Genetics

Mindfulness Interacts with the Genes in Producing Personality Change

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By John M. de Castro, Ph.D.

 

“It had been traditionally assumed that personality traits are relatively stable entities, but more recent research demonstrates that personality, including disposition towards mindfulness, can change over time as a result of life experiences or through mindfulness practice.” – Yi‑Yuan Tang

 

The genes dictate all of the chemical processes in our bodies including brain development and plasticity. One gene, in particular, encodes the production of brain-derived neurotrophic factor (BDNF). It is a protein found in the brain and spinal cord that promotes the survival of nerve cells by playing a role in the growth, maturation, and maintenance of these cells. In the brain, the BDNF protein is active at the connections between nerve cells (synapses), where cell-to-cell communication occurs. The synapses can change and adapt over time in response to experience, a characteristic called neuroplasticity. The BDNF protein helps regulate neuroplasticity, which is important for learning and memory.

 

Since BDNF is involved in the development of the nervous system, and the nervous system, in part, determines our personality characteristics, it would seem reasonable to suspect that the genes underlying BDNF production would be associated with personality. In addition, since BDNF is involved in the plasticity of the nervous system, its ability to change and adapt to the environment and experience, it would seem reasonable to suspect that the genes underlying BDNF production would be associated with variations in brain neuroplasticity. The genes underlying BDNF production have a major variant that is present in approximately 25% of the population. It is possible that this variant may be responsible, in part, for differences between people in personality and neuroplasticity.

 

This reasoning taken together with the facts that mindfulness practices, including meditation, yoga, tai chi, qigong, are known to change the nervous system through neuroplasticity and are known to change some aspects of personality, it would seem reasonable to suspect that different variants of the genes underlying BDNF production would be associated with differences in the ability of mind body practices to change the brain and personality. This complex logic leads to the idea that differences in BDNF gene variants may produce different personality changes in response to mind-body practices.

 

In today’s Research News article “Effects of Mind-Body Training on Personality and Behavioral Activation and Inhibition System According to BDNF Val66Met Polymorphism.” See:

https://www.facebook.com/ContemplativeStudiesCenter/photos/a.628903887133541.1073741828.627681673922429/1276252265732030/?type=3&theater

or below or view the full text of the study at:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4878969/

Jung and colleagues examine this hypothesis. They recruited a group of participants who regularly practiced Brain Wave Vibration, a practice that is a movement based meditation resembling yoga, martial arts, and meditation. They also recruited a group who did not engage in mind-body practices. Both groups were separated into subgroups based upon whether they carried the normal or the variant of the BDNF gene. All participants were measured for personality and behavioral activation/inhibition.

 

They found that the BDNF gene variant affected personality with control participants who had the variant higher in neuroticism and lower in extroversion. Neuroticism is known to be associated with personality problems and mental illness. So, these results suggest that the BDNF gene variant produces personality problems. On the other hand, those participants who engaged in mind-body practices and had the BDNF gene variant were higher in extroversion and openness to experience than the control participants who also had the BDNF gene variant. These results are complex but indicate firstly that the genes are involved in the determination of personality characteristics and secondly that they modify the ability of mind-body practices to change personality. They also show that engagement in mind-body practices can, to some extent, help to correct personality problems resulting from the individual’s inheritance.

 

So, practice mindfulness and improve personality characteristics regardless of your genetic inheritance.

 

“All the benefits of meditation arise from experiencing our mind as more workable. We can focus and guide it better and we can also let it go. More dance, less straitjacket.” – Barry Boyce

 

CMCS – Center for Mindfulness and Contemplative Studies

 

This and other Contemplative Studies posts are also available on Google+ https://plus.google.com/106784388191201299496/posts

 

Study Summary

Jung, Y.-H., Lee, U. S., Jang, J. H., & Kang, D.-H. (2016). Effects of Mind-Body Training on Personality and Behavioral Activation and Inhibition System According to BDNF Val66Met Polymorphism. Psychiatry Investigation, 13(3), 333–340. http://doi.org/10.4306/pi.2016.13.3.333

 

Abstract

OBJECTIVE: It has been known that mind-body training (MBT) can affect personality and behavior system as well as emotional well-being, but different effects of MBT on them has not been reported according to BDNF genetic polymorphism.

