Meditation

Reduce Opioid-Treated Pain and Opioid Dosage with Mindfulness

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Reduce Opioid-Treated Pain and Opioid Dosage with Mindfulness

 

By John M. de Castro, Ph.D.

 

“Mind-body therapies — including meditation, cognitive behavioral therapy and hypnosis — were associated with improvements in pain and reduced opioid doses.” – Erin Michael

 

We all have to deal with pain. It’s inevitable, but hopefully it’s mild and short lived. For a wide swath of humanity, however, pain is a constant in their lives. At least 100 million adult Americans have chronic pain conditions. The most common treatment for chronic pain is drugs. These include over-the-counter analgesics and opioids. But opioids are dangerous and highly addictive. Prescription opioid overdoses kill more than 14,000 people annually. So, there is a great need to find safe and effective ways to lower the psychological distress and improve the individual’s ability to cope with the pain.

 

There is an accumulating volume of research findings that demonstrate that mindfulness practices, in general, are effective in treating pain. What is not known is the most effective mind-body treatments for chronic pain. There are a large variety of mind-body therapies including meditation, hypnosis, relaxation, guided imagery, therapeutic suggestion, and Cognitive Behavioral Therapy (CBT). It is not known which are the most effective for reducing pain and opioid use in patients with chronic pain who are being treated with opioids.

 

In today’s Research News article “Mind-Body Therapies for Opioid-Treated Pain: A Systematic Review and Meta-analysis.” (See summary below or view the full text of the study at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6830441/ ) Garland and colleagues review, summarize, and perform a meta-analysis of the published randomized controlled trials of the effectiveness of mind-body techniques for opioid-treated pain. They identified 60 published trials.

 

They report that the published research found that the studies that used Mind-Body Therapies produced significant reductions in pain outcomes and opioid use. This was true for studies that employed meditation, hypnosis, or Cognitive Behavioral Therapy (CBT), with the largest effect sizes found for meditation. Suggestion, imagery, and relaxation were all found to be less effective.

 

Hence, the published randomized controlled trials support the use of Mind-Body Therapies for the treatment of patients with chronic pain who are being treated with opioids. Meditation, hypnosis, or Cognitive Behavioral Therapy (CBT) are particularly effective in both treating pain and reducing opioid use. This is compatible with other results that mindfulness meditation has been repeatedly shown to reduce pain and improve recovery from opioid addiction.

 

Meditation, hypnosis, or Cognitive Behavioral Therapy (CBT) have a common property of changing the patient’s thought patterns associated with their pain and thereby alter their relationship with the pain. These thought patterns such as worry, rumination, and catastrophizing tend to amplify the physical pain. Reducing these tendencies can eliminate the amplification and thereby reduce the experienced pain. With less pain, less opioids are needed to control it.

 

So, reduce opioid-treated pain and opioid dosage with mindfulness.

 

“Using mindfulness, meditation, hypnosis, therapeutic suggestion, and cognitive behavior therapy, in addition to opioid treatment of acute or chronic pain, provides an additional benefit to patients by reducing pain scores. Some of these interventions will decrease the duration or amount of opioid needed.” – Sumi Sexton

 

CMCS – Center for Mindfulness and Contemplative Studies

 

This and other Contemplative Studies posts are also available on Google+ https://plus.google.com/106784388191201299496/posts and on Twitter @MindfulResearch

 

Study Summary

 

Garland, E. L., Brintz, C. E., Hanley, A. W., Roseen, E. J., Atchley, R. M., Gaylord, S. A., Faurot, K. R., Yaffe, J., Fiander, M., & Keefe, F. J. (2019). Mind-Body Therapies for Opioid-Treated Pain: A Systematic Review and Meta-analysis. JAMA internal medicine, 180(1), 91–105. Advance online publication. https://doi.org/10.1001/jamainternmed.2019.4917

 

Key Points

Question

Are mind-body therapies (ie, meditation, hypnosis, relaxation, guided imagery, therapeutic suggestion, and cognitive behavioral therapy) associated with pain reduction and opioid-related outcome improvement among adults using opioids for pain?

Findings

In this systematic review and meta-analysis of 60 randomized clinical trials with 6404 participants, mind-body therapies were associated with improved pain (Cohen d = −0.51; 95% CI, −0.76 to −0.27) and reduced opioid dose (Cohen d = −0.26; 95% CI, −0.44 to −0.08).

Meaning

Practitioners should be aware that mind-body therapies may be associated with moderate improvements in pain and small reductions in opioid dose.

Abstract

Importance

Mind-body therapies (MBTs) are emerging as potential tools for addressing the opioid crisis. Knowing whether mind-body therapies may benefit patients treated with opioids for acute, procedural, and chronic pain conditions may be useful for prescribers, payers, policy makers, and patients.

Objective

To evaluate the association of MBTs with pain and opioid dose reduction in a diverse adult population with clinical pain.

Data Sources

For this systematic review and meta-analysis, the MEDLINE, Embase, Emcare, CINAHL, PsycINFO, and Cochrane Library databases were searched for English-language randomized clinical trials and systematic reviews from date of inception to March 2018. Search logic included (pain OR analgesia OR opioids) AND mind-body therapies. The gray literature, ClinicalTrials.gov, and relevant bibliographies were also searched.

Study Selection

Randomized clinical trials that evaluated the use of MBTs for symptom management in adults also prescribed opioids for clinical pain.

Data Extraction and Synthesis

Independent reviewers screened citations, extracted data, and assessed risk of bias. Meta-analyses were conducted using standardized mean differences in pain and opioid dose to obtain aggregate estimates of effect size with 95% CIs.

Main Outcomes and Measures

The primary outcome was pain intensity. The secondary outcomes were opioid dose, opioid misuse, opioid craving, disability, or function.

Results

Of 4212 citations reviewed, 60 reports with 6404 participants were included in the meta-analysis. Overall, MBTs were associated with pain reduction (Cohen d = −0.51; 95% CI, −0.76 to −0.26) and reduced opioid dose (Cohen d = −0.26; 95% CI, −0.44 to −0.08). Studies tested meditation (n = 5), hypnosis (n = 25), relaxation (n = 14), guided imagery (n = 7), therapeutic suggestion (n = 6), and cognitive behavioral therapy (n = 7) interventions. Moderate to large effect size improvements in pain outcomes were found for meditation (Cohen d = −0.70), hypnosis (Cohen d = −0.54), suggestion (Cohen d = −0.68), and cognitive behavioral therapy (Cohen d = −0.43) but not for other MBTs. Although most meditation (n = 4 [80%]), cognitive-behavioral therapy (n = 4 [57%]), and hypnosis (n = 12 [63%]) studies found improved opioid-related outcomes, fewer studies of suggestion, guided imagery, and relaxation reported such improvements. Most MBT studies used active or placebo controls and were judged to be at low risk of bias.

Conclusions and Relevance

The findings suggest that MBTs are associated with moderate improvements in pain and small reductions in opioid dose and may be associated with therapeutic benefits for opioid-related problems, such as opioid craving and misuse. Future studies should carefully quantify opioid dosing variables to determine the association of mind-body therapies with opioid-related outcomes.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6830441/Importance

Mind-body therapies (MBTs) are emerging as potential tools for addressing the opioid crisis. Knowing whether mind-body therapies may benefit patients treated with opioids for acute, procedural, and chronic pain conditions may be useful for prescribers, payers, policy makers, and patients.

