Parkinson’s Disease

Parkinson’s Disease Symptoms are Improved by Meditation or Yoga

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Parkinson's Disease | Contemplative Studies

By John M. de Castro, Ph.D.

 

In today’s Research News article “Effects of Meditation and Yoga on Anxiety, Depression and Chronic Inflammation in Patients with Parkinson’s Disease: A Randomized Clinical Trial” (See summary below or view the full text of the study at: https://pmc.ncbi.nlm.nih.gov/articles/PMC11965853/ ) Kwok and colleagues studied the effects of meditation and yoga practice on the symptoms of Parkinson’s Disease. They found that these practices significantly relieved a wide variety of symptoms, including anxiety, depression, inflammation, movement problems, and improved quality of life.

 

Meditation and yoga relieve the symptoms of Parkinson’s disease.

 

CMCS – Center for Mindfulness and Contemplative Studies

 

This and other Contemplative Studies posts are also available on the Contemplative Studies Blog  http://contemplative-studies.org

 

Study Summary

 

Jojo Yan Yan Kwok, Lily Man Lee Chan, Charis Ann Lai, Philip Wing Lok Ho, Zoe Yuen-kiu Choi, Man Auyeung, Shirley Yin Yu Pang, Edmond Pui Hang Choi, Daniel Yee Tak Fong, Doris Sau Fung Yu, Chia-chin Lin, Richard Walker, Samuel Yeung Shan Wong, Rainbow Tin Hung Ho. Effects of Meditation and Yoga on Anxiety, Depression and Chronic Inflammation in Patients with Parkinson’s Disease: A Randomized Clinical Trial. Psychother Psychosom. 2025 Feb 28;94(2):101–118.

Abstract

Introduction

Clinical guidelines recommend a holistic approach to Parkinson’s disease (PD) care, yet randomized trials examining mindfulness-based interventions in this context are scarce. This study investigated the effects of two mindfulness practices – meditation and yoga – on biopsychosocial outcomes in PD patients, including anxiety symptoms, depressive symptoms, motor/nonmotor symptoms, health-related quality-of-life (HRQOL), mindfulness, and stress and inflammation biomarkers, compared to usual care.

Methods

159 participants with a clinical diagnosis of idiopathic PD and a Hoehn and Yahr stage of 1, 2, and 3, were randomized into meditation (n = 53), yoga (n = 52), and control (n = 54). Meditation and yoga were delivered in 90-min groups for 8 weeks. Primary outcomes included anxiety symptoms and depressive symptoms. Secondary outcomes included motor and nonmotor symptoms, HRQOL, mindfulness, and serum levels of interleukin-6, cortisol and TNF-alpha. Assessments were done at baseline (T0), 2 months (T1), and 6 months (T2). Linear mixed models were conducted following intention-to-treat principle.

Results

Compared to control, both meditation, and yoga groups had significant improvements in anxiety symptoms (meditation: mean difference [MD] = −1.36, 95% CI: −2.46 to−0.26; yoga: MD = −1.61, CI: −2.70 to −0.52), motor symptoms (meditation: MD = −5.35, CI: −8.61 to−2.09; yoga: MD = −6.59, CI: −9.82 to−3.36), HRQOL (meditation: MD = −2.01, CI: −3.41 to−0.62; yoga: MD = −1.45, CI: −2.83 to−0.08), and describing skills (meditation: MD = 0.97, CI: 0.04–1.89; yoga: MD = 0.92, CI: 0.01–1.84) at T1, and significant reductions in serum interleukin-6 levels (meditation: MD = −1.14, CI: −2.18 to−0.10; yoga: MD = −1.11, CI: −2.09 to−0.13) at T2. Only meditation significantly reduced depression (MD = −1.44, CI: −2.57 to−0.30) at T1 and sustained the motor and HRQOL improvements at T2.

Conclusion

Meditation and yoga significantly improved anxiety symptoms, chronic inflammation, motor symptoms, mindfulness-describing facet, and HRQOL in PD patients. Meditation provided additional benefits in reducing depressive symptoms and sustaining motor and HRQOL improvements.

 

Tai Chi Improves Balance and Movement in patients with Parkinson’s Disease

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Tai Chi and Parkinson's disease - Parkinson's Nebraska

By John M. de Castro, Ph.D.

 

In today’s Research News article “Tai Chi improves balance, mobility and gait function of the lower limbs in patients with Parkinson’s disease: a systematic review and meta-analysis” (See summary below or view the full text of the study at: https://pmc.ncbi.nlm.nih.gov/articles/PMC11831811/ ) Lou and colleagues review and summarize the published research studies of the effectiveness of Tai Chi practice for the motor functions of patients with Parkinson’s Disease. They report that the published research found that Tai Chi practice improves balance, mobility, and gait speed in patients with Parkinson’s Disease compared to patients undergoing conventional therapies.

 

Tai Chi practice improves motor function in patients with Parkinson’s Disease.

 

CMCS – Center for Mindfulness and Contemplative Studies

 

This and other Contemplative Studies posts are also available on the Contemplative Studies Blog  http://contemplative-studies.org

 

Study Summary

 

Lou L, Xiang C, Hu Y, Yang J. Tai Chi improves balance, mobility and gait function of the lower limbs in patients with Parkinson’s disease: a systematic review and meta-analysis. Eur J Med Res. 2025 Feb 17;30(1):107. doi: 10.1186/s40001-024-02151-5. PMID: 39962570; PMCID: PMC11831811.

 

Abstract

Objective

This study aimed to systematically evaluate the effect of Tai Chi on the balance function, mobility function, and gait function (including gait endurance, gait amplitude, and gait speed) of the lower limbs in patients with Parkinson’s disease.

Methods

The “PICOS” principle was used to search seven English and six Chinese databases. Search for relevant studies published up to September 11, 2023, from the date of database creation. Two authors independently screened all eligible studies. The included studies were assessed for risk of bias based on the criteria outlined in Cochrane Handbook 5.1.0. Quantitative statistics and meta-analyses were conducted using Review Manager 5.4 software.

Results

Th 18 studies that met the inclusion criteria, 16 of which were included in the meta-analysis, included a sample of 963 cases from four countries. The meta-analysis revealed that Tai Chi was effective compared with conventional medication in improving balance function (MD = 2.06, 95% CI [1.35, 2.78], P < 0.00001, I2 =0%), mobility function (MD = − 1.59, 95% CI [− 2.28, − 0.91], P < 0.00001, I2 =14%), and gait speed (SMD =0.59, 95% [0.28, 0.91], P = 0.0002, I2 =29%). However, there was no significant improvement in gait endurance (SMD = 0.14, 95% CI [−0.41, 0.68], P =0.62, I2 = 0%) or gait amplitude (SMD =0.30 , 95% CI [− 0.00, 0.61], P = 0.05, I2 =0%). Compared with other exercise therapies, Tai Chi was significantly superior in improving balance function (MD = 3.05, 95% CI [1.94, 4.16], P <0.00001, I2 = 38%), mobility function (MD =−0.70, 95%CI [− 1.23, − 0.17], P = 0.01, I2 = 0%), and gait range (SMD = 0.36, 95% CI [0.14, 0.58], P = 0.002, I2 = 45%). However, the advantage of improving gait speed (SMD =0.00, 95% CI [− 0.28, 0.29], P = 0.98, I2 =0%) was uncertain.

Conclusion

Tai chi is a safe and effective rehabilitation intervention that can enhance the balance and mobility functions of the lower limbs in patients with Parkinson’s disease.