Author: psyjdc

Yoga Practice Improves Mental Health in Patients with Type 2 Diabetes

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24. Benefits Of Yoga For Type 2 Diabetes

By John M. de Castro, Ph.D.

 

In today’s Research News article “The Impact of Yoga Intervention on Physical and Mental Health of Adults with Type 2 Diabetes” (See summary below or view the full text of the study at: https://pmc.ncbi.nlm.nih.gov/articles/PMC12068464/ )  Subramani and colleagues examined the effectiveness of yoga practice on the mental health of patients with Type 2 Diabetes. They found that yoga practice produced significant reductions in depression and stress and increases in cognitive function and mindfulness.

 

Yoga improves mental health in patients with Type 2 Diabetes.

 

CMCS – Center for Mindfulness and Contemplative Studies

 

This and other Contemplative Studies posts are also available on the Contemplative Studies Blog  http://contemplative-studies.org

 

Study Summary

 

Subramani P, Mohan AR, Satish L, Karthikeyan S, Ravi P, Ulagamathesan V, Kannikan V, Viswanathan M. The Impact of Yoga Intervention on Physical and Mental Health of Adults with Type 2 Diabetes. Int J Yoga. 2025 Jan-Apr;18(1):67-73. doi: 10.4103/ijoy.ijoy_219_24. Epub 2025 Apr 22. PMID: 40365367; PMCID: PMC12068464.

 

Abstract

Aim:

To assess the impact of a yoga intervention on the physical and mental health of adults with type 2 diabetes.

Methods:

This study was conducted at Madras Diabetes Research Foundation, Chennai, for 6 months. Participants aged 18–65 years, diagnosed with type 2 diabetes mellitus (T2DM), and glycated hemoglobin (HbA1c) levels ranging from ≥7.0% to ≤10.5% were recruited. One hundred and fifty-two participants were randomized in 1:1 ratio to either the intervention or control arm by simple random method. The intervention included structured yoga practice for 35 min, every 2 weeks for a period of 12 weeks, and followed up for 3 months. Participants in the control arm received the standard care for diabetes. Sociodemographic data, anthropometric measurements, and blood samples were collected at baseline and final visit. Standard questionnaires were administered for assessing mental health parameters.

Results:

53 of 76 (70%) participants from the intervention arm and 70 of 76 (92%) participants from the control arm completed the study. The mean age of the participants was 53 ± 7.5 years. The mean duration of diabetes of the participants was 10 ± 6.9 years. HbA1c showed reduction postintervention, but this was not statistically significant compared to control. The intervention group showed statistically significant improvements in depression, stress, cognitive function, and mindfulness compared to the control arm.

Conclusion:

Yoga is helpful in reducing depression and stress and enhancing mindfulness and cognitive function in patients with T2DM.

Long-Term Meditation Changes the Brain Toward Processing of the Immediate Environment

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By John M. de Castro, Ph.D.

 

In today’s Research News article “Long-term mindfulness meditation increases occurrence of sensory and attention brain states” (See summary below or view the full text of the study at: https://pmc.ncbi.nlm.nih.gov/articles/PMC11743700/ ) Panitz and colleagues examined brain activity in experienced meditators in comparison to meditation naive participants. They report that at rest the brains of experienced meditators had enhanced activity in the visual and dorsal attention networks. This suggests that long-term meditation practice shifts the brain to emphasize immediate stimulus environments.

 

Meditation changes the brain toward processing of the more immediate sensory environment.

 

CMCS – Center for Mindfulness and Contemplative Studies

 

This and other Contemplative Studies posts are also available on the Contemplative Studies Blog  http://contemplative-studies.org

 

Study Summary

 

Panitz DY, Mendelsohn A, Cabral J, Berkovich-Ohana A. Long-term mindfulness meditation increases occurrence of sensory and attention brain states. Front Hum Neurosci. 2025 Jan 6;18:1482353. doi: 10.3389/fnhum.2024.1482353. PMID: 39834400; PMCID: PMC11743700.

