Mindfulness Training Promotes Perinatal Mental Health

February 19, 2025 psyjdc Leave a comment

How New Moms Can Have a Positive, Mindful Postpartum Journey By John M. de Castro, Ph.D.

In today’s Research News article “Development and Evaluation of a Mindfulness-Based Mobile Intervention for Perinatal Mental Health: Randomized Controlled Trial” (See summary below or view the full text of the study at: https://pmc.ncbi.nlm.nih.gov/articles/PMC11786135/ ) Park and colleagues performed a randomized clinical trial comparing the effectiveness of a 4-week smartphone-based mindfulness program to a wait-list control condition on the mental health of pregnant women. They found that mindfulness training produced significant reductions in anxiety and increases in emotional well-being, mindfulness, and maternal-fetal attachment.

So, mindfulness training improves the mental health of pregnant women.

CMCS – Center for Mindfulness and Contemplative Studies

This and other Contemplative Studies posts are also available on the Contemplative Studies Blog http://contemplative-studies.org

Study Summary

Park S, Cho HY, Park JY, Chung K, Jhung K. Development and Evaluation of a Mindfulness-Based Mobile Intervention for Perinatal Mental Health: Randomized Controlled Trial. J Med Internet Res. 2025 Jan 17;27:e56601. doi: 10.2196/56601. PMID: 39823585; PMCID: PMC11786135.

Abstract

Background

Perinatal mental health problems, such as anxiety, stress, and depression, warrant particularly close monitoring and intervention, but they are often unaddressed in both obstetric and psychiatric clinics, with limited accessibility and treatment resources. Mobile health interventions may provide an effective and more accessible solution for addressing perinatal mental health. Development and evaluation of a mobile mental health intervention specifically for pregnant women are warranted.

Objective

This study aimed to evaluate the effectiveness of a 4-week, self-administered mobile mindfulness intervention in reducing anxiety, depression, and stress, and improving emotional well-being, maternal-fetal attachment, and mindfulness skills in a general population of pregnant women.

Methods

Pregnant women were recruited and randomized to an intervention or a wait-list control group. The intervention group participated in a self-administered 4-week smartphone-based mindfulness program. Anxiety, depression, and stress were assessed as primary outcomes at baseline and postintervention. Secondary outcomes were mental health well-being, maternal-fetal attachment, and skills of mindfulness. The usability of the mobile intervention was also evaluated.

Results

A total of 133 pregnant women were randomly assigned to the intervention (n=66) or the control group (n=67). The overall dropout rate was 30% (39/133). Anxiety scores of the intervention group significantly decreased from baseline to postintervention (P=.03, Wilcoxon Signed-Rank test), whereas no significant changes were observed in the control group. Depression and stress scores showed no significant changes. Emotional well-being significantly improved in the intervention group (P=.01). Improvements were observed in maternal-fetal attachment, particularly in attributing characteristics to the fetus (P=.003) and in differentiating the self from the fetus (P=.006). Mindfulness awareness also showed significant improvement (P=.008). Significant between-group effects were identified for mindfulness awareness (P=.006) and attributing characteristics to the fetus (P=.002). After applying the false discovery rate corrections, within-group improvements in emotional well-being, maternal-fetal attachment, and mindfulness awareness remained significant, while between-group differences for emotional well-being and differentiation were not significant.

Conclusions

A mobile mindfulness program effectively reduced anxiety and improved emotional well-being, maternal-fetal attachment, and mindfulness awareness in the general population of pregnant women. Mobile interventions may offer a cost-effective and feasible method for promoting perinatal mental health.

Mindfulness Reduces Stress in Heart Disease Patients

February 17, 2025February 17, 2025 psyjdc Leave a comment

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By John M. de Castro, Ph.D.

In today’s Research News article “Brief Mindfulness-Based Cognitive Therapy in Women With Myocardial Infarction: Results of a Multicenter Randomized Controlled Trial” (See summary below or view the full text of the study at: https://pmc.ncbi.nlm.nih.gov/articles/PMC11786073/ ) Spruill and colleagues examined the effectiveness of mindfulness training (Mindfulness Based Cognitive Therapy – MBCT) on stress levels of women diagnosed with myocardial infarction. They found that in comparison to an active control condition (heart disease education) the women who received mindfulness training had significantly lower perceived stress levels and the more they practiced the greater the reductions in stress, anxiety, and depression.