Lower Cardiovascular Disease Risk by Improving Emotion Regulation with Mindfulness

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Lower Cardiovascular Disease Risk by Improving Emotion Regulation with Mindfulness

 

By John M. de Castro, Ph.D.

 

“People who meditate regularly reported feeling more balanced and less stressed, and . . . improved the outcomes when they were added to cardiac rehabilitation programmes for patients with CHD.” – Heart Matters

 

Cardiovascular disease is the number one killer. A myriad of treatments has been developed including a variety of surgical procedures and medications. In addition, lifestyle changes have proved to be effective including quitting smoking, weight reduction, improved diet, physical activity, and reducing stresses. Unfortunately, for a variety of reasons, 60% of cardiovascular disease patients decline engaging in these lifestyle changes, making these patients at high risk for another attack.

 

Contemplative practices have been shown to be safe and effective alternative treatments for cardiovascular disease. Practices such as meditation, tai chi, and yoga, have been shown to be helpful for heart health and to reduce the physiological and psychological responses to stress. They have also been shown to be effective in maintaining cardiovascular health and the treatment of cardiovascular disease. The means by which mindfulness reduces cardiovascular disease risk have not been explored using the qualitative experiences of the patients.

 

In today’s Research News article “Mindfulness and cardiovascular health: Qualitative findings on mechanisms from the mindfulness-based blood pressure reduction (MB-BP) study.” (See summary below or view the full text of the study at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7510988/ ) Nardi and colleagues recruited patients with hypertension who had participated in a study of the effectiveness of Mindfulness-Based Stress Reduction (MBSR) modified for hypertension, to reduce blood pressure. The participants participated in focus groups or were interviewed individually with semi-structured interviews. The groups and interviews focused on their experiences with the intervention and its effects. Transcripts of the responses were subjected to thematic analysis to identify common themes and ideas.

 

They found that the participants practiced breath awareness and body scans most in their everyday lives. Breath awareness allowed them to pause and relax to better address issues while the body scans made them more aware of their bodily states. These practices produced a greater awareness of the present moment and their responses to emotional situations allowing them to better regulate their emotions in these situations. They learned to apply self-kindness rather than self-criticism and to direct attention to mindfulness when stressful situations came up rather than worrying about them. All of this resulted in the improved ability to deal with their emotions. The participants indicated that they used the emotion regulation abilities to effectively deal with stress, learning to relax in the face of stress. This led to important changes in their health behaviors particularly diet.

 

These qualitative results suggest that the mindfulness program improved the patients’ cardiovascular health. It provided them with tools to employ when emotional situations arose to heighten their awareness of exactly what was transpiring and how they felt in the present moment. This resulted in better regulation of emotions which in turn led to better responses to stress and improved health behaviors.

 

These qualitative results correspond to the results of controlled empirical studies of the effects of mindfulness training on a wide variety of individuals and conditions. These studies found that mindfulness training produced improved emotion regulation, increased self-kindness, improved responses to stress, and improved cardiovascular health.  Hence, mindfulness training provides individuals with skills that improve their lives and well-beeing.

 

So, lower cardiovascular disease risk by improving emotion regulation with mindfulness.

 

“there are four things that have scientifically been shown to reduce the risk of a heart attack in patients with mild to moderate coronary artery disease and they include – reduced stress (use meditation to do so), diet, exercise and love.” – Jeena Cho

 

CMCS – Center for Mindfulness and Contemplative Studies

 

This and other Contemplative Studies posts are a also available on Google+ https://plus.google.com/106784388191201299496/posts and on Twitter @MindfulResearch

 

Study Summary

 

Nardi, W. R., Harrison, A., Saadeh, F. B., Webb, J., Wentz, A. E., & Loucks, E. B. (2020). Mindfulness and cardiovascular health: Qualitative findings on mechanisms from the mindfulness-based blood pressure reduction (MB-BP) study. PloS one, 15(9), e0239533. https://doi.org/10.1371/journal.pone.0239533

 

Abstract

Background

Mindfulness-based programs hold promise for improving cardiovascular health (e.g. physical activity, diet, blood pressure). However, despite theoretical frameworks proposed, no studies have reported qualitative findings on how study participants themselves believe mindfulness-based programs improved their cardiovascular health. With an emphasis on in-depth, open-ended investigation, qualitative methods are well suited to explore the mechanisms underlying health outcomes. The objective of this qualitative study was to explore the mechanisms through which the mindfulness-based program, Mindfulness-Based Blood Pressure Reduction (MB-BP), may influence cardiovascular health.

Methods

This qualitative study was conducted as part of a Stage 1 single arm trial with one-year follow-up. The MB-BP curriculum was adapted from Mindfulness-Based Stress Reduction to direct participants’ mindfulness skills towards modifiable determinants of blood pressure. Four focus group discussions were conducted (N = 19 participants), and seven additional participants were selected for in-depth interviews. Data analysis was conducted using the standard approach of thematic analysis. Following double-coding of audio-recorded transcripts, four members of the study team engaged in an iterative process of data analysis and interpretation.

Results

Participants identified self-awareness, attention control, and emotion regulation as key mechanisms that led to improvements in cardiovascular health. Within these broader themes, many participants detailed a process beginning with increased self-awareness to sustain attention and regulate emotions. Many also explained that the specific relationship between self-awareness and emotion regulation enabled them to respond more skillfully to stressors. In a secondary sub-theme, participants suggested that higher self-awareness helped them engage in positive health behaviors (e.g. healthier dietary choices).

Conclusion

Qualitative analyses suggest that MB-BP mindfulness practices allowed participants to engage more effectively in self-regulation skills and behaviors lowering cardiovascular disease risk, which supports recent theory. Results are consistent with quantitative mechanistic findings showing emotion regulation, perceived stress, interoceptive awareness, and attention control are influenced by MB-BP.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7510988/

 

Ethnicity Modulates Improvements in Sleep in Prehypertensive Patients with a Smartphone Meditation App

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Ethnicity Modulates Improvements in Sleep in Prehypertensive Patients with a Smartphone Meditation App

 

“Several practices that help calm the mind can also lower blood pressure. All are types of meditation.” – Harvard Health

 

By John M. de Castro, Ph.D.

 

High Blood Pressure (Hypertension) is an insidious disease because there are no overt symptoms. The individual feels fine. But it can be deadly as more than 360,000 American deaths, roughly 1,000 deaths each day, had high blood pressure as a primary or contributing cause. In addition, hypertension markedly increases the risk heart attack, stroke, heart failure, and kidney disease.  It is also a very common disorder with about 70 million American adults (29%) having high blood pressure and only about half (52%) of people with high blood pressure have their condition under control. Treatment frequently includes antihypertensive drugs. But these medications often have adverse side effects. So, patients feel lousy when taking the drugs, but fine when they’re not. So, compliance is a major issue with many patients not taking the drugs regularly or stopping entirely.

 

Obviously, there is a need for alternative to drug treatments for hypertension. Mindfulness practices have been shown to aid in controlling hypertension. The vast majority of the mindfulness training techniques, however, require a trained teacher. This results in costs that many patients can’t afford. In addition, the participants must be available to attend multiple sessions at particular scheduled times that may or may not be compatible with their busy schedules and at locations that may not be convenient. As an alternative, Apps for smartphones have been developed. These have tremendous advantages in decreasing costs, making training schedules much more flexible, and eliminating the need to go repeatedly to specific locations.