METHODS: Healthy subjects consisted of 64 subjects and the MBT group who practiced meditation regularly consisted of 72 practitioners. Participants completed neuroticism-extraversion-openness (NEO) Five-Factor Inventory and Behavioral Activation System/Behavioral Inhibition System (BAS/BIS) scales. All subjects were genotyped for the BDNF Val66Met polymorphism.

RESULTS: In the same genotypes of the BDNF Val/Val+Val/Met group, MBT group showed the increased Extraversion (p=0.033) and the increased Openness to Experience (p=0.004) compared to the control group. Also, in the same Met/Met carriers, MBT group exhibited the increase of Extraversion (p=0.008), the reduction of Neuroticism (p=0.002), and the increase of Openness to Experience (p=0.008) compared to the control group. In the same genotypes of the BDNF Val/Val+Val/Met group, MBT group showed the decreased BAS-Reward Responsiveness (p=0.016) and the decrease of BIS (p=0.004) compared to the control group. In the BDNF Met/Met group, MBT group increased BAS-Fun Seeking (p=0.045) and decreased BIS (p=0.013) compared to the control group.

CONCLUSION: MBT would differently contribute to NEO personality and BAS/BIS according to BDNF genetic polymorphism, compensating for different vulnerable traits based on each genotype.

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4878969/

 

Mindfully Control Inflammation

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“I don’t think anybody would argue that fact that we know inflammation in the body, which comes from a lot of different sources, is the basis for a lot of chronic health problems, so by controlling that, we would expect to see increased life expectancy … but if we’re not changing those things and just taking ibuprofen, I don’t know if we’re really going to make any headway in that, I feel like there are probably a lot of factors that we could change without medicating with risk.”– Josie Znidarsic

 

The immune system is designed to protect the body from threats like stress, infection, injury, and toxic chemicals. One of its tools is the Inflammatory response. Its primary effect is to increase blood circulation around the infected area, dilating the blood vessels around the site of inflammation. It also produces gaps in the cell walls surrounding the infected area, allowing the larger immune cells, to pass. It also tends to increase body temperature to further fight infection. This response works quite well for short-term infections and injuries and as such is an important defense mechanism for the body. But when inflammation is protracted and becomes chronic, it can itself become a threat to health.

 

Chronic inflammation can produce autoimmune diseases such as colitis, Chron’s disease, arthritis, heart disease, increased cancer risk, lung disease, sleep disruption, gum disease, decreased bone health, psoriasis, and depression. Needless to say chronic inflammation can create major health problems. Indeed, the presence of chronic inflammation is associated with reduced longevity. So, it is important for health to control the inflammatory response, allowing it to do its job in fighting off infection but then reducing its activity when no external threat is apparent.

 

Contemplative practices appear to relax the physical systems of the body including the immune system, reducing inflammation. Mind-body techniques such as yoga, Tai Chi and meditation have been shown to adaptively reduce the inflammatory response (see http://contemplative-studies.org/wp/index.php/category/research-news/inflammatory-response/). In today’s Research News article “Mind-body therapies and control of inflammatory biology: A descriptive review”

https://www.facebook.com/ContemplativeStudiesCenter/photos/a.628903887133541.1073741828.627681673922429/1157023674321557/?type=3&theater

Bower and colleagues review the published research literature on the effects of mind-body practices on the inflammatory response. They found mixed and inconclusive results for circulating and cellular markers of inflammation but consistent findings for gene expression inflammatory pathways. These studies consistently demonstrated that mind-body practices including tai chi, yoga, and meditation produced a decrease in inflammatory gene expressions and does so in diverse populations of practitioners.

 

Bower and colleagues suggest that mind-body practices alter gene expression through their well-documented effects on the neuroendocrine system. These techniques are known to reduce the activity of the activating portion of the peripheral nervous system, the sympathetic system, to reduce the release of stress hormones, particularly cortisol, and to lower perceived stress (see http://contemplative-studies.org/wp/index.php/category/research-news/stress/).  Mind-body practices are also known to improve emotion regulation (see http://contemplative-studies.org/wp/index.php/category/research-news/emotions/) and reduce depression (see http://contemplative-studies.org/wp/index.php/category/research-news/depression/), and anxiety (see http://contemplative-studies.org/wp/index.php/2016/01/02/distress-produces-less-stress-with-mindfulness/). All of these effects occur via alterations of the nervous system by mind-body practices. The reduced activation and heightened relaxation then reduce the inflammatory response.

 

Regardless of the explanation, it is clear that mindfulness practices reduce potentially harmful inflammatory responses. So, mindfully control inflammation.