 

Abstract

Interest has been growing in the use of mindfulness meditation (MM) as a therapeutic practice, as accumulating evidence highlights its potential to effectively address a range of mental conditions. While many fMRI studies focused on neural activation and functional connectivity during meditation, the impact of long-term MM practice on spontaneous brain activity, and on the expression of resting state networks over time, remains unclear. Here, intrinsic functional network dynamics were compared between experienced meditators and meditation-naïve participants during rest. Our analysis revealed that meditators tend to spend more time in two brain states that involve synchrony among cortical regions associated with sensory perception. Conversely, a brain state involving frontal areas associated with higher cognitive functions was detected less frequently in experienced meditators. These findings suggest that, by shifting attention toward enhanced sensory and embodied processing, MM effectively modulates the expression of functional network states at rest. These results support the suggested lasting effect of long-term MM on the modulation of resting-state networks, reinforcing its therapeutic potential for disorders characterized by imbalanced network dynamics. Moreover, this study reinforces the utility of analytic approaches from dynamical systems theory to extend current knowledge regarding brain activity and evaluate its response to interventions.

 

Mindfulness Meditation Improves the Mental Health of Police

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Improve the Psychological Well-Being of Police with Mindfulness | Contemplative Studies

By John M. de Castro, Ph.D.

 

In today’s Research News article “Effects of Short Video App Guided Mindfulness Meditation on Policemen’s Communication Anxiety, PTSD, Anger Management, and Mood Disorders” (See summary below or view the full text of the study at: https://pmc.ncbi.nlm.nih.gov/articles/PMC12110842/ ) Liu and colleagues performed a randomize controlled trial of the effects of daily practice with a mindfulness meditation app on the mental health of police. They report that the police who used the app had significant increases in anger management and decreases in communications anxiety and mood disorders.

 

Mindfulness improves police mental health.

 

CMCS – Center for Mindfulness and Contemplative Studies

 

This and other Contemplative Studies posts are also available on the Contemplative Studies Blog  http://contemplative-studies.org

 

Study Summary

 

Liu C, Lin LJ, Zhang KJ, Liu TH, Chiou WK. Effects of Short Video App Guided Mindfulness Meditation on Policemen’s Communication Anxiety, PTSD, Anger Management, and Mood Disorders. Healthcare (Basel). 2025 May 21;13(10):1213. doi: 10.3390/healthcare13101213. PMID: 40428049; PMCID: PMC12110842.

 

Abstract

Background: Law enforcement is a high-stress profession, with officers frequently exposed to traumatic events, leading to mental health challenges such as communication anxiety, post-traumatic stress disorder (PTSD), anger management difficulties, and mood disorders. Mindfulness meditation (MM), particularly when guided through short video applications, has shown promise in addressing these issues by enhancing emotional regulation and resilience. Objective: This study explores the effects of an 8-week MM intervention, delivered via short video apps, on communication anxiety, PTSD, anger management, and mood disorders in police officers. Methods: A randomized controlled trial (RCT) was conducted with 110 full-time police officers aged 25–55 in China. The final 92 eligible participants were divided into two groups: the MM group (n = 46) and the control group (n = 46). The intervention consisted of daily 10–15 min video-guided MM sessions. Pre- and post-intervention measures included validated questionnaires assessing communication anxiety (PRCA-24), PTSD (PCL-5), anger management (STAXI-2), and mood disorders (DASS-21). Data analysis was performed using MANOVA. Results: The intervention group showed significant improvements in communication anxiety (F = 8.505, p = 0.004), PTSD (F = 25.831, p < 0.001), anger management (F = 4.968, p = 0.027), and mood disorders (F = 13.058, p < 0.001) compared to the control group. These improvements were supported by significant interaction effects between group and time, indicating that the MM intervention had a positive impact on these mental health variables. Conclusions: Video-guided MM delivered via short video apps significantly reduced communication anxiety, PTSD symptoms, and mood disorders, and improved anger management among police officers. These findings highlight the potential of digital MM interventions as a scalable and accessible tool for enhancing mental well-being and resilience in law enforcement personnel.

