Meditation

Transcendental Meditation Improves the Symptoms of Post-Traumatic Stress Disorder

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What Is Transcendental Meditation? Benefits, Techniques, & More

By John M. de Castro, Ph.D.

 

In today’s Research News article “Systematic Review and Meta-Analysis of Transcendental Meditation for Post-Traumatic Stress Disorder” (See summary below or view the full text of the study at: https://pmc.ncbi.nlm.nih.gov/articles/PMC12028398/) Orme-Johnson and colleagues review, summarize and perform a meta-analysis of the effectiveness of Transcendental Meditation (TM) for the treatment of Post-Traumatic Stress Disorder (PTSD). They report that the published studies found that TM significantly improves the symptoms of PTSD in miliary and civilian patients.

 

Meditation improves the symptoms of Post-Traumatic Stress Disorder.

 

CMCS – Center for Mindfulness and Contemplative Studies

 

This and other Contemplative Studies posts are also available on the Contemplative Studies Blog  http://contemplative-studies.org

 

Study Summary

 

Orme-Johnson DW, Barnes VA, Rees B, Tobin J. Systematic Review and Meta-Analysis of Transcendental Meditation for Post-Traumatic Stress Disorder. Medicina (Kaunas). 2025;61(4):659. Published 2025 Apr 3. doi:10.3390/medicina61040659

 

Abstract

Background and Objectives. Our recent systematic review and meta-analysis of all studies on meditation as treatment for PTSD (61 studies) found a moderate effect size of Hedges’s g = −0.67 for post-minus-pre change in symptom scores. Separate tests of the four meditation categories found a large effect size of g = −1.13 for the Transcendental Meditation (TM) technique that is significantly greater than for each other category. The present follow-up used a different method, calculating effects relative to internal controls, to better characterize the effects of this meditation technique. Materials and Methods. Our study followed Prisma guidelines. Major databases, research anthologies, and bibliographies were searched for studies that used TM for treating PTSD, all military and civilian populations, and all age groups. Results. The searches located 15 controlled trials on TM that met the inclusion criteria (longitudinal and reporting sufficient statistics to calculate effect sizes), 1248 subjects total, mean age 40.5 years (range 20.6 to 54.4 years), and 46.9% males (range 0% to 100%). Using the random effects model, the pooled effect across all studies of TM compared to other treatments was g = −1.01, 95% CI = −1.29 to −0.74, p < 0.000000001. One-study removed analysis found that no study reduced the pooled effect to less than −1.0. Funnel plots indicated no risk of bias. TM was non-inferior to prolonged exposure therapy, p = 0.0001, and it worked significantly faster (p = 0.04 at week six). Conclusions. TM produced clinically meaningful reductions in PTSD for civilian and military personnel, young and older adults, and for both men and women. We recommend phase-III multisite studies comparing TM with known first-line treatments for PTSD.

 

Psychedelic Use and Meditation Complement Each Other’s Impacts

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Does the combination of psychedelics and meditation enhance mystical experiences?

By John M. de Castro, Ph.D.

 

In today’s Research News article “Associations between psychedelic-related and meditation-related variables: A longitudinal study” (See summary below or view the full text of the study at: https://pmc.ncbi.nlm.nih.gov/articles/PMC11999004/ )  Simonsson and colleagues examined the relationships between meditation and psychedelic use. They found that psychedelic use was associated with mindfulness and loving-kindness or compassion meditation practice while mindfulness was associated with less severe challenging psychedelic experiences, fewer psychedelic-occasioned thoughts or attempts of self- or other-harm.

 

Meditation and psychedelic use complement the impact of each.