 

 

“The mindfulness-based approach to stress reduction may offer a lower-cost alternative or complement to standard treatment, and it can be practiced easily by patients in their own homes, whenever they need.” – Melissa Rosenkranz

 

CMCS – Center for Mindfulness and Contemplative Studies

 

Mind-body Practices Promote Health and Well-being by Changing Gene Expression

psyjdc 3 Comments

 

“We can’t any longer have the conventional understanding of genetics which everybody peddles because it is increasingly obvious that epigenetics – actually things which influence the genome’s function – are much more important than we realised.” – Robert Winston

 

There is an accumulating volume of research findings to demonstrate that Mind-body therapies have highly beneficial effects on the health and well-being of humans. These include meditation, yoga, tai chi, qigong, biofeedback, progressive muscle relaxation, guided imagery, hypnosis, and deep breathing exercises. Because of their proven benefits the application of these practices to relieving human suffering has skyrocketed.

 

It is clear that Mind-body therapies affect the physiology. In other words, the mind can alter the body. In turn, the genes can affect our minds. In fact, the genes have been shown to affect an individual’s inherent level of mindfulness (see http://contemplative-studies.org/wp/index.php/category/research-news/genetics/). These interactions are well documented. The mechanisms by which they occur, however, are not well understood. It has been shown that contemplative practices help create balance in the inflammatory response (see http://contemplative-studies.org/wp/index.php/category/research-news/inflammatory-response/) which is very beneficial for health. But, the mechanism through which contemplative practices affect the immune system is not known.

 

The genes dictate all of the chemical processes in our bodies including immune and inflammatory responses. So, it would seem reasonable to investigate whether alterations in gene expressions might be the intermediary between mind-body therapies and health. In today’s Research News article “Functional Genomics in the Study of Mind-Body Therapies”

https://www.facebook.com/ContemplativeStudiesCenter/photos/a.628903887133541.1073741828.627681673922429/1140382739318984/?type=3&theater

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4295747/

Niles and colleagues review the literature on the effects of mind-body therapies on the functional expression of the genes. Out of the vast number of genomic pathways that can be affected, they found one which appears to be altered by mind-body therapies in general. This was a reduction in activity (downregulation) of the expression of genes that elicit the inflammatory response. In other words mindfulness practices reduce inflammation by reducing the activity of the genes that produce it.

 

This finding is extremely important as an overactive inflammatory system underlies many chronic diseases. Inflammation is a normal response of the body to outside threats like stress, infection, injury, and toxic chemicals. It is designed to protect the body and ward off these threats. It works quite well for short-term infections and injuries and as such is an important defense mechanism for the body. But when inflammation is protracted and becomes chronic, it can itself become a threat to health. Chronic inflammation can produce autoimmune diseases such as colitis, Chron’s disease, arthritis, heart disease, increased cancer risk, lung disease, sleep disruption, gum disease, decreased bone health, psoriasis, and depression. Needless to say chronic inflammation can create major health problems. Indeed, the presence of chronic inflammation is associated with reduced longevity. So, it is important for health to control the inflammatory response, allowing it to do its job in fighting off infection but then reducing its activity when no external threat is apparent. Mind-body therapies appear to do just that by reducing the expression of the genes that produce inflammation.

 

Niles and colleagues also found that a number of mind-body therapies increase the activity of telomerase, an enzyme that protects the genes from deterioration, particularly during aging. Hence, mind-body therapies appear to have anti-aging properties by increasing the activity of genes the reduce age related deterioration (see http://contemplative-studies.org/wp/index.php/2015/07/17/aging-healthily-yoga-and-cellular-aging/).

 

All of these results suggest that mind-body therapies promote health and well-being by altering gene expression. This is interesting and important. The next question is what are the mechanisms by which these practices affect gene expressions? It will be up to future research to investigate this link in the causal chain from mind-body therapies to the promotion of health and well-being.

 

So engage in mind-body practices, change gene expression and promote health and well-being.

 

“Our genes are quite dynamic in their expression and …. the calmness of our mind can actually have a potential influence on their expression.” – Richard Davidson

 

CMCS – Center for Mindfulness and Contemplative Studies

 

 

 

Genes, Mindfulness, Anxiety, and Depression

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“Of course, genes can’t pull the levers of our behavior directly. But they affect the wiring and workings of the brain, and the brain is the seat of our drives, temperaments and patterns of thought.” – Steven Pinker
There are large differences between people in both their physical and psychological characteristics, including their levels of mindfulness, anxiety, and depression. Some of the differences are the result of environmental influences. But, many people still differ considerably even though they have lived in similar environments and had similar experiences. In addition, many of these characteristics seem to be present right at birth. These facts support the notion that both the genes and the environment determine human characteristics.