Psychedelic Drug Use and Meditation Practices are Positively Associated

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New study links mindfulness meditation and psychedelic use to positive leadership outcomes at work

By John M. de Castro, Ph.D.

 

In today’s Research News article “Associations between psychedelic-related and meditation-related variables: A longitudinal study” (See summary below or view the full text of the study at: https://pmc.ncbi.nlm.nih.gov/articles/PMC11999004/ ) Simonsson and colleagues examined the relationships between the use of psychedelic drugs and mindfulness and meditation practices. They found that psychedelic use was associated with greater mindfulness and loving-kindness or compassion meditation practice and mindfulness was associated with less severe challenging psychedelic experiences.

 

Psychedelic drug use and meditation practices are positively associated.

 

CMCS – Center for Mindfulness and Contemplative Studies

 

This and other Contemplative Studies posts are also available on the Contemplative Studies Blog  http://contemplative-studies.org

 

Study Summary

 

Simonsson O, Chaturvedi S, Hendricks PS, Stenfors CUD, Osika W, Narayanan J, Palitsky R, Goldberg SB. Associations between psychedelic-related and meditation-related variables: A longitudinal study. J Psychiatr Res. 2025 Apr;184:457-463. doi: 10.1016/j.jpsychires.2025.03.025. Epub 2025 Mar 17. PMID: 40133019; PMCID: PMC11999004.

 

Abstract

Previous research has investigated associations between psychedelic experiences and meditation practice, but knowledge gaps remain. Using a longitudinal research design with a sample of US residents between 18 and 50 years old (N = 13,012), we investigated associations between psychedelic-related and meditation-related variables. The follow-up survey was completed by 7484 respondents, of whom 336 reported psychedelic use during the two-month study. In covariate-adjusted regression models, psychedelic use was associated with greater increases in the number of days of mindfulness and loving-kindness or compassion meditation practice in the past week, especially among those with no prior experience of psychedelics or meditation. Among those who reported psychedelic use, trait mindfulness and trait self-compassion at baseline were associated with less severe challenging psychedelic experiences, as well as lower odds of psychedelic-occasioned thoughts or attempts of self- or other-harm. However, among those who practiced meditation at baseline, psychedelic use was associated with greater increases in past-week frequency of loving-kindness or compassion meditation-related difficulties and impairments. Future research is warranted.

 

Mindfulness is Associated with Relationship and Sexual Satisfaction in Committed Couples

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By John M. de Castro, Ph.D.

 

In today’s Research News article “A Machine Learning Approach for Investigating Variable Importance in Relationship and Sexual Satisfaction: The Role of Interpersonal Mindfulness and Psychological Safety” (See summary below or view the full text of the study at: https://pmc.ncbi.nlm.nih.gov/articles/PMC12022470/) Dias Martins and colleagues examined the relationships between interpersonal mindfulness and relationship and sexual satisfaction in committed couple relationships. They found that interpersonal mindfulness was strongly positively related to the couples’ relationship and sexual satisfaction.

 

Mindful couples have greater relationship and sexual satisfaction,

 

CMCS – Center for Mindfulness and Contemplative Studies

 

This and other Contemplative Studies posts are also available on the Contemplative Studies Blog  http://contemplative-studies.org

 

Study Summary

 

Dias Martins C, Vergara RC, Khoury B. A Machine Learning Approach for Investigating Variable Importance in Relationship and Sexual Satisfaction: The Role of Interpersonal Mindfulness and Psychological Safety. J Marital Fam Ther. 2025 Apr;51(2):e70026. doi: 10.1111/jmft.70026. PMID: 40275608; PMCID: PMC12022470.

 

ABSTRACT

Numerous studies have shown that mindfulness is positively associated with relationship and sexual satisfaction. However, most have examined the benefits of intrapersonal or trait mindfulness, rather than directly investigating interpersonal mindfulness or considering polyvagal theory. Our main objective was to determine the variable importance of interpersonal mindfulness and psychological safety for relationship and sexual satisfaction using random forests and regression trees and to explore the importance of demographics, social and couple‐related factors, and emotional wellbeing in this analysis. 356 adults in committed romantic relationships were recruited for a self‐report survey. Results suggested that mindfulness in couple relationships, psychological safety, conflict strategies, and depression symptoms were of top importance for relationship and sexual satisfaction. Limitations and future directions involving dyadic data and physiological measures were discussed. The findings will inform the development of interpersonal mindfulness‐ and polyvagal‐based interventions aimed at promoting safety and stability in relationships while enhancing personal wellbeing.

