Improve Alzheimer’s Patients Quality of Life with Yoga

January 21, 2025 psyjdc Leave a comment

FAU | Online Chair Yoga Viable for Isolated Older Adults with Dementia

By John M. de Castro, Ph.D.

In today’s Research News article “Impact of Yoga in Transformation of Quality of Life of Alzheimer’s disease cases” (See summary below or view the full text of the study at: https://pmc.ncbi.nlm.nih.gov/articles/PMC11712740/pdf/ALZ-20-e095088.pdf ) Kaushik and colleagues found that a 12-week yoga practice significantly improved the quality of life and cognitive function while reducing depression in mild to moderate Alzheimer’s Disease patients.

Yoga practice improves the lives of Alzheimer’s Disease patients.

CMCS – Center for Mindfulness and Contemplative Studies

This and other Contemplative Studies posts are also available on the Contemplative Studies Blog http://contemplative-studies.org

Study Summary

Kaushik M. Impact of Yoga in Transformation of Quality of Life of Alzheimer’s disease cases. Alzheimers Dement. 2025 Jan 9;20(Suppl 8):e095088. doi: 10.1002/alz.095088. PMCID: PMC11712740.

Abstract

Background

Alzheimer’s disease (AD) constitutes a formidable challenge, profoundly affecting the fabric of individuals’ lives and intricately entwined with disturbances in their quality of life. This study embarks on a mission to unravel the transformative potential of a carefully crafted 12‐week yoga intervention, specifically tailored to address the multifaceted dimensions of quality of life. Our aim is to unravel the impact of a yoga intervention on their overall quality of life with AD and mild cognitively impairment subjects.

Method

A case control yoga interventional study was conducted on 30 subjects (male‐18 and female‐12) were enrolled from the department of neurology and neurocognitive assessments were done in department of Anatomy, AIIMS, New Delhi, India. All the participants, aged >60 years were recruited. The 12‐week yoga intervention entailed daily hour‐long sessions over 6 days. The multifaceted evaluation encompassed the Geriatric Depression Scale (GDS) including the evaluation of 15 questions and the Montreal Cognitive Assessment (MoCA) scale including for overall quality of life assessment with measuring language, memory, attention, visuospatial, naming, delayed recall, abstraction, and orientation for quality‐of‐life of the AD subjects.

Result

The AD subjects cohort exhibited statistically significant enhancements (P < 0.001) in quality‐of‐life scores (GDS & MoCA) pre and post Yoga intervention. GDS scores of 15 questions experienced a remarkable transition from pre‐yoga (8.36 ± 2.7) to post‐yoga (5.13 ± 3.0). While total MoCA scores ascended from pre yoga (18.65 ± 4.13) to post yoga (25.06 ± 6.3). MoCA scores of individual points pre yoga includes language (1.10 ± 0.2), memory (no points), attention (3.54 ± 1.8), visuospatial (4.0 ± 1.30), naming (2.16 ± 0.4), delayed recall (3.55 ± 0.25), abstraction (0.50 ± 0.0), and orientation (3.80 ± 0.18). MoCA scores of individual points post yoga includes language (2.16 ± 0.6), memory (no points), attention (4.60 ± 1.3), visuospatial (4.90 ± 2.50), naming (2.85 ± 0.75), delayed recall (4.85 ± 0.50), abstraction (1.40 ± 0.20), and orientation (4.30 ± 0.45).

Conclusion

This discerning study illuminates the transformative potential of a 12‐week yoga program, showcasing significant enhancements in the quality of life of individuals grappling with mild to moderate Alzheimer’s disease.

Meditation Reduces Worker Stress

January 20, 2025 psyjdc Leave a comment

Study finds meditation with Headspace app reduces stress in pregnancy By John M. de Castro, Ph.D.

In today’s Research News article “Digital Meditation to Target Employee Stress” (See summary below or view the full text of the study at: https://jamanetwork.com/journals/jamanetworkopen/articlepdf/2829186/radin_2025_oi_241525_1736185782.29032.pdf) Radin and colleagues performed a controlled clinical trial and found that 10 minutes of daily meditation significantly reduced stress levels in employees of a university health system.

CMCS – Center for Mindfulness and Contemplative Studies

Radin RM, Vacarro J, Fromer E, Ahmadi SE, Guan JY, Fisher SM, Pressman SD, Hunter JF, Sweeny K, Tomiyama AJ, Hofschneider LT, Zawadzki MJ, Gavrilova L, Epel ES, Prather AA. Digital Meditation to Target Employee Stress: A Randomized Clinical Trial. JAMA Netw Open. 2025 Jan 2;8(1):e2454435. doi: 10.1001/jamanetworkopen.2024.54435. PMID: 39808431; PMCID: PMC11733700.

Study Summary

This randomized clinical trial investigates whether a digital mindfulness meditation application reduces perceptions of global and job-related stress among adults employed at a large academic medical center.