 

In today’s Research News article “Ethnicity Differences in Sleep Changes Among Prehypertensive Adults Using a Smartphone Meditation App: Dose-Response Trial.” (See summary below or view the full text of the study at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7576537/ ) Sieverdes and colleagues recruited patients diagnosed with prehypertension. They had the participants use a smartphone app, “Tension Tamer” for 6 months. The app provided focused breath following meditation practice and also measured heart rate and blood pressure. The participants were randomized into 3 dosage groups, 5, 10, or 15 minutes of daily practice. They were measured before and after training and at 1 and 3-months during training for sleep with a self-reports and 7-days of wrist actigraphy which also measured activity levels.

 

They found that the 47% of the participants who were African American had significantly shorter sleep durations, poorer sleep quality, and greater sleep disturbance at baseline both in the self-report and actigraphy measures than non-Hispanic white participants. They also found that the effects of the meditation app on sleep varied according to ethnic group. For the Non-Hispanic White participants, the 5-minute per day dose of “Tension timer” use produced significantly greater improvements in sleep efficiency and quality, lower fragmentation, and longer sleep duration than the 10 or 15-minute doses. For the African American participants, the 5-minute dose produced significantly less sleep fragmentation and duration than the 10 or 15-minute doses. In comparing the ethnic groups, they found that the Non-Hispanic White participants had significantly greater improvements in sleep efficiency, reduced fragmentation, and longer sleep duration than the African American participants.

 

These results are interesting and suggest that smartphone app guided meditation practice improves sleep in patients diagnosed as prehypertensive. But the effects are less positive for African American participants than Non-Hispanic White participants. This is a bit surprising as African American participants appear to have more problematic sleep to start with and hence had greater room for improvement. It is also surprising that the lower amount of meditation practice, 5-minutes per day, was more beneficial that the longer daily meditations. It appears that the 5-minute practice participants tended to use the app more often and to use it more often just prior to going to bed than the other dose participants and this may have led to the differences.

 

Improving sleep is important in promoting relaxation and reducing the likelihood that prehypertension will progress to patent hypertension. So, the use of the app may be helpful in maintaining the health of prehypertensive patients. The ethnic differences, however, suggest that app usage may be more beneficial for white as opposed to black participant. The results also suggest that brief daily practice, 5-minutes, may promote more frequent use that improves effectiveness.

 

So, ethnicity modulates improvements in sleep in prehypertensive patients with a smartphone meditation app.

 

“If you struggle with “turning your brain off”, you may find yourself feeling restless and unable to sleep. Fortunately, meditation is one way to quiet your thoughts and fight insomnia. Meditation has been shown to help people who struggle with insomnia and other sleep disturbances.“ – Florida Medical Clinic

 

CMCS – Center for Mindfulness and Contemplative Studies

 

This and other Contemplative Studies posts are also available on Google+ https://plus.google.com/106784388191201299496/posts and on Twitter @MindfulResearch

 

Study Summary

 

Sieverdes, J. C., Treiber, F. A., Kline, C. E., Mueller, M., Brunner-Jackson, B., Sox, L., Cain, M., Swem, M., Diaz, V., & Chandler, J. (2020). Ethnicity Differences in Sleep Changes Among Prehypertensive Adults Using a Smartphone Meditation App: Dose-Response Trial. JMIR formative research, 4(10), e20501. https://doi.org/10.2196/20501

 

Abstract

Background

African Americans (AAs) experience greater sleep quality problems than non-Hispanic Whites (NHWs). Meditation may aid in addressing this disparity, although the dosage levels needed to achieve such benefits have not been adequately studied. Smartphone apps present a novel modality for delivering, monitoring, and measuring adherence to meditation protocols.

Objective

This 6-month dose-response feasibility trial investigated the effects of a breathing awareness meditation (BAM) app, Tension Tamer, on the secondary outcomes of self-reported and actigraphy measures of sleep quality and the modulating effects of ethnicity of AAs and NHWs.

Methods

A total of 64 prehypertensive adults (systolic blood pressure <139 mm Hg; 31 AAs and 33 NHWs) were randomized into 3 different Tension Tamer dosage conditions (5,10, or 15 min twice daily). Sleep quality was assessed at baseline and at 1, 3, and 6 months using the Pittsburgh Sleep Quality Index (PSQI) and 1-week bouts of continuous wrist actigraphy monitoring. The study was conducted between August 2014 and October 2016 (IRB #Pro00020894).

Results

At baseline, PSQI and actigraphy data indicated that AAs had shorter sleep duration, greater sleep disturbance, poorer efficiency, and worse quality of sleep (range P=.03 to P<.001). Longitudinal generalized linear mixed modeling revealed a dose effect modulated by ethnicity (P=.01). Multimethod assessment showed a consistent pattern of NHWs exhibiting the most favorable responses to the 5-min dose; they reported greater improvements in sleep efficiency and quality as well as the PSQI global value than with the 10-min and 15-min doses (range P=.04 to P<.001). Actigraphy findings revealed a consistent, but not statistically significant, pattern in the 5-min group, showing lower fragmentation, longer sleep duration, and higher efficiency than the other 2 dosage conditions. Among AAs, actigraphy indicated lower sleep fragmentation with the 5-min dose compared with the 10-min and 15-min doses (P=.03 and P<.001, respectively). The 10-min dose showed longer sleep duration than the 5-min and 15-min doses (P=.02 and P<.001, respectively). The 5-min dose also exhibited significantly longer average sleep than the 15-min dose (P=.03).

Conclusions

These findings indicate the need for further study of the potential modulating influence of ethnicity on the impact of BAM on sleep indices and user-centered exploration to ascertain the potential merits of refining the Tension Tamer app with attention to cultural tailoring among AAs and NHWs with pre-existing sleep complaints.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7576537/

 

Improve Psychological Health with a Self-Guided, Smartphone-Based Mindfulness App

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Improve Psychological Health with a Self-Guided, Smartphone-Based Mindfulness App

 

By John M. de Castro, Ph.D.

 

“Another part of the appeal of smartphone-based apps is their anonymity. “The apps also allow for privacy and confidentiality and can be a safe space for individuals who may be too ashamed to admit their mental health issues in person or who may feel that they will be negatively labeled or stigmatized by others,” – Sal Raichback

 

Mindfulness training has been shown through extensive research to be effective in improving physical and psychological health. But the vast majority of the mindfulness training techniques, however, require a trained therapist. This results in costs that many clients can’t afford. In addition, the participants must be available to attend multiple sessions at particular scheduled times that may or may not be compatible with their busy schedules and at locations that may not be convenient. As an alternative, mindfulness training with smartphone apps has been developed. These have tremendous advantages in decreasing costs, making training schedules much more flexible, and eliminating the need to go repeatedly to specific locations. In addition, research has indicated that mindfulness training via smartphone apps can be effective for improving the health and well-being of the participants.

