Improve Mental Health with Mindfulness Learned Over the Internet

Improve Mental Health with Mindfulness Learned Over the Internet

 

By John M. de Castro, Ph.D.

 

“With the rise of mental illness and the increasingly pressing need for effective treatments, there’s never been a more important moment for mindfulness — the ability to cultivate a focused, non-judgmental awareness on the present moment. Research has shown mindfulness and meditation-based programs to hold promise for treating a number of psychiatric conditions, including depression, anxiety, post-traumatic stress disorder, bipolar disorder and obsessive-compulsive disorder.” Carolyn Gregoire

 

Mindfulness training has been shown through extensive research to be effective in improving physical and psychological health and particularly with the physical and psychological reactions to stress. The vast majority of the mindfulness training techniques, however, require a certified trained therapist. This results in costs that many clients can’t afford. In addition, the participants must be available to attend multiple sessions at particular scheduled times that may or may not be compatible with their busy schedules and at locations that may not be convenient. As an alternative, online mindfulness training programs have been developed. These have tremendous advantages in decreasing costs, making training schedules much more flexible, and eliminating the need to go repeatedly to specific locations. There is evidence that mindfulness programs delivered online can be quite effective. But there is a need to further investigate the effectiveness of these programs as an alternative to face-to-face trainings for the treatment of clinical mental health problems.

 

In today’s Research News article “Web-Based Mindfulness Interventions for Mental Health Treatment: Systematic Review and Meta-Analysis.” (See summary below or view the full text of the study at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6231788/ ), Sevilla-Llewellyn-Jones and colleagues review, summarize, and perform a meta-analysis of the effectiveness on mindfulness training delivered online for the improvement of clinical mental health. They found 12 published studies employing patients with diagnosed mental health issues who received online mindfulness training.

 

They found that the published research literature reported that online mindfulness training produced significant improvements in depression and anxiety, especially in patients diagnosed with anxiety disorders. In addition, they found that online mindfulness training produced significant improvements in quality of life and mindfulness skills in these clinical patients. The effects were strongest when the control condition was a wait-list and less so, and often non-significant when compared to other active treatments. This suggests the online mindfulness training is not more but equivalently effective as other treatments.

 

These are important results as anxiety disorders and depression are very common diagnoses. It has been well established that mindfulness training improves depression and anxiety. These results extend these prior findings by demonstrating that treatment can be delivered online and to patients with clinical mental health diagnoses. The fact that the treatment was found to be especially effective for patients with anxiety disorders is important as patients with anxiety disorders may be reticent to venture into a clinical environment to receive treatment. Being able to receive treatment without venturing out into the outside world with all of its anxiety evoking situations may be very helpful for these patients.

 

The fact that mindfulness training can be effective when delivered online is very important. Online delivery allows for the application of mindfulness training to a much wider audience at low cost and thus increases the availability of treatment for the relief of suffering,

 

So, improve mental health with mindfulness learned over the internet.

 

“Mindfulness helps to be awakening to the patterns of the mind rather than emptying the mind. It helps you to be in touch with your way of ‘being’ rather than ‘doing’. It is a concept that could be life changing and worth experiencing.” – Christos Papalekas

 

CMCS – Center for Mindfulness and Contemplative Studies

 

This and other Contemplative Studies posts are also available on Google+ https://plus.google.com/106784388191201299496/posts and on Twitter @MindfulResearch

 

Study Summary

 

Sevilla-Llewellyn-Jones, J., Santesteban-Echarri, O., Pryor, I., McGorry, P., & Alvarez-Jimenez, M. (2018). Web-Based Mindfulness Interventions for Mental Health Treatment: Systematic Review and Meta-Analysis. JMIR mental health, 5(3), e10278. doi:10.2196/10278

 

Abstract

Background

Web-based mindfulness interventions are increasingly delivered through the internet to treat mental health conditions.

Objective

The objective of this study was to determine the effectiveness of web-based mindfulness interventions in clinical mental health populations. Secondary aims were to explore the impact of study variables on the effectiveness of web-based mindfulness interventions.

Methods

We performed a systematic review and meta-analysis of studies investigating the effects of web-based mindfulness interventions on clinical populations.

Results

The search strategy yielded 12 eligible studies. Web-based mindfulness interventions were effective in reducing depression in the total clinical sample (n=656 g=−0.609, P=.004) and in the anxiety disorder subgroup (n=313, g=−0.651, P<.001), but not in the depression disorder subgroup (n=251, P=.18). Similarly, web-based mindfulness interventions significantly reduced anxiety in the total clinical sample (n=756, g=−0.433, P=.004) and the anxiety disorder subgroup (n=413, g=−0.719, P<.001), but not in the depression disorder group (n=251, g=−0.213, P=.28). Finally, web-based mindfulness interventions improved quality of life and functioning in the total sample (n=591, g=0.362, P=.02) in the anxiety disorder subgroup (n=370, g=0.550, P=.02) and mindfulness skills in the total clinical sample (n=251, g=0.724, P<.001).

Conclusions

Results support the effectiveness of web-based mindfulness interventions in reducing depression and anxiety and in enhancing quality of life and mindfulness skills, particularly in those with clinical anxiety. Results should be interpreted with caution given the high heterogeneity of web-based mindfulness interventions and the low number of studies included.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6231788/

 

Improve Response Inhibition to Quit Smoking with Mindfulness

Improve Response Inhibition to Quit Smoking with Mindfulness

 

By John M. de Castro, Ph.D.

 

mindfulness home practice significantly predicted reduced smoking behavior, even after controlling for initial craving and cigarette use. In fact, every day the participants meditated meant 1.2 fewer cigarettes, and every day they were mindful with their cravings and in everyday activities meant 1.52 fewer cigarettes.” – Mayo Clinic

 

“Tobacco use remains the single largest preventable cause of death and disease in the United States.” (Centers for Disease Control and Prevention). So, treating nicotine addiction and producing smoking cessation could greatly improve health. But smoking has proved devilishly difficult to treat. There are a wide variety of methods and strategies to quit smoking which are to only a very limited extent effective. According to the National Institutes of Health, about 40% of smokers who want to quit make a serious attempt to do so each year, but fewer than 5% actually succeed. Most people require three or four failed attempts before being successful.

 

One problem is that nicotine is one of the most addictive substances known and withdrawal from nicotine is very stressful, producing many physical and psychological problems, including negative emotional states and depression. In essence, the addict feels miserable without the nicotine. This promotes relapse to relieve the discomfort. Better methods to quit which can not only promote quitting but also prevent relapse are badly needed. Mindfulness practices have been found to be helpful in treating addictions, including nicotine addiction, and reducing the risk of relapse. In order to quit smoking, the addict must learn to withhold responding to smoking related cues. That is the smoker must be better able to inhibit the smoking response.