 

CMCS – Center for Mindfulness and Contemplative Studies

 

This and other Contemplative Studies posts are also available on the Contemplative Studies Blog  http://contemplative-studies.org

 

Study Summary

 

Simonsson O, Chaturvedi S, Hendricks PS, et al. Associations between psychedelic-related and meditation-related variables: A longitudinal study. J Psychiatr Res. 2025;184:457-463. doi:10.1016/j.jpsychires.2025.03.025

 

Abstract

Previous research has investigated associations between psychedelic experiences and meditation practice, but knowledge gaps remain. Using a longitudinal research design with a sample of US residents between 18 and 50 years old (N = 13,012), we investigated associations between psychedelic-related and meditation-related variables. The follow-up survey was completed by 7484 respondents, of whom 336 reported psychedelic use during the two-month study. In covariate-adjusted regression models, psychedelic use was associated with greater increases in the number of days of mindfulness and loving-kindness or compassion meditation practice in the past week, especially among those with no prior experience of psychedelics or meditation. Among those who reported psychedelic use, trait mindfulness and trait self-compassion at baseline were associated with less severe challenging psychedelic experiences, as well as lower odds of psychedelic-occasioned thoughts or attempts of self- or other-harm. However, among those who practiced meditation at baseline, psychedelic use was associated with greater increases in past-week frequency of loving-kindness or compassion meditation-related difficulties and impairments. Future research is warranted.

 

Postpartum Depression is Improved With Virtual Reality Mindfulness and Yoga Training

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Fig. 1

By John M. de Castro, Ph.D.

 

In today’s Research News article “Virtual reality enhanced mindfulness and yoga intervention for postpartum depression and anxiety in the post COVID era” (See summary below or view the full text of the study at: https://pmc.ncbi.nlm.nih.gov/articles/PMC11973155/  ) Liu and colleagues examined the effectiveness of virtual reality (VR) enhanced mindfulness meditation and yoga training in comparison to traditional training and a no-training control on the symptoms of postpartum depression. They report that the VR enhanced training produced greater decreases in depression, anxiety, and stress and increases in cognitive control than the traditional training or no-treatment controls.

 

Improve postpartum depression symptoms with virtual reality mindfulness and yoga training.

 

CMCS – Center for Mindfulness and Contemplative Studies

 

This and other Contemplative Studies posts are also available on the Contemplative Studies Blog  http://contemplative-studies.org

 

Study Summary

 

Liu N, Deng J, Lu F, Xiao J. Virtual reality enhanced mindfulness and yoga intervention for postpartum depression and anxiety in the post COVID era. Sci Rep. 2025;15(1):11766. Published 2025 Apr 6. doi:10.1038/s41598-025-96165-6

Abstract

The postpartum period has witnessed increasing rates of depression and anxiety, particularly in the context of the COVID-19 pandemic, with these conditions often co-occurring and being exacerbated by the lingering effects of long COVID. Traditional interventions, such as mindfulness-based stress reduction (MBSR) and yoga, have demonstrated effectiveness in alleviating these symptoms. However, the limitations of in-person sessions, especially in the context of pandemic-related restrictions, highlight the need for accessible, innovative approaches. Integrating Virtual Reality (VR) technology with these traditional practices presents a novel solution, offering immersive, customizable environments that may enhance engagement and therapeutic outcomes. This study evaluates the effectiveness of a VR-enhanced mindfulness and yoga intervention in treating postpartum depression and anxiety in women affected by long COVID, with additional examination of underlying physiological stress markers and cognitive control mechanisms. In this randomized controlled trial, 111 postpartum women were randomly assigned to experimental (VR-enhanced intervention), control (traditional in-person sessions), or blank groups using computer-generated randomization. The 8-week intervention involved thrice-weekly 60-minute sessions. Outcomes were assessed at baseline, post-intervention, and 4-week follow-up using the Edinburgh Postnatal Depression Scale (EPDS), Generalized Anxiety Disorder-7 (GAD-7) scale, salivary cortisol measurements, and an emotional Stroop task. The VR-enhanced intervention group demonstrated significant improvements in both depression (EPDS: P < 0.001, ηp2 = 0.18) and anxiety symptoms (GAD-7: P < 0.001, ηp2 = 0.17), with these therapeutic effects significantly greater than those observed in the control and blank groups (P < 0.001 for both comparisons). These improvements were strongly correlated (r = 0.68, P < 0.001). Supporting these primary outcomes, salivary cortisol levels showed a significant decrease (P < 0.001, ηp2 = 0.13), and cognitive control improved as evidenced by reduced emotional Stroop task conflict effect (P < 0.001, ηp2 = 0.37). Correlation analysis revealed robust associations between improvements in depression and anxiety symptoms and changes in physiological markers in both short-term and long-term outcomes. This study demonstrates that integrating VR technology with traditional mindfulness and yoga practices effectively reduces both postpartum depression and anxiety symptoms in the post-COVID era. The parallel improvements in physiological stress markers and cognitive control provide insight into potential mechanisms underlying these therapeutic effects. These findings underscore the value of immersive technology in enhancing traditional therapeutic approaches for addressing postpartum depression and anxiety in the post-pandemic context.