Key Points

Question

Can digital mindfulness meditation improve general stress and work-related stress among employees at a large academic medical center?

Findings

In this randomized clinical trial of 1458 employees, those who received mindfulness meditation (vs waiting list control) had significant reductions in perceived stress at 8 weeks.

Meaning

The findings suggest that participating in a brief digital mindfulness-based program is an effective method for reducing general and work-related stress in employees.

Abstract

Importance

Mindfulness meditation may improve well-being among employees; however, effects of digital meditation programs are poorly understood.

Objective

To evaluate the effects of digital meditation vs a waiting list condition on general and work-specific stress and whether greater engagement in the intervention moderates these effects.

Design, Setting, and Participants

This randomized clinical trial included a volunteer sample of adults (aged ≥18 years) employed at a large academic medical center who reported mild to moderate stress, had regular access to a web-connected device, and were fluent in English. Exclusion criteria included being a regular meditator. Participants were recruited from May 16, 2018, through September 28, 2019, and completed baseline, 8-week, and 4-month measures assessing stress, job strain, burnout, work engagement, mindfulness, depression, and anxiety. Data were analyzed from March 2023 to October 2024.

Intervention

Participants were randomized 1:1 to a digital meditation program or the waiting list control condition. Participants in the intervention group were instructed to complete 10 minutes of meditation per day for 8 weeks. The control group was instructed to continue their normal activities and not add any meditation during the study period.

Main Outcomes and Measures

The primary outcome measure was change in Perceived Stress Scale (PSS) score at 8 weeks. Secondary outcome measures included changes in job strain, measured as work effort-reward imbalance.

Results

A total of 1458 participants (mean [SD] age, 35.54 [10.30] years; 1178 [80.80%] female) were included. Those randomized to meditation (n = 728) vs waiting list (n = 730) showed improvements in PSS (Cohen d, 0.85; 95% CI, 0.73-0.96) and in all secondary outcome measures (eg, job strain: Cohen d, 0.34; 95% CI, 0.23-0.46) at 8 weeks. These improvements were maintained at 4 months after randomization (PSS: Cohen d, 0.71; 95% CI, 0.59-0.84; job strain: Cohen d, 0.37; 95% CI, 0.25-0.50). Those using the app from 5 to 9.9 min/d vs less than 5 min/d showed greater reduction in stress (mean PSS score difference, −6.58; 95% CI, −7.44 to −5.73).

Conclusions and Relevance

The findings suggest that a brief, digital mindfulness-based program is an easily accessible and scalable method for reducing perceptions of stress. Future work should seek to clarify mechanisms by which such interventions contribute to improvements in work-specific well-being

This and other Contemplative Studies posts are also available on the Contemplative Studies Blog http://contemplative-studies.org

Meditation is an Effective Therapy for Post-Traumatic Stress Disorder (PTSD)

January 16, 2025 psyjdc Leave a comment

Meditation is an Effective Therapy for Post-Traumatic Stress Disorder (PTSD).

By John M. de Castro, Ph.D.

In today’s Research News article “Effectiveness of Meditation Techniques in Treating Post-Traumatic Stress Disorder: A Systematic Review and Meta-Analysis” (See summary below) Orme-Johnson summarized the published controlled research on the effectiveness of various meditation techniques on Post-traumatic stress disorder (PTSD). They found that the published controlled research demonstrated significant reductions in PTSD symptoms regardless of the meditation technique in veterans, refugees, earthquake victims, prisoners, and civilians.

Hence, mindfulness meditation is an effective treatment for Post-traumatic stress disorder (PTSD).

CMCS – Center for Mindfulness and Contemplative Studies

This and other Contemplative Studies posts are also available on the Contemplative Studies Blog http://contemplative-studies.org

Study Summary

Orme-Johnson DW, Barnes VA, Rees B, Tobin J, Walton KG. Effectiveness of Meditation Techniques in Treating Post-Traumatic Stress Disorder: A Systematic Review and Meta-Analysis. Medicina (Kaunas). 2024 Dec 12;60(12):2050. doi: 10.3390/medicina60122050. PMID: 39768929; PMCID: PMC11678240.