 

In today’s Research News article “Effects of a brief mindfulness-meditation intervention on neural measures of response inhibition in cigarette smokers.” (See summary below or view the full text of the study at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5784955/ ), Andreu and colleagues explore a possible mechanism by which mindfulness may affect smoking cessation; improved response inhibition. This is the ability to stop or withhold a behavior that may be highly motivated. Obviously, smoking is strongly motivated and a behavior that is very hard to stop or withhold.

 

They recruited adult smokers and exposed them to a cigarette and either provided them with a recorded mindfulness instruction or were told to cope with their urge to smoke in any way they could. They then had the Electroencephalogram (EEG) recorded while performing a smoking go/no-go task in which they pushed a button each time a picture was presented with a particularly colored frame on a computer screen and did not press the button when the picture had a different colored frame. The pictures were either smoking related or neutral. The go-no-go task is a standard test for response inhibition.

 

They found that there were no significant differences between the error rates or response speeds between the mindfulness or no instruction groups on the go/no-go task. But there were differences in the EEG. During the task the changes in the electrical activity that occur in response to the pictures was recorded. These event-related potentials or ERPs are the fluctuations of the signal after specific periods of time which are thought to measure different aspects of the nervous system’s processing of the stimulus. The P3 response in the evoked potential (ERP) is a positive going electrical response occurring between a 3 to 5 tenths of a second following the target stimulus presentation. These responses were significantly larger with the smoking related than neutral pictures. Importantly, the mindfulness instruction group had significantly smaller P3 responses on the no-go trials than the no-instruction group.

 

The P3 component is thought to reflect response inhibition. The lower P3 response after mindfulness instruction suggests that mindfulness reduces the effort needed to withhold a response when needed (no-go trials). By paying closer attention in the present moment, detection of the no-go stimulus may be enhanced making it easier to withhold responding. Hence, the results suggest that mindfulness improves response inhibition in smokers. This may be, in part, the mechanism by which mindfulness training improves smoking cessation and reduces relapse. It makes it easier to not respond to smoking related situation with smoking.

 

So, improve response inhibition to quit smoking with mindfulness.

 

mindfulness training may actually target the addictive loop, breaking the relationship between craving and smoking and resulting in greater smoking cessation.” – Lori Pbert

 

CMCS – Center for Mindfulness and Contemplative Studies

 

This and other Contemplative Studies posts are also available on Google+ https://plus.google.com/106784388191201299496/posts and on Twitter @MindfulResearch

 

Study Summary

 

Andreu, C. I., Cosmelli, D., Slagter, H. A., & Franken, I. (2018). Effects of a brief mindfulness-meditation intervention on neural measures of response inhibition in cigarette smokers. PloS one, 13(1), e0191661. doi:10.1371/journal.pone.0191661

 

Abstract

Research suggests that mindfulness-practices may aid smoking cessation. Yet, the neural mechanisms underlying the effects of mindfulness-practices on smoking are unclear. Response inhibition is a main deficit in addiction, is associated with relapse, and could therefore be a candidate target for mindfulness-based practices. The current study hence investigated the effects of a brief mindfulness-practice on response inhibition in smokers using behavioral and electroencephalography (EEG) measures. Fifty participants (33 females, mean age 20 years old) underwent a protocol of cigarette exposure to induce craving (cue-exposure) and were then randomly assigned to a group receiving mindfulness-instructions or control-instructions (for 15 minutes approximately). Immediately after this, they performed a smoking Go/NoGo task, while their brain activity was recorded. At the behavioral level, no group differences were observed. However, EEG analyses revealed a decrease in P3 amplitude during NoGo vs. Go trials in the mindfulness versus control group. The lower P3 amplitude might indicate less-effortful response inhibition after the mindfulness-practice, and suggest that enhanced response inhibition underlies observed positive effects of mindfulness on smoking behavior.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5784955/

 

Competition for Attention is Responsible for Fluctuations in Mindfulness

Competition for Attention is Responsible for Fluctuations in Mindfulness

 

By John M. de Castro, Ph.D.

 

With so many stimuli competing for attention, any hope for making it through the day without our brains feeling like scrambled eggs rests on being more conscious of how you parse attention over specific tasks.” – Jeremy Hunter

 

One of the primary effects of mindfulness training is an improvement in the ability to pay attention to the task at hand and ignore interfering stimuli. This is an important consequence of mindfulness training and produces improvements in thinking, reasoning, and creativity. The importance of heightened attentional ability to the individual’s ability to navigate the demands of complex modern life cannot be overstated. It helps at work, in relationships, in coping with emotion laden situations, or simply driving a car.

 

Attention can be a double-edged sword in relation to mindfulness. In daily life there is a barrage of stimuli vying for attention. Many can draw away our focus on the present moment. Hence, outside events can disrupt mindfulness. Unfortunately, little is known regarding the effects of everyday events to distract from mindfulness.

 

In today’s Research News article “Explaining Variations in Mindfulness Levels in Daily Life.” (See summary below or view the full text of the study at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6244631/ ), Suelmann and colleagues recruited adults with active mindfulness practices for a 7 to 10 day experience sampling. Five times per day the participants received a signal on their smartphones at random times that prompted them to answer questions on their smartphones. The brief questionnaire asked the participants to indicate their state of mindful awareness and non-reactivity, intention to be mindful, threat to mindfulness, social interaction, fatigue, business, and good feeling.

 

They found that most participants answered the questions within 3 minutes of receiving the signal. They found that mindfulness levels fluctuated often during the day with no correlation of mindfulness at one moment with mindfulness in the next sampled moment. They also found, not surprisingly, that mindfulness was higher when there was an intention to be mindful and when they felt good and lower when they were busy, when they were fatigued, and when they were involved in a social interaction.

 

These are interesting results that in many ways are not surprising. Everyone who practices mindfulness recognizes that mindfulness changes from moment to moment particularly in response to the environment including social interactions and business. But this study is a wonderful attempt to begin to study the factors that influence mindfulness on a moment-to-moment basis. This could lead to a better understanding of how to promote mindfulness, decrease distractibility from mindfulness, and recover it once lost. These understandings could lead to new mindfulness training programs that had heightened effectiveness, maintaining mindfulness in busy and social contexts where mindfulness may be particularly important.

 

The results demonstrate that competition for attention is responsible for fluctuations in mindfulness.