 

Sexual mindfulness can help increase arousal and desire

Decrease Pain and Dysfunction with Chronic Non-Specific Low Back Pain with Qigong Practice

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integrated tai chi and qigong class

By John M. de Castro, Ph.D.

 

In today’s Research News article “Effect of qigong on pain and disability in patients with chronic non-specific low back pain: a systematic review and meta-analysis of randomized controlled trials” (See summary below or view the full text of the study at: https://pmc.ncbi.nlm.nih.gov/articles/PMC11849339/)  Yu and colleagues reviewed and summarized the published randomized controlled research studies on the effectiveness of Qigong practice for the relief of Chronic non-specific low back pain. They report that the published research found that Qigong practice significantly decreased pain and the degree of dysfunction to a greater extent than control short-term or long-term interventions.

 

Qigong practice improves chronic non-specific low back pain.

 

CMCS – Center for Mindfulness and Contemplative Studies

 

This and other Contemplative Studies posts are also available on the Contemplative Studies Blog  http://contemplative-studies.org

 

Study Summary

 

Yu D, Wu M, Zhang J, Song W, Zhu L. Effect of qigong on pain and disability in patients with chronic non-specific low back pain: a systematic review and meta-analysis of randomized controlled trials. J Orthop Surg Res. 2025 Feb 24;20(1):194. doi: 10.1186/s13018-025-05576-8. PMID: 39994723; PMCID: PMC11849339.

 

Abstract

Background

Chronic non-specific low back pain (CNLBP) is a common health problem worldwide. Patients with CNLBP often suffer from persistent pain, with a few being disabled by their pain, affecting their daily functioning and social participation. This study aims to systematically evaluate the effects of pain and dysfunction in Qigong patients with chronic non-specific back pain through systematic evaluation and gathered analysis of random control test data.

Methods

We searched nine databases from their inception dates until April 2024. Relevant randomized controlled trials (RCTs) were included. Patients were assessed for pain using the Visual Analog Scale and Numeric Pain Rating Scale and for disability using the Oswestry Disability Index and Roland-Morris disability questionnaire. The risk of bias was assessed using the Cochrane Collaboration tool. CMA V3.0 was used to analyze data.

Results

Sixteen RCTs involving 1175 participants were included. These studies have different designs, and the participants are mainly around 60 years old. The results showed that the qigong practice improved pain significantly more than the control measures ([Mean Difference MD] = − 1.34, 95% confidence intervals [CI] − 1.76 to − 0.92, p < 0.001 Minimal Clinically Important Differences MCID = 1.5), and the efficacy of short-term interventions (MD = − 1.88, 95% CI − 2.87 to − 0.9, p < 0.001) was superior to that of long-term interventions (MD = − 1.07, 95% CI − 1.49 to − 0.65, p < 0.001). For improvement in the degree of dysfunction, qigong practice showed a higher effect size (MD = − 5.88, 95% CI − 7.98 to − 3.78, p < 0.001 MCID = 5) than that observed in the control group.

Conclusion

Qigong practice is effective in improving disability in patients with CNLBP, but has no significant effect on improving pain. However, due to the high heterogeneity, the results need to be interpreted with caution.

 

Decrease Stress, Anxiety, Burnout, and Depression with Yoga Practice

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Zen lounges, yoga helping HCA Houston nurses relieve stress

By John M. de Castro, Ph.D.

 

In today’s Research News article “A Systematic Review of Yoga Interventions on the Mental Health of Nursing Professionals and Students” (See summary below or view the full text of the study at: https://pmc.ncbi.nlm.nih.gov/articles/PMC12068460/ ) Arya and colleagues reviewed and summarized the published research studies on the effects of yoga on nursing professionals and students. They report that the research found that yoga practice significantly reduced stress, anxiety, burnout, and depression and increased mindfulness and sleep quality in the nurses.