https://pmc.ncbi.nlm.nih.gov/articles/PMC11678240/pdf/medicina-60-02050.pdf

Abstract

Background and Objectives: Post-traumatic stress disorder (PTSD) is a debilitating condition worldwide. The limited effectiveness of current psychological and pharmacological treatments has motivated studies on meditation techniques. This study is a comprehensive, multiple-treatments meta-analysis comparing the effectiveness of different categories of meditation in treating PTSD. Methods and Materials: We followed Prisma guidelines in our published protocol to search major databases and to conduct a meta-analysis of the studies. Results: We located 61 studies with 3440 subjects and divided them logically into four treatment groups: Mindfulness-Based Stress Reduction (MBSR, 13 studies); Mindfulness-Based Other techniques (MBO, 16 studies), Transcendental Meditation (TM, 18 studies), and Other Meditations that were neither mindfulness nor TM (OM, 14 studies). Trauma populations included war veterans, war refugees, earthquake and tsunami victims, female survivors of interpersonal violence, clinical nurses, male and female prison inmates, and traumatized students. Of those offered, 86% were willing to try meditation. The baseline characteristics of subjects were similar across meditation categories: mean age = 52.2 years, range 29–75; sample size = 55.4, range 5–249; % males = 65.1%, range 0–100; and maximum study duration = 13.2 weeks, range 1–48. There were no significant differences between treatment categories on strength of research design nor evidence of publication bias. The pooled mean effect sizes in Hedges’s g for the four categories were MBSR = −0.52, MBO = −0.66, OM = −0.63, and TM = −1.13. There were no appreciable differences in the study characteristics of research conducted on different meditations in terms of the types of study populations included, outcome measures, control conditions, gender, or length of time between the intervention and assessment of PTSD. TM’s effect was significantly larger than for each of the other categories, which did not differ from each other. No study reported serious side effects. Conclusions: All categories of meditation studied were helpful in mitigating symptoms of PTSD. TM produced clinically significant reductions in PTSD in all trauma groups. We recommend a multisite Phase 3 clinical trial to test TM’s efficacy compared with standard treatment.

January 3, 2025 psyjdc Leave a comment

May be an image of 1 person and sleepwear Mindfulness Meditation Reduces Pain.

By John M. de Castro, Ph.D.

In today’s Research News article “Mindfulness Meditation and Placebo Modulate Distinct Multivariate Neural Signatures to Reduce Pain” (See summary below) Riegner and colleagues demonstrate that mindfulness meditation reduces both subjective pain and the brain responses to pain to a greater extent than a placebo.

Hence, mindfulness meditation is an effective treatment for pain.

CMCS – Center for Mindfulness and Contemplative Studies

This and other Contemplative Studies posts are also available on the Contemplative Studies Blog http://contemplative-studies.org

Study Summary

Riegner G, Dean J, Wager TD, Zeidan F. Mindfulness Meditation and Placebo Modulate Distinct Multivariate Neural Signatures to Reduce Pain. Biol Psychiatry. 2025 Jan 1;97(1):81-88. doi: 10.1016/j.biopsych.2024.08.023. Epub 2024 Aug 30. PMID: 39216636; PMCID: PMC11608143.

Abstract

Background: Rather than a passive reflection of nociception, pain is shaped by the interplay between one’s experiences, current cognitive-affective states, and expectations. The placebo response, a paradoxical yet reliable phenomenon, is postulated to reduce pain by engaging mechanisms shared with active therapies. It has been assumed that mindfulness meditation, practiced by sustaining nonjudgmental awareness of arising sensory events, merely reflects mechanisms evoked by placebo. Recently, brain-based multivariate pattern analysis has been validated to successfully disentangle nociceptive-specific, negative affective, and placebo-based dimensions of the subjective pain experience.

Methods: To determine whether mindfulness meditation engages distinct brain mechanisms from placebo and sham mindfulness to reduce pain, multivariate pattern analysis pain signatures were applied across 2 randomized clinical trials that employed overlapping psychophysical pain testing procedures (49 °C noxious heat; visual analog pain scales) and distinct functional magnetic resonance imaging techniques (blood oxygen level-dependent; perfusion based). After baseline pain testing, 115 healthy participants were randomized into a 4-session mindfulness meditation (n = 37), placebo-cream conditioning (n = 19), sham mindfulness meditation (n = 20), or book-listening control (n = 39) intervention. After each intervention, noxious heat was administered during functional magnetic resonance imaging and each manipulation.

Results: A double dissociation in the multivariate pattern analysis signatures supporting pain regulation was revealed by mindfulness meditation compared with placebo cream. Mindfulness meditation produced significantly greater reductions in pain intensity and pain unpleasantness ratings and nociceptive-specific and negative affective pain signatures than placebo cream, sham mindfulness meditation, and control interventions. The placebo-cream group significantly lowered the placebo-based signature.

Conclusions: Mindfulness meditation and placebo engaged distinct and granular neural pain signatures to reduce pain.

Meditation Practice is Perfect

August 20, 2024 psyjdc Leave a comment

Today's Meditation: Stay in Your Own Lane - Bare Bones Yoga

Meditation Practice is Perfect

John M. de Castro

“Sometimes we get the idea that there’s a best practice, a right practice, a most powerful practice. But different practices and different qualities or nuances of practice might be most appropriate for us at different times as our practice, understanding, and recognition of what’s helpful, needed, or skillful evolves.” – Martin Aylward

The human mind is always judgmental and critical. This has been a very good thing for our adaptation to the environment. It causes us to constantly analyze our experience and the results of our activities producing adjustments that improve the outcomes. This process is one of the key reasons why humans have learned to control and dominate our environment. But when applied to meditation practice it is counterproductive.