 

If left to its own devices, our human mind habitually wanders away from the present moment. When we’re not in the here and now, we dwell in the past, grasping and replaying it, or we project into the future, trying to anticipate the unknown (and often catastrophizing) These habitual thought patterns don’t serve our ultimate well-being.” – Jennifer Wolkin

 

CMCS – Center for Mindfulness and Contemplative Studies

 

This and other Contemplative Studies posts are also available on Google+ https://plus.google.com/106784388191201299496/posts and on Twitter @MindfulResearch

 

Study Summary

Suelmann, H., Brouwers, A., & Snippe, E. (2018). Explaining Variations in Mindfulness Levels in Daily Life. Mindfulness, 9(6), 1895–1906.

 

Abstract

Despite the apparent benefits of being mindful, people are often not very mindful. There seem to be forces that drive people toward as well as away from mindfulness. These forces are conceptualised in terms of competition for scarce attentional resources. To explore these forces and to test this framework, an experience sampling study was performed among people with an explicit intention to be mindful and an ongoing practice to examine concurrent associations between state mindfulness and daily life experiences that may affect it. Participants (N = 29, 1012 observations) filled out questions on momentary experiences at semi-random intervals, five times a day, over a period of 7 to 10 days. Predictors of within-person variations in awareness of Present Moment Experience (PME) and non-reactivity to PME were examined using multilevel analyses. Participants were more aware of PME when they had an activated intention to be mindful and when they felt good, and not very busy or hurried, and were not involved in social interaction. They were more reactive to PME when they experienced unpleasant affect, and when they were hurried or tired. An activated intention to be mindful was also associated with an increased tendency to analyse PME. Experiencing threat was associated with increased reactivity, but not with decreased awareness. Our study generally supports the idea that competition for attention can be a fruitful framework to describe mechanisms behind being or not being mindful.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6244631/

 

Improve Psychological Health with Online Mindfulness Training

Improve Psychological Health with Online Mindfulness Training

 

By John M. de Castro, Ph.D.

 

“The research is strong for mindfulness’ positive impact in certain areas of mental health, including stress reduction, emotion and attention regulation, reduced rumination, for reducing mild to moderate depression and anxiety, and preventing depressive relapse.” – Kelle Walsh

 

Mindfulness training has been shown through extensive research to be effective in improving physical and psychological health and particularly with the physical and psychological reactions to stress. The vast majority of the mindfulness training techniques, however, require a certified trained therapist. This results in costs that many clients can’t afford. In addition, the participants must be available to attend multiple sessions at particular scheduled times that may or may not be compatible with their busy schedules and at locations that may not be convenient. As an alternative, online mindfulness training programs have been developed. These have tremendous advantages in decreasing costs, making training schedules much more flexible, and eliminating the need to go repeatedly to specific locations. There is evidence that mindfulness programs delivered online can be quite effective. But there is a need to further investigate the effectiveness of these programs as an alternative to face-to-face trainings.

 

In today’s Research News article “The Effects of an Online Mindfulness Intervention on Perceived Stress, Depression and Anxiety in a Non-clinical Sample: A Randomised Waitlist Control Trial.” (See summary below or view the full text of the study at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6244637/ ), Querstet and colleagues recruited adult participants online and randomly assigned them to either a wait-list control condition or to receive a 4-week online mindfulness course. The course was implemented with audio and video components and required about 2 hours each week and additional homework. The participants were measured before and after the training for mindfulness, perceived stress, anxiety, and depression. After the wait-list controls completed their mindfulness training they completed follow-up measures at 3 and 6 months after the training.

 

They found that in comparison to the wait-list controls, the participants who received mindfulness training had significant reductions in perceived stress, anxiety, and depression. There were also significant increases in mindfulness including the observing, describing, acting with awareness, and non-judging facets. These effects were sustained 3 and 6 months after the completion of training. They also found that the decreases in perceived stress, anxiety, and depression, produced by the intervention were mediated by the increases in the non-judging facet of mindfulness. The effect on depression was also meditated by the describing facet of mindfulness.

 

It is interesting that the facet of mindfulness that appeared to have the greatest impact on the psychological health of the participants was non-judging. Hence, being able to be aware of varied experiences simply as experiences and not judging them is a key to improved psychological well-being. This makes sense as most of the things that happen to an individual are not under their control. What can be controlled are the reactions to the experiences. These are best accomplished if they can be seen as not good or bad, important or trivial, or due to some personal characteristic, but simply as they are.

 

The results add to the accumulating evidence that mindfulness can be trained online and that it produces similar benefits as face-to-face training. This is very important as this makes mindfulness training inexpensive and available to a very large population regardless of schedule and location. This makes it possible to bring the benefits of mindfulness training, promoting psychological health and well-being, to a wide audience.

 

So, improve psychological health with online mindfulness training.

 

“Mindfulness helps to train individuals in bringing back the attention time and time again when it has wandered. And it is precisely through helping individuals to not get carried away by their thoughts that mindfulness has been shown to be so effective for conditions like anxiety and depression.” – Carolyn Gregoire

 

CMCS – Center for Mindfulness and Contemplative Studies

 

This and other Contemplative Studies posts are also available on Google+ https://plus.google.com/106784388191201299496/posts and on Twitter @MindfulResearch

 

Study Summary

Querstret, D., Cropley, M., & Fife-Schaw, C. (2018). The Effects of an Online Mindfulness Intervention on Perceived Stress, Depression and Anxiety in a Non-clinical Sample: A Randomised Waitlist Control Trial. Mindfulness, 9(6), 1825–1836.

 

Abstract

Mindfulness interventions have been shown to be effective for health and wellbeing, and delivering mindfulness programmes online may increase accessibility and reduce waiting times and associated costs; however, research assessing the effectiveness of online interventions is lacking. We sought to: (1) assess the effects of an online mindfulness intervention on perceived stress, depression and anxiety; (2) assess different facets of mindfulness (i.e. acting with awareness, describing, non-judging and non-reacting) as mechanisms of change and (3) assess whether the effect of the intervention was maintained over time. The sample was comprised of 118 adults (female, n = 95) drawn from the general population. Using a randomised waitlist control design, participants were randomised to either an intervention (INT) or waitlist control (WLC) group. Participants completed the online intervention, with the WLC group starting after a 6-week waitlist period. Participants completed measures of depression (PHQ-9), anxiety (GAD-7) and perceived stress (PSS-10) at baseline, post-treatment, 3- and 6-month follow-up. Participants who completed the mindfulness intervention (n = 60) reported significantly lower levels of perceived stress (d = − 1.25 [− 1.64, − 0.85]), anxiety (d = − 1.09 [− 1.47, − 0.98]) and depression (d = − 1.06 [− 1.44, − 0.67]), when compared with waitlist control participants (n = 58), and these effects were maintained at follow-up. The effect of the intervention was primarily explained by increased levels of non-judging. This study provides support for online mindfulness interventions and furthers our understanding with regards to how mindfulness interventions exert their positive effects.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6244637/

 

Decrease Suicide Ideation with Skills Learned in Dialectical Behavior Therapy

Decrease Suicide Ideation with Skills Learned in Dialectical Behavior Therapy

 

By John M. de Castro, Ph.D.