 

Yoga reduces stress, anxiety, burnout, and depression in nurses and nursing students.

 

CMCS – Center for Mindfulness and Contemplative Studies

 

This and other Contemplative Studies posts are also available on the Contemplative Studies Blog  http://contemplative-studies.org

 

Study Summary

 

Arya RG, Srivastava D, Divya BR, Madhu, Bhargav H. A Systematic Review of Yoga Interventions on the Mental Health of Nursing Professionals and Students. Int J Yoga. 2025 Jan-Apr;18(1):13-26. doi: 10.4103/ijoy.ijoy_195_24. Epub 2025 Apr 22. PMID: 40365361; PMCID: PMC12068460.

 

Abstract

This systematic review aimed to evaluate the impact of yoga interventions on preventing and alleviating mental health issues, including stress, anxiety, burnout, depression, and other related factors among nursing professionals and students. The review adhered to the PRISMA guidelines and was registered in PROSPERO (CRD42024512366). A comprehensive literature search was conducted in Google Scholar and PubMed using keywords such as “nursing students,” “nursing professionals,” “yoga interventions,” and “mental health.” Eligible studies were randomized controlled trials (RCTs) published from 1st January 2014 to 31st December 2024, involving nursing population and yoga-based interventions targeting mental health outcomes. The risk of bias was assessed using the CASP tool. The search identified 14 RCTs (967 participants, predominantly female, age range – 18 to 69 years) that met the eligibility criteria. The yoga intervention varied in duration (10 minutes to 1 hour per session), frequency (once to five times weekly), and protocols (Laughter yoga being the most common). Mental health outcomes such as stress, anxiety, burnout, mindfulness, depression, quality of sleep, and life satisfaction were assessed. Most studies reported significant improvements in these outcomes in the yoga

Promoting Spirituality Improves Blood Pressure in Hypertensive Patients

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Spirituality, religion linked to heart health among Black Americans | National Institutes of Health (NIH)

By John M. de Castro, Ph.D.

 

In today’s Research News article “Spirituality-Based Intervention in Hypertension: EFfects on Blood PrEssure and EndotheliaL Function-FEEL Trial Results” (See summary below or view the full text of the study at: https://pmc.ncbi.nlm.nih.gov/articles/PMC11759529/) Teixeira and colleagues compared the effectiveness of an online based spirituality intervention to a routine care control condition on patients with hypertension. Hey found that the spirituality intervention produced significant reductions in systolic blood pressure and flow mediated dilation.

 

Spirituality improved blood pressure in patients with hypertension.

 

CMCS – Center for Mindfulness and Contemplative Studies

 

This and other Contemplative Studies posts are also available on the Contemplative Studies Blog  http://contemplative-studies.org

 

Study Summary

 

Teixeira MEF, Barroso WKS, Brandão AA, et al. Spirituality-Based Intervention in Hypertension: EFfects on Blood PrEssure and EndotheliaL Function-FEEL Trial Results. Glob Heart. 2025;20(1):6. Published 2025 Jan 21. doi:10.5334/gh.1390

 

Abstract

Background:

Emerging evidence suggests that spirituality improves patient outcomes, however, this has undergone only limited evaluation in randomized trials. Hypertension is a major cause of cardiovascular morbidity and mortality worldwide.

Objectives:

To evaluate whether a spirituality-based intervention, compared to a control group, can reduce blood pressure (BP) and improve endothelial function after 12 weeks in patients with mild or moderate hypertension (HTN).

Methods:

Open randomized controlled trial of adults with stage I or II hypertension. Following baseline evaluation, including lifestyle questionnaires, and measurements of office and central blood pressure (BP), home blood pressure monitoring (HBPM) and flow mediated dilation (FMD), patients were randomized to a spirituality-based intervention, which included training for forgiveness, gratitude, optimism, and life purpose delivered by daily WhatsApp communications, or to the control group (CG). Main outcomes were between group difference in change from baseline to 12 weeks in office and central BP, HBPM and FMD, using t-tests, analyses of covariance (ANCOVA) adjusting for baseline differences, and, in addition, missing data imputation as a sensitivity analysis.