Being judgmental and critical regarding meditation practice is contrary to the nature of practice. The core practice of meditation involves seeing and accepting everything just as it is in the present moment. There is no need to analyze it. There is no need to criticize it. Indeed, there is no need to change it in any way. This includes the practice itself. It just is as it is. It just needs to be experienced and accepted. There is no such thing as good practice or bad practice. There is only practice as it is. There is no need to change it or try to improve it.

In meditation, if the mind wanders, there is no need to feel bad. It is just what experience is in that moment. There is no need to try to make the mind wander less. Just observe that the mind is wandering letting go of all judgment. If the mind is focused and calm, there is no need to feel good about it. There is no need to try to keep it up or stay focused. Just observe that the mind is focused and let go of all judgment.

In meditation no matter what transpires, the experience arises in awareness. Simply being aware of it is all that is needed. In fact, awareness in the present moment is all there is. There is nothing more to existence. In meditation, we amplify that experience of awareness allowing the mind to better see and accept it. But what the mind does and doesn’t do is irrelevant. Awareness simply is, regardless of the mind’s appreciation of it. So, there is no need to do things to make the mind better see it. That makes no difference. Awareness simply is. In fact, the mind’s activity is simply a part of what we’re aware of.

Awareness and the objects of awareness are not separate processes. Without objects of awareness there is no awareness. Conversely, without awareness there are no objects of awareness. They are one and the same thing. During meditation there is seeing, there is hearing, there is feeling, there are many sensory experiences. They do not just occur in awareness they are awareness itself. It is all one. Meditation is simply observing the co-arising of awareness and experience.

I often repeat during meditation “just be.” This is a reminder to not try to do or be anything, to not judge what is going on, to not criticize or analyze it, and to not try to alter it. Just be. In fact, the implicit speech of “just be” is also simply an object in awareness. It is not something to be acted upon. It is a means to keep the mind from interfering with experience.

So, relax and enjoy meditation, regardless of its nature. Just be.

Reduce Hypertension with Mindfulness

July 24, 2024July 24, 2024 psyjdc Leave a comment

Reduce Hypertension with Mindfulness

By John M. de Castro, Ph.D.

“High blood pressure is a silent killer. It can strike without warning, but with proper care and lifestyle changes, it can be controlled.” – Dr. David B. Ryder

High Blood Pressure (Hypertension) is an insidious disease because there are no overt symptoms. The individual feels fine. But it can be deadly as more than 360,000 American deaths, roughly 1,000 deaths each day, had high blood pressure as a primary or contributing cause. In addition, hypertension markedly increases the risk heart attack, stroke, heart failure, and kidney disease. It is also a very common disorder with about 70 million American adults (29%) having high blood pressure and only about half (52%) of people with high blood pressure have their condition under control. Treatment frequently includes antihypertensive drugs. But these medications often have adverse side effects. So, patients feel lousy when taking the drugs, but fine when they’re not. So, compliance is a major issue with many patients not taking the drugs regularly or stopping entirely. Obviously, there is a need for alternative to drug treatments for hypertension. Mindfulness practices have been shown to aid in controlling hypertension.

In today’s Research News article “Effect of Adapted Mindfulness Training in Participants With Elevated Office Blood Pressure: The MB-BP Study: A Randomized Clinical Trial” (See summary below or view the full text of the study at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10381983/ ) Loucks and colleagues recruited adults with elevated blood pressure and randomly assigned them to either enhanced usual care or to receive Mindfulness-Based Blood Pressure Reduction, based upon Mindfulness-Based Stress Reduction (MBSR) program, consisting of 8 weekly 2,5 hour group sessions along with home mindfulness practice. The participants were measured at baseline and at 3 and 6 months later for blood pressure, health behaviors, physical activity, diet, alcohol consumption, antihypertensive medication, perceived stress, and mindfulness.

They found that mindfulness training produced a significantly greater reduction in blood pressure at 3 and 6 months. They also found significant reductions in sedentary activity and perceived stress and a significant increase in mindfulness.

Hence, mindfulness training was found to be an effective treatment for hypertension.

“The secret to managing blood pressure is a healthy lifestyle”– Dr. Andrew Hall

CMCS – Center for Mindfulness and Contemplative Studies

This and other Contemplative Studies posts are also available on the Contemplative Studies Blog http://contemplative-studies.org

Study Summary

Loucks EB, Schuman-Olivier Z, Saadeh FB, Scarpaci MM, Nardi WR, Proulx JA, Gutman R, King J, Britton WB, Kronish IM. Effect of Adapted Mindfulness Training in Participants With Elevated Office Blood Pressure: The MB-BP Study: A Randomized Clinical Trial. J Am Heart Assoc. 2023 Jun 6;12(11):e028712. doi: 10.1161/JAHA.122.028712. Epub 2023 May 23. PMID: 37218591; PMCID: PMC10381983.