 

Yoga Meditation Improves Mental Health in Female College Students

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Why should college students go for Yoga & Meditation? - Blog | Graphic Era

By John M. de Castro, Ph.D.

 

In today’s Research News article “From contemplation to serenity: how yoga meditation improves the mental health of female college students” (See summary below or view the full text of the study at: https://pmc.ncbi.nlm.nih.gov/articles/PMC11931514/ ) Liu and colleagues studied the effects of yoga meditation on the mental health of female college students. They report that yoga meditation improved the women’s mental health including significantly reduced anxiety, depression, and stress and increased emotional regulation and self-awareness.

 

Improve mental health with yoga meditation.

 

CMCS – Center for Mindfulness and Contemplative Studies

 

This and other Contemplative Studies posts are also available on the Contemplative Studies Blog  http://contemplative-studies.org

 

Study Summary

 

Liu L, Liu C, Tang L, Wang X, Feng Q. From contemplation to serenity: how yoga meditation improves the mental health of female college students?. Front Psychol. 2025;16:1545943. Published 2025 Mar 10. doi:10.3389/fpsyg.2025.1545943

Abstract

Objective

This study aims to investigate the impact of yoga meditation on the mental health of female college students, focusing on how meditation improves emotional regulation, alleviates stress and strengthens psychological resilience.

Methods

Employing a combination of quantitative assessment and qualitative analysis, the study measured participants’ emotional states, stress levels, and psychological resilience across multiple time points to track participants’ mental health changes dynamically. In-depth interviews and analysis of meditation journals were also conducted.

Results

Yoga meditation significantly reduced anxiety, depression, and perceived stress while enhancing emotional regulation and self-awareness. Meditation positively influenced neuroplasticity, inducing beneficial changes in brain regions associated with emotional control and cognitive flexibility. Additionally, improved autonomic nervous system function was observed, with increased parasympathetic activity and reduced sympathetic response. Meditation strengthened psychological resilience in female college students, improved stress-coping strategies, and sustained positive mental health benefits even after the intervention.

Conclusion

Yoga meditation is an effective mental health intervention, bolstering emotional regulation and reducing stress among female college students. Integrating yoga meditation into campus mental health programs is recommended to provide students with greater practice opportunities and personalized guidance.

Parkinson’s Disease Symptoms are Improved by Meditation or Yoga

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Parkinson's Disease | Contemplative Studies

By John M. de Castro, Ph.D.

 

In today’s Research News article “Effects of Meditation and Yoga on Anxiety, Depression and Chronic Inflammation in Patients with Parkinson’s Disease: A Randomized Clinical Trial” (See summary below or view the full text of the study at: https://pmc.ncbi.nlm.nih.gov/articles/PMC11965853/ ) Kwok and colleagues studied the effects of meditation and yoga practice on the symptoms of Parkinson’s Disease. They found that these practices significantly relieved a wide variety of symptoms, including anxiety, depression, inflammation, movement problems, and improved quality of life.

 

Meditation and yoga relieve the symptoms of Parkinson’s disease.

 

CMCS – Center for Mindfulness and Contemplative Studies

 

This and other Contemplative Studies posts are also available on the Contemplative Studies Blog  http://contemplative-studies.org

 

Study Summary

 

Jojo Yan Yan Kwok, Lily Man Lee Chan, Charis Ann Lai, Philip Wing Lok Ho, Zoe Yuen-kiu Choi, Man Auyeung, Shirley Yin Yu Pang, Edmond Pui Hang Choi, Daniel Yee Tak Fong, Doris Sau Fung Yu, Chia-chin Lin, Richard Walker, Samuel Yeung Shan Wong, Rainbow Tin Hung Ho. Effects of Meditation and Yoga on Anxiety, Depression and Chronic Inflammation in Patients with Parkinson’s Disease: A Randomized Clinical Trial. Psychother Psychosom. 2025 Feb 28;94(2):101–118.