 

In today’s Research News article “Testing the Efficacy of a Multicomponent, Self-Guided, Smartphone-Based Meditation App: Three-Armed Randomized Controlled Trial. JMIR mental health.” (See summary below or view the full text of the study at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7732708/ ) Goldberg and colleagues recruited adults who did not have extensive meditation experience and randomly assigned them to a wait-list control condition or to receive either of 2 8-week smartphone app mindfulness training with the Healthy Minds Program. They received 4 weeks of awareness training including awareness of breathing and awareness of sounds. They were then again randomly assigned to receive 4 weeks of either Connection training consisting or gratitude and kindness practices or Insight Training consisting of “the changing nature of the phenomenon (ie, impermanence) and examining how thoughts and emotions influence perception” practices. They were measured before after the first 4-week module and after the second 4-week module for mindfulness, psychological distress, perceived stress, interpersonal connections, interpersonal reactivity, compassion, self-reflection, rumination, and defusion.

 

They found that compared to baseline and the wait-list control group both intervention conditions produced significant increases in mindfulness, social connection, self-reflection and defusion and significant decreases in psychological distress, and rumination with no significant differences between the smartphone interventions. There were no differences between the wait-list controls and the intervention in compassion and empathy.

 

These are interesting findings that correspond to the finding in prior research that training the increases mindfulness produces significant increases in social connection, self-reflection and defusion and significant decreases in psychological distress, and rumination. They demonstrate that smartphone trainings that improve mindfulness produce improvement in the psychological health of the participants.

 

It was a bit surprising that the benefits of the awareness plus connection training did not significantly differ from the benefits of awareness plus insight training. But since both trainings equivalently higher mindfulness and increased mindfulness has been shown to produce these benefits, it is reasonable to conclude that any training the improves mindfulness will improve psychological health..

 

So, improve psychological health with a self-guided, smartphone-based mindfulness App.

 

“Using a smartphone app, may provide immediate effects on mood and stress while also providing long-term benefits for attentional control. . . there is evidence that with continued usage, [mindfulness training] via a smartphone app may provide long-term benefits in changing how one relates to their inner and outer experiences.” – Kathleen Marie Walsh

 

CMCS – Center for Mindfulness and Contemplative Studies

 

This and other Contemplative Studies posts are also available on Google+ https://plus.google.com/106784388191201299496/posts and on Twitter @MindfulResearch

 

Study Summary

 

Goldberg, S. B., Imhoff-Smith, T., Bolt, D. M., Wilson-Mendenhall, C. D., Dahl, C. J., Davidson, R. J., & Rosenkranz, M. A. (2020). Testing the Efficacy of a Multicomponent, Self-Guided, Smartphone-Based Meditation App: Three-Armed Randomized Controlled Trial. JMIR mental health, 7(11), e23825. https://doi.org/10.2196/23825

 

Abstract

Background

A growing number of randomized controlled trials (RCTs) suggest psychological benefits associated with meditation training delivered via mobile health. However, research in this area has primarily focused on mindfulness, only one of many meditative techniques.

Objective

This study aims to evaluate the efficacy of 2 versions of a self-guided, smartphone-based meditation app—the Healthy Minds Program (HMP)—which includes training in mindfulness (Awareness), along with practices designed to cultivate positive relationships (Connection) or insight into the nature of the self (Insight).

Methods

A three-arm, fully remote RCT compared 8 weeks of one of 2 HMP conditions (Awareness+Connection and Awareness+Insight) with a waitlist control. Adults (≥18 years) without extensive previous meditation experience were eligible. The primary outcome was psychological distress (depression, anxiety, and stress). Secondary outcomes were social connection, empathy, compassion, self-reflection, insight, rumination, defusion, and mindfulness. Measures were completed at pretest, midtreatment, and posttest between October 2019 and April 2020. Longitudinal data were analyzed using intention-to-treat principles with maximum likelihood.

Results

A total of 343 participants were randomized and 186 (54.2%) completed at least one posttest assessment. The majority (166/228, 72.8%) of those assigned to HMP conditions downloaded the app. The 2 HMP conditions did not differ from one another in terms of changes in any outcome. Relative to the waitlist control, the HMP conditions showed larger improvements in distress, social connectedness, mindfulness, and measures theoretically linked to insight training (d=–0.28 to 0.41; Ps≤.02), despite modest exposure to connection- and insight-related practice. The results were robust to some assumptions about nonrandom patterns of missing data. Improvements in distress were associated with days of use. Candidate mediators (social connection, insight, rumination, defusion, and mindfulness) and moderators (baseline rumination, defusion, and empathy) of changes in distress were identified.

Conclusions

This study provides initial evidence of efficacy for the HMP app in reducing distress and improving outcomes related to well-being, including social connectedness. Future studies should attempt to increase study retention and user engagement.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7732708/

 

Lower Stress and Improve the Psychological Health of Healthcare Workers with Mind-Body Practices

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Lower Stress and Improve the Psychological Health of Healthcare Workers with Mind-Body Practices

 

By John M. de Castro, Ph.D.

 

“mind-body programs. . . emphasize the importance of mindfulness, getting more sleep and reducing stress. Not long ago, those life strategies were viewed as irrelevant to a person’s health care. But these are all things that boost one’s mood. An added bonus? They make a huge difference in improving physical health.” – Hal Paz

 

Stress is epidemic in the western workplace with almost two thirds of workers reporting high levels of stress at work. In high stress occupations, like healthcare, burnout is all too prevalent. Burnout is the fatigue, cynicism, emotional exhaustion, sleep disruption, and professional inefficacy that comes with work-related stress. These stressors have been vastly amplified during the Covid-19 pandemic. Improving the psychological health of health care professionals, then, has to be a priority.

 

Contemplative practices have been shown to reduce the psychological and physiological responses to stress. Indeed, mindfulness has been shown to be helpful in treating and preventing burnout, increasing resilience, and improving sleep.  Hence, it is reasonable to examine the ability of mind-body practices as a means to improve the well-being of healthcare professionals.

 

In today’s Research News article “Long-term beneficial effects of an online mind-body training program on stress and psychological outcomes in female healthcare providers: A non-randomized controlled study.” (See summary below or view the full text of the study at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7593019/ ) Lee and colleagues recruited female healthcare workers and randomly assigned them to a wait-list control condition or to receive an 8-week online program of mind-body training. The participants practiced at home for 10 minutes, 5 days per week, for 8 weeks. The training included relaxation training, breathing exercises, and meditation. The participants were measured before and after training and 4 weeks later for occupational stress, stress responses, emotional intelligence, resilience, coping strategies, positive and negative emotions, and anxiety.

 

They found that in comparison to baseline and the wait-list control group, the mind-body training group had significant reduction in overall stress levels, anger, and depression and a significant increase in a social support coping strategy that were maintained 4 weeks after the end of training. They also found that the mind-body group had a significant increase in emotion regulation, a problem-solving coping strategy ,and resilience and a significant decrease in negative emotions at the end of training but these improvements were no longer significant 4 weeks later.

 

This is an interesting study but conclusions must be tempered by the fact that the comparison condition was passive, leaving open the possibility for contaminants such as experimenter bias or participant expectancy, or attentional effects as alternative explanations. But the results are similar to other controlled studies that mindfulness training decreases stress, anger, negative emotions. and depression and increases emotion regulation and adaptive coping. So, it would appear that the mind-body training improves the psychological health of female healthcare workers with lasting improvements in stress levels, anger, depression and social support coping but transitory improvements in emotion regulation, resilience, negative emotions and problem-solving coping.