Hence, mindfulness improves the mental health of women with heart disease.

CMCS – Center for Mindfulness and Contemplative Studies

This and other Contemplative Studies posts are also available on the Contemplative Studies Blog http://contemplative-studies.org

Study Summary

Spruill TM, Park C, Kalinowski J, Arabadjian ME, Xia Y, Shallcross AJ, Visvanathan P, Smilowitz NR, Hausvater A, Bangalore S, Zhong H, Park K, Mehta PK, Thomas DK, Trost J, Bainey KR, Heydari B, Wei J, Dickson VV, Ogedegbe G, Berger JS, Hochman JS, Reynolds HR. Brief Mindfulness-Based Cognitive Therapy in Women With Myocardial Infarction: Results of a Multicenter Randomized Controlled Trial. JACC Adv. 2025 Jan 16;4(2):101530. doi: 10.1016/j.jacadv.2024.101530. PMID: 39898341; PMCID: PMC11786073.

Abstract

Background

Elevated perceived stress is associated with adverse outcomes following myocardial infarction (MI) and may account for poorer recovery among women vs men.

Objectives

This randomized controlled trial tested effects of a mindfulness-based intervention on stress levels among women with MI.

Methods

Women with elevated stress (Perceived Stress Scale [PSS-4]≥6) at least 2 months after MI were enrolled from 12 hospitals in the United States and Canada and via community advertising. Participants were randomized to a remotely delivered mindfulness intervention (MBCT-Brief) or heart disease education, both 8 weeks long. Follow-up was 6 months. Changes in stress (PSS-10; primary outcome) and secondary outcomes (depressive symptoms, anxiety, quality of life, disease-specific health status, actigraphy-assessed sleep) were compared between groups.

Results

The sample included 130 women with MI (mean age 59.8 ± 12.8 years, 34% racial/ethnic minorities). In intention-to-treat analysis, PSS-10 scores declined in the MBCT-Brief arm (−0.52 [95% CI: −0.77 to −0.28]) but not the heart disease education arm (−0.19 [95% CI: −0.45 to 0.06]; group×time interaction P = 0.070). The effect was stronger in per-protocol analysis of participants who completed ≥4 intervention sessions (P = 0.049). There were no significant differences in secondary outcomes in intention-to-treat or per-protocol analyses. Within the MBCT-Brief arm, more frequent mindfulness practice was associated with greater reductions in stress (P = 0.007), depressive symptoms (P = 0.017), and anxiety (P = 0.036).

Conclusions

MBCT-Brief was associated with greater 6-month reductions in stress than an active control among adherent participants. More frequent mindfulness practice was associated with greater improvements in psychological outcomes. Strategies to engage women with MI in mindfulness training and support regular home practice may enhance these effects.

Adding a Psychedelic Drug to Mindfulness Training Enhances Relief of Burnout and Depression

February 13, 2025 psyjdc Leave a comment

Combining psychedelics with meditation increases mindfulness and mystical-type transcendence

By John M. de Castro, Ph.D.

In today’s Research News article “Psilocybin-Assisted Group Psychotherapy + Mindfulness Based Stress Reduction (MBSR) for Frontline Healthcare Provider COVID-19 Related Depression and Burnout: A Randomized Clinical Trial” (See summary below or view the full text of the study at: https://pmc.ncbi.nlm.nih.gov/articles/PMC11722457/pdf/nihpp-2024.12.31.24319806v1.pdf ) Lewis and colleagues performed a randomized clinical trial of the effectiveness of Mindfulness training (8-wks of Mindfulness Based Stress Reduction – MBSR) with or without an additional Psychedelic drug (psilocybin) on the mental health of healthcare workers suffering from burnout and depression.

They found that the addition of the psychedelic drug significantly increased the relief of depression, burnout, and demoralization and the improvement of connectedness produced by the mindfulness training.

Hence, psychedelic drugs enhance the effectiveness of mindfulness training on burnout.

CMCS – Center for Mindfulness and Contemplative Studies

This and other Contemplative Studies posts are also available on the Contemplative Studies Blog http://contemplative-studies.org

Study Summary

Lewis BR, Hendrick J, Byrne K, Odette M, Wu C, Garland EL. Psilocybin-Assisted Group Psychotherapy + Mindfulness Based Stress Reduction (MBSR) for Frontline Healthcare Provider COVID-19 Related Depression and Burnout: A Randomized Clinical Trial. medRxiv [Preprint]. 2025 Jan 1:2024.12.31.24319806. doi: 10.1101/2024.12.31.24319806. PMID: 39802794; PMCID: PMC11722457.