Abstract

Introduction

Clinical guidelines recommend a holistic approach to Parkinson’s disease (PD) care, yet randomized trials examining mindfulness-based interventions in this context are scarce. This study investigated the effects of two mindfulness practices – meditation and yoga – on biopsychosocial outcomes in PD patients, including anxiety symptoms, depressive symptoms, motor/nonmotor symptoms, health-related quality-of-life (HRQOL), mindfulness, and stress and inflammation biomarkers, compared to usual care.

Methods

159 participants with a clinical diagnosis of idiopathic PD and a Hoehn and Yahr stage of 1, 2, and 3, were randomized into meditation (n = 53), yoga (n = 52), and control (n = 54). Meditation and yoga were delivered in 90-min groups for 8 weeks. Primary outcomes included anxiety symptoms and depressive symptoms. Secondary outcomes included motor and nonmotor symptoms, HRQOL, mindfulness, and serum levels of interleukin-6, cortisol and TNF-alpha. Assessments were done at baseline (T0), 2 months (T1), and 6 months (T2). Linear mixed models were conducted following intention-to-treat principle.

Results

Compared to control, both meditation, and yoga groups had significant improvements in anxiety symptoms (meditation: mean difference [MD] = −1.36, 95% CI: −2.46 to−0.26; yoga: MD = −1.61, CI: −2.70 to −0.52), motor symptoms (meditation: MD = −5.35, CI: −8.61 to−2.09; yoga: MD = −6.59, CI: −9.82 to−3.36), HRQOL (meditation: MD = −2.01, CI: −3.41 to−0.62; yoga: MD = −1.45, CI: −2.83 to−0.08), and describing skills (meditation: MD = 0.97, CI: 0.04–1.89; yoga: MD = 0.92, CI: 0.01–1.84) at T1, and significant reductions in serum interleukin-6 levels (meditation: MD = −1.14, CI: −2.18 to−0.10; yoga: MD = −1.11, CI: −2.09 to−0.13) at T2. Only meditation significantly reduced depression (MD = −1.44, CI: −2.57 to−0.30) at T1 and sustained the motor and HRQOL improvements at T2.

Conclusion

Meditation and yoga significantly improved anxiety symptoms, chronic inflammation, motor symptoms, mindfulness-describing facet, and HRQOL in PD patients. Meditation provided additional benefits in reducing depressive symptoms and sustaining motor and HRQOL improvements.

 

Meditation Improves Attention

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How to Help Patients Improve Sustained Attention - HappyNeuron Pro - Blog

By John M. de Castro, Ph.D.

 

In today’s Research News article “The impact of meditation on sustained attention in nonclinical population: An extensive review” (See summary below or view the full text of the study at: https://pmc.ncbi.nlm.nih.gov/articles/PMC11925505/ )  Roy and Subramanya review and summarize the published research on the impact of focused and open monitoring meditation on sustained attention. They report that the published research found that both meditation techniques significant improved sustained attention while focused meditation additionally significantly lowering perceived stress.

 

Improve attention with meditation.

 

CMCS – Center for Mindfulness and Contemplative Studies

 

This and other Contemplative Studies posts are also available on the Contemplative Studies Blog  http://contemplative-studies.org

 

Study Summary

 

Roy A, Subramanya P. The impact of meditation on sustained attention in nonclinical population: An extensive review. J Ayurveda Integr Med. 2025 Mar-Apr;16(2):101057. doi: 10.1016/j.jaim.2024.101057. Epub 2025 Mar 4. PMCID: PMC11925505.

 

Abstract

Background

Meditation, encompassing focussed attention (FA) and open monitoring (OM) approaches, is recognised for its potential to enhance cognitive functions. Sustained attention, a critical component of attentional processes, influences cognitive capacity and is linked to meditation benefits. However, a robust and extensive review analysis needs to address the specific relationship between meditation and sustained attention in nonclinical populations.