 

An important characteristic of the mind-body training in the present study was that it was provided online and only involved 10 minutes of daily practice. This type of program is convenient and doesn’t add a major time commitment to the healthcare workers’ already very busy schedule. So, it is easy to inexpensively and conveniently provide it to large numbers of healthcare workers without adding extra stress. Such a program, then, can improve the well-being of these stressed workers, potentially reducing burnout and improving job effectiveness. This is particularly important during the Covid-19 pandemic.

 

So, lower stress and improve the psychological health of healthcare workers with min-body practices.

 

“Mind-body therapies are safe, noninvasive techniques that have been shown to reduce stress and anxiety . . . Furthermore, they have demonstrated preliminary effects in improving psychological outcomes in physicians and health-care providers.” – Ting Bao

 

CMCS – Center for Mindfulness and Contemplative Studies

 

This and other Contemplative Studies posts are also available on Google+ https://plus.google.com/106784388191201299496/posts and on Twitter @MindfulResearch

 

Study Summary

 

Lee, D., Lee, W. J., Choi, S. H., Jang, J. H., & Kang, D. H. (2020). Long-term beneficial effects of an online mind-body training program on stress and psychological outcomes in female healthcare providers: A non-randomized controlled study. Medicine, 99(32), e21027. https://doi.org/10.1097/MD.0000000000021027

 

Abstract

Mind-body training (MBT) programs are effective interventions for relieving stress and improving psychological capabilities. To expand our previous study which demonstrated the short-term effects of an 8-week online MBT program, the present study investigated whether those short-term effects persist up to a month after the end of the intervention.

Among previous participants, 56 (64%) participated in this follow-up study, 25 in the MBT group and 31 in the control group. Outcome measures included the stress response, emotional intelligence, resilience, coping strategies, positive and negative affect, and anger expression of both groups at baseline, at 8 weeks (right after the training or waiting period), and at 12 weeks (a month after the training or waiting period).

The MBT group showed a greater decrease in stress response at 8 weeks, and this reduction remained a month after the end of the intervention. The effect of MBT on resilience and effective coping strategies was also significant at 8 weeks and remained constant a month later. However, the improvement to emotional intelligence and negative affect did not persist a month after training.

These findings suggest that the beneficial short-term effects of MBT may last beyond the training period even without continuous practice, but the retention of these benefits seems to depend on the outcome variables. Through a convenient, affordable, and easily accessible online format, MBT may provide cost-effective solutions for employees at worksites.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7593019/

 

Reduce Menopausal Symptoms with Meditation

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Reduce Menopausal Symptoms with Meditation

 

By John M. de Castro, Ph.D.

 

‘midlife women with higher mindfulness scores experienced fewer menopausal symptoms,” – Dr. Richa Sood

 

Menopause occurs in the 40s and 50s in most women, on average at 51 years of age. It is a natural physical process that marks the end of the menstrual cycle. The symptoms that occur over the years preceding menopause include irregular periods, vaginal dryness, hot flashes, chills

night sweats, sleep problems, mood changes, weight gain and slowed metabolism, thinning hair and dry skin, and loss of breast fullness. This is a natural process that is healthy and needs to occur. So, treatments are designed for symptomatic relief and include drugs and hormone treatments. Mindfulness training including meditation is a more natural treatment that has been shown to improve the symptoms of menopause.

 

In today’s Research News article “A potential association of meditation with menopausal symptoms and blood chemistry in healthy women: A pilot cross-sectional study.” (See summary below or view the full text of the study at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7478772/ ) Sung and colleagues recruited healthy adult women, 25-60 years of age, who were either long-term meditators or non-meditators. The particular meditation practice was a combination of focused meditation and mindful movement practice. The groups were divided into premenopausal and postmenopausal women. They were measured for menopausal symptoms, including psychological, somatic, and urogenital domains, and blood was drawn and assayed for HDL, glucose, triglyceride, total protein, creatinine, blood urea nitrogen, lactate dehydrogenase, aspartate aminotransferase, and alanine aminotransferase;

 

They found overall that the meditation group was lower than the non-meditators in menopausal symptoms especially depression and irritability. In the premenopausal women there was significantly higher HDL levels in the meditation group while in the postmenopausal group there were significantly higher HDL and glucose levels in the non-meditators.

 

This is a cross-sectional pilot study and causation cannot be definitively assigned. But these results replicates previous findings from controlled studies that mindfulness practices produce reduced menopausal symptoms, depression, and irritability. So, it is likely that the present findings are due to a causal connection between meditation practice and reduced menopausal symptoms.

 

So, reduce menopausal symptoms with meditation.

 

“Among the different natural remedies available for managing middle age, meditation for menopause has some unique benefits. It is a totally natural, completely free way to approach navigating the hormonal rollercoaster of midlife.” – Karen Shopoff Rooff

 

CMCS – Center for Mindfulness and Contemplative Studies

 

This and other Contemplative Studies posts are also available on Google+ https://plus.google.com/106784388191201299496/posts and on Twitter @MindfulResearch

 

Study Summary

 

Sung, M. K., Lee, U. S., Ha, N. H., Koh, E., & Yang, H. J. (2020). A potential association of meditation with menopausal symptoms and blood chemistry in healthy women: A pilot cross-sectional study. Medicine, 99(36), e22048. https://doi.org/10.1097/MD.0000000000022048

 

Abstract

Owing to hormonal changes, women experience various psychophysiological alterations over a wide age range, which may result in decreased quality of life as well as in increased risks of diseases, such as cardiovascular diseases. Although studies have been performed to research complementary methods, such as meditation, the research field still requires an adequate amount of studies for public health guidelines. This pilot cross-sectional study aims to investigate a potential association of meditation with menopausal symptoms and blood chemistry for healthy women. In this study, data of 65 healthy women (age range 25–67) including 33 meditation practitioners and 32 meditation-naïve controls were analyzed to compare the Menopausal Rating Scale scores and blood chemistry with 7 more dropouts in the blood chemistry. For blood chemistry, nine components including glucose (GLU) and high-density lipoprotein cholesterol (HDL) were measured. Two-way analysis of variance was performed by dividing the total participants into 2 groups: premenopausal and postmenopausal participants. Compared to the control group, the meditation group showed a trend of reductions in the Menopausal Rating Scale total score (P = .054) and its 2 subcomponents: depressive mood (P = .064) and irritability (P = .061). In HDL level, there was a significant interaction between group and menopausal state (P = .039) with following post hoc results: among the premenopausal participants, a significant increase in the meditation group compared to the control group (P = .005); among the control group, a significant increase in the postmenopausal compared to the premenopausal participants (P = .030). In GLU level, there was a mild interaction between group and menopausal state (P = .070) with following post hoc results: among the postmenopausal participants, a trend of increase in the control group compared to the meditation group (P = .081); among the control group, a significant increase in the postmenopausal compared to the premenopausal participants (P = .040). Our research suggests a potential association of practicing meditation with alleviations in menopausal symptoms and changes in blood chemistry, warranting further studies with a longitudinal study design and larger populations to understand the underlying causal relationships.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7478772/

 

Improve Cardiac Health in Heart Failure Patients with Meditation

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Improve Cardiac Health in Heart Failure Patients with Meditation

 

By John M. de Castro, Ph.D.