Abstract

Objective

This clinical trial sought to evaluate the safety and preliminary efficacy of psilocybin and MBSR for frontline healthcare providers with symptoms of depression and burnout related to the COVID-19 pandemic.

Methods

This was a randomized controlled trial that enrolled physicians and nurses with frontline clinical work during the COVID-19 pandemic and symptoms of depression and burnout. Participants were randomized in a 1:1 ratio to either an 8-week MBSR curriculum alone or an 8-week MBSR curriculum plus group psilocybin-assisted psychotherapy (PAP) with 25mg psilocybin. Symptoms of depression and burnout were assessed at baseline, and 2-weeks and 6-months post intervention utilizing the Quick Inventory of Depressive Symptoms (QIDS-SR-16) and Maslach Burnout Inventory Human Services Survey for Medical Professionals (MBI-HSS-MP), respectively. Secondary outcome measures included the Demoralization Scale (DS-II) and the Watt’s Connectedness Scale (WCS). Adverse events and suicidality were assessed through 6-month follow-up.

Results

25 participants were enrolled and randomized. There were 12 study-related AEs recorded that were Grade 1-2 and no serious AEs. There was larger decrease in QIDS score for the MBSR+PAP arm compared to MBSR-only from baseline to 2-weeks post-intervention and significant between-group differences favoring MBSR+PAP on subscales of the MBI-HSS-MP as well as the DS-II and WCS.

Conclusions

Group psilocybin-assisted therapy plus MBSR was associated with clinically significant improvement in depressive symptoms without serious adverse events and with greater reduction in symptoms than MBSR alone. Study findings suggest that integrating psilocybin with mindfulness training may represent a promising treatment for depression and burnout among physicians and nurses.

Mindfulness and Humor Reduce Stress and Improve Well-Being

February 11, 2025 psyjdc Leave a comment

Mindfulness, Communication and Humor: Navigating Remission

By John M. de Castro, Ph.D.

In today’s Research News article “Mindfulness Interfused with Humor: Insights From a Randomized Controlled Trial of a Humor-Enriched Mindfulness-Based Program” (See summary below or view the full text of the study at: https://pmc.ncbi.nlm.nih.gov/articles/PMC11785597/ ) Kastner examined the effects of mindfulness training (Mindfulness Based Stress Reduction; MBSR) either alone or mixed with humor on participants well-being. They found that whether mixed with humor or not, mindfulness training reduced perceived stress and increased psychological well-being and life satisfaction.

So, mindfulness improves the psychological state of normal adults.

CMCS – Center for Mindfulness and Contemplative Studies

This and other Contemplative Studies posts are also available on the Contemplative Studies Blog http://contemplative-studies.org

Study Summary

Kastner CT. Mindfulness Interfused with Humor: Insights From a Randomized Controlled Trial of a Humor-Enriched Mindfulness-Based Program. Mindfulness (N Y). 2025;16(1):186-204. doi: 10.1007/s12671-024-02491-7. Epub 2025 Jan 6. PMID: 39898273; PMCID: PMC11785597.

Abstract

Objectives

Both mindfulness and humor are inherently connected to well-being. Recent research found evidence for their combined effect in a joint training, the Humor-Enriched Mindfulness-Based Program (HEMBP). This study extends these findings by exploring (1) effects of Mindfulness-Based Stress Reduction (MBSR) on different forms of humor, (2) differential effects of the HEMBP on outcomes compared to MBSR, and (3) whether the HEMBP and MBSR may alter worldviews.

Method

Ninety participants were randomly allocated to three conditions: the HEMBP, MBSR, and a wait-list control group. Participants’ mindfulness, psychological well-being, life satisfaction, perceived stress, comic styles, and primal world beliefs (primals) were assessed before and after the trainings, and at 1-, 3-, and 6-month follow-ups. Changes in outcome variables over time were modeled by applying linear mixed-effects models.