Methods

Following PRISMA guidelines, the authors reviewed English articles published from 2013 to 2023 in Q1 SCOPUS-indexed journals. Inclusion criteria comprised original research studies exploring the impact of meditation on sustained attention in healthy individuals. The modified Jadad Scale assessed methodological quality.

Results

12 studies (four RCTs, eight non-RCTs) with 1447 participants were included. Concentrative or FA meditation demonstrated consistent positive effects on sustained attention, including reduced perceived stress and increased focussed attention. OM meditation significantly improved sustained attention, as evidenced by reduced mind wandering and enhanced N2 responses. Meditators consistently outperformed non-meditators in sustained attention tasks, demonstrating faster reactions and lower error rates.

Discussion

This review explored the impact of meditation on sustained attention across diverse non-clinical populations through 12 investigations involving 1447 subjects with meditation interventions spanning from 21 days to 3 months. The study revealed that both FA and OM meditation approaches positively impact sustained attention, highlighting their potential role in enhancing cognitive function. Meditators consistently exhibited superior sustained attention abilities, suggesting the cognitive benefits of regular meditation practice. The findings of this study are consistent with prior research, contributing to the growing body of knowledge on the advantageous impacts of meditation on sustained attention. However, caution is needed in generalizing findings due to study limitations. Future research should use standardized methodologies and conduct longer-term follow-ups to better elucidate the effects of meditation interventions on sustained attention across diverse populations.

 

Change the Brain to Improve Personal Qualities with Loving Kindness Meditation

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Loving-Kindness Meditation – Teacher-Life-Coach

By John M. de Castro, Ph.D.

 

In today’s Research News article “Loving-Kindness Meditation: Systematic Review of Neuroimaging Correlates in Long-Term Practitioners and Clinical Implications.” (See summary below or view the full text of the study at: https://pmc.ncbi.nlm.nih.gov/articles/PMC11870839/ ) Bashir and colleagues review and summarize the published research studies on changes in the brain resulting from long-term practice of Loving Kindness Meditation (LKM). They report that the brains of LKM practitioners have changes in the superior parietal lobe, inferior frontal gyrus, medial frontal lobe, and insular cortex. These areas are associated with self‐compassion, cognitive and affective empathy, and prosociality.

 

Long-term Loving Kindness Meditation changes brain structures responsible for the personal qualities produced by the practice.

 

CMCS – Center for Mindfulness and Contemplative Studies

 

This and other Contemplative Studies posts are also available on the Contemplative Studies Blog  http://contemplative-studies.org

 

Study Summary

 

Bashir K, Edstrom SB, Barlow SJ, Gainer D, Lewis JD. Loving-Kindness Meditation: Systematic Review of Neuroimaging Correlates in Long-Term Practitioners and Clinical Implications. Brain Behav. 2025 Mar;15(3):e70372. doi: 10.1002/brb3.70372. PMID: 40022190; PMCID: PMC11870839.

 

ABSTRACT

Introduction

Loving‐kindness meditation (LKM), a meditation type focused on nurturing love and compassion for oneself and others, has been shown to provide mental health benefits, and LKM interventions are being investigated for mental disorders. The benefits of long‐term practice, such as increased self‐compassion, greater cognitive and affective empathy, and prosocial behavior, are proposed to be due to neuroplastic changes that support well‐being. This systematic review aims to summarize the differences in brain structure and function in long‐term practitioners (LTPs) of LKM versus controls to identify possible underlying mechanisms that support mental health and drive treatment effect.

Methods

The literature search included Google Scholar, PubMed, and APA PsycINFO from inception through November 13, 2023.

Results

After review, five studies (64 LTPs and 67 controls total) were included. Brain regions with between‐group differences reported in at least two studies include the superior parietal lobe, inferior frontal gyrus, medial frontal lobe, and insular cortex.

Conclusion

These areas are responsible for self‐compassion, cognitive and affective empathy, and prosociality—personal qualities believed to be fostered through LKM practice. Longitudinal neuroimaging and neurophysiological studies incorporating LKM interventions for specific mental disorders are needed to further inform the biological basis of these treatments and may provide surrogate outcome measures for future clinical trials to refine this promising treatment modality.