 

“Not only can meditation improve how your heart functions, but a regular practice can enhance your outlook on life and motivate you to maintain many heart-healthy behaviors, like following a proper diet, getting adequate sleep, and keeping up regular exercise,” – John Denninger

 

Cardiovascular disease is the number one killer. A myriad of treatments have been developed for heart disease including a variety of surgical procedures and medications. In addition, lifestyle changes have proved to be effective including quitting smoking, weight reduction, improved diet, physical activity, and reducing stresses. Unfortunately, for a variety of reasons, 60% of cardiovascular disease patients decline to alter these lifestyle factors, making these patients at high risk for another attack.

 

Congestive heart failure (CHF) is a major type of cardiovascular disease. “CHF is a chronic progressive condition that affects the pumping power of your heart muscles. While often referred to simply as “heart failure,” CHF specifically refers to the stage in which fluid builds up around the heart and causes it to pump inefficiently” (Healthline). Heart failure is a very serious life-threatening condition. About 5.7 million adults in the United States have congestive heart failure. One in 9 deaths include heart failure as a contributing cause. The seriousness of heart failure is underscored by the fact that about half of people who develop heart failure die within 5 years of diagnosis. Hence, effective treatment is very important.

 

Mindfulness trainings such as meditation practice are known to help with a wide range of physical and psychological problems, including heart failure. So, it would make sense to further investigate the ability of meditation practice to the improve the health and longevity of patients with heart failure.

 

In today’s Research News article “Meditation for Improved Clinical Outcomes in Patients with Implantable Defibrillators for Heart Failure- Pilot Study.” (See summary below or view the full text of the study at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7533122/ ) Aditee and colleagues recruited adult patients with heart failure and an implantable cardioverter defibrillator. They were randomly assigned to receive either 6 months of focused meditation or treatment as usual. Breath following meditation was trained in 3 session during the first week and then once every 2 weeks for 6 months. They were encouraged to meditate at home daily. They were measured before and after training and then yearly for 7 years for a 6-minute walk, brain natriuretic peptide (BNP) levels, atrial fibrillation, mortality, heart failure hospitalization and ventricular arrhythmias.

 

They found that in comparison to baseline and the treatment as usual group, the meditation group had significantly fewer atrial fibrillations and ventricular tachycardias which remained true 7 years later. Although at the 7-year follow-up 67% in treatment as usual group vs 87.5% in meditation group were still alive, this difference was not statistically significant. Hence, meditation practice appears to improve cardiac function in heart failure patients.

 

This was a pilot study that was not sufficiently powered to detect small differences. So, the fact that cardiac function was significantly improved by meditation was particularly significant. Had a greater number of participants been included, the reduced mortality may have also been significant. Future studies should include an active control condition and a greater number of participants. Regardless, it is clear that meditation is good for heart failure patients. Since stress aggravates the condition, perhaps the improved cardiac function in the meditators was due to the known ability of meditation to improve the physiological and psychological responses to stress.

 

So, improve cardiac health in heart failure patients with meditation.

 

“Given the low costs and low risks of this intervention, meditation may be considered as an adjunct to guideline‐directed cardiovascular risk reduction.” – Glenn Levine

 

CMCS – Center for Mindfulness and Contemplative Studies

 

This and other Contemplative Studies posts are also available on Google+ https://plus.google.com/106784388191201299496/posts and on Twitter @MindfulResearch

 

Study Summary

 

Aditee, D., Pankaj, M., Neil, B., Nayereh, P., Dali, F., & N Srivatsa, U. (2020). Meditation for Improved Clinical Outcomes in Patients with Implantable Defibrillators for Heart Failure- Pilot Study. Journal of atrial fibrillation, 12(6), 2314. https://doi.org/10.4022/jafib.2314

 

Abstract

Background

Sympathetic activation is associated with congestive heart failure (CHF) and leads to adverse clinical events. We hypothesized that meditation by reducing emotional reactivity would have beneficial effect in reducing arrhythmias compared to control patients.

Methods

Patients known to have CHF and implantable cardioverter defibrillators (ICD) were randomized to Vipassana meditation or usual care control group. Meditation group underwent meditation classes three times during the first week, thereafter every once two weeks. They were encouraged to practice meditation at least once everyday. The ICD was followed by clinic/ remote visits. Atrial (AA) and ventricular arrhythmias (VA) as well cardiac events were assessed in follow up. Chi square test was used to compare nominal variables and t test for continuous variables.

Results

Patients (n=25, 65% male, mean LVEF 25%, HTN 38%, Diabetes 12%, coronary artery disease 38%, NYHA class 2.2) were followed for 79 + 36 months. Comparing meditation vs control, survival was higher (88%vs 67%); there was less cumulative sustained AF episodes (mean 0.9, IQR 0-1 vs 2.5, IQR 2-4, p=0.045), sustained VT occurred (25% vs 55%, amiodarone use (none vs 44%), and VT ablation in 6.6% vs 33% in the meditation group.

Conclusions

In this first pilot study of meditation in CHF patients with ICD, during long term follow up, there is a trend for improved survival and reduced arrhythmias in patients randomized to meditation.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7533122/

 

Neurofeedback in Novice Meditators Can Alter Brain Activity like that Observed in Expert Meditators

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Neurofeedback in Novice Meditators Can Alter Brain Activity like that Observed in Expert Meditators

 

By John M. de Castro, Ph.D.

 

“Modern researchers and practitioners are finding a possible new solution to these challenges by using EEG biofeedback to increase awareness of subtle states of consciousness and speed the learning process.” – Jeff Tarrant

 

Meditation training has been shown to improve health and well-being. It has also been found to be effective for a large array of medical and psychiatric conditions, either stand-alone or in combination with more traditional therapies. As a result, meditation training has been called the third wave of therapies. But meditation can be challenging to learn and many people become discouraged and drop the practice. But modern neuroscience has developed a tool called neurofeedback that can assist the meditator in improving the meditative experience.

 

In today’s Research News article “Closed-Loop Frontal Midlineθ Neurofeedback: A Novel Approach for Training Focused-Attention Meditation.” (See summary below or view the full text of the study at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7344173/ ) Brandmeyer and Delorme recruited healthy meditation-naïve adults and assigned them to either a neurofeedback group or to an age and gender matched active sham control group. Training occurred over 2 weeks in 8 sessions. All participants had their electroencephalogram (EEG) recorded while performing breath focused meditation while receiving feedback as to the level of theta activity (4-6 hz.) from the frontal midline. They were instructed to try to increase the level of frontal midline theta. The neurofeedback group received feedback based upon their own brain activity while the sham group received the feedback, not from their own brain activity but from the activity of their paired experimental participant. At the beginning and end of the 8 training sessions the participants were measured for executive functioning including memory, sustained attention, and focused attention.

 

They found that the neurofeedback produced a significant progressive increase in frontal midline theta power over the 8 sessions while the sham control had none. The neurofeedback group also had a significant improvement in short-term memory while the sham group had a significant deterioration in short-term memory. While the neurofeedback group was performing the short-term memory task, they had a significant increase in gamma activity in the EEG which was absent in the sham group.