Results

The HEMBP enhanced participants’ mindfulness, benevolent humor, psychological well-being, and life satisfaction compared to the wait-list control. Similarly, MBSR increased participants’ mindfulness and life satisfaction while reducing perceived stress and primal good, but no effects on humor were observed. Comparison between the two trainings revealed trends toward a greater increase in benevolent humor in the HEMBP group and a greater decrease in good in the MBSR group.

Conclusion

The results largely replicate previous research on the efficacy of the HEMBP. Both programs demonstrated similar effects on outcomes, with only the HEMBP increasing benevolent humor and psychological well-being, while MBSR reduced stress. Further research is needed to investigate qualitative aspects of the integration of humor in MBPs and the long-term impact of MBPs on individuals’ worldviews.

Mindful Meditators are More Environmentally Friendly

January 27, 2025 psyjdc Leave a comment

May be an image of grass
By John M. de Castro, Ph.D.

In today’s Research News article “How does meditation relate to quality of life, positive lifestyle habits and carbon footprint?” (See summary below or view the full text of the study at: https://pmc.ncbi.nlm.nih.gov/articles/PMC11730546/) Somarathne and colleagues examined the environmentally friendly behaviors of skilled meditators. They found that meditator’s mindfulness was associated with higher levels of environmentally friendly behaviors.

Hence, mindfulness is associated with environmentally friendly behaviors.

CMCS – Center for Mindfulness and Contemplative Studies

This and other Contemplative Studies posts are also available on the Contemplative Studies Blog http://contemplative-studies.org

Study Summary

Somarathne EASK, Gunathunga MW, Lokupitiya E. How does meditation relate to quality of life, positive lifestyle habits and carbon footprint? Heliyon. 2024 Dec 12;11(1):e41144. doi: 10.1016/j.heliyon.2024.e41144. PMID: 39811348; PMCID: PMC11730546.

Abstract
There is increasing scientific interest in the potential links between meditation practice and pro-environmental behaviours. The present research investigates relationships between Vipassana meditation experience (temporal variables of meditation, five facets of trait mindfulness), positive lifestyle habits (PLH), quality of life (QoL) and per-head carbon footprint (CF) among 25 skilled meditators. Self-reported validated questionnaires were given to a group of native speakers of Sri Lanka to collect data on meditation experience, PLH, and perceived QoL. In estimating CF four domains (food and beverage consumption, electricity consumption, traveling and solid waste disposal) were considered. Correlation analyses revealed that trait mindfulness showed strong associations (r > 0.4) with PLH. None of the temporal variables of meditation experience was significantly correlated with any domain of CF. Two facets of mindfulness (observing and non-reactivity to present-moment experience) demonstrated statistically strong associations (p < 0.05) with perceived QoL. It was found that the PLH significantly mediates the relationship between the observing facet of trait mindfulness and CF associated with food and beverage consumption (indirect effect – 0.002, SE = 0.001 95 % CI [0.010, 0.417]). Further, the relationship between acting with awareness and CF associated with solid waste disposal at landfill sites was significantly mediated by the PLH (indirect effect – (−0.003), SE = 0.003 95 % CI [-0.012, −0.0001]). The current study will serve as a foundation for future longitudinal studies on the same subject by providing evidence for the relationships between meditation experience and PLH, perceived QoL and CF

Mindfulness Improves the Symptoms of Attention Deficit Hyperactivity Disorder (ADHD) in children and adolescents

January 23, 2025 psyjdc Leave a comment

child with ADHD symptoms By John M. de Castro, Ph.D.

In today’s Research News article “Assessing the impact of mindfulness programs on attention-deficit/ hyperactivity disorder in children and adolescents: a systematic review” (See summary below or view the full text of the study at: https://pmc.ncbi.nlm.nih.gov/articles/PMC11730125/) Sultan and colleagues review and summarize the research studies on the effectiveness of mindfulness training in treating the symptoms of attention deficit hyperactivity disorder (ADHD) in children and adolescents. They report that mindfulness training significantly improves attention and reduces hyperactivity and impulsiveness in children and adolescents.

Improve ADHD symptoms in children and adolescents with mindfulness.