 

Mindfulness Meditation Alters the Brain to Accentuate Sensory Information Processing

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Figure 3

By John M. de Castro, Ph.D.

 

In today’s Research News article “Long-term mindfulness meditation increases occurrence of sensory and attention brain states” (See summary below or view the full text of the study at: https://pmc.ncbi.nlm.nih.gov/articles/PMC11743700/ ) Panitz and colleagues examined the activity of brain systems in experienced mindfulness meditators in comparison to non-meditators and found that experienced meditators had greater activity in brain systems associated with sensory processing and lower activity in systems associated with cognitive processing, This suggests that mindfulness meditation practice alters brain activity to accentuate immediate sensations.

 

Mindfulness meditation increases brain sensory processing while decreasing brain cognitive processing.

 

CMCS – Center for Mindfulness and Contemplative Studies

 

This and other Contemplative Studies posts are also available on the Contemplative Studies Blog  http://contemplative-studies.org

 

Study Summary

 

Panitz DY, Mendelsohn A, Cabral J, Berkovich-Ohana A. Long-term mindfulness meditation increases occurrence of sensory and attention brain states. Front Hum Neurosci. 2025 Jan 6;18:1482353. doi: 10.3389/fnhum.2024.1482353. PMID: 39834400; PMCID: PMC11743700.

 

Abstract

Interest has been growing in the use of mindfulness meditation (MM) as a therapeutic practice, as accumulating evidence highlights its potential to effectively address a range of mental conditions. While many fMRI studies focused on neural activation and functional connectivity during meditation, the impact of long-term MM practice on spontaneous brain activity, and on the expression of resting state networks over time, remains unclear. Here, intrinsic functional network dynamics were compared between experienced meditators and meditation-naïve participants during rest. Our analysis revealed that meditators tend to spend more time in two brain states that involve synchrony among cortical regions associated with sensory perception. Conversely, a brain state involving frontal areas associated with higher cognitive functions was detected less frequently in experienced meditators. These findings suggest that, by shifting attention toward enhanced sensory and embodied processing, MM effectively modulates the expression of functional network states at rest. These results support the suggested lasting effect of long-term MM on the modulation of resting-state networks, reinforcing its therapeutic potential for disorders characterized by imbalanced network dynamics. Moreover, this study reinforces the utility of analytic approaches from dynamical systems theory to extend current knowledge regarding brain activity and evaluate its response to interventions.

 

Meditation is Associated with a Reduction in Brain Aging Indicators

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Figure 2

By John M. de Castro, Ph.D.

 

In today’s Research News article “Meditation Linked to Enhanced MRI Signal Intensity in the Pineal Gland and Reduced Predicted Brain Age” (See summary below or view the full text of the study at: https://pmc.ncbi.nlm.nih.gov/articles/PMC11822093/ ) Plini and colleagues examined the brains of long-term meditators and found that the activity of their Pineal Glands was enhanced and an indicator of brain aging was reduced. This suggests that meditation leads to less aging of the brain. This could be a mechanism whereby meditation reduces cognitive decline with aging.

 

Reduce brain aging with meditation.

 

CMCS – Center for Mindfulness and Contemplative Studies

 

This and other Contemplative Studies posts are also available on the Contemplative Studies Blog  http://contemplative-studies.org

 

Study Summary

 

Plini ERG, Melnychuk MC, Dockree PM. Meditation Linked to Enhanced MRI Signal Intensity in the Pineal Gland and Reduced Predicted Brain Age. J Pineal Res. 2025 Mar;77(2):e70033. doi: 10.1111/jpi.70033. PMID: 39940075; PMCID: PMC11822093.