 

A strength of the present study is that the control condition was active and the participants went through the same protocol as the neurofeedback participants with the sole difference being that the neurofeedback participants received feedback on their own brain activity while the sham group did not. This is an excellent control condition that accounts for many potential sources of confounding. So, the results can be interpreted as due to the neurofeedback and not some other spurious cause.

 

High levels of midline frontal theta power in the EEG is characteristic of experienced meditators. It can be speculated that the neurofeedback procedure by increasing midline frontal theta power produce brain activity in novices similar to that produced by years of meditation training. The improved short-term memory is also observed in expert meditators. This suggests that neurofeedback may be used to rapidly improve meditation. It remains for future studies to examine whether the increased midline frontal theta power is associated with increased depth of meditation. If so, this may be a method to rapidly improve meditation in novices.

 

So, neurofeedback in novice meditators can alter brain activity like that observed in expert meditators.

 

“Effective meditation practice is associated with several specific patterns of brain waves. This is one reason why neurofeedback is so effective, you can literally teach your brain to take on the right brain wave pattern for the style of meditation you are trying to practice.” – James V. Hardt

 

CMCS – Center for Mindfulness and Contemplative Studies

 

This and other Contemplative Studies posts are also available on Google+ https://plus.google.com/106784388191201299496/posts and on Twitter @MindfulResearch

 

Study Summary

 

Brandmeyer, T., & Delorme, A. (2020). Closed-Loop Frontal Midlineθ Neurofeedback: A Novel Approach for Training Focused-Attention Meditation. Frontiers in human neuroscience, 14, 246. https://doi.org/10.3389/fnhum.2020.00246

 

Abstract

Cortical oscillations serve as an index of both sensory and cognitive processes and represent one of the most promising candidates for training and targeting the top-down mechanisms underlying executive functions. Research findings suggest that theta (θ) oscillations (3–7 Hz) recorded over frontal-midline electrodes are broadly associated with a number of higher-order cognitive processes and may serve as the mechanistic backbone for cognitive control. Frontal-midline theta (FMθ) oscillations have also been shown to inversely correlate with activity in the default mode network (DMN), a network in the brain linked to spontaneous thought processes such as mind-wandering and rumination. In line with these findings, we previously observed increased FMθ oscillations in expert meditation practitioners during reported periods of focused-attention meditation practice when compared to periods of mind-wandering. In an effort to narrow the explanatory gap by directly connecting observed neurophysiological activity in the brain to the phenomenological nature of reported experience, we designed a methodologically novel and adaptive neurofeedback protocol with the aim of modulating FMθ while having meditation novice participants implement breath-focus strategies derived from focused-attention mediation practices. Participants who received eight sessions of the adaptive FMθ-meditation neurofeedback protocol were able to significantly modulate FMθ over frontal electrodes using focused-attention meditation strategies relative to their baseline by the end of the training and demonstrated significantly faster reaction times on correct trials during the n-back working memory task assessed before and after the FMθ-meditation neurofeedback protocol. No significant differences in frontal theta activity or behavior were observed in the active control participants who received age and gender matched sham neurofeedback. These findings help lay the groundwork for the development of brain training protocols and neurofeedback applications that aim to train features of the mental states and traits associated with focused-attention meditation.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7344173/

 

Improve Mental Health and Blood Biomarker Levels with Meditation and Yoga

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Improve Mental Health and Blood Biomarker Levels with Meditation and Yoga

 

By John M. de Castro, Ph.D.

 

“The main purpose of meditation is to access, recognize and enhance the positive qualities of mind. The more we can do this, the less we need to rely on external situations for our happiness and the more we can rely on the natural, positive qualities of mind: love, contentment, well-being and peace.” – Trinlay Rinpoche

 

Over the last several decades, research and anecdotal experiences have accumulated an impressive evidential case that the development of mindfulness has positive benefits for the individual’s mental, physical, and spiritual life. Mindfulness appears to be beneficial both for healthy people and for people suffering from a myriad of mental and physical illnesses. It appears to be beneficial across ages, from children to the elderly. And it appears to be beneficial across genders, personalities, race, and ethnicity. The breadth and depth of benefits is unprecedented. There is no other treatment or practice that has been shown to come anyway near the range of mindfulness’ positive benefits.

 

It is not known exactly how mindfulness training produces these benefits. It is possible that one mechanism is by altering blood bourn hormonal levels. In today’s Research News article “Inner Engineering Practices and Advanced 4-day Isha Yoga Retreat Are Associated with Cannabimimetic Effects with Increased Endocannabinoids and Short-Term and Sustained Improvement in Mental Health: A Prospective Observational Study of Meditators.” (See summary below or view the full text of the study at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7293737/ ) Sadhasivam and colleagues recruited healthy adults and had them attend a 4-day intensive training in yoga and meditation. Before and after the training and 1 month later they were measured for mindfulness, happiness, anxiety, depression, and psychological well-being. They also drew blood before and after training and assayed it for the brain-derived neurotrophic factor (BDNF), and the biomarkers of Endocannabinoids, (anandamide, 2-arachidonoylglycerol (2-AG), 1-arachidonoylglycerol (1-AG), docosatetraenoylethanolamide (DEA), and oleoylethanolamide (OLA)).

 

They found that after the training there were significant decreases in anxiety and depression and significant increases in mindfulness, happiness, and psychological well-being. These changes were maintained at the 1-month follow-up. There were also significant increases in all of the blood biomarkers of Endocannabinoids and also brain-derived neurotrophic factor (BDNF).

 

It should be kept in mind that this was a pilot study that did not have a control, comparison, condition. So, the results might have been due to a number of confounding factors rather than the training itself. But previous controlled research has convincingly demonstrated that mindfulness training increases happiness, and psychological well-being and decreases anxiety and depression. So, these changes were likely due to the training.

 

There were also novel findings in the present study that Endocannabinoids and brain-derived neurotrophic factor (BDNF) were significantly increased by the training. These provide objective measures of the subjective reports of psychological improvements. Endocannabinoids in the blood are associated with positive mood states. BDNF is a neurotrophic factor that is thought to signal neuroplastic changes in the nervous system. Mindfulness training has been previously shown to produce neuroplastic changes in the brain. So, the increases in these biomarkers indicate that the training not only improves the psychological health of the participants but also alters the brain, perhaps making the improvements longer lasting. This suggests a potential mechanism for the ability of meditation and yoga to improve mood, by increasing hormones that improve mood.

 

So, improve mental health and blood biomarker levels with meditation and yoga.

 

“The more you practice invoking states of well-being, the more available they are. Use the following practice to teach your mind and body to experience joy in the moment. As you invite happiness into your life in this way, you will have more access to a joyful life.” – Yoga Journal

 

CMCS – Center for Mindfulness and Contemplative Studies

 

This and other Contemplative Studies posts are also available on Google+ https://plus.google.com/106784388191201299496/posts and on Twitter @MindfulResearch

 

Study Summary

 

Sadhasivam, S., Alankar, S., Maturi, R., Vishnubhotla, R. V., Mudigonda, M., Pawale, D., Narayanan, S., Hariri, S., Ram, C., Chang, T., Renschler, J., Eckert, G., & Subramaniam, B. (2020). Inner Engineering Practices and Advanced 4-day Isha Yoga Retreat Are Associated with Cannabimimetic Effects with Increased Endocannabinoids and Short-Term and Sustained Improvement in Mental Health: A Prospective Observational Study of Meditators. Evidence-based complementary and alternative medicine : eCAM, 2020, 8438272. https://doi.org/10.1155/2020/8438272

 

Abstract

Background

Anxiety and depression are common in the modern world, and there is growing demand for alternative therapies such as meditation. Meditation can decrease perceived stress and increase general well-being, although the physiological mechanism is not well-characterized. Endocannabinoids (eCBs), lipid mediators associated with enhanced mood and reduced anxiety/depression, have not been previously studied as biomarkers of meditation effects. Our aim was to assess biomarkers (eCBs and brain-derived neurotrophic factor [BDNF]) and psychological parameters after a meditation retreat.