 

“DBT provided me with a rubric for figuring out what was causing my anxiety, anger or sadness, and new options for how to behave in light of it. Once a week, for the last two-and-a-half years, I’ve attended a DBT group and learned a set of skills that have been nothing short of transformative.” – Will Lippincott

 

Borderline Personality Disorder (BPD) is a very serious mental illness that is estimated to affect 1.6% of the U.S. population. It involves unstable moods, behavior, and relationships, problems with regulating emotions and thoughts, impulsive and reckless behavior, and unstable relationships. BPD is associated with high rates of co-occurring depression, anxiety disorders, substance abuse, eating disorders, self-harm, suicidal behaviors, and completed suicides. Needless to say, it is widespread and debilitating.

 

One of the few treatments that appears to be effective for Borderline Personality Disorder (BPD) is Dialectical Behavior Therapy (DBT). It is targeted at changing the problem behaviors characteristic of BPD including self-injury. Behavior change is accomplished through focusing on changing the thoughts and emotions that precede problem behaviors, as well as by solving the problems faced by individuals that contribute to problematic thoughts, feelings and behaviors. In DBT five core skills are practiced; mindfulness, distress tolerance, emotion regulation, the middle path, and interpersonal effectiveness. How important it is for the patients to be successful in the development and employment of these skills is unknown.

 

In today’s Research News article “Suicidal Ideation and Skill Use During In-patient Dialectical Behavior Therapy for Borderline Personality Disorder. A Diary Card Study.” (See summary below or view the full text of the study at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5920639/ ), Probst and colleagues recruited patients diagnosed with Borderline Personality Disorder (BPD) and provided them with a 5-week program of Dialectical Behavior Therapy (DBT). The patients completed diary entries after each treatment day with ratings of their levels of suicide ideation and their use of the five core skills of DBT.

 

They found that the patients used skills and found them useful on 80% of treatment days. They found that the patients who had successful skill use on most days had greater reductions in suicide ideation than less successful patients. In addition, on days where skill use was successful there were lower levels of suicide ideation. Hence, successful employment of the five core skills of DBT appears to be very important for progress in therapy.

 

During the course of therapy, the BPD patient is encouraged to practice and use the five core skills; mindfulness, distress tolerance, emotion regulation, the middle path, and interpersonal effectiveness. If they are successful in using these skills, suicidal thoughts appear to diminish. This emphasizes the importance of stressing skill development and use during Dialectical Behavior Therapy (DBT) treatment for Borderline Personality Disorder (BPD) as it can influence the effectiveness of treatment.

 

So, decrease suicide ideation with skills learned in Dialectical Behavior Therapy.

 

“A variety of dialectical behavioral therapy (DBT) interventions can reduce suicidal behavior in women with borderline personality disorder (BPD), but skills training is a “necessary component” of any intervention.” – Megan Brooks

 

CMCS – Center for Mindfulness and Contemplative Studies

 

This and other Contemplative Studies posts are also available on Google+ https://plus.google.com/106784388191201299496/posts and on Twitter @MindfulResearch

 

Study Summary

Probst, T., Decker, V., Kießling, E., Meyer, S., Bofinger, C., Niklewski, G., Mühlberger, A., … Pieh, C. (2018). Suicidal Ideation and Skill Use During In-patient Dialectical Behavior Therapy for Borderline Personality Disorder. A Diary Card Study. Frontiers in psychiatry, 9, 152. doi:10.3389/fpsyt.2018.00152

 

Abstract

Associations between suicidal ideation and skill use were investigated during in-patient dialectical behavior therapy (DBT) for borderline personality disorder (BPD). Participants were N = 44 patients with BPD undergoing a 5-week in-patient DBT program in a psychiatric clinic. They filled in a diary card each treatment day resulting in 1,334 skill use ratings and 1,364 suicidal ideation ratings. Treatment days were categorized as days with successful skill use (using skills and perceiving them as effective), days with no skill use, days with unsuccessful skill use (using skills but perceiving them as ineffective). Multilevel models were performed to account for the nested data structure. The results showed that suicidal ideation improved more for patients who applied skills successfully more often during treatment (p < 0.05). Moreover, suicidal ideation was lower on treatment days with successful skill use compared to treatment days with no skill use and compared to treatment days with unsuccessful skill use (p < 0.05). When treatment days with no skill use were compared to treatment days with unsuccessful skill use, suicidal ideation was higher on treatment days with unsuccessful skill use (p < 0.05). To conclude, using skills successfully on as many treatment days as possible is associated with lower suicidal ideation

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5920639/

 

Improve Health Anxiety with Online Acceptance and Commitment Therapy

Improve Health Anxiety with Online Acceptance and Commitment Therapy

 

By John M. de Castro, Ph.D.

 

Most of us care about our health but for up to 5% of people, worrying about health has become a significant problem in itself. Severe health anxiety, or hypochondriasis, is said to exist when someone holds a strong fear of having a serious disease, despite all medical assurances to the contrary.” – Fabio Fuchelli

 

Anxiety disorders are the most common mental illness in the United States, affecting 40 million adults, or 18% of the population. A characterizing feature of anxiety disorders is that the suffer overly identifies with and personalizes their thoughts. The sufferer has recurring thoughts, such as impending disaster, that they may realize are unreasonable, but are unable to shake. Health anxiety is a fear of a serious illness can interfere with their daily life. It often leads to seeking unnecessary testing and to spend days consumed by worry. Health anxiety is a relatively common condition, affecting 4% to 5% of both men and women equally.

 

Anxiety disorders have generally been treated with drugs. But there are considerable side effects and these drugs are often abused. There are a number of psychological therapies for anxiety. But, about 45% of the patients treated do not respond to the therapy. So, there is a need to develop alternative treatments. Recently, it has been found that mindfulness training can be effective for anxiety disorders.

 

A therapeutic technique that contains mindfulness training is Acceptance and Commitment Therapy (ACT). It is a mindfulness-based psychotherapy technique that is employs many of the techniques of Cognitive Behavioral Therapy (CBT) and has also been shown to relieve anxietyACT focuses on the individual’s thoughts, feelings, and behavior and how they interact to impact their psychological and physical well-being. It then works to change thinking to alter the interaction and produce greater life satisfaction. ACT employs mindfulness practices to increase awareness and develop an attitude of acceptance and compassion in the presence of painful thoughts and feelings. Additionally, ACT helps people strengthen aspects of cognition such as in committing to valued living. ACT teaches individuals to “just notice”, accept and embrace private experiences and focus on behavioral responses that produce more desirable outcomes.

