mobile health interventions may provide an effective and more accessible solution for addressing perinatal mental health. Development and evaluation of a mobile mental health intervention specifically for pregnant women are warranted.

Objective

This study aimed to evaluate the effectiveness of a 4-week, self-administered mobile mindfulness intervention in reducing anxiety, depression, and stress, and improving emotional well-being, maternal-fetal attachment, and mindfulness skills in a general population of pregnant women.

Methods

Pregnant women were recruited and randomized to an intervention or a wait-list control group. The intervention group participated in a self-administered 4-week smartphone-based mindfulness program. Anxiety, depression, and stress were assessed as primary outcomes at baseline and postintervention. Secondary outcomes were mental health well-being, maternal-fetal attachment, and skills of mindfulness. The usability of the mobile intervention was also evaluated.

Results

A total of 133 pregnant women were randomly assigned to the intervention (n=66) or the control group (n=67). The overall dropout rate was 30% (39/133). Anxiety scores of the intervention group significantly decreased from baseline to postintervention (P=.03, Wilcoxon Signed-Rank test), whereas no significant changes were observed in the control group. Depression and stress scores showed no significant changes. Emotional well-being significantly improved in the intervention group (P=.01). Improvements were observed in maternal-fetal attachment, particularly in attributing characteristics to the fetus (P=.003) and in differentiating the self from the fetus (P=.006). Mindfulness awareness also showed significant improvement (P=.008). Significant between-group effects were identified for mindfulness awareness (P=.006) and attributing characteristics to the fetus (P=.002). After applying the false discovery rate corrections, within-group improvements in emotional well-being, maternal-fetal attachment, and mindfulness awareness remained significant, while between-group differences for emotional well-being and differentiation were not significant.

Conclusions

A mobile mindfulness program effectively reduced anxiety and improved emotional well-being, maternal-fetal attachment, and mindfulness awareness in the general population of pregnant women. Mobile interventions may offer a cost-effective and feasible method for promoting perinatal mental health.

 

Mindfulness Reduces Stress in Heart Disease Patients

psyjdc Leave a comment

graphic file with name ga1.jpg

By John M. de Castro, Ph.D.

 

In today’s Research News article “Brief Mindfulness-Based Cognitive Therapy in Women With Myocardial Infarction: Results of a Multicenter Randomized Controlled Trial” (See summary below or view the full text of the study at: https://pmc.ncbi.nlm.nih.gov/articles/PMC11786073/ ) Spruill and colleagues examined the effectiveness of mindfulness training (Mindfulness Based Cognitive Therapy – MBCT) on stress levels of women diagnosed with myocardial infarction. They found that in comparison to an active control condition (heart disease education) the women who received mindfulness training had significantly lower perceived stress levels and the more they practiced the greater the reductions in stress, anxiety, and depression.

 

Hence, mindfulness improves the mental health of women with heart disease.

 

CMCS – Center for Mindfulness and Contemplative Studies

 

This and other Contemplative Studies posts are also available on the Contemplative Studies Blog  http://contemplative-studies.org

 

Study Summary

 

Spruill TM, Park C, Kalinowski J, Arabadjian ME, Xia Y, Shallcross AJ, Visvanathan P, Smilowitz NR, Hausvater A, Bangalore S, Zhong H, Park K, Mehta PK, Thomas DK, Trost J, Bainey KR, Heydari B, Wei J, Dickson VV, Ogedegbe G, Berger JS, Hochman JS, Reynolds HR. Brief Mindfulness-Based Cognitive Therapy in Women With Myocardial Infarction: Results of a Multicenter Randomized Controlled Trial. JACC Adv. 2025 Jan 16;4(2):101530. doi: 10.1016/j.jacadv.2024.101530. PMID: 39898341; PMCID: PMC11786073.

 

Abstract

Background

Elevated perceived stress is associated with adverse outcomes following myocardial infarction (MI) and may account for poorer recovery among women vs men.

Objectives

This randomized controlled trial tested effects of a mindfulness-based intervention on stress levels among women with MI.