Methods

This was an observational pilot study of adults before and after the 4-day Isha Yoga Bhava Spandana Program retreat. Participants completed online surveys (before and after retreat, and 1 month later) to assess anxiety, depression, focus, well-being, and happiness through validated psychological scales. Voluntary blood sampling for biomarker studies was done before and within a day after the retreat. The biomarkers anandamide, 2-arachidonoylglycerol (2-AG), 1-arachidonoylglycerol (1-AG), docosatetraenoylethanolamide (DEA), oleoylethanolamide (OLA), and BDNF were evaluated. Primary outcomes were changes in psychological scales, as well as changes in eCBs and BDNF.

Results

Depression and anxiety scores decreased while focus, happiness, and positive well-being scores increased immediately after retreat from their baseline values (P < 0.001). All improvements were sustained 1 month after BSP. All major eCBs including anandamide, 2-AG, 1-AG, DEA, and BDNF increased after meditation by > 70% (P < 0.001). Increases of ≥20% in anandamide, 2-AG, 1-AG, and total AG levels after meditation from the baseline had weak correlations with changes in happiness and well-being.

Conclusions

A short meditation experience improved focus, happiness, and positive well-being and reduced depression and anxiety in participants for at least 1 month. Participants had increased blood eCBs and BDNF, suggesting a role for these biomarkers in the underlying mechanism of meditation. Meditation is a simple, organic, and effective way to improve well-being and reduce depression and anxiety.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7293737/

 

Improve Attention and the Brain Systems Underlying Attention with Meditation

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Improve Attention and the Brain Systems Underlying Attention with Meditation

 

By John M. de Castro, Ph.D.

 

“the primary outcome of meditation may be to control attention and internal state in the face of the barrage of stimuli, negative and otherwise, that we experience everyday.” – Aaron D. Nitzkin

 

One of the primary effects of mindfulness training is an improvement in the ability to pay attention to the task at hand and ignore interfering stimuli. This is an important consequence of mindfulness training and produces improvements in thinking, reasoning, and creativity. The importance of heightened attentional ability to the individual’s ability to navigate the demands of complex modern life cannot be overstated. It helps in school, at work, in relationships, or simply driving a car. As important as attention is, it’s surprising that little is known about the mechanisms by which mindfulness improves attention

 

There is evidence that mindfulness training improves attention by altering the brain. It appears That mindfulness training increases the size, connectivity, and activity of areas of the brain that are involved in paying attention. A common method to study the activity of the nervous system is to measure the electrical signal at the scalp above brain regions. Changes in this activity are measurable with mindfulness training.

 

One method to observe attentional processing in the brain is to measure the changes in the electrical activity that occur in response to specific stimuli. These are called event-related, or evoked, potentials or ERPs. The signal following a stimulus changes over time. The fluctuations of the signal after specific periods of time are thought to measure different aspects of the nervous system’s processing of the stimulus. The P3 response in the evoked potential (ERP) is a positive going electrical response occurring between a 2.5 to 5 tenths of a second following the target stimulus presentation. The P3 component is thought to reflect attentional processing.

 

In today’s Research News article “Focused attention meditation training modifies neural activity and attention: longitudinal EEG data in non-meditators.” (See summary below or view the full text of the study at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7304517/ ) Yoshida and colleagues recruited meditation-naïve college students and randomly assigned them to receive either focused meditation training or relaxation training, listening to classical music. The training occurred once a week for 30 minutes for 8 weeks. They also practiced meditation or relaxation at home for 10 minutes per day. They were measured before and after training for mindfulness. They also had brain activity measured with an electroencephalogram (EEG) before, during and after either a 5-minute meditation or relaxation and while performing an oddball task where they were asked to respond whenever a different tone the usual was presented. The evoked potentials to the tone presentations were recorded.

 

They found that in comparison to baseline and the relaxation group, the group that received focused meditation training had significantly faster reactions to the target stimuli during the oddball task. The evoked potentials to the oddball stimuli also demonstrated significantly larger P3 potentials in the meditation group. They also report that during meditation there was a significant increase in theta rhythm power in the EEG particularly in the frontal regions of the brain. They also found that only after 8 weeks of meditation training the greater the increase in theta power during meditation the smaller the increase in P3 magnitude during the oddball task.

 

These results suggest that meditation training produces an improvement in attention both behaviorally during the oddball task and also in the brain’s response to the stimuli. The results demonstrated that these changes occurred only after 8 weeks of meditation training and not after relaxation training. That mindfulness training improves attention and the P3 response in the evoked potential has been demonstrated previously.

 

Hence, meditation training in meditation-naïve college students improves attention both in the brain and in behavior. This improved attention should, although not investigated, produce improved performance in college academics. It remains for future research to investigate this hypothesis.

 

So, improve attention and the brain systems underlying attention with meditation.

 

“Nondirective meditation yields more marked changes in electrical brain wave activity associated with wakeful, relaxed attention, than just resting without any specific mental technique.” – ScienceDaily

 

CMCS – Center for Mindfulness and Contemplative Studies

 

This and other Contemplative Studies posts are also available on Google+ https://plus.google.com/106784388191201299496/posts and on Twitter @MindfulResearch

 

Study Summary

 

Yoshida, K., Takeda, K., Kasai, T., Makinae, S., Murakami, Y., Hasegawa, A., & Sakai, S. (2020). Focused attention meditation training modifies neural activity and attention: longitudinal EEG data in non-meditators. Social cognitive and affective neuroscience, 15(2), 215–224. https://doi.org/10.1093/scan/nsaa020

 

Abstract

Focused attention meditation (FAM) is a basic meditation practice that cultivates attentional control and monitoring skills. Cross-sectional studies have highlighted high cognitive performance and discriminative neural activity in experienced meditators. However, a direct relationship between neural activity changes and improvement of attention caused by meditation training remains to be elucidated. To investigate this, we conducted a longitudinal study, which evaluated the results of electroencephalography (EEG) during three-stimulus oddball task, resting state and FAM before and after 8 weeks of FAM training in non-meditators. The FAM training group (n = 17) showed significantly higher P3 amplitude during the oddball task and shorter reaction time (RT) for target stimuli compared to that of the control group (n = 20). Furthermore, a significant negative correlation between F4-Oz theta band phase synchrony index (PSI) during FAM and P3 amplitude during the oddball task and a significant positive correlation between F4-Pz theta band PSI during FAM and P3 amplitude during the oddball task were observed. In contrast, these correlations were not observed in the control group. These findings provide direct evidence of the effectiveness of FAM training and contribute to our understanding of the mechanisms underpinning the effects of meditation on brain activity and cognitive performance.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7304517/