 

Acceptance and Commitment Therapy (ACT), however, requires a certified trained therapist. This results in costs that many clients can’t afford. In addition, the participants must be available to attend multiple sessions at particular scheduled times that may or may not be compatible with their busy schedules and at locations that may not be convenient. As an alternative, mindfulness-based treatments delivered over the internet have been developed. These have tremendous advantages in decreasing costs, making training schedules much more flexible, and eliminating the need to go repeatedly to specific locations. But the question arises as to the effectiveness of these internet applications in inducing mindfulness and improving psychological health.

 

In today’s Research News article “Development and Feasibility Testing of Internet-Delivered Acceptance and Commitment Therapy for Severe Health Anxiety: Pilot Study.” (See summary below or view the full text of the study at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5938695/ ), Hoffman and colleagues examine the acceptability and effectiveness of an internet-based Acceptance and Commitment Therapy (ACT) module applied to the treatment of Health Anxiety Disorder. They recruited participants who expressed symptoms of Health Anxiety Disorder and delivered 7 once-a-week online modules of ACT including 10-15 pages of textual instructions, videos, and home exercises. The participants were measured before and after treatment and 3 months later for health anxiety, depression, anxiety, health related quality of life, life satisfaction, and psychological flexibility.

 

They found that 80% of the participants completed the program. The participants found the internet format acceptable and some commented that it produced less anxiety working on this at home instead of a hospital or clinic. They found that after treatment there were significant decreases in health anxiety, depression, and anxiety and significant increases in life satisfaction and psychological flexibility. These effects were maintained at the 3-month follow-up. Hence the internet-based Acceptance and Commitment Therapy (ACT) was acceptable to patients and produced lasting benefits in reducing health anxiety and improving psychological health.

 

This study did not have a comparable control condition and as such has to be seen as a pilot feasibility study. A randomized clinical trial is needed to verify the results. But the present findings are encouraging and suggest that a large controlled study is warranted. The development of an effective online version of ACT would be particularly significant as it would markedly open up accessibility of this therapy to a much wider patient population, reduce costs, and improve outcomes.

 

So, improve health anxiety with online Acceptance and Commitment Therapy.

 

“mindfulness allows us to interrupt automatic, reflexive fight, flight, or freeze reactions—reactions that can lead to anxiety, fear, foreboding, and worry.” – Bob Stahl

 

CMCS – Center for Mindfulness and Contemplative Studies

 

This and other Contemplative Studies posts are also available on Google+ https://plus.google.com/106784388191201299496/posts and on Twitter @MindfulResearch

 

Study Summary

Hoffmann, D., Rask, C. U., Hedman-Lagerlöf, E., Ljótsson, B., & Frostholm, L. (2018). Development and Feasibility Testing of Internet-Delivered Acceptance and Commitment Therapy for Severe Health Anxiety: Pilot Study. JMIR mental health, 5(2), e28. doi:10.2196/mental.9198

 

Abstract

Background

Severe health anxiety (hypochondriasis), or illness anxiety disorder according to the Diagnostic and Statistical Manual of Mental Disorders, 5th edition, is characterized by preoccupation with fear of suffering from a serious illness in spite of medical reassurance. It is a debilitating, prevalent disorder associated with increased health care utilization. Still, there is a lack of easily accessible specialized treatment for severe health anxiety.

Objective

The aims of this paper were to (1) describe the development and setup of a new internet-delivered acceptance and commitment therapy (iACT) program for patients with severe health anxiety using self-referral and a video-based assessment; and (2) examine the feasibility and potential clinical efficacy of iACT for severe health anxiety.

Methods

Self-referred patients (N=15) with severe health anxiety were diagnostically assessed by a video-based interview. They received 7 sessions of clinician-supported iACT comprising self-help texts, video clips, audio files, and worksheets over 12 weeks. Self-report questionnaires were obtained at baseline, post-treatment, and at 3-month follow-up. The primary outcome was Whiteley-7 Index (WI-7) measuring health anxiety severity. Depressive symptoms, health-related quality of life (HRQoL), life satisfaction, and psychological flexibility were also assessed. A within-group design was employed. Means, standard deviations, and effect sizes using the standardized response mean (SRM) were estimated. Post-treatment interviews were conducted to evaluate the patient experience of the usability and acceptability of the treatment setup and program.

Results

The self-referral and video-based assessments were well received. Most patients (12/15, 80%) completed the treatment, and only 1 (1/15, 7%) dropped out. Post-treatment (14/15, 93%) and 3-month follow-up (12/15, 80%) data were available for almost all patients. Paired t tests showed significant improvements on all outcome measures both at post-treatment and 3-month follow-up, except on one physical component subscale of HRQoL. Health anxiety symptoms decreased with 33.9 points at 3-month follow-up (95% CI 13.6-54.3, t11= 3.66, P=.004) with a large within-group effect size of 1.06 as measured by the SRM.

Conclusions

Treatment adherence and potential efficacy suggest that iACT may be a feasible treatment for health anxiety. The uncontrolled design and small sample size of the study limited the robustness of the findings. Therefore, the findings should be replicated in a randomized controlled trial. Potentially, iACT may increase availability and accessibility of specialized treatment for health anxiety.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5938695/

 

Improve the Physical and Psychological State of the Elderly with Qigong Exercise

Improve the Physical and Psychological State of the Elderly with Qigong Exercise

 

By John M. de Castro, Ph.D.

 

Qi Gong is an excellent form of exercise for Seniors because of its gentle and soothing nature, anyone can do Qi Gong, regardless of age, ability, flexibility, or activity level! It is also significantly effective in improving balance, relieving pain, encouraging mobility and reducing stress.” – Exercise to heal

 

The aging process involves a systematic progressive decline in every system in the body, the brain included. This includes our mental abilities (cognition) which decline with age including impairments in memory, attention, and problem solving ability. It is inevitable and cannot be avoided. An encouraging new development is that mindfulness practices such as meditation training can significantly reduce these declines in cognitive ability. In addition, it has been found that mindfulness practices reduce the deterioration of the brain that occurs with aging restraining the loss of neural tissue.

 

Qigong is gentle and safe mindfulness practice. It is appropriate for all ages including the elderly and for individuals with illnesses that limit their activities or range of motion. It is inexpensive to administer, can be performed in groups or alone, at home or in a facility, and can be quickly learned. In addition, it can be practiced in social groups. This can make it fun, improving the likelihood of long-term engagement in the practice. So, Qigong practice would appear to be an almost ideal gentle mindfulness training and light exercise to improve physical and psychological health in aging individuals.