Clinical Perspective

What Is New?

This study represents the first randomized controlled trial of a mindfulness‐based program that has been customized to participants with elevated blood pressure.

What Are the Clinical Implications?

This study demonstrated a clinically significant reduction in systolic blood pressure, with evidence of effects on sedentary activity, Dietary Approaches to Stop Hypertension dietary pattern, and mindfulness.

This program may offer an appealing approach to help control blood pressure of the 46% of Americans with hypertension, of which >75% is uncontrolled.

Abstract

Background

Hypertension is a leading risk factor for cardiovascular disease. Despite availability of effective lifestyle and medication treatments, blood pressure (BP) is poorly controlled in the United States. Mindfulness training may offer a novel approach to improve BP control. The objective was to evaluate the effects of Mindfulness‐Based Blood Pressure Reduction (MB‐BP) versus enhanced usual care control on unattended office systolic BP.

Methods and Results

Methods included a parallel‐group phase 2 randomized clinical trial conducted from June 2017 to November 2020. Follow‐up time was 6 months. Outcome assessors and data analyst were blinded to group allocation. Participants had elevated unattended office BP (≥120/80 mm Hg). We randomized 201 participants to MB‐BP (n=101) or enhanced usual care control (n=100). MB‐BP is a mindfulness‐based program adapted for elevated BP. Loss‐to‐follow‐up was 17.4%. The primary outcome was change in unattended office systolic BP at 6 months. A total of 201 participants (58.7% women; 81.1% non‐Hispanic White race and ethnicity; mean age, 59.5 years) were randomized. Results showed that MB‐BP was associated with a 5.9‐mm Hg reduction (95% CI, −9.1 to −2.8 mm Hg) in systolic BP from baseline and outperformed the control group by 4.5 mm Hg at 6 months (95% CI, −9.0 to −0.1 mm Hg) in prespecified analyses. Plausible mechanisms with evidence to be impacted by MB‐BP versus control were sedentary activity (−350.8 sitting min/wk [95% CI, −636.5 to −65.1] sitting min/wk), Dietary Approaches to Stop Hypertension diet (0.32 score [95% CI, −0.04 to 0.67]), and mindfulness (7.3 score [95% CI, 3.0–11.6]).

Conclusions

A mindfulness‐based program adapted for individuals with elevated BP showed clinically relevant reductions in systolic BP compared with enhanced usual care. Mindfulness training may be a useful approach to improve BP.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10381983/

Mindfulness Protects Against Depression and Psychopathology in Alzheimer’s Disease

November 28, 2023 psyjdc Leave a comment

By John M. de Castro, Ph.D.

“People do not realize that Alzheimer’s is not old age. It is a progressive and fatal disease and staggering amounts of people develop Alzheimer’s every day.” – Melina Kanakaredes

The normal aging process involves a systematic progressive decline in every system in the body, the brain included. The elderly often have problems with attention, thinking, and memory, known as mild cognitive impairment. But sometimes the decline is rapid and results in dementia; a progressive loss of mental function produced by degenerative diseases of the brain. It is quite common with about 3% of adults ages 70 to 74, 22% of adults ages 85 to 89 and 33% of adults ages 90 and older. Between 60% to 80% of dementia cases are classified as Alzheimer’s Disease.

An encouraging new development is that mindfulness practices such as meditation training and mindful movement practices can significantly reduce these declines in cognitive ability and dementia. In addition, it has been found that mindfulness practices reduce the deterioration of the brain that occurs with aging restraining the loss of neural tissue. This suggests that mindfulness may help to relieve some of the symptoms and/or slow the progression of mild Alzheimer’s Disease.

In today’s Research News article “Mindfulness Prevents Depression and Psychopathology in Elderly People with Mild to Moderate Alzheimer’s Disease: A Randomized Clinical Trial.” (See summary below or view the full text of the study at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9881020/) Quintana-Hernández and colleagues recruited elderly patients with mild to moderate Alzheimer’s Disease and randomly assigned them to one of four conditions; Mindfulness-based Alzheimer’s Stimulation; CS, Cognitive Stimulation; PMR, Progressive Muscle Relaxation; or no treatment. All participants received 3 weekly sessions for 2 years combined with daily 10 mg Donepezil. They were measured for depression, geriatric depression, and neuropsychological symptoms at baseline or 6, 12, 18, and 24 months later.

They found that the groups did not differ at baseline but that the Mindfulness-based Alzheimer’s Stimulation group had significantly lower scores than the other 3 groups at the 6-, 12-, 18-, and 24-months for depression, insomnia, agitation, anxiety, somatic symptoms, weight loss, delusions, apathy, irritability, and night time behaviors and higher levels of appetite and insight. These measures for the mindfulness group did not differ from baseline at any follow up while the other 3 groups significantly deteriorated over time relative to baseline.