CMCS – Center for Mindfulness and Contemplative Studies

This and other Contemplative Studies posts are also available on the Contemplative Studies Blog http://contemplative-studies.org

Study Summary

Sultan MA, Nawaz FA, Alattar B, Khalaf E, Shadan S, El-Abiary N, Tegginmani S, Qasba RK, Jogia J. Assessing the impact of mindfulness programs on attention-deficit/ hyperactivity disorder in children and adolescents: a systematic review. BMC Pediatr. 2025 Jan 14;25(1):32. doi: 10.1186/s12887-024-05310-z. PMID: 39810118; PMCID: PMC11730125. Abstract

Background

Attention Deficit Hyperactivity Disorder (ADHD) is a prevalent neurodevelopmental disorder which poses challenges for the individuals with the disorder and their families. While stimulant medications are effective, a comprehensive approach, including psychosocial and behavioral interventions, is recommended. There is a growing body of research exploring the potential benefits of mindfulness-based interventions for children with ADHD. Our study aims to assess the effectiveness of mindfulness interventions in reducing ADHD symptoms in children and adolescents through a systematic review of relevant studies.

Methods

Following PRISMA guidelines, our systematic review searched PubMed, Cochrane library, Psycinfo, and Scopus from January 2000 to August 2022. We included studies focusing on mindfulness for pediatric ADHD, comprising various study designs with a minimum 8-week duration. Descriptive statistics summarized results, while risk of bias was assessed using Cochrane RoB and ROBANS tools. The quality of RCTs was further evaluated using the Correlation of Quality Measures tool.

Results

In the initial search, 450 records were identified, and after removing duplicates, 339 underwent screening. Forty-one studies underwent full text assessment for eligibility, with 11 studies meeting inclusion criteria, including seven RCTs, two Quasi RCTs, and three cohort studies. These studies, conducted in five countries, involved participants aged 7 to 18 years. Six studies showed improvement in hyperactivity/inattentive symptoms, and five studies showed improvement in impulsivity.

Conclusions

This systematic review demonstrates the potential benefits of mindfulness programs on ADHD symptoms in children and adolescents. This study emphasizes the need for high-quality research to explore mindfulness-based interventions for ADHD management in younger populations.

Meditation Reduces Worker Stress

January 20, 2025 psyjdc Leave a comment

Study finds meditation with Headspace app reduces stress in pregnancy By John M. de Castro, Ph.D.

In today’s Research News article “Digital Meditation to Target Employee Stress” (See summary below or view the full text of the study at: https://jamanetwork.com/journals/jamanetworkopen/articlepdf/2829186/radin_2025_oi_241525_1736185782.29032.pdf) Radin and colleagues performed a controlled clinical trial and found that 10 minutes of daily meditation significantly reduced stress levels in employees of a university health system.

CMCS – Center for Mindfulness and Contemplative Studies

Radin RM, Vacarro J, Fromer E, Ahmadi SE, Guan JY, Fisher SM, Pressman SD, Hunter JF, Sweeny K, Tomiyama AJ, Hofschneider LT, Zawadzki MJ, Gavrilova L, Epel ES, Prather AA. Digital Meditation to Target Employee Stress: A Randomized Clinical Trial. JAMA Netw Open. 2025 Jan 2;8(1):e2454435. doi: 10.1001/jamanetworkopen.2024.54435. PMID: 39808431; PMCID: PMC11733700.

Study Summary

This randomized clinical trial investigates whether a digital mindfulness meditation application reduces perceptions of global and job-related stress among adults employed at a large academic medical center.

Key Points

Question

Can digital mindfulness meditation improve general stress and work-related stress among employees at a large academic medical center?

Findings

In this randomized clinical trial of 1458 employees, those who received mindfulness meditation (vs waiting list control) had significant reductions in perceived stress at 8 weeks.

Meaning

The findings suggest that participating in a brief digital mindfulness-based program is an effective method for reducing general and work-related stress in employees.

Abstract

Importance

Mindfulness meditation may improve well-being among employees; however, effects of digital meditation programs are poorly understood.

Objective

To evaluate the effects of digital meditation vs a waiting list condition on general and work-specific stress and whether greater engagement in the intervention moderates these effects.

Design, Setting, and Participants

This randomized clinical trial included a volunteer sample of adults (aged ≥18 years) employed at a large academic medical center who reported mild to moderate stress, had regular access to a web-connected device, and were fluent in English. Exclusion criteria included being a regular meditator. Participants were recruited from May 16, 2018, through September 28, 2019, and completed baseline, 8-week, and 4-month measures assessing stress, job strain, burnout, work engagement, mindfulness, depression, and anxiety. Data were analyzed from March 2023 to October 2024.