 

In today’s Research News article “Acute Physiological and Psychological Effects of Qigong Exercise in Older Practitioners.” (See summary below or view the full text of the study at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5902057/ ), Lin and colleagues recruited practitioners of Chinese Bioenergy Qigong who were between the ages of 50 to 70 years. They were measured before and after a Qigong practice session for skin conduction, heart rate, anxiety, and overall health.

 

They found that after the single Qigong practice session there was a significant increase in skin conductance and heart rate and a significant decrease in anxiety. This suggests that there was an improvement in cardiovascular function and the practitioners psychological state after a single session of Qigong practice.

 

This study was a simple pre post comparison of the physical and psychological state of aging experienced practitioners after a single Qigong practice session. As such conclusions are severely limited. But, they do provide a glimpse at the short-term effects of Qigong practice that may underlie its long-term effectiveness. Indeed, the observed acute effects are in line with those observed over the long term, with Qigong practice improving cardiovascular function and the psychological state after practicing over a number of months. These effects are particularly important for the health and well-being of aging populations.

 

So, improve the physical and psychological state of the elderly with Qigong exercise.

 

qigong exercise helps the body to heal itself. In this sense, qigong is a natural anti-aging medicine.” – Qigong Institute

 

CMCS – Center for Mindfulness and Contemplative Studies

 

This and other Contemplative Studies posts are also available on Google+ https://plus.google.com/106784388191201299496/posts and on Twitter @MindfulResearch

 

Study Summary

 

Lin, C. Y., Wei, T. T., Wang, C. C., Chen, W. C., Wang, Y. M., & Tsai, S. Y. (2018). Acute Physiological and Psychological Effects of Qigong Exercise in Older Practitioners. Evidence-based complementary and alternative medicine : eCAM, 2018, 4960978. doi:10.1155/2018/4960978

 

Abstract

Qigong is a gentle exercise that promotes health and well-being. This study evaluated the acute physiological and psychological effects of one session of qigong exercise in older practitioners. A total of 45 participants (mean age, 65.14 years) were recruited. Meridian electrical conductance, State-Trait Anxiety Inventory (STAI), heart rate variability (HRV), and Short Form 36 (SF-36) were evaluated and compared before and after one session of qigong exercise. The results revealed that the electrical conductance of all meridians, except spleen and bladder meridians, increased significantly (p < 0.05). Compared with baseline values, upper to lower body ratio and sympathetic/vagal index were significantly improved and closer to 1 (p = 0.011 and p = 0.007, resp.). STAI-S and STAI-T scores decreased significantly (p < 0.001 and p = 0.001, resp.). The RR interval of HRV decreased significantly (p = 0.035), a significant positive correlation was observed between kidney meridian electrical conductance and SF-36 physical scores (r = 0.74, p = 0.018), and a positive correlation was observed between pericardium meridian electrical conductance and SF-36 mental scores (r = 0.50, p = 0.06). In conclusion, one session of qigong exercise increased meridian electrical conductance, reduced anxiety, and improved body and autonomic nervous system balance. These findings provide scientific evidence for acute physiological and psychological effects of qigong exercise in older practitioners.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5902057/

 

Improve Schizophrenia Symptoms with Yoga

Improve Schizophrenia Symptoms with Yoga

 

By John M. de Castro, Ph.D.

 

Using a combination of asanas (poses and stretches) and pranayama (systematic breathing practices), yoga can help you achieve a state of focus and relaxation that makes it easier to shine a lens on the nature of your thoughts. Understanding this nature and how it affects and distorts your reality is a key part of treating schizophrenia and helping you realize just how much it’s affecting your life and the relationships that you have with others.” – Tyler Dabel

 

Schizophrenia is the most common form of psychosis. Its effects about 1% of the population worldwide. It appears to be highly heritable and involves changes in the brain. It is characterized by both positive and negative symptoms. Positive symptoms include hallucinations; seeing and, in some cases, feeling, smelling or tasting things that aren’t there, or delusions; unshakable beliefs that, when examined rationally, are obviously untrue. Negative symptoms include a reduced ability to function normally, neglect of personal hygiene, lack of emotion, blank facial expressions, speaking in a monotone, loss of interest in everyday activities, social withdrawal, an inability to experience pleasure, and a lack of insight into their symptoms. The symptoms of schizophrenia usually do not appear until late adolescence or early adulthood.

 

Schizophrenia is very difficult to treat with psychotherapy and is usually treated with antipsychotic drugs. These drugs, however, are not always effective, sometimes lose effectiveness, and can have some difficult side effects. Mindfulness training has been shown to be beneficial for a variety of mental health problems, including psychosis. Mindfulness has also been shown to associated with lower symptom severity of schizophrenia. Yoga is a mindfulness practice that has been shown to improve the symptoms of schizophrenia. Hence it is important to further investigate the effectiveness of yoga practice for the treatment of schizophrenia.

 

In today’s Research News article “Add-on Yoga Therapy for Social Cognition in Schizophrenia: A Pilot Study.” (See summary below or view the full text of the study at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6134743/ ), Govindaraj and colleagues performed an uncontrolled pilot study of yoga practice for the treatment of schizophrenia. They recruited schizophrenia patients who were stabilized on antipsychotic medications and provided for them 20, 1-hour, yoga sessions over 6 weeks. The practice consisted of poses, breathing practices, and chanting. They were measured before and after treatment for positive and negative symptoms of schizophrenia, social disability, and social cognition.

 

They found that after the 6 weeks of yoga practice there were significant reductions in both positive and negative symptoms of schizophrenia and in social disability, and significant increases in social cognition. This was an uncontrolled pilot study, so conclusions must be tempered, But the results are encouraging and support the potential application of yoga practice for the treatment of the symptoms of schizophrenia. They provide the support needed to launch a large randomized controlled trial to firmly establish whether yoga practice may be a beneficial add-on treatment for schizophrenia.

 

So, improve schizophrenia symptoms with yoga.

 

“yoga has significant benefits to those diagnosed with schizophrenia. The effects of yoga therapy are multifaceted, including reduction of psychotic symptoms and depression, improving cognition, increasing quality of life, and producing neurobiological changes, such as increased oxytocin levels.” – Namita Nayyar

 

CMCS – Center for Mindfulness and Contemplative Studies

 

This and other Contemplative Studies posts are also available on Google+ https://plus.google.com/106784388191201299496/posts and on Twitter @MindfulResearch

 

Study Summary

Govindaraj, R., Naik, S., Manjunath, N. K., Mehta, U. M., Gangadhar, B. N., & Varambally, S. (2018). Add-on Yoga Therapy for Social Cognition in Schizophrenia: A Pilot Study. International journal of yoga, 11(3), 242-244.