Results:

Fifty-one patients were randomized to spirituality-based intervention and 49 to control group. Baseline characteristics were well balanced between groups. Spirituality training, compared with control, improved 7.6 mmHg office systolic blood pressure (SBP), 4.1 mmHg central SBP and 4.1 percentage points FMD. Compared to control group, t-test demonstrated statistical significance for office SBP (–7.04 mmHg, p = 0.047) and FMD (7.46 percentage points, p < 0.001), and ANCOVA adjustment for baseline differences showed statistical significance for central SBP (–6.99 mmHg, p = 0.038) and FFMD (7.95 percentage points, p < 0.001) There was no significant effect on HBPM.

Conclusion:

A spirituality-based intervention was associated with improved control of office SBP and FMD. These findings will be prospectively evaluated in a nationwide larger and well-powered RCT.

 

Improve Mental Health and Well-Being with Yoga Practice

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Zen lounges, yoga helping HCA Houston nurses relieve stress

By John M. de Castro, Ph.D.

 

In today’s Research News article “A Systematic Review of Yoga Interventions on the Mental Health of Nursing Professionals and Students” (See summary below or view the full text of the study at: https://pmc.ncbi.nlm.nih.gov/articles/PMC12068460/ ) Arya and colleagues reviewed and summarized the published research studies on the effectiveness of yoga interventions on the mental health of nurses and nursing students. They report that the published studies found that yoga interventions significantly improved mental health including reductions in stress, depression, and burnout and significant increases in sleep quality, mindfulness, and life satisfaction.

 

Yoga is effective in improving mental health and well-being among nurses and students.

 

CMCS – Center for Mindfulness and Contemplative Studies

 

This and other Contemplative Studies posts are also available on the Contemplative Studies Blog  http://contemplative-studies.org

 

Study Summary

 

Arya RG, Srivastava D, Divya BR, Madhu, Bhargav H. A Systematic Review of Yoga Interventions on the Mental Health of Nursing Professionals and Students. Int J Yoga. 2025;18(1):13-26. doi:10.4103/ijoy.ijoy_195_24

 

Abstract

This systematic review aimed to evaluate the impact of yoga interventions on preventing and alleviating mental health issues, including stress, anxiety, burnout, depression, and other related factors among nursing professionals and students. The review adhered to the PRISMA guidelines and was registered in PROSPERO (CRD42024512366). A comprehensive literature search was conducted in Google Scholar and PubMed using keywords such as “nursing students,” “nursing professionals,” “yoga interventions,” and “mental health.” Eligible studies were randomized controlled trials (RCTs) published from 1st January 2014 to 31st December 2024, involving nursing population and yoga-based interventions targeting mental health outcomes. The risk of bias was assessed using the CASP tool. The search identified 14 RCTs (967 participants, predominantly female, age range – 18 to 69 years) that met the eligibility criteria. The yoga intervention varied in duration (10 minutes to 1 hour per session), frequency (once to five times weekly), and protocols (Laughter yoga being the most common). Mental health outcomes such as stress, anxiety, burnout, mindfulness, depression, quality of sleep, and life satisfaction were assessed. Most studies reported significant improvements in these outcomes in the yoga intervention groups compared to control groups. Nine studies showed a significant stress reduction, and 3 studies found a decrease in anxiety. No adverse effects were reported, and dropout rates varied between 0% to 52.1%. Yoga was found to be effective in improving mental health and well-being among nursing professionals and students. Yoga mainly reduced stress, anxiety, burnout, and depression, suggesting its potential as a low-cost, accessible intervention for mental health management in this population. Future studies should focus on refining protocols and exploring long-term effects to establish yoga as an integral part of mental health care for nursing professionals and students.