 

ABSTRACT

Growing evidence demonstrates that meditation practice supports cognitive functions, including attention and interoceptive processing, and is associated with structural changes across cortical networks, including prefrontal regions and the insula. However, the extent of subcortical morphometric changes linked to meditation practice is less appreciated. A noteworthy candidate is the pineal gland, a key producer of melatonin, which regulates circadian rhythms that augment sleep‐wake patterns and may also provide neuroprotective benefits to offset cognitive decline. Increased melatonin levels, as well as increased fMRI BOLD signal in the pineal gland, have been observed in meditators versus controls. However, it is not known if long‐term meditators exhibit structural changes in the pineal gland linked to the lifetime duration of practice. In the current study, we performed voxel‐based morphometry (VBM) analysis to investigate: (1) whether long‐term meditators (LTMs) (n = 14) exhibited greater pineal gland MRI‐derived signal intensity compared to a control group (n = 969), (2) a potential association between the estimated lifetime hours of meditation (ELHOM) and pineal gland signal intensity, and (3) whether LTMs show greater grey matter (GM) maintenance (BrainPAD) that is associated with pineal gland signal intensity. The results revealed greater pineal gland signal intensity and lower BrainPAD scores (younger brain age) in LTMs compared to controls. Exploratory analysis revealed a positive association between ELHOM and greater signal intensity in the pineal gland but not with GM maintenance as measured by BrainPAD score. However, greater pineal signal intensity and lower BrainPAD scores were correlated in LTMs. The potential mechanisms by which meditation influences pineal gland function, hormonal metabolism, and GM maintenance are discussed – in particular, melatonin’s roles in sleep, immune response, inflammation modulation, and stem cell and neural regeneration.

 

Deep Meditative States are Associated with Disruption of Brain Cortical Circuits

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Discover the Secret to How to Get Into Deep Meditation

By John M. de Castro, Ph.D.

 

In today’s Research News article “Multimodal neurophenomenology of advanced concentration absorption meditation: An intensively sampled case study of Jhana” (See summary below or view the full text of the study at: https://pmc.ncbi.nlm.nih.gov/articles/PMC11770875/ ) Chowdhury and colleagues studied brain activity during deep absorptive meditative states. These states are associated with intense concentration and feelings of bliss, peace, and clarity. They report that during these meditative states the activity of primary neural circuits in the brain are dysregulated (disrupted). This suggests that deep meditation practice deconstructs the brain’s cortical hierarchy, likely inhibiting thoughts and imagery.

 

CMCS – Center for Mindfulness and Contemplative Studies

 

This and other Contemplative Studies posts are also available on the Contemplative Studies Blog  http://contemplative-studies.org

 

Study Summary

 

Chowdhury A, Bianciardi M, Chapdelaine E, Riaz OS, Timmermann C, van Lutterveld R, Sparby T, Sacchet MD. Multimodal neurophenomenology of advanced concentration absorption meditation: An intensively sampled case study of Jhana. Neuroimage. 2025 Jan;305:120973. doi: 10.1016/j.neuroimage.2024.120973. Epub 2024 Dec 14. PMID: 39681243; PMCID: PMC11770875.

 

Abstract

Using a combination of fMRI, EEG, and phenomenology ratings, we examined the neurophenomenology of advanced concentrative absorption meditation, namely jhanas (ACAM-J), in a practitioner with over 23,000 h of meditation practice. Our study shows that ACAM-J states induce reliable changes in conscious experience and that these experiences are related to neural activity. Using resting-state fMRI functional connectivity, we found that ACAM-J is associated with decreased within-network modularity, increased global functional connectivity (GFC), and desegregation of the default mode and visual networks. Compared to control tasks, the ACAM-J were also related to widespread decreases in broadband EEG oscillatory power and increases in Lempel-Ziv complexity (LZ, a measure of brain entropy). Some fMRI findings varied by the control task used, while EEG results remained consistent, emphasizing both shared and unique neural features of ACAM-J. These differences in fMRI and EEG-measured neurophysiological properties correlated with specific changes in phenomenology – and especially with ACAM-J-induced states of bliss – enriching our understanding of these advanced meditative states. Our results show that advanced meditation practices markedly dysregulate high-level brain systems via practices of enhanced attention to sensations, corroborating recent neurocognitive theories of meditation as the deconstruction of the brain’s cortical hierarchy. Overall, our results suggest that ACAM-J is associated with the modulation of large-scale brain networks in both fMRI and EEG, with potential implications for understanding the mechanisms of deep concentration practices and their effects on subjective experience.