 

Abstract

Background:

Yoga as a mind–body therapy is useful in lifestyle-related disorders including neuropsychiatric disorders. In schizophrenia patients, yoga has been shown to significantly improve negative symptoms, functioning, and plasma oxytocin level.

Aim:

The aim of the study was to study the effect of add-on yoga therapy on social cognition in schizophrenia patients.

Materials and Methods:

In a single pre-post, study design, 15 schizophrenia patients stabilized on antipsychotic medication for 6 weeks were assessed for social cognition (theory of mind, facial emotion recognition, and social perception [SP]) and clinical symptoms (negative and positive symptoms and social disability) before and after twenty sessions of add-on yoga therapy.

Results:

There was a significant improvement in the social cognition composite score after 20 sessions of yoga (t[13] = −5.37, P ≤ 0.001). Clinical symptoms also reduced significantly after twenty sessions of yoga.

Conclusion:

Results are promising to integrate yoga in clinical practice, if proven in well-controlled clinical trials.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6134743/

 

Improve Irritable Bowel Syndrome (IBS) with Mindfulness

Improve Irritable Bowel Syndrome (IBS) with Mindfulness

 

By John M. de Castro, Ph.D.

 

“IBS causes a huge public health and economic burden in the U.S. The standard of care currently has been diet changes along with medications. A mind-based . . . has the potential to minimize both the public health and economic burden of this debilitating disease,” – Saurabh Sethi

 

Irritable bowel syndrome (IBS) is the most common functional gastrointestinal (GI) disorder with worldwide prevalence rates ranging from 9–23%. In the U.S. the rates generally in the area of 10–15% affecting between 25 and 45 million people. IBS is not life threatening but it is very uncomfortable producing changes in bowel movement patterns, bloating and excess gas, and pain in the lower belly. It is also a major source of absenteeism both at work and in school. IBS is also associated with a marked reduction in the individual’s health quality of life, with disruption of the physical, psychological and social routines of the individuals. At present, there are no known cures for IBS and treatments involve symptomatic relief, often with fairly radical dietary changes.

 

The cause(s) of IBS are not known. But emotion dysregulation is suspected to be involved. It is clear that psychological stress exacerbates the illnesses and anxiety amplifies the symptoms. This suggests that mindfulness or the lack thereof may be involved as mindfulness is known to be helpful in reducing the psychological and physical responses to stress and mindfulness is known to improve emotion regulation. In addition, It has been shown that meditation and yoga can help relieve IBS symptoms.  So, it would make sense to further investigate the effectiveness of mindfulness training and emotion regulation for Irritable Bowel Syndrome (IBS).

 

In today’s Research News article “Comparing the Efficacy of Mindfulness-Based Stress Reduction Therapy with Emotion Regulation Treatment on Quality of Life and Symptoms of Irritable Bowel Syndrome.” (See summary below or view the full text of the study at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6178327/ ), Ghandi and colleagues recruited patients with Irritable Bowel Syndrome (IBS) and randomly assigned them to receive either an 8-week, once a week for 90 minutes program of Mindfulness Based Stress Reduction (MBSR), Emotion Regulation group training, or a wait-list. The MBSR treatment consisted of body scan, meditation, and yoga practices and group discussion with homework. Emotion Regulation training consisted in training on “emotional awareness” and “acceptance”. The patients were measured before and after training and 2 months later for IBS severity and quality of life with IBS.

 

They found that both Mindfulness Based Stress Reduction (MBSR) and Emotion Regulation training produced significant improvements in IBS severity and the quality of life with IBS and that this effectiveness was maintained 2 months later. There were no significant differences in the effectiveness of MBSR and emotion regulation training. Hence, both MBSR and emotion regulation training produce large and lasting improvements in the symptoms of IBS and the quality of life of the patients.

 

Since MBSR training is known to improve emotion regulation, the fact that MBSR and emotion regulation training produced equivalent benefits suggests that MBSR may be effective for IBS because of its ability to improve emotion regulation, particularly improving the emotional responses to stress. It will require further research to examine this possibility.

 

So, improve Irritable Bowel Syndrome (IBS) with mindfulness.

 

“For a person who has IBS, mindfulness-based therapies are thought to help to reduce anxiety related to digestive symptoms. Due to our body’s natural stress response, such anxiety can actually exacerbate the very digestive symptoms that a person with IBS is most concerned about. The theory behind mindfulness-based therapies for IBS is that when you experience less reactivity to physical sensations related to your digestive system, you will experience less unwanted symptoms.” – Barbara Bolen

 

CMCS – Center for Mindfulness and Contemplative Studies

 

This and other Contemplative Studies posts are also available on Google+ https://plus.google.com/106784388191201299496/posts and on Twitter @MindfulResearch

 

Study Summary

Abstract

 

Ghandi, F., Sadeghi, A., Bakhtyari, M., Imani, S., Abdi, S., & Banihashem, S. S. (2018). Comparing the Efficacy of Mindfulness-Based Stress Reduction Therapy with Emotion Regulation Treatment on Quality of Life and Symptoms of Irritable Bowel Syndrome. Iranian journal of psychiatry, 13(3), 175-183.

 

Objective: Irritable bowel syndrome is a common gastrointestinal disorder. The perception of stress and GI-specific anxiety play a key role in irritable bowel syndrome (IBS). The present study aims at comparing the efficacy of mindfulness-based stress reduction therapy with emotion regulation on the quality of life and severity in patients IBS.

Method : This randomized clinical trial was conducted in 3 phases: pretest, posttest, and follow-up. Follow-up was performed 2 months after the last intervention. The study population consisted of 24 IBS patients who were randomly selected according to Rome-IV Criteria and were then divided into 3 eight-member groups: (1) mindfulness-based stress reduction, (2) emotion regulation, and (3) control group. IBS-QOL34 and IBS-SSS were administered as assessment tools to all the 3 groups. The experimental groups were subjected to MBSR and ER psychotherapy, while the control group received no psychological intervention. After the 2-month follow-up, the 3 groups were evaluated again.

Results: The results revealed that MBSR improved the quality of life of IBS patients and dicreased severity of their condition. The findings of between and within subjects design revealed that the difference between MBSR and control groups was significant in IBS at follow-up (p = 0.01).