 

Older Adults Have Enhanced Benefits of Meditation and Precepts Practice

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Buddhism: Practices - RELIGION, PHILOSOPHY AND ETHICS AT HABERDASHERS' ABRAHAM DARBY.

By John M. de Castro, Ph.D.

 

In today’s Research News article “A comparative study of the impact of meditation and Buddhist five precepts on stress and depression between older adults and younger adults.” (See summary below or view the full text of the study at: https://pmc.ncbi.nlm.nih.gov/articles/PMC12053757/) Wongpakaran and colleagues investigated the relationships between meditation and the practice of the five precepts on stress and depression in older (average 68 years) and younger (average 29 years) adults. The five precepts involve refraining from killing or harming living beings, stealing or taking others’ property without permission, engaging in sexual misconduct, speaking falsely, and consuming alcohol or intoxicants. They report that meditation and the practice of the five precepts enhances the reductions in stress and depression in older but not younger adults.

 

Meditation and practice of the five precepts reduces stress and depression in older adults.

 

CMCS – Center for Mindfulness and Contemplative Studies

 

This and other Contemplative Studies posts are also available on the Contemplative Studies Blog  http://contemplative-studies.org

 

Study Summary

 

Wongpakaran N, Klaychaiya S, Panuspanudechdamrong C, et al. A comparative study of the impact of meditation and Buddhist five precepts on stress and depression between older adults and younger adults. Sci Rep. 2025;15(1):15739. Published 2025 May 6. doi:10.1038/s41598-025-99430-w

 

Abstract

Older adults frequently face a myriad of physical and mental health challenges, which can contribute to feelings of stress and subsequent depression. Nevertheless, with age often comes a wealth of life experience and resilience. Perceived stress commonly predicts depression across all age groups, while meditation has been associated with lower levels of depression. Additionally, adherence to the Five Precepts is a prevalent practice among Thai individuals, particularly among older adults. However, it remains unclear how the combination of meditation and the Buddhist Five Precepts influences depression levels. This study aims to explore the predictive roles of meditation, the practice of the Five Precepts, and perceived stress on depression among older adults, with comparisons drawn to younger adults. A sample of 1472 individuals (232 were older adults and 1240 were adults) participated in the study. All completed the questionnaires for depression, perceived stress, meditation, and five precepts using the core symptom index, perceived stress scale, and inner strength-based inventory. Moderation model and mediation model analyses were employed to analyze the relationship between the perceived stress scores and the symptoms of depression for both older and younger samples. In the older adults group, 59.9% were female, with a mean age of 67.96 years (SD 6.8). In the adult group, 71.3% were male, with a mean age of 29.04 years (SD 10.5). The findings revealed that among the older adults’ group, precepts, meditation, and their interaction significantly predicted a lower level of depressive symptoms (estimated coefficient = − 0.1082, 95% CI = − 0.1865, − 0.03). However, this association was not observed in the younger adults’ group (estimated coefficient = -0.0199, 95% CI = − 0.0465, 0.0066). The variance explained in depressive symptoms changed from 24.9% in the linear model of perceived stress to 31.8% in the moderated moderation model, representing a 27.7% increase. Conversely, meditation and the five precepts mediated the relationship between stress and depressive symptoms in younger people but not in older adults. The indirect effect of perceived stress was significant only through the five precepts (estimated coefficient = − 0.3173, 95% CI = − 0.4787, − 0.1558; p = .0001). The variance explained in depressive symptoms changed from 42.2% in the linear model of perceived stress to 43.2% in the mediation model, representing a 2.5% increase. This study emphasizes that older adults may experience enhanced benefits from meditation and adherence to the Five Precepts compared to younger adults. Additionally, the effectiveness of meditation appears to be influenced by the extent of precept practice. Older individuals who actively engage in both high levels of precept adherence and meditation demonstrate a more significant buffering effect on the relationship between stress and depression. These findings suggest that lifestyle factors, such as religious practices like meditation and adherence to precepts, may have a differential impact on older adults compared to younger counterparts. The implications for older individuals are promising and warrant encouragement, while further research is needed to explore relevant factors contributing to reduced depression among younger populations.