Intervention

Participants were randomized 1:1 to a digital meditation program or the waiting list control condition. Participants in the intervention group were instructed to complete 10 minutes of meditation per day for 8 weeks. The control group was instructed to continue their normal activities and not add any meditation during the study period.

Main Outcomes and Measures

The primary outcome measure was change in Perceived Stress Scale (PSS) score at 8 weeks. Secondary outcome measures included changes in job strain, measured as work effort-reward imbalance.

Results

A total of 1458 participants (mean [SD] age, 35.54 [10.30] years; 1178 [80.80%] female) were included. Those randomized to meditation (n = 728) vs waiting list (n = 730) showed improvements in PSS (Cohen d, 0.85; 95% CI, 0.73-0.96) and in all secondary outcome measures (eg, job strain: Cohen d, 0.34; 95% CI, 0.23-0.46) at 8 weeks. These improvements were maintained at 4 months after randomization (PSS: Cohen d, 0.71; 95% CI, 0.59-0.84; job strain: Cohen d, 0.37; 95% CI, 0.25-0.50). Those using the app from 5 to 9.9 min/d vs less than 5 min/d showed greater reduction in stress (mean PSS score difference, −6.58; 95% CI, −7.44 to −5.73).

Conclusions and Relevance

The findings suggest that a brief, digital mindfulness-based program is an easily accessible and scalable method for reducing perceptions of stress. Future work should seek to clarify mechanisms by which such interventions contribute to improvements in work-specific well-being

This and other Contemplative Studies posts are also available on the Contemplative Studies Blog http://contemplative-studies.org

Meditation is an Effective Therapy for Post-Traumatic Stress Disorder (PTSD)

January 16, 2025 psyjdc Leave a comment

Meditation is an Effective Therapy for Post-Traumatic Stress Disorder (PTSD).

By John M. de Castro, Ph.D.

In today’s Research News article “Effectiveness of Meditation Techniques in Treating Post-Traumatic Stress Disorder: A Systematic Review and Meta-Analysis” (See summary below) Orme-Johnson summarized the published controlled research on the effectiveness of various meditation techniques on Post-traumatic stress disorder (PTSD). They found that the published controlled research demonstrated significant reductions in PTSD symptoms regardless of the meditation technique in veterans, refugees, earthquake victims, prisoners, and civilians.

Hence, mindfulness meditation is an effective treatment for Post-traumatic stress disorder (PTSD).

CMCS – Center for Mindfulness and Contemplative Studies

This and other Contemplative Studies posts are also available on the Contemplative Studies Blog http://contemplative-studies.org

Study Summary

Orme-Johnson DW, Barnes VA, Rees B, Tobin J, Walton KG. Effectiveness of Meditation Techniques in Treating Post-Traumatic Stress Disorder: A Systematic Review and Meta-Analysis. Medicina (Kaunas). 2024 Dec 12;60(12):2050. doi: 10.3390/medicina60122050. PMID: 39768929; PMCID: PMC11678240.

https://pmc.ncbi.nlm.nih.gov/articles/PMC11678240/pdf/medicina-60-02050.pdf

Abstract

Background and Objectives: Post-traumatic stress disorder (PTSD) is a debilitating condition worldwide. The limited effectiveness of current psychological and pharmacological treatments has motivated studies on meditation techniques. This study is a comprehensive, multiple-treatments meta-analysis comparing the effectiveness of different categories of meditation in treating PTSD. Methods and Materials: We followed Prisma guidelines in our published protocol to search major databases and to conduct a meta-analysis of the studies. Results: We located 61 studies with 3440 subjects and divided them logically into four treatment groups: Mindfulness-Based Stress Reduction (MBSR, 13 studies); Mindfulness-Based Other techniques (MBO, 16 studies), Transcendental Meditation (TM, 18 studies), and Other Meditations that were neither mindfulness nor TM (OM, 14 studies). Trauma populations included war veterans, war refugees, earthquake and tsunami victims, female survivors of interpersonal violence, clinical nurses, male and female prison inmates, and traumatized students. Of those offered, 86% were willing to try meditation. The baseline characteristics of subjects were similar across meditation categories: mean age = 52.2 years, range 29–75; sample size = 55.4, range 5–249; % males = 65.1%, range 0–100; and maximum study duration = 13.2 weeks, range 1–48. There were no significant differences between treatment categories on strength of research design nor evidence of publication bias. The pooled mean effect sizes in Hedges’s g for the four categories were MBSR = −0.52, MBO = −0.66, OM = −0.63, and TM = −1.13. There were no appreciable differences in the study characteristics of research conducted on different meditations in terms of the types of study populations included, outcome measures, control conditions, gender, or length of time between the intervention and assessment of PTSD. TM’s effect was significantly larger than for each of the other categories, which did not differ from each other. No study reported serious side effects. Conclusions: All categories of meditation studied were helpful in mitigating symptoms of PTSD. TM produced clinically significant reductions in PTSD in all trauma groups. We recommend a multisite Phase 3 clinical trial to test TM’s efficacy compared with standard treatment.