 

Indeed, there is evidence that our level of mindfulness is in part inherited and transmitted with the genes but is also affected by the environment (See http://contemplative-studies.org/wp/index.php/2015/07/17/we-are-born-to-be-mindful/). It has also been shown that depression and our overall levels of anxiety are to a large extent inherited factors that also are affected by the environment. This taken together with the fact that mindfulness training is an effective treatment for depression (see http://contemplative-studies.org/wp/index.php/2015/08/19/this-is-the-brain-on-meditation-major-depressive-disorder/), and anxiety (see http://contemplative-studies.org/wp/index.php/2015/08/13/get-the-brain-to-reduce-anxiety-with-meditation/) raises the question of to what extent are the genes and environment underlying mindfulness also related to the genes and environment underlying depression and the genes and environment underlying anxiety.

 

In today’s Research News article “A Multivariate Twin Study of Trait Mindfulness, Depressive Symptoms, and Anxiety Sensitivity.”

https://www.facebook.com/ContemplativeStudiesCenter/photos/a.628903887133541.1073741828.627681673922429/1104498792907379/?type=3&theater

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4413043/

Waszczuk and colleagues investigated the genetic and environmental determination of mindfulness, anxiety, and depression using a twin model including identical and fraternal twins. They found that low mindfulness was associated with high levels of anxiety and depression. They also found that there were significant influences of both heredity and environment on all three characteristics. In addition, they found that common genetic influences explained most of the association between low mindfulness, depressive symptoms, and anxiety sensitivity. In other words, not only was depression and anxiety related to low mindfulness, and that each of the characteristics were influenced by heredity, but also the relationship between them was also influenced by heredity.

 

It is important to keep in mind that although heredity was found to be an important contributor to each of these characteristics and their relationships, there were also significant environmental contributors. Hence, although biology, influenced by the genes is an important determinant, the environment is also. This suggests that environmental interventions such as mindfulness training could alter these characteristics and their relationships.

 

These are interesting and important observations. They go a long way toward explaining why people are so different in their inherent levels of mindfulness, anxiety and depression. They also help us to understand why different people may respond differently to mindfulness training for anxiety and depression.

 

So, develop mindfulness to assist your genes in fighting anxiety and depression.

 

CMCS – Center for Mindfulness and Contemplative Studies

 

 

We are born to be Mindful

psyjdc 3 Comments

We normally think of mindfulness as something we do that has effects on our physiology and indeed developing mindfulness has been clearly shown to do just that. Most of these physiological effects are positive and enhance our health and well-being. We also tend to think that through our experience and learning, external events, we decide to begin to cultivate mindfulness through contemplative practice.

But, is it possible that in fact the physiology may in part determine our level of mindfulness, perhaps there are factors that affect mindfulness from both our environment and our physiology? Today’s Research News article “A Multivariate Twin Study Of Trait Mindfulness, Depressive Symptoms, And Anxiety Sensitivity”

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4413043/pdf/da0032-0254.pdf

explores just that question. They show that a substantial amount of our mindfulness is due to our inheritance. Indeed, they find that the environment is also responsible, just as we thought, but surprisingly, so are our genes. In other words, mindfulness originates in both our environment and our physiology. In a sense, we are born to be mindful and our experiences shape our mindfulness from there.

In a modern environment, the influence of the environment on mindfulness is negative. That is, it shapes us not to be mindful. We learn to immerse ourselves in thought to the detriment of our awareness of the present moment. Nature endows us with mindfulness. We are programmed to be attentive to our immediate surroundings, but our culture intervenes to replace it with thinking, thinking, and thinking.

This is not the fault of our parents. In fact, today’s article demonstrates that our family environment, what they termed shared environment, has no influence whatsoever on our mindfulness. It is the influences outside of the family, our culture, which affects our degree of mindfulness. So, don’t blame your parents, blame the society and world that we’ve created for making us oblivious to our present moment.

The mindfulness movement, the current revolution of engagement in contemplative practice is hopefully the antidote bringing us back to our primal state of mindfulness, bringing us back also to our primal state of happiness.

CMCS