These findings suggest that mindfulness training prevents deterioration in depression and psychopathology while other treatments or no treatment continue to deteriorate. Hence mindfulness training would appear be beneficial in the treatment of patients with mild to moderate Alzheimer’s Disease.

“You only know yourself because of your memories.” – Andrea Gillies

CMCS – Center for Mindfulness and Contemplative Studies

This and other Contemplative Studies posts are also available on the Contemplative Studies Blog http://contemplative-studies.org

Study Summary

Quintana-Hernández DJ, Rojas-Hernández J, Santana-Del Pino A, Céspedes Suárez C, Pellejero Silva M, Miró-Barrachina MT, Ibáñez Fernández I, Estupiñán López JA, Borkel LF. Mindfulness Prevents Depression and Psychopathology in Elderly People with Mild to Moderate Alzheimer’s Disease: A Randomized Clinical Trial. J Alzheimers Dis. 2023;91(1):471-481. doi: 10.3233/JAD-220889. PMID: 36442199; PMCID: PMC9881020.

Abstract

Background:

This longitudinal study addressed whether mindfulness practice prevents psychological and behavioral symptoms, especially mood disorders, in Alzheimer’s disease (AD).

Objective:

To assess the incidence of depression in the course of AD and to determine which non-pharmacological treatment (NPT) is most effective in preventing psychopathological symptoms.

Methods:

We conducted a longitudinal, non-inferiority and equivalence randomized clinical trial, repeated-measures design, with a control group and three experimental treatments: mindfulness, cognitive stimulation, and relaxation. Each experimental group performed three weekly sessions for two years. The pharmacological treatment of all participants was donepezil (10 mg). Participants were patients with probable AD without diagnosed depression from the public neurology services of the Canary Health Service, Spain. Psychological evaluation was performed using the Geriatric Depression Scale (GDS), Hamilton Depression Rating Scale (HDRS), and Neuropsychiatric Inventory (NPI-Q). The statistical analysis included only patients who attended at least 75% of the sessions. A nonparametric, repeated-measures analysis was performed with Kruskal-Wallis H test and between-group differences with Mann-Whitney U test with Bonferroni correction (p < 0.008). Effect size was calculated with partial eta-squared.

Results:

The results showed significant differences with large effect sizes (η2p>0.14) between mindfulness and the rest of the experimental groups as well as the control in the GDS, HDRS, and NPI-Q scales.

Conclusion:

Compared to the other experimental groups, only mindfulness prevented the onset of depression and other psychopathologies in early-stage AD. Based on its effectiveness in maintaining cognitive functions and preventing psychopathology, we recommend mindfulness as the first-choice NPT for mild to moderate AD.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9881020/

Improve Mild Cognitive Impairment in the Elderly with Tai Chi

November 1, 2023 psyjdc Leave a comment

By John M. de Castro, Ph.D.

“Tai Chi Chuan, the great ultimate, strengthens the weak, raises the sick, invigorates the debilitated, and encourages the timid.” –Cheng Man-ch’ing

The aging process involves a systematic progressive decline in every system in the body, the brain included. The elderly frequently have problems with attention, thinking, and memory abilities, known as mild cognitive impairment. This is often a prelude to more severe decline such a dementia. An encouraging new development is that mindfulness practices such as meditation training and mindful movement practices can significantly reduce these declines in cognitive ability.

Tai Chi is an ancient Chinese practice involving mindfulness and gentle movements. It is easy to learn, safe, and gentle. Tai Chi has been practiced for thousands of years with benefits for health and longevity. Tai Chi training is designed to enhance function and regulate the activities of the body through controlled breathing, mindful concentration, and gentle movements. Only recently though have the effects of this practice been scrutinized with empirical research. This research has found that it is effective for an array of physical and psychological issues. It appears to strengthen the immune system, reduce inflammation and increase the number of cancer killing cells in the bloodstream, improve cardiovascular health, reduce arthritis pain, improve balance and reduce falls. It also appears to improve attentional ability improve cognitive ability in the elderly, and relieve depression.

In today’s Research News article “Mitigating effects and mechanisms of Tai Chi on mild cognitive impairment in the elderly.” (See summary below or view the full text of the study at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9906996/ ) Wang and colleagues review and summarize the published randomized controlled studies of the effects of Tai Chi practice on patients diagnosed with mild cognitive decline.

They report that Tai Chi practice relieved the symptoms of mild cognitive decline and delayed the onset of more severe dementia. The benefits include improved memory, executive function, and sleep and reduced body pain. They also report that Tai Chi practice appears to produce these benefits by altering the brain including increased brain volume, connectivity, and white matter efficiency and reduce inflammation.

Hence, the published research suggests that Tai Chi practice is an effective treatment for patients with mild cognitive impairment.