Conclusion: MBSR could be considered as a new, effective, and stable method in psychotherapy, in irritable bowel syndrome.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6178327/

 

Mindfulness Improves the Symptoms of Post-Traumatic Stress Disorder (PTSD) by Altering Gene Expression

Mindfulness Improves the Symptoms of Post-Traumatic Stress Disorder (PTSD) by Altering Gene Expression

 

By John M. de Castro, Ph.D.

 

“Mindfulness has been shown to be an effective stress reduction practices in general, but there may be other ways it works for people with PTSD as well. Recent research suggests that mindfulness may help to mitigate the relationship between maladaptive thinking and posttraumatic distress.” – Matthew Tull

 

Experiencing trauma is quite common. It has been estimated that 60% of men and 50% of women will experience a significant traumatic event during their lifetime. But only a fraction will develop Post-Traumatic Stress Disorder (PTSD). But this still results in a frightening number of people with 7%-8% of the population developing PTSD at some point in their life.

 

PTSD involves a number of troubling symptoms including reliving the event with the same fear and horror in nightmares or with a flashback. PTSD sufferers avoid situations that remind them of the event this may include crowds, driving, movies, etc. and may avoid seeking help because it keeps them from having to think or talk about the event. They often experience negative changes in beliefs and feelings including difficulty experiencing positive or loving feelings toward other people, avoiding relationships, memory difficulties, or see the world as dangerous and no one can be trusted. Sufferers may feel hyperarousal, feeling keyed up and jittery, or always alert and on the lookout for danger. They may experience sudden anger or irritability, may have a hard time sleeping or concentrating, may be startled by a loud noise or surprise.

 

Obviously, these are troubling symptoms that need to be addressed. There are a number of therapies that have been developed to treat PTSD. One of which, mindfulness training has been found to be particularly effectiveMindfulness Based Stress Reduction (MBSR) has been found to improve PTSD symptoms. It has been shown that mindfulness practices can alter the brain structures and connectivity and this may underlie the beneficial effects of mindfulness on PTSD. These alterations probably involve changes in the chemistry of the brain particularly with systems associated with stress and depression.

 

In today’s Research News article “Methylation of FKBP5 and SLC6A4 in Relation to Treatment Response to Mindfulness Based Stress Reduction for Posttraumatic Stress Disorder.” (See summary below or view the full text of the study at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6153325/ ), Bishop and colleagues examine the activation of genes associated with stress and depression in patients with PTSD who responded and did not respond to treatment with Mindfulness Based Stress Reduction (MBSR), They examined patients from a previous study of the effectiveness of MBSR for the treatment of PTSD who showed a significant reduction in PTSD symptoms and those that did not. The MBSR treatment consisted of body scan, meditation, and yoga practices and group discussion and occurred in 9 weekly, 2.5 hour sessions. with homework. Blood samples were drawn before and after treatment. They measured the degree of methylation of genes in the he promoter region of SLC6A4 previously associated with depression risk and symptoms and genes in the FKBP5 Intron 7 region identified as a functional regulator of glucocorticoid signaling.

 

They found that after Mindfulness Based Stress Reduction (MBSR) treatment there was a significant reduction in methylation of genes in the FKBP5 Intron 7 region in responders but an increase in non-responders. These genes are associated with stress related responding. Methylation tends to suppress gene expression, So, decreased methylation indicates an increased level of activity in stress related hormonal pathways.

 

These findings are interesting but not surprising as MBSR was developed specifically to improve stress responses. It is interesting that only patients who responded to treatment had this change to the genes underlying stress responding. So, it appears that MBSR is effective for PTSD symptoms but only if it changes stress related gene expression. It will be interesting to examine in the future the factors that result in non-responders being resistant to treatment with MBSR.

 

So, improve the symptoms of post-traumatic stress disorder (PTSD) by altering gene expression with mindfulness.

 

Many people cope with trauma by distancing themselves from the sensations in their bodies and minds (the most extreme example of this is dissociation). Therefore, bringing one’s attention deliberately back to the body can unzip trauma symptoms they may not be prepared to address. However, mindfulness meditation can be helpful to those with PTSD and a history of trauma when practiced under the guidance of a mental healthcare provider and modified to be better suited for trauma survivors.” – Julia Ozog

 

CMCS – Center for Mindfulness and Contemplative Studies

 

This and other Contemplative Studies posts are also available on Google+ https://plus.google.com/106784388191201299496/posts and on Twitter @MindfulResearch

 

Study Summary

Bishop, J. R., Lee, A. M., Mills, L. J., Thuras, P. D., Eum, S., Clancy, D., Erbes, C. R., Polusny, M. A., Lamberty, G. J., … Lim, K. O. (2018). Methylation of FKBP5 and SLC6A4 in Relation to Treatment Response to Mindfulness Based Stress Reduction for Posttraumatic Stress Disorder. Frontiers in psychiatry, 9, 418. doi:10.3389/fpsyt.2018.00418

 

Abstract

Mindfulness Based Stress Reduction (MBSR) is an effective non-pharmacologic treatment for veterans with PTSD. Extensive work has identified epigenetic factors related to PTSD disease risk and pathophysiology, but how these factors influence treatment response is unclear. Serotonin signaling and hypothalamic-pituitary-adrenal (HPA) axis functioning may be perturbed in PTSD and are molecular pathways targeted by PTSD treatments. To identify potential biomarkers for treatment response, we utilized genomic DNA isolated from peripheral blood samples from veterans with PTSD who were responders (n = 11) or non-responders (n = 11) to MBSR as part of a clinical trial. We assessed methylation levels at CpG sites in regions of the serotonin transporter (SLC6A4) previously associated with expression and depression outcomes, as well as the Intron 7 region of the FK506 binding protein 5 (FKBP5) containing known glucocorticoid response elements suggested to regulate this gene. Selected subjects were matched across MBSR responder status by baseline symptoms, age, sex, current smoking status, and current antidepressant use. Percent methylation was compared between responders and non-responders at baseline (pre-MBSR treatment). Additionally, percent change in methylation from baseline to post-treatment was compared between responders and non-responders. There was a significant time x responder group interaction for methylation in FKBP5 intron 7 bin 2 [F(1, 19) = 7.492, p = 0.013] whereby responders had a decrease in methylation and non-responders had an increase in methylation from before to after treatment in this region. Analyses of the three CpG sites within bin 2 revealed a significant time x responder group interaction for CpG_35558513 [F(1, 19) = 5.551, p = 0.029] which resides in a known glucocorticoid response element (GRE). Decreases in FKBP5 methylation after treatment in responders as compared to increases in non-responders suggest that effective meditation intervention may be associated with stress-related pathways at the molecular level. These preliminary findings suggest that DNA methylation signatures within FKBP5 are potential indicators of response to meditation treatment in PTSD and require validation in larger cohorts.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6153325/