Methods

Women with elevated stress (Perceived Stress Scale [PSS-4]≥6) at least 2 months after MI were enrolled from 12 hospitals in the United States and Canada and via community advertising. Participants were randomized to a remotely delivered mindfulness intervention (MBCT-Brief) or heart disease education, both 8 weeks long. Follow-up was 6 months. Changes in stress (PSS-10; primary outcome) and secondary outcomes (depressive symptoms, anxiety, quality of life, disease-specific health status, actigraphy-assessed sleep) were compared between groups.

Results

The sample included 130 women with MI (mean age 59.8 ± 12.8 years, 34% racial/ethnic minorities). In intention-to-treat analysis, PSS-10 scores declined in the MBCT-Brief arm (−0.52 [95% CI: −0.77 to −0.28]) but not the heart disease education arm (−0.19 [95% CI: −0.45 to 0.06]; group×time interaction P = 0.070). The effect was stronger in per-protocol analysis of participants who completed ≥4 intervention sessions (P = 0.049). There were no significant differences in secondary outcomes in intention-to-treat or per-protocol analyses. Within the MBCT-Brief arm, more frequent mindfulness practice was associated with greater reductions in stress (P = 0.007), depressive symptoms (P = 0.017), and anxiety (P = 0.036).

Conclusions

MBCT-Brief was associated with greater 6-month reductions in stress than an active control among adherent participants. More frequent mindfulness practice was associated with greater improvements in psychological outcomes. Strategies to engage women with MI in mindfulness training and support regular home practice may enhance these effects.

 

Adding a Psychedelic Drug to Mindfulness Training Enhances Relief of Burnout and Depression

psyjdc Leave a comment

Combining psychedelics with meditation increases mindfulness and mystical-type transcendence

By John M. de Castro, Ph.D.

 

In today’s Research News article “Psilocybin-Assisted Group Psychotherapy + Mindfulness Based Stress Reduction (MBSR) for Frontline Healthcare Provider COVID-19 Related Depression and Burnout: A Randomized Clinical Trial” (See summary below or view the full text of the study at: https://pmc.ncbi.nlm.nih.gov/articles/PMC11722457/pdf/nihpp-2024.12.31.24319806v1.pdf )  Lewis and colleagues performed a randomized clinical trial of the effectiveness of Mindfulness training (8-wks of Mindfulness Based Stress Reduction – MBSR) with or without an additional Psychedelic drug (psilocybin) on the mental health of healthcare workers suffering from burnout and depression.

 

They found that the addition of the psychedelic drug significantly increased the relief of depression, burnout, and demoralization and the improvement of connectedness produced by the mindfulness training.

 

Hence, psychedelic drugs enhance the effectiveness of mindfulness training on burnout.

 

CMCS – Center for Mindfulness and Contemplative Studies

 

This and other Contemplative Studies posts are also available on the Contemplative Studies Blog  http://contemplative-studies.org

 

Study Summary

 

Lewis BR, Hendrick J, Byrne K, Odette M, Wu C, Garland EL. Psilocybin-Assisted Group Psychotherapy + Mindfulness Based Stress Reduction (MBSR) for Frontline Healthcare Provider COVID-19 Related Depression and Burnout: A Randomized Clinical Trial. medRxiv [Preprint]. 2025 Jan 1:2024.12.31.24319806. doi: 10.1101/2024.12.31.24319806. PMID: 39802794; PMCID: PMC11722457.

 

Abstract

Objective

This clinical trial sought to evaluate the safety and preliminary efficacy of psilocybin and MBSR for frontline healthcare providers with symptoms of depression and burnout related to the COVID-19 pandemic.