“The moment we believe that success is determined by an ingrained level of ability as opposed to resilience and hard work, we will be brittle in the face of adversity.” – Joshua Waitzkin

CMCS – Center for Mindfulness and Contemplative Studies

This and other Contemplative Studies posts are also available on the Contemplative Studies Blog http://contemplative-studies.org

Study Summary

Wang X, Si K, Gu W, Wang X. Mitigating effects and mechanisms of Tai Chi on mild cognitive impairment in the elderly. Front Aging Neurosci. 2023 Jan 6;14:1028822. doi: 10.3389/fnagi.2022.1028822. PMID: 36760710; PMCID: PMC9906996.

Abstract

Mild cognitive impairment (MCI) is a major public health concern that endangers health and decreases the quality of life of the elderly around the world. A recent clinical guideline has recommended regular exercise (twice per week) for patients with MCI as part of an overall approach to management. Tai Chi, a form of light-to-moderate-intensity mind-body exercise, is particularly suitable for seniors. This review aims to summarize epidemiological studies related to the effects of Tai Chi on symptom remission in older adults with MCI and reveal the potential mechanisms. Evidence suggested that Tai Chi can improve cognitive functions and alleviate the accompanying symptoms of MCI in the elderly potentially by activating the expression of signals in different brain regions, altering their connectivity, increasing the brain volume, and modulating brain-derived neurotropic and inflammation factors. Studies comparing various types of Tai Chi may contribute to the identification of paradigms that have appropriate intensities and difficulty and exert good effects on older people with MCI. In addition, studies are warranted to determine the frequency and duration of training that can optimize the beneficial effects of Tai Chi on MCI.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9906996/

Improve the Cognitive, Social, and Psychological States of Mild Alzheimer’s Patients with Mindfulness

July 12, 2023 psyjdc Leave a comment

Improve the Cognitive, Social, and Psychological States of Mild Alzheimer’s Patients with Mindfulness

By John M. de Castro, Ph.D.

“You have to be patient with Alzheimer’s. Once you understand that it’s a medical condition, you become a little more compassionate. You get less frustrated.” – Kim Campbell

An encouraging new development is that mindfulness practices such as meditation training and mindful movement practices can significantly reduce these declines in cognitive ability. In addition, it has been found that mindfulness practices reduce the deterioration of the brain that occurs with aging restraining the loss of neural tissue. This suggests that mindfulness may help to relieve some of the symptoms and/or slow the progression of mild Alzheimer’s Disease.

In today’s Research News article “Effects of Mindfulness-Based Interventions (MBIs) in Patients with Early-Stage Alzheimer’s Disease: A Pilot Study.” (See summary below or view the full text of the study at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10046197/ ) Giulietti and colleagues recruited elderly (>70 years old) patients suffering from mild Alzheimer’s disease. They were randomly assigned to either receive no treatment or a once a week for 6-month mindfulness-based intervention including stress management, relaxation, and 15-minute meditations once in treatment and twice at home per week. At baseline and after 6-months the patients were measured with the Mini Mental States Inventory, and for health-related quality of life, depression, spiritual well-being, social status, everyday cognition, and neuropsychiatric symptoms.

In comparison to baseline the patients that received the mindfulness-based intervention had significantly greater levels of everyday cognition, spiritual well-being, and social functioning, and lower levels of depression, agitation/aggression, anxiety, apathy, euphoria, sleep, apathy, and appetite. Whereas the control patients had significantly worsening Mini Mental States Inventory, apathy, appetite, and depression.

Caution should be exercised in interpreting these results as it was a relatively small pilot study without an active control condition.

But the results suggest that mindfulness training improved the cognitive, social, and psychological states of mild Alzheimer’s disease patients while the untreated patients showed a worsening of their cognitive and psychological states.

“People do not realize that Alzheimer’s is not old age. It is a progressive and fatal disease and staggering amounts of people develop Alzheimer’s every day.” – Melina Kanakaredes

CMCS – Center for Mindfulness and Contemplative Studies

This and other Contemplative Studies posts are also available on the Contemplative Studies Blog http://contemplative-studies.org

Study Summary

Giulietti MV, Spatuzzi R, Fabbietti P, Vespa A. Effects of Mindfulness-Based Interventions (MBIs) in Patients with Early-Stage Alzheimer’s Disease: A Pilot Study. Brain Sci. 2023 Mar 13;13(3):484. doi: 10.3390/brainsci13030484. PMID: 36979294; PMCID: PMC10046197.

