By John M. de Castro, Ph.D.
“Mindfulness is a valuable practice for improving the cognitive symptoms of depression, such as distorted thinking and distractibility. It helps individuals recognize these more subtle symptoms, realize that thoughts are not facts and refocus their attention to the present.” – Margarita Tartakovsky
Major depression is one of the most common mental disorders. In 2014, an estimated 15.7 million adults aged 18 or older in the United States had at least one major depressive episode in the past year. This number represented 6.7% of all adults. In addition, major depression carries the heaviest burden of disability among mental and behavioral disorders. It is most frequently treated with anti-depressive drugs. But, these frequently do not work or lose effectiveness over time and have many troublesome side effects. So, there is a need for better treatment methods.
Depression has been linked to chronic inflammation. Patients with major depressive disorder exhibit all of the cardinal features of an inflammatory response, including increased expression of pro-inflammatory cytokines and their receptors. In addition, administration of inflammatory cytokines to otherwise non-depressed individuals cause symptoms of depression. This suggests that chronic inflammation may be a contributing factor to the development, promotion, or maintenance of depression.
Mindfulness practice has been shown to be effective in the treatment of chronic depression. It has also been shown to reduce inflammation and the inflammatory cytokines. So, it would make sense to study the relationship of mindfulness training to depression and the inflammatory response in depressed individuals. In today’s Research News article “Brief Mindfulness Training Reduces Salivary IL-6 and TNF-α in Young Women with Depressive Symptomatology.” See:
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Walsh and colleagues do just that. They recruited female college students who had mild to moderate depression and assigned them to either a mindfulness training group or a contact control group. Mindfulness training was modelled after a Mindfulness Based Stress Reduction (MBSR) program and included meditation, body scan, and yoga, but the program was conducted over only 4 weeks rather than the customary 8 weeks. The contact control group met in a group on a similar schedule but simple filled out questionnaires. The participants were measured for salivary inflammatory cytokine levels, depression, and other mental issues both before and training and 3 months later.
They found that mindfulness training decreased the levels of the inflammatory cytokines IL-6 and TNF-α between 59% to 76% and this decrease was maintained at the 3 month follow up. There was also a significant decrease in depression but this was true for both the mindfulness and contact groups. The higher the levels of baseline depression the greater the effect of mindfulness training on reducing inflammatory cytokines. These results suggest that mindfulness training is effective in reducing the inflammatory response and that the more depressed the individual is the greater the benefit.
These are exciting findings. They suggest that mindfulness training reduces chronic inflammation in depressed women. The fact that the depression levels were low to start with may have produced a floor effect making it impossible to detect a benefit of mindfulness training on the levels of depression. This prohibits and analysis of the relationship of the reduction in the inflammatory cytokines to the reduction in depression. But, the results are suggestive of a potential effect in that the most depressed women showed the greatest reductions in the inflammatory response. It will require further work with women exhibiting higher levels of depression and perhaps with a longer treatment period to conclusively demonstrate whether there’s a causal connection between the two.
Mindfulness training has a number of known effects that may underlie its ability to reduce depression and inflammation. In particular mindfulness training has been shown to reduce the psychological and physiological responses to stress. This decreased stress response may be responsible for the reduction in inflammation. In addition, mindfulness training is known to improve focus on the present moment and thereby reduce rumination about the past or worry about the future, both of which are characteristic of depression. This may well underlie the ability of mindfulness training to reduce depression.
So, reduce inflammation and depression with mindfulness.
CMCS – Center for Mindfulness and Contemplative Studies
“Everyone can benefit from mindfulness meditation, but some can more than others. There are no negative side effects of mindfulness, and there are the positive benefits of stress reduction and relaxation. Reducing inflammation and boosting immune health can help fight a broad range of ailments, from a stubbed toe to chronic inflammatory conditions.” – Amanda Page
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Study Summary
Walsh, E., Eisenlohr-Moul, T., & Baer, R. (2016). Brief Mindfulness Training Reduces Salivary IL-6 and TNF-α in Young Women with Depressive Symptomatology. Journal of Consulting and Clinical Psychology, doi:10.1037/ccp0000122
Abstract
OBJECTIVE: Pro-inflammatory cytokines have been implicated in the pathophysiology and maintenance of depression. This study investigated the effects of a brief mindfulness intervention on salivary pro-inflammatory correlates of depression (IL-6, TNF-α) and self-reported symptoms of depression in college women.
METHODS: Sixty-four females with a cut score of ≥16 on the Center for Epidemiological Studies for Depression Scale (CES-D) were assigned to a 4-week mindfulness-based intervention (MBI; N = 31) or a contact-control group (N = 33). For both groups, salivary cytokines and depressive symptoms were assessed at baseline and posttreatment. For the mindfulness group only, salivary cytokines were also assessed at a 3-month follow-up.
RESULTS: Both groups showed similar reductions in depression. However, MBI (vs. control) predicted greater reductions in IL-6 and TNF-α; changes in IL-6 were sustained at 3-month follow-up. Higher baseline depressive symptoms predicted greater reductions in inflammation in the mindfulness group.
CONCLUSION: MBIs may reduce inflammatory immune markers commonly implicated in depression. Individuals with greater depressive symptoms may benefit more from mindfulness training. Although reductions in salivary cytokines in the mindfulness condition were not attributable to changes in depressive symptoms, future work should examine the possibility that such reductions are protective against the development of future depressive episodes.