January 3, 2025 psyjdc Leave a comment

May be an image of 1 person and sleepwear Mindfulness Meditation Reduces Pain.

By John M. de Castro, Ph.D.

In today’s Research News article “Mindfulness Meditation and Placebo Modulate Distinct Multivariate Neural Signatures to Reduce Pain” (See summary below) Riegner and colleagues demonstrate that mindfulness meditation reduces both subjective pain and the brain responses to pain to a greater extent than a placebo.

Hence, mindfulness meditation is an effective treatment for pain.

CMCS – Center for Mindfulness and Contemplative Studies

This and other Contemplative Studies posts are also available on the Contemplative Studies Blog http://contemplative-studies.org

Study Summary

Riegner G, Dean J, Wager TD, Zeidan F. Mindfulness Meditation and Placebo Modulate Distinct Multivariate Neural Signatures to Reduce Pain. Biol Psychiatry. 2025 Jan 1;97(1):81-88. doi: 10.1016/j.biopsych.2024.08.023. Epub 2024 Aug 30. PMID: 39216636; PMCID: PMC11608143.

Abstract

Background: Rather than a passive reflection of nociception, pain is shaped by the interplay between one’s experiences, current cognitive-affective states, and expectations. The placebo response, a paradoxical yet reliable phenomenon, is postulated to reduce pain by engaging mechanisms shared with active therapies. It has been assumed that mindfulness meditation, practiced by sustaining nonjudgmental awareness of arising sensory events, merely reflects mechanisms evoked by placebo. Recently, brain-based multivariate pattern analysis has been validated to successfully disentangle nociceptive-specific, negative affective, and placebo-based dimensions of the subjective pain experience.

Methods: To determine whether mindfulness meditation engages distinct brain mechanisms from placebo and sham mindfulness to reduce pain, multivariate pattern analysis pain signatures were applied across 2 randomized clinical trials that employed overlapping psychophysical pain testing procedures (49 °C noxious heat; visual analog pain scales) and distinct functional magnetic resonance imaging techniques (blood oxygen level-dependent; perfusion based). After baseline pain testing, 115 healthy participants were randomized into a 4-session mindfulness meditation (n = 37), placebo-cream conditioning (n = 19), sham mindfulness meditation (n = 20), or book-listening control (n = 39) intervention. After each intervention, noxious heat was administered during functional magnetic resonance imaging and each manipulation.

Results: A double dissociation in the multivariate pattern analysis signatures supporting pain regulation was revealed by mindfulness meditation compared with placebo cream. Mindfulness meditation produced significantly greater reductions in pain intensity and pain unpleasantness ratings and nociceptive-specific and negative affective pain signatures than placebo cream, sham mindfulness meditation, and control interventions. The placebo-cream group significantly lowered the placebo-based signature.

Conclusions: Mindfulness meditation and placebo engaged distinct and granular neural pain signatures to reduce pain.

Mindfulness Protects Against Depression and Psychopathology in Alzheimer’s Disease

November 28, 2023 psyjdc Leave a comment

By John M. de Castro, Ph.D.

“People do not realize that Alzheimer’s is not old age. It is a progressive and fatal disease and staggering amounts of people develop Alzheimer’s every day.” – Melina Kanakaredes

The normal aging process involves a systematic progressive decline in every system in the body, the brain included. The elderly often have problems with attention, thinking, and memory, known as mild cognitive impairment. But sometimes the decline is rapid and results in dementia; a progressive loss of mental function produced by degenerative diseases of the brain. It is quite common with about 3% of adults ages 70 to 74, 22% of adults ages 85 to 89 and 33% of adults ages 90 and older. Between 60% to 80% of dementia cases are classified as Alzheimer’s Disease.