Methods

This was a randomized controlled trial that enrolled physicians and nurses with frontline clinical work during the COVID-19 pandemic and symptoms of depression and burnout. Participants were randomized in a 1:1 ratio to either an 8-week MBSR curriculum alone or an 8-week MBSR curriculum plus group psilocybin-assisted psychotherapy (PAP) with 25mg psilocybin. Symptoms of depression and burnout were assessed at baseline, and 2-weeks and 6-months post intervention utilizing the Quick Inventory of Depressive Symptoms (QIDS-SR-16) and Maslach Burnout Inventory Human Services Survey for Medical Professionals (MBI-HSS-MP), respectively. Secondary outcome measures included the Demoralization Scale (DS-II) and the Watt’s Connectedness Scale (WCS). Adverse events and suicidality were assessed through 6-month follow-up.

Results

25 participants were enrolled and randomized. There were 12 study-related AEs recorded that were Grade 1-2 and no serious AEs. There was larger decrease in QIDS score for the MBSR+PAP arm compared to MBSR-only from baseline to 2-weeks post-intervention and significant between-group differences favoring MBSR+PAP on subscales of the MBI-HSS-MP as well as the DS-II and WCS.

Conclusions

Group psilocybin-assisted therapy plus MBSR was associated with clinically significant improvement in depressive symptoms without serious adverse events and with greater reduction in symptoms than MBSR alone. Study findings suggest that integrating psilocybin with mindfulness training may represent a promising treatment for depression and burnout among physicians and nurses.

 

Mindfulness and Humor Reduce Stress and Improve Well-Being

psyjdc Leave a comment

Mindfulness, Communication and Humor: Navigating Remission

By John M. de Castro, Ph.D.

 

In today’s Research News article “Mindfulness Interfused with Humor: Insights From a Randomized Controlled Trial of a Humor-Enriched Mindfulness-Based Program” (See summary below or view the full text of the study at: https://pmc.ncbi.nlm.nih.gov/articles/PMC11785597/ )  Kastner examined the effects of mindfulness training (Mindfulness Based Stress Reduction; MBSR) either alone or mixed with humor on participants well-being. They found that whether mixed with humor or not, mindfulness training reduced perceived stress and increased psychological well-being and life satisfaction.

 

So, mindfulness improves the psychological state of normal adults.

 

CMCS – Center for Mindfulness and Contemplative Studies

 

This and other Contemplative Studies posts are also available on the Contemplative Studies Blog  http://contemplative-studies.org

 

Study Summary

 

Kastner CT. Mindfulness Interfused with Humor: Insights From a Randomized Controlled Trial of a Humor-Enriched Mindfulness-Based Program. Mindfulness (N Y). 2025;16(1):186-204. doi: 10.1007/s12671-024-02491-7. Epub 2025 Jan 6. PMID: 39898273; PMCID: PMC11785597.

 

Abstract

Objectives

Both mindfulness and humor are inherently connected to well-being. Recent research found evidence for their combined effect in a joint training, the Humor-Enriched Mindfulness-Based Program (HEMBP). This study extends these findings by exploring (1) effects of Mindfulness-Based Stress Reduction (MBSR) on different forms of humor, (2) differential effects of the HEMBP on outcomes compared to MBSR, and (3) whether the HEMBP and MBSR may alter worldviews.

Method

Ninety participants were randomly allocated to three conditions: the HEMBP, MBSR, and a wait-list control group. Participants’ mindfulness, psychological well-being, life satisfaction, perceived stress, comic styles, and primal world beliefs (primals) were assessed before and after the trainings, and at 1-, 3-, and 6-month follow-ups. Changes in outcome variables over time were modeled by applying linear mixed-effects models.

Results

The HEMBP enhanced participants’ mindfulness, benevolent humor, psychological well-being, and life satisfaction compared to the wait-list control. Similarly, MBSR increased participants’ mindfulness and life satisfaction while reducing perceived stress and primal good, but no effects on humor were observed. Comparison between the two trainings revealed trends toward a greater increase in benevolent humor in the HEMBP group and a greater decrease in good in the MBSR group.

Conclusion

The results largely replicate previous research on the efficacy of the HEMBP. Both programs demonstrated similar effects on outcomes, with only the HEMBP increasing benevolent humor and psychological well-being, while MBSR reduced stress. Further research is needed to investigate qualitative aspects of the integration of humor in MBPs and the long-term impact of MBPs on individuals’ worldviews.