Abstract

Bachground In this study, we hypothesize that mindfulness-based interventions (MBIs) may improve well-being and the related outcomes in Alzheimer’s dementia patients (AD-P) at an early stage. MBIs consist of the practice of consciously observing the psychic contents in the present moment (thoughts, sensations, feelings, and other events). This attention allows one to become aware of the psychic contents and integrate them, thus favoring the quality of life and an increase in the mood of practitioners. Methods The randomized controlled study enrolled 22 AD-P at an early stage (age ≥ 60 years) treated with MBIs and 22 patients without treatment (six months of MBI training). Tests (T0–T1 six months): Mini-Mental State Examination (MMPI); Spiritual Well-Being (SWB); Beck Depression Inventory (BDI); SF36. Test-Caregiver: Everyday Cognition scales (ECOG). Results AD-P with mindfulness: Improvement of ECOG (p = 0.026), quality of life (p < 0.001), spiritual well-being (p < 0.001); decrease in depression BDI (p < 0.001). The MMSE remains unchanged. The control group of untreated patients showed a significant worsening in all these dimensions. Conclusions MBI training is effective in increasing quality of life and preventing worsening in patients with early-stage Alzheimer’s dementia.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10046197/

Long-Term Meditation Changes Large-Scale Brain Connectivity

July 7, 2023 psyjdc Leave a comment

Long-Term Meditation Changes Large-Scale Brain Connectivity

By John M. de Castro, Ph.D.

There has accumulated a large amount of research demonstrating that meditation practice has significant benefits for psychological, physical, and spiritual wellbeing. One way that meditation practices may produce these benefits is by altering the brain. The nervous system is a dynamic entity, constantly changing and adapting to the environment. It will change size, activity, and connectivity in response to experience. These changes in the brain are called neuroplasticity. Over the last decade neuroscience has been studying the effects of contemplative practices on the brain and has identified neuroplastic changes in widespread areas. In other words, meditation practice appears to mold and change the brain structures and connectivity, producing psychological, physical, and spiritual benefits, especially mindfulness.

Two in particular types of meditation can be characterized on a continuum with the degree and type of attentional focus. In focused attention meditation, the individual practices paying attention to a single meditation object, learns to filter out distracting stimuli, including thoughts, and learns to stay focused on the present moment, filtering out thoughts centered around the past or future. In open monitoring meditation, the individual opens up awareness to everything that’s being experienced regardless of its origin. These include bodily sensations, external stimuli, and even thoughts. The meditator just observes these thoughts and lets them arise and fall away without paying them any further attention. These differences are likely to produce different effects on the practitioners, their psychology and their brains.

In today’s Research News article “Long-Term and Meditation-Specific Modulations of Brain Connectivity Revealed Through Multivariate Pattern Analysis.” (See summary below or view the full text of the study at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10164028/ ) Guidotti and colleagues recruited established long-term meditators (Buddhist Monks) and novice meditators. The novices practiced both focused and open monitoring meditation for 30 minutes per day for 10 days. Both groups then practiced both focused and open monitoring meditation while having their brains scanned with functional Magnetic Resonance Imaging (fMRI).

The found that large-scale functional interactions in the brain could better predict both focused and open monitoring meditation styles in practiced meditators as opposed to novices. Open Monitoring meditation enhanced connectivity between regions that process somatosensory, auditory, and visual information. On the other hand, Focused Meditation enhanced connectivity between regions that are involved in attentional control and self-awareness.

These findings suggest that long-term meditation changes the brain to process different information in large-scale networks for focused versus open monitoring meditations, but not so much in novice meditators. Hence, long-term meditation practice changes the brain to facilitate brain processing of meditation type specific functions.

CMCS – Center for Mindfulness and Contemplative Studies

This and other Contemplative Studies posts are also available on Twitter @MindfulResearch

Study Summary

Guidotti R, D’Andrea A, Basti A, Raffone A, Pizzella V, Marzetti L. Long-Term and Meditation-Specific Modulations of Brain Connectivity Revealed Through Multivariate Pattern Analysis. Brain Topogr. 2023 May;36(3):409-418. doi: 10.1007/s10548-023-00950-3. Epub 2023 Mar 28. PMID: 36977909; PMCID: PMC10164028.

Abstract

Neuroimaging studies have provided evidence that extensive meditation practice modifies the functional and structural properties of the human brain, such as large-scale brain region interplay. However, it remains unclear how different meditation styles are involved in the modulation of these large-scale brain networks. Here, using machine learning and fMRI functional connectivity, we investigated how focused attention and open monitoring meditation styles impact large-scale brain networks. Specifically, we trained a classifier to predict the meditation style in two groups of subjects: expert Theravada Buddhist monks and novice meditators. We showed that the classifier was able to discriminate the meditation style only in the expert group. Additionally, by inspecting the trained classifier, we observed that the Anterior Salience and the Default Mode networks were relevant for the classification, in line with their theorized involvement in emotion and self-related regulation in meditation. Interestingly, results also highlighted the role of specific couplings between areas crucial for regulating attention and self-awareness as well as areas related to processing and integrating somatosensory information. Finally, we observed a larger involvement of left inter-hemispheric connections in the classification. In conclusion, our work supports the evidence that extensive meditation practice modulates large-scale brain networks, and that the different meditation styles differentially affect connections that subserve style-specific functions.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10164028/