An encouraging new development is that mindfulness practices such as meditation training and mindful movement practices can significantly reduce these declines in cognitive ability and dementia. In addition, it has been found that mindfulness practices reduce the deterioration of the brain that occurs with aging restraining the loss of neural tissue. This suggests that mindfulness may help to relieve some of the symptoms and/or slow the progression of mild Alzheimer’s Disease.

In today’s Research News article “Mindfulness Prevents Depression and Psychopathology in Elderly People with Mild to Moderate Alzheimer’s Disease: A Randomized Clinical Trial.” (See summary below or view the full text of the study at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9881020/) Quintana-Hernández and colleagues recruited elderly patients with mild to moderate Alzheimer’s Disease and randomly assigned them to one of four conditions; Mindfulness-based Alzheimer’s Stimulation; CS, Cognitive Stimulation; PMR, Progressive Muscle Relaxation; or no treatment. All participants received 3 weekly sessions for 2 years combined with daily 10 mg Donepezil. They were measured for depression, geriatric depression, and neuropsychological symptoms at baseline or 6, 12, 18, and 24 months later.

They found that the groups did not differ at baseline but that the Mindfulness-based Alzheimer’s Stimulation group had significantly lower scores than the other 3 groups at the 6-, 12-, 18-, and 24-months for depression, insomnia, agitation, anxiety, somatic symptoms, weight loss, delusions, apathy, irritability, and night time behaviors and higher levels of appetite and insight. These measures for the mindfulness group did not differ from baseline at any follow up while the other 3 groups significantly deteriorated over time relative to baseline.

These findings suggest that mindfulness training prevents deterioration in depression and psychopathology while other treatments or no treatment continue to deteriorate. Hence mindfulness training would appear be beneficial in the treatment of patients with mild to moderate Alzheimer’s Disease.

“You only know yourself because of your memories.” – Andrea Gillies

CMCS – Center for Mindfulness and Contemplative Studies

This and other Contemplative Studies posts are also available on the Contemplative Studies Blog http://contemplative-studies.org

Study Summary

Quintana-Hernández DJ, Rojas-Hernández J, Santana-Del Pino A, Céspedes Suárez C, Pellejero Silva M, Miró-Barrachina MT, Ibáñez Fernández I, Estupiñán López JA, Borkel LF. Mindfulness Prevents Depression and Psychopathology in Elderly People with Mild to Moderate Alzheimer’s Disease: A Randomized Clinical Trial. J Alzheimers Dis. 2023;91(1):471-481. doi: 10.3233/JAD-220889. PMID: 36442199; PMCID: PMC9881020.

Abstract

Background:

This longitudinal study addressed whether mindfulness practice prevents psychological and behavioral symptoms, especially mood disorders, in Alzheimer’s disease (AD).

Objective:

To assess the incidence of depression in the course of AD and to determine which non-pharmacological treatment (NPT) is most effective in preventing psychopathological symptoms.

Methods:

We conducted a longitudinal, non-inferiority and equivalence randomized clinical trial, repeated-measures design, with a control group and three experimental treatments: mindfulness, cognitive stimulation, and relaxation. Each experimental group performed three weekly sessions for two years. The pharmacological treatment of all participants was donepezil (10 mg). Participants were patients with probable AD without diagnosed depression from the public neurology services of the Canary Health Service, Spain. Psychological evaluation was performed using the Geriatric Depression Scale (GDS), Hamilton Depression Rating Scale (HDRS), and Neuropsychiatric Inventory (NPI-Q). The statistical analysis included only patients who attended at least 75% of the sessions. A nonparametric, repeated-measures analysis was performed with Kruskal-Wallis H test and between-group differences with Mann-Whitney U test with Bonferroni correction (p < 0.008). Effect size was calculated with partial eta-squared.

Results:

The results showed significant differences with large effect sizes (η2p>0.14) between mindfulness and the rest of the experimental groups as well as the control in the GDS, HDRS, and NPI-Q scales.

Conclusion:

Compared to the other experimental groups, only mindfulness prevented the onset of depression and other psychopathologies in early-stage AD. Based on its effectiveness in maintaining cognitive functions and preventing psychopathology, we recommend mindfulness as the first-choice NPT for mild to moderate AD.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9881020/